KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3

References

• Bourillot PY, Savatier P. 2010. Krüppel-like transcription factors and control of pluripotency. BMC Biol. 8:125–127. doi: 10.1186/1741-7007-8-125.
   PubMed Web of Science ®Google Scholar
• Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng C. 1999. Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest. 104:1517–1525. doi: 10.1172/JCI6690.
   PubMed Web of Science ®Google Scholar
• Chen FH, Tuan RS. 2008. Mesenchymal stem cells in arthritic diseases. Arthr Res Ther. 10:223–228. doi: 10.1186/ar2514.
   PubMed Web of Science ®Google Scholar
• Dailey L, Ambrosetti D, Mansukhani A, Claudio B. 2005. Mechanisms underlying differential responses to FGF signaling. Cytok Growth Fact Rev. 16:233–247. doi: 10.1016/j.cytogfr.2005.01.007.
   PubMed Web of Science ®Google Scholar
• Dorey K, Amaya E. 2010. FGF signaling: diverse roles during early vertebrate embryogenesis. Development. 137:3731–3742. doi: 10.1242/dev.037689.
   PubMed Web of Science ®Google Scholar
• Du X, Xie Y, Xian CJ, Chen L. 2004. Role of FGFs/FGFRs in skeletal development and bone regeneration. J Cell Physiol. 227:3731–3743. doi: 10.1002/jcp.24083.
   Google Scholar
• Feng B, Jiang J, Kraus P, Ng JH, Dominic JC, Chan YS, Yaw LP, Zhang WW, Loh YH, Han JY, Vinsensius BV, Valere C, Bing L, Thomas L, Ng HH. 2009. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor ESRB. Nat Cell Biol. 11:197–203. doi: 10.1038/ncb1827.
   PubMed Web of Science ®Google Scholar
• Hall J, Guo G, Wray J, Isobel E, Jennifer N, Lars G, Sofia M, Peter H, William M, Rachael W, Simon T, Austin S. 2009. Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell. 5:597–609. doi: 10.1016/j.stem.2009.11.003.
   PubMed Web of Science ®Google Scholar
• Hutley L, Shurety W, Newell F, Ross M, Nicole P, Jennifer G, Adrian H, Donald C, Jon W, Johannes P. 2004. Fibroblast growth factor 1: a key regulator of human adipogenesis. Diabetes. 53:3097–3106. doi: 10.2337/diabetes.53.12.3097.
   PubMed Web of Science ®Google Scholar
• Iwata T, Chen L, Li C, Ovchinnikov DA, Behringer RR, Francomano CA, Deng CX. 2000. A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet. 9:1603–1613. doi: 10.1093/hmg/9.11.1603.
   PubMed Web of Science ®Google Scholar
• Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Paul R, Sheng Z, Ng HH. 2008. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 10:353–360. doi: 10.1038/ncb1698.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Jahagirdar BN, Reinhardt RL, Robert ES, Dirk KC, Xilma RO, Morayma R, Todd L, Troy L, Mark B, Du JB, Aldrich S, Lisberg A, Walter CL, David AL, Verfaillie CM. 2002. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41–49. doi: 10.1038/nature00870.
   PubMed Web of Science ®Google Scholar
• Kähkönen TE, Ivaska KK, Jiang M, Büki KG, Väänänen HK, Härkönen PL. 2018. Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes. Mol Cell Endocrinol. 461:194–204. doi: 10.1016/j.mce.2017.09.015.
   PubMed Web of Science ®Google Scholar
• Katoh Y, Katoh M. 2009. FGFR2-related pathogenesis and FGFR2-targeted therapeutics. Rev Int J Mol Med. 23:307–311. doi: 10.3892/ijmm_00000132.
   PubMed Web of Science ®Google Scholar
• Katoh M, Nakagama H. 2014. FGF receptors: cancer biology and therapeutics. Med Res Rev. 34:280–300. doi: 10.1002/med.21288.
   PubMed Web of Science ®Google Scholar
• Korc M, Friesel RE. 2009. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targ. 9:639–651. doi: 10.2174/156800909789057006.
   PubMed Web of Science ®Google Scholar
• Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX. 1999. A Lys644Glu substitution in fibroblast growth factor receptor 3 FGFR3. causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet. 8:35–44. doi: 10.1093/hmg/8.1.35.
   PubMed Web of Science ®Google Scholar
• Meirelles LS, Fontes AM, Covas DT, Caplan AI. 2009. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytok Growth Fact Rev. 20:419–427. doi: 10.1016/j.cytogfr.2009.10.002.
