Adhesion to Bone Marrow Stroma Inhibits Apoptosis of Chronic Lymphocytic Leukemia Cells

References

• Dameshek W. Chronic lymphocytic leukemia: an accumulative disease of immunologically incompetent lymphocytes. Blood 1967; 29: 566–72
   PubMed Web of Science ®Google Scholar
• Andreeff M, Darzynkiewicz Z, Sharpless T, Clarkson B D, Melamed M R. Discrimination of human leukemia subtype by flow cytometric analysis of cellular DNA and RNA. Blood 1980; 55: 282–93
   PubMed Web of Science ®Google Scholar
• Hoffbrand A V, Panayiotidis P, Reittie J, Ganeshaguru K. Autocrine and paracrine growth loops in chronic lymphocytic leukemia. Semin Hematol 1993; 30: 306–17
   PubMed Web of Science ®Google Scholar
• Hanada M, Delia D, Aiello A, Stadtmauer E, Reed J C. Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993; 82: 1820–28
   PubMed Web of Science ®Google Scholar
• Collins R J, Verschuur L A, Harmon B V, Prentice R L, Pape J H, Kerr J F R. Spontaneous programmed cell death (apoptosis) of B-chronic lymphocytic leukemia cells following their culture in vitro. Br J Haematol 1989; 71: 343–50
   PubMed Web of Science ®Google Scholar
• McConkey D J, Aguilar-Santelises M, Hartzell P, Reiksson I, Mellstedt H, Ouenius S, Jondal M. Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells. J Immunol 1991; 146: 1072–76
   PubMed Web of Science ®Google Scholar
• Long B W, Witte P L, Abraham G N, Gregory S A, Plate J M D. Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells. Proc Natl Acad Sci USA 1995; 92: 1416–20
   PubMed Web of Science ®Google Scholar
• Jewell A P, Yong K L. Regulation and function of adhesion molecules in B-cell chronic lymphocytic leukemia. Acta Haematol 1997; 97: 67–72
   PubMed Web of Science ®Google Scholar
• Kincade P W, Lee G, Pietrangeli C E, Hayashi S, Gimble J M. Cells and molecules that regulate B lymphopoiesis in bone marrow. Annu Rev Immunol 1990; 7: 111–43
   Web of Science ®Google Scholar
• Manabe A, Murti K G, Coustan-Smith E, Kumagai M, Behm F G, Raimondi S C, Campana D. Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 1994; 83: 758–66
   PubMed Web of Science ®Google Scholar
• Mainou-Fowler T, Prentice A G. Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma 1996; 21: 369–77
   PubMed Web of Science ®Google Scholar
• Tangye S G, Raison R L. Leukemic CD5+ B cell apoptosis coincidence of cell death and DNA fragmentation with reduced bcl-2 expression. Br J Haematol 1996; 92: 950–953
   PubMed Web of Science ®Google Scholar
• Lagneaux L, Delforge A, Bernier M, Stryckmans P, Bron D. TGF-β activity and expression of its receptors in B-cell chronic lymphocytic leukemia. Leuk Lymphoma 1998; 31: 99–106
   PubMed Web of Science ®Google Scholar
• Nowell P C, Moore J S. Aberrant responses of human lymphocytic neoplasms to cytokine regulation. Immunol Res 1998; 17: 171–7
   PubMed Web of Science ®Google Scholar
• Patrick C W, Jr., Smith T W, McIntire L V, Juneja H S. Cellular interactions among marrow stromal and normal/neoplastic pre-B and B-lymphoblastic cells. Leuk Lymphoma 1996; 22: 205–19
   PubMed Web of Science ®Google Scholar
• Lagneaux L, Delforge A, Bron D, De Bruyn C, Stryckmans P. Chronic lymphocytic leukemic B-cells but not normal B-cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 1998; 91: 1–11
   PubMedGoogle Scholar
• Nicoletti I, Migliorati G, Ragliacci M C, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271–9
