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Articles

Effects of oxidative stress and apoptosis on vascularity and viability of perforator flaps

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References

  • Almeida KG, Oliveira RJ, Dourado DM, Filho EA, Fernandes WS, Souza AS, Araujo FHS. 2015. Morphological study of rat skin flaps treated with subcutaneous dimethyl sulfoxide combined with hyperbaric oxygen therapy. Gen Mol Res. 14:18160–18171.
  • Ayatollahi SA, Ajami M, Reyhanfard H, Asadi Y, Nassiri-Kashani M, Rashighi Firoozabadi M, Davoodi SH, Habibi E, Pazoki-Toroudi H. 2012. BCL-2 and Bax expression in skin flaps treated with finasteride or azelaic acid. Iran J Pharm Res. 11:1285–1290.
  • Aydemir I, Ş K, Tuğlu Mİ. 2018. Histological investigations on thymus of male rats prenatally exposed to bisphenol A. Chemosphere. 206:1–8. doi:https://doi.org/10.1016/j.chemosphere.2018.04.145.
  • Bali U, Gungor M, Yoleri L. 2016. Lateral thoracic artery perforator-based flap: a new experimental model. J Surg Res. 200:738–742.
  • Chehelcheraghi F, Chien S, Bayat M. 2019. Mesenchymal stem cells improve survival in ischemic diabetic random skin flap via increased angiogenesis and VEGF expression. J Cell Biochem. 120:17491–17499. doi:https://doi.org/10.1002/jcb.29013.
  • Chen GJ, Chen YH, Yang XQ, Li ZJ. 2016. Nano-microcapsule basic fibroblast growth factor combined with hypoxia-inducible factor-1 improves random skin flap survival in rats. Mol Med Rep. 13:1661–1666.
  • Chen M, Li X, Jiang Z, Gong X. 2019. Visualizing the pharmacologic preconditioning effect of botulinum toxin type A by infrared thermography in a rat pedicled perforator island flap model. Plast Reconstr Surg. 144:1016e–1024e. doi:https://doi.org/10.1097/PRS.0000000000006251.
  • Chin LC, Kumar P, Palmer JA, Rophael JA, Dolderer JH, Thomas GP, Morrison WA, Penington AJ, Stewart AG, Mitchell GM. 2011. The influence of nitric oxide synthase 2 on cutaneous wound angiogenesis. Br J Dermatol. 165:1223–1235.
  • Çil N, Oğuz EO, Mete E, Çetinkaya A, Mete GA. 2017. Effects of umbilical cord blood stem cells on healing factors for diabetic foot injuries. Biotech Histochem. 92:15–28.
  • da Rocha FP, Fagundes DJ, Rivoire HC, Rech FV, Almeida MW, Pires JA. 2011. Immunohistochemical expression of apoptosis and VEGF expression on random skin flaps in rats treated with hyperbaric oxygen and N-acetylcysteine. Undersea Hyperb Med. 38:1671–1674.
  • Eisenhardt SU, Schmidt Y, Thiele JR, Iblher N, Penna V, Torio-Padron N, Stark GB, Bannasch H. 2012. Negative pressure wound therapy reduces the ischaemia/reperfusion-associated inflammatory response in free muscle flaps. J Plast Reconstr Aesthet Surg. 65:640–649.
  • Foresta C, Schipilliti M, De Toni L, Magagna S, Lancerotto L, Azzena B, Vindigni V, Mazzoleni F. 2011. Blood levels, apoptosis, and homing of the endothelial progenitor cells after skin burns and escharectomy. J Trauma. 70:459–465.
  • Furuta S, Vadiveloo P, Romeo-Meeuw R, Morrison W, Stewart A, Mitchell G. 2004. Early inducible nitric oxide synthase 2 (NOS 2) activity enhances ischaemic skin flap survival. Angiogenesis. 7:33–43.
  • Gao ZM, Lin DM, Wang Y, Li JJ, Chen S, Gao WY. 2015. Role of the NO/cGMP pathway in postoperative vasodilation in perforator flaps. J Reconstr Microsurg. 31:107–112.
  • Gribbe O, Samuelson UE, Wiklund NP. 2007. Effects of nitric oxide synthase inhibition on blood flow and survival in experimental skin flaps. J Plast Reconstr Aesth Surg. 60:287–293.
  • Harder Y, Amon M, Erni D, Menger MD. 2004. Evolution of ischemic tissue injury in a random pattern flap: a new mouse model using intravital microscopy. J Surg Res. 121:197–205.
  • Jin Z, Chen S, Wu H, Wang J, Wang L, Gao W. 2018. Inhibition of autophagy after perforator flap surgery increases flap survival and angiogenesis. J Surg Res. 231:83–93. doi:https://doi.org/10.1016/j.jss.2018.05.018.
  • Johnson KE, Wilgus TA. 2014. Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Adv Wound Care. 3:647–661. doi:https://doi.org/10.1089/wound.2013.0517.
  • Kerem H, Akdemır O, Ates U, Uyanıkgıl Y, Demırel Sezer E, Bılkay U, Turgut M, Sozmen E, Songur E. 2014. The effect of melatonin on a dorsal skin flap model. J Invest Surg. 27:57–64.