   PubMed Web of Science ®Google Scholar
• Minina E, Kreschel C, Naski MC, David MO, Andrea V. 2002. Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell. 3:439–449. doi: 10.1016/S1534-5807(02)00261-7.
   PubMed Web of Science ®Google Scholar
• Miraoui H, Oudina K, Petite H, Yukiho T, Keiji M, Marie PJ. 2009. Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling. J Biol Chem. 284:4897–4904. doi: 10.1074/jbc.M805432200.
   PubMed Web of Science ®Google Scholar
• Nilsson EM, Brokken LJ, Harkonen PL. 2010. Fibroblast growth factor 8 increases breast cancer cell growth by promoting cell cycle progression and by protecting against cell death. Exp Cell Res. 316:800–812. doi: 10.1016/j.yexcr.2009.11.019.
   PubMed Web of Science ®Google Scholar
• Nombela-Arrieta C, Ritz J, Silberstein LE. 2011. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 12:126–131. doi: 10.1038/nrm3049.
   PubMed Web of Science ®Google Scholar
• Noth U, Steinert AF, Tuan RS. 2008. Technology insight: adult mesenchymal stem cells for osteoarthritis therapy. Nat Clin Pract Rheumatol. 4:371–380. doi: 10.1038/ncprheum0816.
   PubMedGoogle Scholar
• Ornitz DM. 2005. FGF signaling in the developing endochondral skeleton. Cytok Growth Fact Rev. 16:205–213. doi: 10.1016/j.cytogfr.2005.02.003.
   PubMed Web of Science ®Google Scholar
• Ota S, Zhou ZQ, Link JM, Peter JH. 2009. The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects. Hum Mol Genet. 18:2609–2621. doi: 10.1093/hmg/ddp195.
   PubMed Web of Science ®Google Scholar
• Patel NG, Kumar S, Eggo MC. 2005. Essential role of fibroblast growth factor signaling in preadipoctye differentiation. J Clin Endocrinol Metabol. 90:1226–1232. doi: 10.1210/jc.2004-1309.
   PubMed Web of Science ®Google Scholar
• Percharde M, Lavial F, Ng JH, Vibhor K, Rute AT, Nadine M, Yeo JC, Jesús G, Shyam P, Ng HH, Malcolm GP, Véronique A. 2012. Ncoa3 functions as an essential ESRRB coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 26:2286–2298. doi: 10.1101/gad.195545.112.
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. 1999. Multilineage potential of adult human mesenchymal stem cells. Science. 284:143–147. doi: 10.1126/science.284.5411.143.
   PubMed Web of Science ®Google Scholar
• Porebska N, Latko M, Kucinska M, Małgorzata Z, Jacek O, Opaliński Ł. 2018. Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment. J Clin Microbiol. 8:7–11. doi: 10.3390/jcm8010007.
   Google Scholar
• Powers CJ, McLeskey SW, Wellstein A. 2000. Fibroblast growth factors, their receptors and signaling. Endocr Rel Cancer. 7:165–197. doi: 10.1677/erc.0.0070165.
   PubMed Web of Science ®Google Scholar
• Somoza RA, Rubio FJ. 2012. Cell therapy using induced pluripotent stem cells orsomatic stem cells: this is the question. Curr Stem Cell Res Ther. 7:191–196. doi: 10.2174/157488812799859865.
   PubMed Web of Science ®Google Scholar
• Su N, Sun Q, Li C, Lu XM, Qi HB, Chen SY, Jing Y, Du XL, Zhao L, He QF, Jin M, Shen Y, Chen D, Chen L. 2010. Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum Mol Genet. 19:1199–1210. doi: 10.1093/hmg/ddp590.
   PubMed Web of Science ®Google Scholar
• Trueb B. 2011. Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cell Mol Life Sci. 68:951–964. doi: 10.1007/s00018-010-0576-3.
   PubMed Web of Science ®Google Scholar
• Wang H, Zhou Y, Yu D, Zhu HY. 2016. Klf2 contributes to the stemness and self-renewal of human bone marrow stromal cells. Cytotechnology. 68:839–848. doi: 10.1007/s10616-014-9837-6.
   PubMed Web of Science ®Google Scholar
• Wei X, Yang X, Han ZP, Qu FF, Li S, Shi YF. 2013. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin. 34:747–754. doi: 10.1038/aps.2013.50.
   PubMed Web of Science ®Google Scholar
• Zuk PA, Zhu M, Ashjian P, Daniel AD, Jerry IH, Hiroshi M, Zeni CA, John KF, Prosper B, Marc HH. 2002. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 13:4279–4295. doi: 10.1091/mbc.e02-02-0105.
   PubMed Web of Science ®Google Scholar