Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats

References

• Ali YF, Desouky OS, Selim NS, Ereiba KM. 2015. Assessment of the role of α-lipoic acid against the oxidative stress of induced iron overload. J Rad Res Appl Sci. 8:26–35.
   Web of Science ®Google Scholar
• Barnett LMA, Cummings BS. 2018. Nephrotoxicity and renal pathophysiology: a contemporary perspective. Toxicol Sci. 164:379–390.
   PubMed Web of Science ®Google Scholar
• Bonventre JV, Zuk A. 2004. Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66:480–485.
   PubMed Web of Science ®Google Scholar
• Camiolo G, Tibullo D, Giallongo C, Romano A, Parrinello NL, Musumeci G, Di Rosa M, Vicario N, Brundo MV, Amenta F, Ferrante M, Copat C, Avola R, Volti GL, Salvaggio A, Raimondo FD, Palumbo GA. 2019. α-Lipoic acid reduces iron induced toxicity and oxidative stress in a model of ıron overload. Int J Mol Sci. 20:E609. doi:10.3390/ijms20030609
   PubMed Web of Science ®Google Scholar
• Cavdar Z, Ozbal S, Celik A, Ergur BU, Guneli E, Ural C, Camsari T, Guner GA. 2014. The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. Biotech Histochem. 89:304–314.
   PubMed Web of Science ®Google Scholar
• Cavdar Z, Oktan MA, Ural C, Calisir M, Kocak A, Heybeli C, Yildiz S, Arici A, Ellidokuz H, Celik A, Yilmaz O, Sarioglu S, Cavdar C. 2020. Reno-protective effects of alpha lipoic acid on iron overload-induced kidney injury in rats by suppressing NADPH oxidase 4 and p38 MAPK signaling. Biol Trace Elem Res. 193:483–493.
   PubMed Web of Science ®Google Scholar
• Chomczynski P. 1993. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins rom cell and tissue samples. Biotechniques. 15:532–534.
   PubMed Web of Science ®Google Scholar
• Choudhary GS, Al-Harbi S, Almasan A. 2015. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol Biol. 1219:1–9.
   PubMedGoogle Scholar
• Clegg MS, Keen CL, Lönnerdal B, Hurley LS. 1981. Influence of ashing techniques on the analysis of trace elements in animal tissue. I. Wet ashing. Biol Trace Elem Res. 3:107–115.
   PubMed Web of Science ®Google Scholar
• de Souza AJ, Oak JS, Jordanhazy R, DeKruyff RH, Fruman DA, Kane LP. 2008. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J Immunol. 180:6518–6526.
   PubMed Web of Science ®Google Scholar
• Ergur BU, Cilaker Micili S, Yilmaz O, Akokay P. 2015. The effects of α-lipoic acid on aortic injury and hypertension in the rat remnant kidney (5/6 nephrectomy) model. Anatol J Cardiol. 15:443–449.
   PubMed Web of Science ®Google Scholar
• Galaris D, Pantopoulos K. 2008. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci. 45:1–23.
   PubMed Web of Science ®Google Scholar
• Gill PS, Wilcox CS. 2006. NADPH oxidases in the kidney. Antiox Redox Sign. 810:1597–1607.
   Google Scholar
• Gorąca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B. 2011. Lipoic acid-biological activity and therapeutic potential. Pharmacol Rep. 63:849–858.
   PubMed Web of Science ®Google Scholar
• Gravesen E, Hofman-Bang J, Mace ML, Lewin E, Olgaard K. 2013. High dose intravenous iron, mineral homeostasis and intact FGF23 in normal and uremic rats. BMC Nephrol. 14:1–8. doi:10.1186/1471-2369-14-281
   PubMed Web of Science ®Google Scholar
• Guo C, Yuan H, He Z. 2012. Melamine causes apoptosis of rat kidney epithelial cell line (NRK-52e cells) via excessive intracellular ROS (reactive oxygen species) and the activation of p38 MAPK pathway. Cell Biol Int. 36:383–389.
   PubMed Web of Science ®Google Scholar
• Ikeda Y, Enomoto H, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. 2013. Dietary iron restriction inhibits progression of diabetic nephropathy in db/db mice. Am J Physiol Ren Physiol. 304:1028–1036.
   Web of Science ®Google Scholar
• Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T. 2014. Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction. PLoS One. 9:e89355. doi:10.1371/journal.pone.0089355
   PubMed Web of Science ®Google Scholar
• Jha JC, Gray SP, Barit D, Okabe J, El-Osta A, Namikoshi T, Thallas-Bonke V, Wingler K, Szyndralewiez C, Heitz F, Touyz RM, Cooper ME, Schmidt HHHW, Jandeleit-Dahm KA. 2014. Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in long-term diabetic nephropathy. J Am Soc Nephrol. 25:1237–1254.
   PubMed Web of Science ®Google Scholar
• Kang KP, Kim DH, Jung YJ, Lee AS, Lee S, Lee SY, Jang KY, Sung MJ, Park SK, Kim W. 2009. Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation. Nephrol Dial Transpl. 24:3012–3020.
   PubMed Web of Science ®Google Scholar
• Kurien BT, Scofield RH. 2003. Protein blotting: a review. J Immunol Methods. 274:1–15.
   PubMed Web of Science ®Google Scholar
• Li L, Frei B. 2006. Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity. Arterioscler Thromb Vasc Biol. 26:2638–2643.