  • Koshima I, Moriguchi T, Soeda S, Tanaka H, Umeda N. 1992. Free thin paraumbilical perforator-based flaps. Ann Plast Surg. 29:12–17.
  • Lese I, Graf DA, Tsai C, Taddeo A, Matter MT, Constantinescu MA, Herrmann IK, Olariu R. 2018. Bioactive nanoparticle-based formulations increase survival area of perforator flaps in a rat model. PLoS One. 13:e0207802. doi:https://doi.org/10.1371/journal.pone.0207802.
  • Lin D, Wu H, Zhou Z, Tao Z, Gao W, Jia T. 2020. The effect of leonurine on multi-territory perforator flap survival in rats. J Surg Res. 245:453–460. doi:https://doi.org/10.1016/j.jss.2019.07.085.
  • Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K. 2019. Protective effects of resveratrol on random-pattern skin flap survival: an experimental study. Am J Transl Res. 11:379–392.
  • Liu YQ, Liu YF, Ma XM, Xiao YD, Wang YB, Zhang MZ, Cheng AX, Wang TT, Li JL, Zhao PX, Xie F, Zhang X. 2015. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. J Plast Reconstr Aesthet Surg. 68:e147–e156.
  • Luna LG. 1968. Manual of histologic staining methods of the Armed Forces Institute of Pathology: processing of tissue. 3rd ed. McGraw Hill Inc: New York.
  • Lyons AJ. 2006. Perforator flaps in head and neck surgery. Int J Oral Maxillofac Surg. 35:199–207.
  • Moraes MS, Costa PE, Batista WL, Paschoalin T, Curcio MF, Borges RE, Taha MO, Fonseca FV, Stern A, Monteiro HP. 2014. Endothelium-derived nitric oxide (NO) activates the NO-epidermal growth factor receptor-mediated signaling pathway in bradykinin-stimulated angiogenesis. Arch Biochem Biophys. 558:14–27.
  • Ozkok E, Yorulmaz H, Ates G, Serdaroglu-Oflazer P, Tamer AS. 2014. Effects of prior treatment with simvastatin on skeletal muscle structure and mitochondrial enzyme activities during early phases of sepsis. Int J Clin Exp Pathol. 7:8356–8365.
  • Penna C, Perrelli MG, Karam JP, Angotti C, Muscari C, Montero-Menei CN, Pagliaro P. 2013. Pharmacologically active microcarriers influence VEGF-A effects on mesenchymal stem cell survival. J Cell Mol Med. 17:192–204.
  • Pourheydar B, Soleimani Asl S, Azimzadeh M, Rezaei Moghadam A, Marzban A, Mehdizadeh M. 2016. Neuroprotective effects of bone marrow mesenchymal stem cells on bilateral common carotid arteries occlusion model of cerebral ischemia in rat. Behav Neurol. 2016:2964712. doi:https://doi.org/10.1155/2016/2964712.
  • Scioli MG, Lo Giudice P, Bielli A, Tarallo V, De Rosa A, De Falco S, Orlandi A. 2015. Propionyl-L-carnitine enhances wound healing and counteracts microvascular endothelial cell dysfunction. PLOS One. 10:e0140697.
  • Tepedelen BE, Korkmaz M, Tatlisumak E, Türköz Uluer E, Ölmez E, Değerli İ, Soya E, İnan S. 2017. A study on the anticarcinogenic effects of calcium fructoborate. Biol Trace Elem Res. 178:210–217. doi:https://doi.org/10.1007/s12011-016-0918-6.
  • Wang J, Ji E, Lin C, Wang L, Dai L, Gao W. 2019. Effects of bradykinin on the survival of multi-territory perforator flaps in rats. World J Surg Oncol. 17:44. doi:https://doi.org/10.1186/s12957-019-1570-3.
  • Wang L, Jin Z, Wang J, Chen S, Dai L, Lin D, Wu L, Gao W. 2017. Detrimental effect of hypoxia-inducible factor-1α-induced autophagy on multi-territory perforator flap survival in rats. Sci Rep. 7:11791. doi:https://doi.org/10.1038/s41598-017-12034-x.
  • West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, Podres EA, Salomon RG, Byzova TV. 2010. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 467:972–976.
  • Xie XG, Zhang M, Dai YK, Ding MS, Meng SD. 2015. Combination of vascular endothelial growth factor-loaded microspheres and hyperbaric oxygen on random skin flap survival in rats. Exp Ther Med. 10:954–958.
  • Yamamoto Y, Sakurai H, Nakazawa H, Nozaki M. 2009. Effect of vascular augmentation on the haemodynamics and survival area in a rat abdominal perforator flap model. J Plast Reconstr Aesthet Surg. 62:244–249.
  • Zhang F, Lineaweaver W. 2011. Acute and sustained effects of vascular endothelial growth factor on survival of flaps and skin grafts. Ann Plast Surg. 66:581–582.
  • Zheng J, Xi S, Ding M, Li H, Xu W, Tang M, Chen S. 2016. Effects of venous superdrainage and arterial supercharging on dorsal perforator flap in a rat Model. PLoS One. 11:e0160942. doi:https://doi.org/10.1371/journal.pone.0160942.

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