Expression of PDGF-A, PDGFRA, integrin subunit alpha V and selectin E is increased in canine cutaneous fibrosarcomas

References

• Aslam MI, Hettmer S, Abraham J, Latocha D, Soundararajan A, Huang ET, Goros MW, Michalek JE, Wang S, Mansoor A, Druker BJ, Wagers AJ, Tyner JW, Keller C. 2013. Dynamic and nuclear expression of PDGFR-alpha and IGF-1R in alveolar rhabdomyosarcoma. Mol Cancer Res. 11:1303–1313.
   PubMed Web of Science ®Google Scholar
• Aulakh K, Kielb J, Hsiao S, Barnes K, Aulakh H. 2018. Malignant soft tissue sarcoma at the site of corticosteroid injection in a dog. J Vet Sci Anim Husb. 6:1–6. doi:https://doi.org/10.15744/2348-9790.6.102.
   PubMedGoogle Scholar
• Bancroft JD, Layton C. 2018. Connective and other mesenchymal tissues with their stains. In: Suvarna SK, Bancroft JD, Layton C, editors. Bancroft’s theory and practice of histological techniques, 8th ed. Churchill Livngston: London; p. 153–175.
   Google Scholar
• Bekki H, Yamamoto H, Takizawa K, Iwasaki T, Otsuka H, Yamada Y, Kohashi K, Harimaya K, Iwamoto Y, Oda Y. 2017. Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. Pathol Res Pract. 213:674–679.
   PubMed Web of Science ®Google Scholar
• Bhaskar V, Law DA, Ibsen E, Breinberg D, Cass KM, DuBridge RB, Evangelista F, Henshall SM, Hevezi P, Miller JC. 2003. E-selectin up-regulation allows for targeted drug delivery in prostate cancer. Cancer Res. 63:6387–6394.
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Bonthu N, Swanson BJ, Batra SK. 2011. Role of mucins in the skin during benign and malignant conditions. Cancer Lett. 301:127–141.
   PubMed Web of Science ®Google Scholar
• Couto S, Griffey SM, Duarte P, Madewell B. 2002. Feline vaccine-associated fibrosarcoma: morphologic distinctions. Vet Pathol. 39:33–41.
   PubMed Web of Science ®Google Scholar
• Dennis M, McSporran K, Bacon N, Schulman F, Foster R, Powers B. 2011. Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs. Vet Pathol. 48:73–84.
   PubMed Web of Science ®Google Scholar
• Doddy F, Glickman L, Glickman N, Janovitz E. 1996. Feline fibrosarcomas at vaccination sites and non-vaccination sites. J Comp Pathol. 114:165–174.
   PubMed Web of Science ®Google Scholar
• Ferrara N, Kerbel RS. 2005. Angiogenesis as a therapeutic target. Nature. 438:967–974.
   PubMed Web of Science ®Google Scholar
• Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. 1995. In: Suvarna SK, Bancroft JD, Layton C, editors. Definition of two angiogenic pathways by distinct αv integrins. Science. 270:1500–1502.
   PubMed Web of Science ®Google Scholar
• Gogali A, Charalabopoulos K, Zampira I, Konstantinidis AK, Tachmazoglou F, Daskalopoulos G, Constantopoulos SH, Dalavanga Y. 2010. Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers. Chest. 138:1173–1179.
   PubMed Web of Science ®Google Scholar
• Heldin CH, Westermark B. 1999. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 79:1283–1316.
   PubMed Web of Science ®Google Scholar
• Heldin C-H, Östman A, Rönnstrand L. 1998. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta Rev Cancer. 1378:79–113.
   PubMed Web of Science ®Google Scholar
• Hendrick MJ. 2017. Mesenchymal tumors of the skin and soft tissues. Tumors Domest Anim. 5:142–175.
   Google Scholar
• Holzer TR, O’Neill Reising L, Credille KM, Schade AE, Oakley GJ. 2016. Variability in platelet-derived growth factor receptor alpha antibody specificity may impact clinical utility of immunohistochemistry assays. J Histochem Cytochem. 64:785–810.
