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Articles

Role of bone marrow-derived mesenchymal stem cells in alleviating pulmonary epithelium damage and extracellular matrix remodeling in a rat model of lung fibrosis induced by amiodarone

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References

  • Abreu SC, Antunes MA, Xisto DG, Cruz FF, Branco VC, Bandeira E, Zola Kitoko J, de Araújo AF, Dellatorre-Texeira L, Olsen PC, Weiss DJ, Diaz BL, Morales MM, Rocco PRM. 2017. Bone marrow, adipose, and lung tissue-derived murine mesenchymal stromal cells release different mediators and differentially affect airway and lung parenchyma in experimental asthma. Stem Cells Transl Med. 6:1557–1567. doi:10.1002/sctm.16-0398.
  • Adamson IY, Bakowska J. 1999. Relationship of keratinocyte growth factor and hepatocyte growth factor levels in rat lung lavage fluid to epithelial cell regeneration after bleomycin. Am J Pathol. 155:949–954. doi:10.1016/S0002-9440(10)65194-2.
  • Akram KM, Samad S, Spiteri MA, Forsyth NR. 2013. Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms. Resp Res. 14:1–16. doi:10.1186/1465-9921-14-9.
  • Alhadlaq A, Mao JJ. 2004. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 13:436–448. doi:10.1089/scd.2004.13.436.
  • Antoniou KM, Margaritopoulos GA, Siafakas NM. 2013. Pharmacological treatment of idiopathic pulmonary fibrosis: from the past to the future. Eur Resp Rev. 22:281–291. doi:10.1183/09059180.00002113.
  • Balakumaran A, Pawelczyk E, Ren J, Sworder B, Chaudhry A, Sabatino M, Stroncek D, Frank JA, Robey PG. 2010. Superparamagnetic iron oxide nanoparticles labeling of bone marrow stromal (mesenchymal) cells does not affect their “stemness. PLoS One. 5:e11462. doi:10.1371/journal.pone.0011462.
  • Bianco P, Cao X, Frenette PS, Mao JJ, Robey PG, Simmons PJ, Wang CY. 2013. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med. 19:35–42. doi:10.1038/nm.3028.
  • Brigstock DR. 2010. Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals. J Cell Commun Sign. 4:1–4. doi:10.1007/s12079-009-0071-5.
  • Broeckaert F, Clippe A, Knoops B, Hermans C, Bernard A. 2000. Clara cell secretory protein (CC16): features as a peripheral lung biomarker. Ann NY Acad Sci. 923:68–77. doi:10.1111/j.1749-6632.2000.tb05520.x.
  • Burdon TJ, Paul A, Noiseux N, Prakash S, Shum-Tim D. 2011. Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res. 22011:207326. doi:10.1155/2011/207326.
  • Crosby LM, Waters CM. 2010. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 298:L715–L731. doi:10.1152/ajplung.00361.2009.
  • Cruz FF, Rocco PRM. 2020. The potential of mesenchymal stem cell therapy for chronic lung disease. Exp Rev Resp Med. 14:31–39. doi:10.1080/17476348.2020.1679628.
  • Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O’Brien T, O’Toole D, Laffey JG. 2012. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 67:496–501. doi:10.1136/thoraxjnl-2011-201059.
  • De Becker A, Riet IV. 2016. Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy? World J Stem Cells. 8:73–87. doi:10.4252/wjsc.v8.i3.73.
  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. 2006. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 8:315–317. doi:10.1080/14653240600855905.
  • Farini A, Sitzia C, Erratico S, Meregalli M, Torrente Y. 2014. Clinical applications of mesenchymal stem cells in chronic diseases. Stem Cells Int. 2014:306573. doi:10.1155/2014/306573.
  • Fernandez IE, Eickelberg O. 2012. New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet. 380:680–688. doi:10.1016/S0140-6736(12)61144-1.
  • Gao J, Dennis JE, Muzic RF, Lundberg M, Caplan AI. 2001. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Org. 169:12–20. doi:10.1159/000047856.
  • Hardie WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. 2010. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 9:2769–2776. doi:10.4161/cc.9.14.12268.
  • Harrell CR, Sadikot R, Pascual J, Fellabaum C, Jankovic MG, Jovicic N, Djonov V, Arsenijevic N, Volarevic V. 2019. Mesenchymal stem cell-based therapy of inflammatory lung diseases: current understanding and future perspectives. Stem Cells Int. 2019:4236973. doi:10.1155/2019/4236973.
  • Ionescu L, Byrne RN, van Haaften T, Vadivel A, Alphonse RS, Rey-Parra GJ, Weissmann G, Hall A, Eaton F, Thébaud B. 2012. Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol. 303:L967–L977. doi:10.1152/ajplung.00144.2011.
  • Javazon EH, Beggs KJ, Flake AW. 2004. Mesenchymal stem cells: paradoxes of passaging. Exp Hematol. 32:414–425. doi:10.1016/j.exphem.2004.02.004.
  • Kennelly H, Mahon BP, English K. 2016. Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD. Sci Rep. 6:38207. doi:10.1038/srep38207.
  • King TE, Pardo A, Selman M. 2011. Idiopathic pulmonary fibrosis. Lancet. 378:1949–1961. doi:10.1016/s0140-6736(11)60052-4.
  • Kolettis TM, Agelaki MG, Baltogiannis GG, Vlahos AP, Mourouzis I, Fotopoulos A, Pantos C. 2007. Comparative effects of acute vs. chronic oral amiodarone treatment during acute myocardial infarction in rats. Europace. 9:1099–1104. doi:10.1093/europace/eum196.
