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Pairing obinutuzumab with venetoclax in relapsed CLL

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Pages 543-545 | Received 20 Feb 2024, Accepted 21 Feb 2024, Published online: 18 Mar 2024

References

  • Seymour JF, Kipps TJ, Eichhorst B, et al. Venetoclax-rituximab in relapsed or refractory chronic lymphocytic leukemia. N Engl J Med. 2018;378(12):1107–1120. doi:10.1056/NEJMoa1713976
  • Fischer K, Al-Sawaf O, Bahlo J, et al. Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. N Engl J Med. 2019;380(23):2225–2236. doi:10.1056/NEJMoa1815281
  • Eichhorst B, Niemann CU, Kater AP, et al. First-line venetoclax combinations in chronic lymphocytic leukemia. N Engl J Med. 2023;388(19):1739–1754. doi:10.1056/NEJMoa2213093
  • Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101–1110. doi:10.1056/NEJMoa1313984
  • Lei MM, Sorial MN, Lou U, et al. Real-world evidence of obinutuzumab and venetoclax in previously treated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. Leuk Lymphoma. 2024;1–7. doi:10.1080/10428194.2024.2310144
  • Jones JA, Mato AR, Wierda WG, et al. Venetoclax for chronic lymphocytic leukaemia progressing after ibrutinib: an interim analysis of a multicentre, open-label, phase 2 trial. Lancet Oncol. 2018;19(1):65–75. doi:10.1016/S1470-2045(17)30909-9
  • Lew TE, Bennett R, Lin VS, et al. Venetoclax-rituximab is active in patients with BTKi-exposed CLL, but durable treatment-free remissions are uncommon. Blood Adv. 2024, PMID 38231032.
  • Hampel PRK, Wang K, Kenderian S, et al. Clinical outcomes in patients with chronic lymphocytic leukemia (CLL) treated with Veneto-clax-based regimens. Leukemia Lymphoma 2023;64(sup1):1.

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