   PubMed Web of Science ®Google Scholar
• Jacobs TM, Poehlmann CE, Kiupel M. 2017. Injection-site sarcoma in a dog: clinical and pathological findings. Case Rep Vet Med. 2017:6952634. doi:https://doi.org/10.1155/2017/6952634.
   PubMedGoogle Scholar
• Katayama R, Huelsmeyer MK, Marr AK, Kurzman ID, Thamm DH, Vail DM. 2004. Imatinib mesylate inhibits platelet-derived growth factor activity and increases chemosensitivity in feline vaccine-associated sarcoma. Cancer Chemother Pharmacol. 54:25–33.
   PubMed Web of Science ®Google Scholar
• Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ. 1995. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature. 376:517–519.
   PubMed Web of Science ®Google Scholar
• Lasky LA. 1992. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science. 258:964–969.
   PubMed Web of Science ®Google Scholar
• Lauri D, Needham L, Martin-Padura I, Dejana E. 1991. Tumor cell adhesion to endothelial cells: endothelial leukocyte adhesion molecule-1 as an inducible adhesive receptor specific for colon carcinoma cells. J Natl Cancer Inst. 83:1321–1324.
   PubMed Web of Science ®Google Scholar
• Lawrence J, Saba C, Jr R G, Lamberth O, Vandenplas M, Hurley D, Dubreuil P, Hermine O, Dobbin K, Turek M. 2012. Masitinib demonstrates anti‐proliferative and pro‐apoptotic activity in primary and metastatic feline injection‐site sarcoma cells. Vet Comp Oncol. 10:143–154.
   PubMed Web of Science ®Google Scholar
• Lieder AM, Prior TG, Wood KJ, Werner JA. 2005. The relevance of adhesion molecules in the classification of squamous cell carcinoma of the head and neck. Anticancer Res. 25:4141–4147.
   PubMed Web of Science ®Google Scholar
• Lieubeau B, Heymann MF, Henry F, Barbieux I, Meflah K, Gregoire M. 1999. Immunomodulatory effects of tumor‐associated fibroblasts in colorectal‐tumor development. Int J Cancer. 81:629–636.
   PubMed Web of Science ®Google Scholar
• Malhotra B, Schuetze SM. 2012. Dermatofibrosarcoma protruberans treatment with platelet-derived growth factor receptor inhibitor: a review of clinical trial results. Curr Opin Oncol. 24:419–424.
   PubMed Web of Science ®Google Scholar
• Maniscalco L, Iussich S, Morello E, Martano M, Biolatti B, Riondato F, Della Salda L, Romanucci M, Malatesta D, Bongiovanni L. 2013. PDGFs and PDGFRs in canine osteosarcoma: new targets for innovative therapeutic strategies in comparative oncology. Veterinary J. 195:41–47.
   PubMed Web of Science ®Google Scholar
• Maurer CA, Friess H, Kretschmann B, Wildi S, Müller C, Graber H, Schilling M, Büchler MW. 1998. Over‐expression of ICAM‐1, VCAM‐1 and ELAM‐1 might influence tumor progression in colorectal cancer. Int J Cancer. 79:76–81.
   PubMed Web of Science ®Google Scholar
• Meuten DJ, Moore FM, George JW. 2016. Mitotic count and the field of view area: time to standardize. Vet Pathol. 53:7–9.
   PubMed Web of Science ®Google Scholar
• Meuten DJ. 2017. Canine soft tissue mesenchymal tumor (Sarcoma). In: Meuten DJ, editor. Tumors in domestic animals. 5th ed. John Wiley & Sons: Ames, IA; p. 957–958.
   Google Scholar
• Mierke CT, Frey B, Fellner M, Herrmann M, Fabry B. 2011. Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces. J Cell Sci. 124:369–383.
   PubMed Web of Science ®Google Scholar
• Milovancev M, Helfand SC, Marley K, Goodall CP, Löhr CV, Bracha S. 2016. Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro. BMC Vet Res. 12:1–13. doi:https://doi.org/10.1186/s12917-016-0712-x.
   PubMed Web of Science ®Google Scholar
• Mowry RW. 1956. Alcian blue technics for the histochemical study of Alcian carbohydrates. J Histochem Cytochem. 4:407–411.