   PubMed Web of Science ®Google Scholar
• Koopman G, Reutelingsperger C P M, Kuijten G A M, Keehnen R M J, Pals S T, De Oers M H J. Annexin-V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415–20
   PubMed Web of Science ®Google Scholar
• Bendall L J, Kortlepel K, Gottlieb D J. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta 1 and beta-2 integrin mechanisms. Blood 1993; 82: 3125–32
   PubMed Web of Science ®Google Scholar
• Panayiotidis P, Jones K, Ganeshaguru K, Foroni L, Hoffbrand A V. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol 1996; 92: 97–103
   PubMed Web of Science ®Google Scholar
• Buske C, Gogowski G, Schreiber K, Rave-Frank M, Hiddemann W, Wörmann B. Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies and the soluble CD40 ligand. Exp Hematol 1997; 25: 329–37
   PubMed Web of Science ®Google Scholar
• Korsmeyer S J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992; 80: 879–86
   PubMed Web of Science ®Google Scholar
• Tangye S G, Raison R L. Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bcl-2. Immunol Cell Biol 1997; 75: 127–35
   PubMed Web of Science ®Google Scholar
• Dancescu M, Rubio-Trujillo M, Biron G, Bron D, Delespesse G, Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl 2 expression. J Exp Med 1992; 176: 1319–26
   PubMed Web of Science ®Google Scholar
• Takuchi H, Katayama I. Surface phenotype and adhesion activity of B-cell chronic lymphoid leukemia. Leuk Lymphoma 1993; 10: 209–16
   PubMed Web of Science ®Google Scholar
• Eksioglu-Demiralp E, Alpdogan O, Aktan M, Firalti T, Oztürk A, Budak T, Bayik M, Akoglu T. Variable expression of CD49d antigen in B cell chronic lymphocytic leukemia is related to disease stages. Leukemia 1996; 10: 1331–9
   PubMed Web of Science ®Google Scholar
• De Rossi G, Zarcone D, Mauro F, Cerruti G, Tenca C, Puccetti A, Mandelli F, Grossi C E. Adhesion molecule expression on B cell chronic lymphocytic leukemia cells: malignant cell phenotypes define distinct disease subsets. Blood 1993; 81: 2679–87
   PubMed Web of Science ®Google Scholar
• Vincent A M, Cawley J C, Borthem J. Integrin function in chronic lymphocytic leukemia. Blood 1996; 87: 4780–8
   PubMed Web of Science ®Google Scholar
• Scott G, Cassidy L, Busacco A. Fibronectin suppresses apoptosis in normal human melanocytes through an integrin-dependent mechanism. J Invest Dermatol 1997; 108: 147–53
   PubMed Web of Science ®Google Scholar
• Texeido J, Hemler M, Greenberger J S, Anklesaria P. Role of β1 and β2 integrins in the adhesion of human CD34 HI stem cells to bone marrow. J Clin Invest 1992; 90: 358–67
   PubMed Web of Science ®Google Scholar
• Bendall L J, Kortlepel K, Gottlieb D J. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of β1 and β2 integrin mechanisms. Blood 1993; 82: 3125–32
   PubMed Web of Science ®Google Scholar
• Koopman G, Keehnen R Mj, Lindhout E, Newman W, Schimizu Y, Seventer G A, de Groot C, Pals S T. Adhesion through the LFA-1 (CD 11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) patwhays prevents apoptosis of germinal center B cells. J Immunol 1994; 152: 3760–7
   PubMed Web of Science ®Google Scholar
• Tretter T, Schuler M, Schneller F, Brass V, Esswein M, Aman J, Huber C, Peschel C. Direct cellular interaction with activated CD4+ T cells overcomes hyporesponsiveness of B-cell chronic lymphocytic leukemia in vitro. Cell Immunol 1998; 189: 41–50
   PubMed Web of Science ®Google Scholar