Plant-Derivatives and Herbs Used for the Promotion of Sexual Health and the Treatment of Sexual Problems

References

• Abebe , W. 2002 . Herbal medication: Potential for adverse interactions with analgesic drugs . Journal of Clinical Pharmacy and Therapeutics , 27 : 391 – 401 .
   PubMed Web of Science ®Google Scholar
• Adaikan , P. G. , Gauthaman , K. , Prasad , R. N. and Ng , S. C. 2000 . Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum . Annals of the Academy of Medicine, Singapore , 29 : 22 – 26 .
   PubMedGoogle Scholar
• Adeniyi , A. A. , Brindley , G. S. , Pryor , J. P. and Ralph , D. J. 2007 . Yohimbine in the treatment of orgasmic dysfunction . Asian Journal of Andrology , 9 ( 3 ) : 403 – 407 .
   Google Scholar
• Adimoelja , A. 2000 . Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions . International Journal of Andrology , 23 : 77 – 84 .
   Google Scholar
• Ang , H. H. , Cheang , H. S. and Yusof , A. P. 2000 . Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats . Experimental Animals/Japanese Association for Laboratory Animal Science , 49 ( 1 ) : 35 – 38 .
   Google Scholar
• Ang , H. H. , Lee , K. H. and Kiyoshi , M. 2004 . Sexual arousal in sexually sluggish old male rats after oral administration of eurycoma longifolia jack . Journal of Basic and Clinical Physiology and Pharmacology , 15 ( 3–4 ) : 303 – 309 .
   PubMedGoogle Scholar
• Ang , H. H. and Sim , M. K. 1997 . Eurycoma longifolia Jack enhances libido in sexually experienced male rats . Experimental Animals/Japanese Association for Laboratory Animal Science , 46 ( 4 ) : 287 – 290 .
   Google Scholar
• Arletti , R. , Benelli , A. , Cavazzuti , E. , Scarpetta , G. and Bertolini , A. 1999 . Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats . Psychopharmacology , 143 : 15 – 19 .
   PubMed Web of Science ®Google Scholar
• Ashton , A. K. , Ahrens , K. , Gupta , S. and Masand , P. S. 2000 . Antidepressant-induced sexual dysfunction and gingko biloba . American Journal of Psychiatry , 157 : 836 – 837 .
   PubMedGoogle Scholar
• Auguet , M. , DeFeudis , F. V. and Clostre , F. 1982 . Effects of Ginkgo biloba on arterial smooth muscle responses to vasoactive stimuli . General Pharmacology , 13 : 169 – 171 .
   Google Scholar
• Aung , H. H. , Dey , L. , Rand , V. and Yuan , C. S. 2004 . Alternative therapies for male and female sexual dysfunction . American Journal of Chinese Medicine , 32 ( 2 ) : 161 – 173 .
   Google Scholar
• Bardia , A. , Nisly , N. L. , Zimmerman , M. B. , Gryzlak , B. M. and Wallace , R. B. Use of herbs among adults based on evidence-based indications: Findings from the National Health Interview Survey . Mayo Clinic Proceedings . 82, 5
   Google Scholar
• Bent , S. , Kane , C. , Shinohara , K. , Neuhaus , J. , Hudes , E. S. Goldberg , H. 2006 . Saw Palmetto for Benign Prostratic Hyperplasia . New England Journal of Medicine , 354 ( 6 ) : 557 – 566 .
   PubMed Web of Science ®Google Scholar
• Bogani , P. , Simonini , F. , Iriti , M. , Rossoni , M. , Faoro , F. Poletti . 2005 . Lepidium meyenii (Maca) does not exert direct androgenic activities . Journal of Ethnopharmacology , 104 ( 3 ) : 415 – 417 .
   Google Scholar
• Bonnar-Pizzorno , R. M. , Littman , A. J. , Kestin , M. and White , E. 2006 . Saw palmetto supplement use and prostate cancer risk . Nutrition and Cancer , 55 ( 1 ) : 21 – 27 .
   PubMed Web of Science ®Google Scholar
• Boyle , P. , Robertson , C. , Lowe , F. and Roehrborn , C. 2004 . Updated meta-analysis of clinical trials of Serona repens extract in the treatment of symptomatic benign prostatic hyperplasia . BJU International , 93 : 751 – 756 .