   Web of Science ®Google Scholar
• Mowry RW. 1963. The special value of methods that color both acidic and vicinal hydroxyl groups in the histochemical study of mucins. With revised directions for the colloidal iron stain, the use of Alcian blue G8X and their combinations with the periodic acid‐Schiff reaction. Ann NY Acad Sci. 106::402–423.
   Web of Science ®Google Scholar
• Nejjari M, Hafdi Z, Gouysse G, Fiorentino M, Béatrix O, Dumortier J, Pourreyron C, Barozzi C, D’Errico A, Grigioni WF. 2002. Expression, regulation, and function of αV integrins in hepatocellular carcinoma: an in vivo and in vitro study. Hepatology. 36:418–426.
   PubMed Web of Science ®Google Scholar
• Östman A, Heldin CH. 2007. PDGF receptors as targets in tumor treatment. Adv Cancer Res. 97:247–274.
   PubMed Web of Science ®Google Scholar
• Rawlings N, Simko E, Bebchuk T, Caldwell S, Singh B. 2003. Localization of integrin αvß3 and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in cutaneous and oral melanomas of dog. Histol Histopathol. 18:819–826.
   PubMed Web of Science ®Google Scholar
• Seftor RE, Seftor EA, Hendrix MJ. 1999. Molecular role(s) for integrins in human melanoma invasion. Cancer Metas Rev. 18:359–375.
   PubMed Web of Science ®Google Scholar
• Shaker OG, MAA E-D, MTA E-R, Talaat RM. 2006. Gene expression of E-selectin in tissue and its protein level in serum of breast cancer patients. Tumori. 92:524–530.
   PubMed Web of Science ®Google Scholar
• Silletti S, Kessler T, Goldberg J, Boger DL, Cheresh DA. 2001. Disruption of matrix metalloproteinase 2 binding to integrin αvβ3 by an organic molecule inhibits angiogenesis and tumor growth in vivo. Proc Natl Acad Sci USA. 98:119–124.
   PubMed Web of Science ®Google Scholar
• Srivastav A, Kass PH, Mcgill LD, Kent MS, Farver TB. 2011. Methodologic approaches to histologically distinguishing vaccine versus nonvaccine-associated sarcomas using validated time and location vaccination histories in cats. Int Schol Res Net Pathol. 6.375143:1–6. doi:https://doi.org/10.5402/2011/375143
   Google Scholar
• Teyssonneau D, Italiano A. 2017. Olaratumab for soft tissue sarcoma. Exp Opin Biol Ther. 17:1019–1025.
   PubMed Web of Science ®Google Scholar
• Vascellari M, Melchiotti E, Bozza M, Mutinelli F. 2003. Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non‐vaccination site fibrosarcomas and feline post‐vaccinal fibrosarcomas. J Vet Med A Physiol Pathol Clin Med. 50:286–291.
   PubMedGoogle Scholar
• Vascellari M, Melchiotti E, Mutinelli F. 2006. Fibrosarcoma with typical features of post-injection sarcoma at site of microchip implant in a dog: histologic and immunohistochemical study. Vet Pathol. 43:545–548.
   PubMed Web of Science ®Google Scholar
• Villamil JA, Henry CJ, Bryan JN, Ellersieck M, Schultz L, Tyler JW, Hahn AW. 2011. Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J Am Vet Med Assoc. 239:960–965.
   PubMed Web of Science ®Google Scholar
• Wernicke M, Pineiro LC, Caramutti D, Dorn VG, Raffo MM, Guixa HG, Telenta M, Morandi AA. 2003. Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: a central role for hyaluronan. Mod Pathol. 16:99–107.
   PubMed Web of Science ®Google Scholar
• Williamson MM, Middleton DJ. 1998. Cutaneous soft tissue tumours in dogs: classification, differentiation, and histogenesis. Vet Dermatol. 9:43–48.
   Web of Science ®Google Scholar
• Woodard AS, García-Cardeña G, Leong M, Madri JA, Sessa WC, Languino LR. 1998. The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci. 111:469–478.
   PubMed Web of Science ®Google Scholar
• Yardimci B, Yardimci C, Aksoy O. 2011. Clinical and pathological evaluation of the injection site masses in 12 dogs. Rev Méd Vét. 162:508–513.
   Google Scholar