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Original Articles

Phase 1 study of selinexor in combination with salvage chemotherapy in Adults with relapsed or refractory Acute myeloid leukemia

, , , , , , , , , , , , , , , & show all
Pages 2091-2100 | Received 19 May 2023, Accepted 22 Aug 2023, Published online: 04 Sep 2023

References

  • Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–1152. doi:10.1056/NEJMra1406184
  • Christian S, Arain S, Patel P, et al. A multi-institutional comparison of mitoxantrone, etoposide, and cytarabine vs high-dose cytarabine and mitoxantrone therapy for patients with relapsed or refractory acute myeloid leukemia. Am J Hematol. 2020;95(8):937–943. doi:10.1002/ajh.25838
  • Kohrt HE, Patel S, Ho M, et al. Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experience. Am J Hematol. 2010;85(11):877–881. doi:10.1002/ajh.21857
  • Megías-Vericat JE, Martínez-Cuadrón D, Sanz M, et al. Salvage regimens using conventional chemotherapy agents for relapsed/refractory adult AML patients: a systematic literature review. Ann Hematol. 2018;97(7):1115–1153. doi:10.1007/s00277-018-3304-y
  • Park H, Youk J, Kim I, et al. Comparison of cladribine- and fludarabine-based induction chemotherapy in relapsed or refractory acute myeloid leukaemia. Ann Hematol. 2016;95(11):1777–1786. doi:10.1007/s00277-016-2774-z
  • Price SL, Lancet JE, George TJ, et al. Salvage chemotherapy regimens for acute myeloid leukemia: is one better? Efficacy comparison between CLAG and MEC regimens. Leuk Res. 2011;35(3):301–304. doi:10.1016/j.leukres.2010.09.002
  • Scheckel CJ, Meyer M, Betcher JA, et al. Efficacy of mitoxantrone-based salvage therapies in relapsed or refractory acute myeloid leukemia in the Mayo clinic cancer center: analysis of survival after ‘CLAG-M’ vs. ‘MEC. Leuk Res. 2020;90:106300. doi:10.1016/j.leukres.2020.106300
  • Stommel JM, Marchenko ND, Jimenez GS, et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. Embo J. 1999;18(6):1660–1672. doi:10.1093/emboj/18.6.1660
  • Turner JG, Sullivan DM. CRM1-mediated nuclear export of proteins and drug resistance in cancer. Curr Med Chem. 2008;15(26):2648–2655. doi:10.2174/092986708786242859
  • Siddiqui N, Borden KL. mRNA export and cancer. Wiley Interdiscip Rev RNA. 2012;3(1):13–25. doi:10.1002/wrna.101
  • Etchin J, Sun Q, Kentsis A, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013;27(1):66–74. doi:10.1038/leu.2012.219
  • Lapalombella R, Sun Q, Williams K, et al. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood. 2012;120(23):4621–4634. doi:10.1182/blood-2012-05-429506
  • Ranganathan P, Yu X, Na C, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012;120(9):1765–1773. doi:10.1182/blood-2012-04-423160
  • Walker CJ, Oaks JJ, Santhanam R, et al. Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph + leukemias. Blood. 2013;122(17):3034–3044. doi:10.1182/blood-2013-04-495374
  • Kojima K, Kornblau SM, Ruvolo V, et al. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood. 2013;121(20):4166–4174. doi:10.1182/blood-2012-08-447581
  • Garzon R, Savona M, Baz R, et al. A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia. Blood. 2017;129(24):3165–3174. doi:10.1182/blood-2016-11-750158
  • Bhatnagar B, Zhao Q, Mims AS, et al. Selinexor in combination with decitabine in patients with acute myeloid leukemia: results from a phase 1 study. Leuk Lymphoma. 2020;61(2):387–396. doi:10.1080/10428194.2019.1665664
  • Ranganathan P, Kashyap T, Yu X, et al. XPO1 inhibition using selinexor synergizes with chemotherapy in acute myeloid leukemia by targeting DNA repair and restoring topoisomerase IIα to the nucleus. Clin Cancer Res. 2016;22(24):6142–6152. doi:10.1158/1078-0432.CCR-15-2885
  • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol. 2003;21(24):4642–4649. doi:10.1200/JCO.2003.04.036
  • Bader JC, Abdul Razak AR, Shacham S, et al. Pharmacokinetics of selinexor: the first-in-class selective inhibitor of nuclear export. Clin Pharmacokinet. 2021;60(8):957–969. doi:10.1007/s40262-021-01016-y
  • Marconi G, Talami A, Abbenante MC, et al. Mitoxantrone, etoposide and cytarabine (MEC) can induce deep complete remission and is an effective bridge therapy to allotransplantation (SCT) in refractory/relapsed acute myeloid leukemia (AML) patients. Blood. 2018;132(Supplement 1):4036–4036. doi:10.1182/blood-2018-99-113036
  • Greenberg PL, Lee SJ, Advani R, et al. Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995). J Clin Oncol. 2004;22(6):1078–1086. doi:10.1200/JCO.2004.07.048
  • Fiedler W, Heuser M, Chromik J, et al. Phase II results of Ara-C and idarubicin in combination with the selective inhibitor of nuclear export (SINE) compound selinexor (KPT-330) in patients with relapsed or refractory AML. Blood. 2016;128(22):341–341. doi:10.1182/blood.V128.22.341.341
  • Abboud R, Chendamarai E, Rettig MP, et al. Selinexor combined with cladribine, cytarabine, and filgrastim in relapsed or refractory acute myeloid leukemia. Haematologica. 2020;105(8):e404–e407. doi:10.3324/haematol.2019.236810
  • Martínez Sánchez MP, Megías-Vericat JE, Rodríguez-Veiga R, et al. A phase I trial of selinexor plus FLAG-Ida for the treatment of refractory/relapsed adult acute myeloid leukemia patients. Ann Hematol. 2021;100(6):1497–1508. doi:10.1007/s00277-021-04542-8

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