   PubMed Web of Science ®Google Scholar
• Bressler , R. 2005 . Herb-drug interactions: Interactions between saw palmetto and prescription medications . Geriatric , 60 ( 11 ) : 32 – 34 .
   Google Scholar
• Burdette , J. E. , Liu , J. , Chen , S. N. , Fabricant , D. S. , Piersen , C. E. Barker , E. L. 2003 . Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor . Journal of Agricultural and Food Chemistry , 51 ( 19 ) : 5661 – 5670 .
   PubMed Web of Science ®Google Scholar
• Carro-Juarez , M. and Rodriguez-Manzo , G. 2006 . Alpha-adrenergic agents modulate the activity of the spinal pattern generator for ejaculation . International Journal of Impotence Research , 18 : 32 – 38 .
   PubMed Web of Science ®Google Scholar
• Carroll , D. G. 2006 . Nonhormonal therapies for hot flashes in menopause . American Family Physician , 73 : 457 – 464 .
   PubMed Web of Science ®Google Scholar
• Chen , K. K. and Chiu , J. H. 2006 . Effect of Epimedium brevicornum Maxim extract on elicitation of penile erection in the rat . Urology , 67 ( 3 ) : 631 – 635 .
   Google Scholar
• Chiu , J.-H. , Chen , K-K. , Chien , T.-M. , Chiou , W-F. , Chen , C.-C. Wang , J.-Y. 2006 . Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway . International Journal of Impotence Research , 18 : 335 – 342 .
   PubMed Web of Science ®Google Scholar
• Choi , H. K. , Seong , D. H. and Rha , K. H. 1995 . Clinical efficacy of Korean red ginseng for erectile dysfunction . International Journal of Impotence Research , 7 : 181 – 186 .
   PubMedGoogle Scholar
• Ciocon , J. O. , Ciocon , D. G. and Galindo , D. J. 2004 . Dietary supplements in primary care: Botanicals can affect surgical outcomes and follow-up . Geriatrics , 59 : 20 – 24 .
   Google Scholar
• Cohen , A. J. and Bartlik , B. 1998 . Ginkgo biloba for antidepressant-induced sexual dysfunction . Journal of Sex & Marital Therapy , 24 : 139 – 143 .
   PubMed Web of Science ®Google Scholar
• Cuzzolin , L. , Zaffani , S. and Benoni , G. 2006 . Safety implications regarding use of phytomedicines . European Journal of Clinical Pharmacology , 62 : 37 – 42 .
   Google Scholar
• de Andrade , E. , de Mesquita , A. A. , Claro , J. A. , de Andrade , P. M. , Ortiz , V. Paranhos , M. 2007 . Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction . Asian Journal of Andrology , 9 ( 2 ) : 241 – 244 .
   PubMed Web of Science ®Google Scholar
• Ernst , E. and Pittler , M. H. 1998 . Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials . The Journal of Urology , 159 : 433 – 436 .
   PubMed Web of Science ®Google Scholar
• Fahim , M. S. , Fahim , Z. , Harman , J. M. , Clevenger , T. E. , Mullins , W. and Hafez , E. S. 1982 . Effect of Panax ginseng on testosterone level and prostate in male rats . Archives of Andrology , 8 : 261 – 263 .
   Web of Science ®Google Scholar
• Foster , S. and Tyler , V. E. 2000 . Tyler's honest herbal, , 4th ed. , New York : The Haworth Herbal Press .
   Google Scholar
• Gardiner , P. , Graham , R. G. , Legedza , A. T. R. , Ahn , A. C. , Eisenberg , D. M. and Phillips , R. S. 2007 . Factors associated with herbal therapy use by adults in the United States . Alternative Therapies in Health and Medicine , 13 ( 2 ) : 22 – 29 .
   PubMed Web of Science ®Google Scholar
• Gauthaman , K. and Adaikan , P. G. 2005 . Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain . Journal of Ethnopharmacology , 96 : 127 – 132 .
