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Original Articles

Consecutive day dosing of high-dose cytarabine consolidation over 3 days is resource-efficient and safe in older adult patients with acute myeloid leukemia

ORCID Icon, , , , & ORCID Icon
Pages 2123-2132 | Received 18 Apr 2023, Accepted 15 Aug 2023, Published online: 01 Sep 2023

References

  • Roloff GW, Odenike O, Bajel A, et al. Contemporary approach to acute myeloid leukemia therapy in 2022. Am Soc Clin Oncol Educ Book. 2022; 42:1–16. doi:10.1200/EDBK_349605
  • Mayer RJ, Davis RB, Schiffer CA, et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and leukemia group B. N Engl J Med. 1994;331(14):896–903. doi:10.1056/NEJM199410063311402
  • Schaich M, Röllig C, Soucek S, et al. Cytarabine dose of 36 g/m2 compared with 12 g/m2 within first consolidation in acute myeloid leukemia: results of patients enrolled onto the prospective randomized AML96 study. J Clin Oncol. 2011;29(19):2696–2702. doi:10.1200/JCO.2010.33.7303
  • Löwenberg B, Pabst T, Vellenga E, et al. Cytarabine dose for acute myeloid leukemia. N Engl J Med. 2011;364(11):1027–1036. doi:10.1056/NEJMoa1010222
  • Löwenberg B. Sense and nonsense of high-dose cytarabine for acute myeloid leukemia. Blood. 2013;121(1):26–28. doi:10.1182/blood-2012-07-444851
  • Dumas PY, Bertoli S, Bérard E, et al. Delivering HDAC over 3 or 5 days as consolidation in AML impacts health care resource consumption but not outcome. Blood Adv. 2020;4(16):3840–3849. doi:10.1182/bloodadvances.2020002511
  • Miyawaki S, Ohtake S, Fujisawa S, et al. A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 study. Blood. 2011;117(8):2366–2372. doi:10.1182/blood-2010-07-295279
  • Jaramillo S, Benner A, Krauter J, et al. Condensed versus standard schedule of high-dose cytarabine consolidation therapy with pegfilgrastim growth factor support in acute myeloid leukemia. Blood Cancer J. 2017;7(5):e564–e564. doi:10.1038/bcj.2017.45
  • Schlenk RF. Post-remission therapy for acute myeloid leukemia. Haematologica. 2014;99(11):1663–1670. doi:10.3324/haematol.2014.114611
  • Burnett AK, Russell NH, Hills RK, et al. Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial. J Clin Oncol. 2013;31(27):3360–3368. doi:10.1200/JCO.2012.47.4874
  • Sperr WR, Piribauer M, Wimazal F, et al. A novel effective and safe consolidation for patients over 60 years with acute myeloid leukemia: intermediate dose cytarabine (2 x 1 g/m2 on days 1, 3, and 5). Clin Cancer Res. 2004;10(12 Pt 1):3965–3971. doi:10.1158/1078-0432.CCR-04-0185
  • Grimwade D, Walker H, Oliver F, et al. The medical research council adult and children’s leukaemia working parties. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 1998;92(7):2322–2333. doi:10.1182/blood.V92.7.2322
  • Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022;140(12):1345–1377. doi:10.1182/blood.2022016867
  • Lykon J, Madarang E, Nguyen N, et al. Use of high dose cytarabine (HiDAC) for post-remission or re-induction therapy is safe and effective in select older AML patients. Blood. 2021;138(Supplement 1):4422–4422. doi:10.1182/blood-2021-153143
  • Gonen C, Celik I, Cetinkaya YS, et al. Cytarabine-induced fever complicating the clinical course of leukemia. Anticancer Drugs. 2005;16(1):59–62. doi:10.1097/00001813-200501000-00008

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