  • Leask A, Abraham DJ. 2006. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci. 119:4803–4810. doi:10.1242/jcs.03270.
  • Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA. 2011. Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells. 29:913–919. doi:10.1002/stem.643.
  • Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. 2013. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Resp Crit Care Med. 187:751–760. doi:10.1164/rccm.201206-0990OC.
  • Ley B, Collard HR, King TE Jr. 2011. Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Resp Crit Care Med. 183:431–440. doi:10.1164/rccm.201006-0894CI.
  • Li F, Han F, Li H, Zhang J, Qiao X, Shi J, Yang L, Dong J, Luo M, Wei J, Liu X. 2017. Human placental mesenchymal stem cells of fetal origins-alleviated inflammation and fibrosis by attenuating MyD88 signaling in bleomycin-induced pulmonary fibrosis mice. Mol Immunol. 90:11–21. doi:10.1016/j.molimm.2017.06.032.
  • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 25:402–408. doi:10.1006/meth.2001.1262.
  • Mahmoud NS, Ahmed HH, Mohamed MR, Amr KS, Aglan HA, Ali MAM, Tantawy MA. 2020. Role of nanoparticles in osteogenic differentiation of bone marrow mesenchymal stem cells. Cytotechnology. 72:1–22. doi:10.1007/s10616-019-00353-y.
  • McAuley DF, Matthay MA. 2009. Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. Chest. 135:1408–1410. doi:10.1378/chest.09-0304.
  • Min F, Gao F, Li Q, Liu Z. 2015. Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury. Mol Med Rep. 11:2387–2396. doi:10.3892/mmr.2014.3025.
  • Mohamed MR, Emam MA, Hassan NS, Mogadem AI. 2014. Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression. Env Toxicol Pharmacol. 38:531–541. doi:10.1016/j.etap.2014.08.004.
  • Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, Ilancheran S, Boyd R, Trounson A. 2009. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol. 175:303–313. doi:10.2353/ajpath.2009.080629.
  • Moroncini G, Paolini C, Orlando F, Capelli C, Grieco A, Tonnini C, Agarbati S, Mondini E, Saccomanno S, Goteri G, Svegliati Baroni S, Provinciali M, Introna M, Del Papa N, Gabrielli A. 2018. Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice. PLoS One. 13:e0196048. doi:10.1371/journal.pone.0196048.
  • Noble PW, Barkauskas CE, Jiang D. 2012. Pulmonary fibrosis: patterns and perpetrators. J Clin Invest. 122:2756–2762. doi:10.1172/JCI60323.
  • Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. 2003. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA. 100:8407–8411. doi:10.1073/pnas.1432929100.
  • Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED. 2010. Amiodarone: review of pulmonary effects and toxicity. Drug Safe. 33:539–558. doi:10.2165/11532320-000000000-00000.
  • Parekkadan B, Milwid JM. 2010. Mesenchymal stem cells as therapeutics. Ann Rev Biomed Eng. 12:87–117. doi:10.1146/annurev-bioeng-070909-105309.
  • Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL. 2005. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Resp Cell Mol Biol. 33:145–152. doi:10.1165/rcmb.2004-0330OC.
  • Salem HK, Thiemermann C. 2010. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells. 28:585–596. doi:10.1002/stem.269.
  • Savukinas UB, Enes SR, Sjoland AA, Westergren-Thorsson G. 2016. Concise review: the bystander effect: mesenchymal stem cell-mediated lung repair. Stem Cells. 34:1437–1444. doi:10.1002/stem.2357.
  • Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP. 2007. Stem cell transplantation: the lung barrier. Transpl Proc. 39:573–576. doi:10.1016/j.transproceed.2006.12.019.
  • Shen Q, Chen B, Xiao Z, Zhao L, Xu X, Wan X, Jin M, Dai J, Dai H. 2015. Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis. Mol Med Rep. 11:2831–2837. doi:10.3892/mmr.2014.3092.
  • Sugahara K, Iyama K, Kuroda MJ, Sano K. 1998. Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats. J Pathol. 186:90–98. doi:10.1002/(SICI)1096-9896(199809)186:1<90::aid-path137>3.0.CO;2-X.
  • Tzouvelekis A, Toonkel R, Karampitsakos T, Medapalli K, Ninou I, Aidinis V, Bouros D, Glassberg MK. 2018. mesenchymal stem cells for the treatment of idiopathic pulmonary fibrosis. Front Med. 5:1–8. doi:10.3389/fmed.2018.00142.
  • van Erven L, Schalij MJ. 2010. Amiodarone: an effective antiarrhythmic drug with unusual side effects. Heart. 96:1593–1600. doi:10.1136/hrt.2008.152652.
  • Wynn TA, Ramalingam TR. 2012. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 18:1028–1040. doi:10.1038/nm.2807.
  • Xiang B, Chen L, Wang X, Zhao Y, Wang Y, Xiang C. 2017. Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury. Int J Mol Sci. 18:E689. doi:10.3390/ijms18040689.
  • Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML. 2010. Mesenchymal stem cells: mechanisms of immunomodulation and homing. Cell Transpl. 19:667–679. doi:10.3727/096368910X508762.
  • Yu SH, Liu LJ, Lv B, Che CL, Fan DP, Wang LF, Zhang YM. 2015. Inhibition of bleomycin-induced pulmonary fibrosis by bone marrow-derived mesenchymal stem cells might be mediated by decreasing MMP9, TIMP-1, INF-gamma and TGF-beta. Cell Biochem Funct. 33:356–366. doi:10.1002/cbf.3118.

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