   PubMed Web of Science ®Google Scholar
• Gauthaman , K. , Ganesan , A. P. and Prasad , R. N. V. 2003 . Sexual effects of puncturevine (tribulus terrestris) extract (protodioscin): An evaluation using a rat model . The Journal of Alternative and Complementary Medicine , 9 ( 2 ) : 257 – 265 .
   PubMed Web of Science ®Google Scholar
• Gonzales , G. F. , Cordova , A. , Vega , K. , Chung , A. , Villena , C. Gonez , C. 2002 . Effects of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men . Andrologia , 34 : 367 – 372 .
   PubMed Web of Science ®Google Scholar
• Gonzales , G. F. , Miranda , S. , Nieto , J. , Fernandez , G. , Yucra , S. Rubio , J. 2005 . Red maca (Lepidium meyenii) reduced prostate size in rats . Reproductive Biology and Endocrinology , : 3 Retrieved November 11, 2007, from http://rbej.com/content/3/1/5
   Google Scholar
• Hirata , J. D. , Swiersz , L. M. , Zell , B. , Small , R. and Ettinger , B. 1997 . Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial . Fertility and Sterility , 68 ( 6 ) : 981 – 986 .
   PubMed Web of Science ®Google Scholar
• Hong , B. , Ji , Y. H. , Hong , J. H. , Nam , K. Y. and Ahn , T. Y. 2002 . A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: A preliminary report . Journal of Urology , 168 : 2070 – 2073 .
   PubMed Web of Science ®Google Scholar
• Huntley , A. L. and Ernst , E. 2003 . A systematic review of herbal medicinal products for the treatment of menopausal symptoms . Menopause: The Journal of the North American Menopause Society , 10 ( 5 ) : 465 – 476 .
   Google Scholar
• Ito , T. Y. , Kawahara , K. and Das , A. 1998 . The effects of ArginMax, a natural dietary supplement for enhancement of male sexual function . Hawaii Medical Journal , 57 : 741 – 744 .
   PubMedGoogle Scholar
• Ito , T. Y. , Polan , M. L. , Whipple , B. and Trant , A. S. 2006 . The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status . Journal of Sex & Marital Therapy , 32 ( 5 ) : 369 – 378 .
   PubMed Web of Science ®Google Scholar
• Ito , T. Y. , Trant , A. S. and Polan , M. L. 2001 . A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function . Journal of Sex & Marital Therapy , 27 : 541 – 549 .
   PubMed Web of Science ®Google Scholar
• Kang , B. J. , Lee , S. J. , Kim , M. D. and Cho , M. J. 2002 . A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction . Human Psychopharmacology: Clinical & Experimental , 17 : 279 – 284 .
   PubMed Web of Science ®Google Scholar
• Kapadia , G. J. , Azuine , M. A. , Tokuda , H. , Hang , E. , Mukainaka , T. Nishino , H. 2002 . Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation . Pharmacological Research: The Official Journal of The Italian Pharmacological Society , 45 ( 3 ) : 213 – 230 .
   Google Scholar
• Kellogg-Spadt , S. and Albaugh , J. A. 2003 . Herbs, amino acids, and female libido . Urological Nursing , 23 ( 2 ) : 160 – 161 .
   Google Scholar
• Kim , N. N. , Christianson , D. W. and Traish , A. M. 2004 . Role of arginase in the male and female sexual arousal response . The Journal of Nutrition , 134 ( Suppl. 10 ) : 2873S – 2879S . discussion 2895S
   Google Scholar
• Kligler , B. 2003 . Black cohosh . American Family Physician , 68 ( 1 ) : 114 – 116 .
   Google Scholar
• Lauritzen , C. , Reuter , H. D. , Repges , R. , Bohnert , K. J. and Schmidt , U. 1997 . Treatment of premenstrual tension syndrome with Vitex agnus castus: Controlled, double study vs. pyridoxine . Phytomedicine , 4 : 183 – 189 .
   PubMed Web of Science ®Google Scholar
• Lentz , A. , Gravitt , K. , Carson , C. C. and Marson , L. 2007 . Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior . The Journal of Sexual Medicine , 4 : 332 – 340 .
