Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model

References

• Abou-Fadel J, Qu Y, Gonzalez EM, Smith M, Zhang J. 2020. Emerging roles of CCM genes during tumorigenesis with potential application as novel biomarkers across major types of cancers. Oncol Rep. 43:1945–1963. doi: 10.3892/or.2020.7550.
   PubMed Web of Science ®Google Scholar
• Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. 2014. Cerebral cavernous malformation proteins at a glance. J Cell Sci. 127:701–707. doi: 10.1242/jcs.138388.
   PubMed Web of Science ®Google Scholar
• Erin N, Boyer PJ, Bonneau RH, Clawson GA, Welch DR. 2004. Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res. 24:1003–1009.
   PubMed Web of Science ®Google Scholar
• Erin N, Wang N, Xin P, Bui V, Weisz J, Barkan GA, Zhao W, Shearer D, Clawson GA. 2009. Altered gene expression in breast cancer liver metastases. Int J Cancer. 124, 1503–1516.
   PubMed Web of Science ®Google Scholar
• Erin N, Zhao W, Bylander J, Chase G, Clawson G. 2006. Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. Breast Cancer Res Treat. 99:351–364. doi: 10.1007/s10549-006-9219-7.
   PubMed Web of Science ®Google Scholar
• Glading A, Han J, Stockton RA, Ginsberg MH. 2007. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions. J Cell Biol. 179:247–254. doi: 10.1083/jcb.200705175.
   PubMed Web of Science ®Google Scholar
• Jiang X, Padarti A, Qu Y, Sheng S, Abou-Fadel J, Badr A, Zhang J. 2019. Alternatively spliced isoforms reveal a novel type of PTB domain in CCM2 protein. Sci rep. 9:15808.
   PubMed Web of Science ®Google Scholar
• Labauge P, Denier C, Bergametti F, Tournier-Lasserve E. 2007. Genetics of cavernous angiomas. Lancet Neurol. 6:237–244. doi: 10.1016/S1474-4422(07)70053-4.
   PubMed Web of Science ®Google Scholar
• Ma X, Zhao H, Shan J, Long F, Chen Y, Zhang Y, Han X, Ma D. 2007. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. Mol Biol Cell. 18: 1965–1978. doi: 10.1091/mbc.e06-07-0608.
   PubMed Web of Science ®Google Scholar
• McGuire A, Brown JA, Kerin MJ. 2015. Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring. Cancer Metas Rev. 34:145–155. doi: 10.1007/s10555-015-9551-7.
   PubMed Web of Science ®Google Scholar
• Orso F, Balzac F, Marino M, Lembo A, Retta SF, Taverna D. 2013. miR-21 coordinates tumor growth and modulates KRIT1 levels. Biochem Biophys Res Commun. 438:90–96. doi: 10.1016/j.bbrc.2013.07.031.
   PubMed Web of Science ®Google Scholar
• Padarti A, Zhang J. 2018. Recent advances in cerebral cavernous malformation research. Vessel Plus. 2:21. doi: 10.20517/2574-1209.2018.34.
   PubMedGoogle Scholar
• Stahl S, Gaetzner S, Voss K, Brackertz B, Schleider E, Surucu O, Kunze E, Netzer C, Korenke C, Finckh U, Habek M, Poljakovic Z, Elbracht M, Rudnik-Schoneborn S, Bertalanffy H, Sure U, Felbor U. 2008. Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex. Hum Muta. 29:709–717. doi: 10.1002/humu.20712.
   PubMed Web of Science ®Google Scholar
• Tanriover G, Boylan AJ, Diluna ML, Pricola KL, Louvi A, Gunel M. 2008. PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. Neurosurgery. 62:930–938. doi: 10.1227/01.neu.0000318179.02912.ca.
   PubMed Web of Science ®Google Scholar
• Tanriover G, Eyinc MB, Aliyev E, Dilmac S, Erin N. 2018. Presence of S100A8/Gr1-positive myeloid-derived suppressor cells in primary tumors and visceral organs invaded by breast carcinoma cells. Clin Breast Cancer. 18:e1067–e1076. doi: 10.1016/j.clbc.2018.03.013.
   PubMed Web of Science ®Google Scholar
• Tanriover G, Seval Y, Sati L, Gunel M, Demir N. 2009. CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta. Histol Histopathol. 24:1287–1294. doi: 10.14670/HH-24.1287.
   PubMed Web of Science ®Google Scholar
• Tanriover G, Sozen B, Seker A, Kilic T, Gunel M, Demir N. 2013. Ultrastructural analysis of vascular features in cerebral cavernous malformations. Clin Neurol Neurosurg. 115:438–444. doi: 10.1016/j.clineuro.2012.06.023.
   PubMed Web of Science ®Google Scholar
• Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y, Hynes N. 2018. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 16:e3000051. doi: 10.1371/journal.pbio.3000051.
   PubMed Web of Science ®Google Scholar
• Vikkula M, Boon LM, Mulliken JB. 2001. Molecular genetics of vascular malformations. Matrix Biol. 20:327–335. doi: 10.1016/S0945-053X(01)00150-0.
   PubMed Web of Science ®Google Scholar
• Zhang J, Dubey P, Padarti A, Zhang A, Patel R, Patel V, Cistola D, Badr A. 2017. Novel functions of CCM1 delimit the relationship of PTB/PH domains. Biochim Biophys Acta Prot Proteom. 1865:1274–1286. doi: 10.1016/j.bbapap.2017.07.002.
   PubMed Web of Science ®Google Scholar