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Leukemia & Lymphoma Volume 65, 2024 - Issue 4
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Letters to the Editor

Drug sensitivity profiling identifies potential therapies for myeloid neoplasm with eosinophilia driven by a novel G3BP1-PDGFRB fusion gene

Jianli Wanga Department of Internal Medicine, Hebei North University, Zhangjiakou, ChinaView further author information
,
Lei Xub Department of Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-3573-8334View further author information
ORCID Icon,
Yuqing Lib Department of Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China;c Graduate School of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Jun Wangb Department of Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Yangliu Shaob Department of Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China;c Graduate School of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Weifeng Laid Suzhou Geekgene Technology Co. Ltd., Beijing, ChinaView further author information
,
Jun Yongd Suzhou Geekgene Technology Co. Ltd., Beijing, ChinaView further author information
,
Ling Zhaoe Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Xuemin Weie Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Chunji Gaoe Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Daihong Liue Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Xiaoning Gaob Department of Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Yongqing Zhanga Department of Internal Medicine, Hebei North University, Zhangjiakou, China;e Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected]
View further author information
 show all
Pages 521-525 | Received 06 Sep 2023, Accepted 20 Dec 2023, Published online: 29 Dec 2023

References

  • Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022;36(7):1703–1719. doi:10.1038/s41375-022-01613-1
  • Golub TR, Barker GF, Lovett M, et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77(2):307–316. doi:10.1016/0092-8674(94)90322-0
  • Reiter A, Gotlib J. Myeloid neoplasms with eosinophilia. Blood. 2017;129(6):704–714. doi:10.1182/blood-2016-10-695973
  • Gotlib J. World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management. Am J Hematol. 2017;92(11):1243–1259. doi:10.1002/ajh.24880
  • Jan M, Grinshpun DE, Villalba JA, et al. A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia. Blood Adv. 2020;4(3):445–448. doi:10.1182/bloodadvances.2019001182
  • Jawhar M, Naumann N, Schwaab J, et al. Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase. Ann Hematol. 2017;96(9):1463–1470. doi:10.1007/s00277-017-3067-x
  • Reid SE, Patel SA. Myocarditis, kidney injury, and hypereosinophilia: FIP1L1-PDGFRA-positive myeloid/lymphoid neoplasm with eosinophilia. Blood. 2021;138(12):1086–1086. doi:10.1182/blood.2021011930
  • Cheah CY, Burbury K, Apperley JF, et al. Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib. Blood. 2014;123(23):3574–3577. doi:10.1182/blood-2014-02-555607

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