   PubMed Web of Science ®Google Scholar
• Liu , J. J. , Li , S. P. and Wang , Y. T. 2006 . Optimization for quantitative determination of four flavinoids in Epimedium by capillary zone electrophoresis coupled with diode array detection using central composite design . Journal of Chromatography A , 1103 ( 2 ) : 344 – 349 .
   PubMed Web of Science ®Google Scholar
• Liu , W. J. , Xin , Z. C. , Xin , H. , Yuan , Y. M. , Tian , L. and Guo , Y. L. 2005 . Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats . Asian Journal of Andrology , 7 ( 4 ) : 381 – 388 .
   PubMed Web of Science ®Google Scholar
• Lupu , R. , Mehmi , I. , Atlas , E. , Tsai , M. S. , Pisha , E. Oketch-Rabah , H. A. 2003 . Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth . International Journal of Oncology , 23 ( 5 ) : 1407 – 1412 .
   Google Scholar
• MacKay , D. 2004 . Nutrients and botanicals for erectile dysfunction: Examining the evidence . Alternative Medicine Review , 9 : 4 – 16 .
   PubMedGoogle Scholar
• Marcocci , L. , Maguire , J. J. , Droy-Lefaix , M. T. and Packer , L. 1994 . The nitric oxide-scavenging properties of Ginkgo biloba extract EGb 761 . Biochemical and Biophysical Research Communications , 201 : 748 – 755 .
   PubMed Web of Science ®Google Scholar
• Meston , C. M. and Rellini , A. A double-blind, randomized, placebo-controlled study of gingko biloba versus sex therapy for female sexual dysfunction . Archives of Sexual Behavior , (in press)
   Google Scholar
• Meston , C. M. and Worcel , M. 2002 . The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder . Archives of Sexual Behavior , 31 : 323 – 332 .
   PubMed Web of Science ®Google Scholar
• Moyad , M. A. , Barada , J. H. , Lue , T. F. , Mulhall , J. P. , Goldstein , I. and Fawzy , A. 2004 . Prevention and treatment of erectile dysfunction using lifestyle changes and dietary supplements: What works and what is worthless, Part II . Urologic Clinics of North America , 31 : 259 – 273 .
   PubMedGoogle Scholar
• Murphy , L. L. and Lee , T. J. 2002 . Ginseng, sex behavior, and nitric oxide . Annals of the New York Academy of Sciences , 962 : 372 – 377 .
   Google Scholar
• Neychev , V. K. and Mitev , V. I. 2005 . The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men . Journal of Ethnopharmacology , 101 : 319 – 323 .
   PubMed Web of Science ®Google Scholar
• Oshima , M. , Gu , Y. and Tsukada , S. 2003 . Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone and the rate of embryo implantation in mice . The Journal of Veterinary Medical Science/ The Japanese Society of Veterinary Science , 65 ( 10 ) : 1145 – 1146 .
   Google Scholar
• Panjari , M. and Davis , S. R. 2007 . DHEA therapy for women: Effect on sexual function and wellbeing . Human Reproduction Update , 13 ( 3 ) : 239 – 248 .
   PubMed Web of Science ®Google Scholar
• Polan , M. L. , Hochberg , R. B. , Trant , A. S. and Hank , C. K. 2004 . Estrogen bioassay of ginseng extract and Arginmax®, a nutritional supplement for the enhancement of female sexual function . Journal of Women's Health , 13 ( 4 ) : 427 – 430 .
   Google Scholar
• Roemheld-Hamm , B. 2005 . Chasteberry . American Family Physician , 72 ( 5 ) : 821 – 824 .
   PubMed Web of Science ®Google Scholar
• Rowland , D. L. and Tai , W. 2003 . A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions . Journal of Sex & Marital Therapy , 29 ( 3 ) : 185 – 205 .
   PubMed Web of Science ®Google Scholar
• Rubio , J. , Riqueros , M. I. , Gasco , M. , Yucra , S. , Miranda , S. and Gonzales , G. F. 2006 . Lepidium meyenii (Maca) reversed the lead acetate induced—Damage on reproductive function in male rats . Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association , 44 : 1114 – 1122 .
   PubMed Web of Science ®Google Scholar
• Sakurai , N. , Wu , J. H. , Sashida , Y. , Mimaki , