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Leukemia & Lymphoma Volume 64, 2023 - Issue 11
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Letters to the Editor

Impact of corticosteroids on efficacy of BCMA targeted CAR-T therapy in multiple myeloma

Eva Duvalyana School of Medicine, University of California, San Francisco, CA, USAORCID Iconhttps://orcid.org/0009-0005-5132-6750View further author information
ORCID Icon,
Nina Shahb Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USAView further author information
,
Mimi Loc Department of Pharmaceutical Services, University of California, San Francisco, CA, USAView further author information
,
Thomas Martin IIIb Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USAView further author information
,
Jeffrey L. Wolfb Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USACorrespondence[email protected]
View further author information
,
Alfred Chungb Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USAView further author information
,
Shagun Arorab Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USAView further author information
,
Chiung-Yu Huangd Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USAView further author information
&
Sandy W. Wongb Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USAView further author information
 show all
Pages 1888-1891 | Received 18 May 2023, Accepted 20 Jul 2023, Published online: 21 Aug 2023

References

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  • Topp M, van Meerten T, Houot R, et al. Earlier steroid use with axicabtagene ciloleucel (Axi-Cel) in patients with relapsed/refractory large B cell lymphoma. Blood. 2019;134(Suppl_1):243–243. doi:10.1182/blood-2019-126081
  • Strati P, Ahmed S, Furqan F, et al. Prognostic impact of corticosteroids on efficacy of chimeric antigen receptor T-cell therapy in large B-cell lymphoma. Blood. 2021;137(23):3272–3276. doi:10.1182/blood.2020008865
  • Gardner RA, Ceppi F, Rivers J, et al. Preemptive mitigation of CD19 CAR T-cell cytokine release syndrome without attenuation of antileukemic efficacy. Blood. 2019;134(24):2149–2158. doi:10.1182/blood.2019001463
  • Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 2014;6(224):224ra25. doi:10.1126/scitranslmed.3008226
  • Liu S, Deng B, Yin Z, et al. Corticosteroids do not influence the efficacy and kinetics of CAR-T cells for B-cell acute lymphoblastic leukemia. Blood Cancer J. 2020;10(2):15. doi:10.1038/s41408-020-0280-y
  • Kumar S, Paiva B, Anderson KC, et al. International myeloma working group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016;17(8):e328–e346. doi:10.1016/S1470-2045(16)30206-6
  • Brookmeyer R, Crowley J. A confidence interval for the median survival time. Biometrics. 1982;38(1):29–41. http://www.jstor.org/stable/2530286 doi:10.2307/2530286

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