   PubMed Web of Science ®Google Scholar
• Li L, Frei B. 2009. Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine. Arterioscler Thromb Vasc Biol. 29:732–738.
   PubMed Web of Science ®Google Scholar
• Ma FY, Liu J, Nikolic-Paterson DJ. 2009. The role of stress-activated protein kinase signaling in renal pathophysiology. Braz J Med Biol Res. 42:29–37.
   PubMed Web of Science ®Google Scholar
• Martines AM, Masereeuw R, Tjalsma H, Hoenderop JG, Wetzels JF, Swinkels DW. 2013. Iron metabolism in the pathogenesis of iron induced kidney injury. Nat Rev Nephrol. 9:385–398.
   PubMed Web of Science ®Google Scholar
• Murugavel P, Pari L. 2004. Attenuation of chloroquine-induced renal damage by alpha-lipoic acid: possible antioxidant mechanism. Ren Fail. 26:517–524.
   PubMed Web of Science ®Google Scholar
• Oktan MA, Heybeli C, Cavdar Z. 2019. Chronic renal failure, anemia, and parenteral iron treatment: from bench to bedside. Turk J Nephrol. 28:138–146.
   Web of Science ®Google Scholar
• Phatak P, Brissot P, Wurster M, Adams PC, Bonkovsky HL, Gross J, Malfertheiner P, McLaren GD, Niederau C, Piperno A, Powell LW, Russo MW, Stoelzel U, Stremmel W, Griffel L, Lynch N, Zhang Y, Pietrangelo A. 2010. A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis. Hepatology. 52:1671–1779.
   PubMed Web of Science ®Google Scholar
• Rajaram RD, Dissard R, Jaquet V, de Seigneux S. 2019. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrol Dial Transpl. 34:567–576.
   PubMed Web of Science ®Google Scholar
• Schmittgen TD, Livak KJ. 2008. Analyzing real-time PCR data by the comparative Ct method. Nat Protoc. 6:1101–1108.
   Google Scholar
• Sen P, Mukherjee S, Ray D, Raha S. 2003. Involvement of the Akt/PKB signaling pathway with disease processes. Mol Cell Biochem. 253:241–246.
   PubMed Web of Science ®Google Scholar
• Song J, Yu J, Prayogo GW, Cao W, Wu Y, Jia Z, Zhang A. 2019. Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology. Am J Transl Res. 11:1219–1229.
   PubMed Web of Science ®Google Scholar
• Takahashi S, Takahashi I, Sato H, Kubota Y, Yoshida S, Muramatsu Y. 2000. Determination of major and trace elements in the liver of Wistar rats by inductively coupled plasma-atomic emission spectrometry and mass spectrometry. Lab Anim. 34:97–105.
   PubMedGoogle Scholar
• Tucker PS, Scanlan AT, Dalbo VJ. 2015. Chronic kidney disease influences multiple systems: describing the relationship between oxidative stress, inflammation, kidney damage, and concomitant disease. Oxid Med Cell Longev. 2015:1–8. doi:10.1155/2015/806358
   Web of Science ®Google Scholar
• Wang J, Huang H, Liu P, Tang F, Qin J, Huang W, Chen F, Guo F, Liu W, Yang B. 2006. Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats. Eur J Pharmacol. 553:297–303.
   PubMed Web of Science ®Google Scholar
• Wiechelman KJ, Braun RD, Fitzpatrek JD. 1988. Investigation of bicinchoninic acid protein assay: identification of the groups responsible for color formation. Anal Biochem. 175:231–237.
   PubMed Web of Science ®Google Scholar
• Xie H, Li J, Gao H, Wang J, Li C, Xu Y, Liu C. 2018. Total flavone of desmodium styracifolium relieved apoptosis and autophagy of COM-induced HK-2 cells by regulating KIM-1 via p38/MAPK pathway. Mol Cell Biochem. 442:169–175.
   PubMed Web of Science ®Google Scholar
• Yang Q, Wu FR, Wang JN, Gao L, Jiang L, Li HD, Ma Q, Liu XQ, Wei B, Zhou L, Wen J, Ma TT, Li J, Meng XM. 2018. Nox4 in renal diseases: an update. Free Rad Biol Med. 124:466–472.
   PubMed Web of Science ®Google Scholar
• Ye S, Zhu Y, Ming Y, She X, Liu H, Ye Q. 2014. Glycyrrhizin protects mice against renal ischemia-reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen-activated protein kinase signaling. Exp Ther Med. 7:1247–1252.
   PubMed Web of Science ®Google Scholar
• Yildiz S, Cavdar Z, Bozkaya E, Unlu M, Ural C, Aksuner N, Cavdar C, Yilmaz O, Camsari T 2016. The investigation of the effect of lipoic acid on oxidant-antioxidant system and renal damage in rats after intravenous iron. In: proceedings of the Turkish nephrology, dialysis and transplantation journal, 33rd National Congress of Nephrology, Hypertension, Dialysis and Transplantation, Oct. 19–23; Antalya, Turkey.
   Google Scholar
• Yu X, Liu H, Zou J, Zhu J, Xu X, Ding X. 2012. Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid. Ren Fail. 34:907–914.
   PubMed Web of Science ®Google Scholar
• Zhang J, McCullough PA. 2016. Lipoic acid in the prevention of acute kidney injury. Nephron. 134:133–140.
   PubMed Web of Science ®Google Scholar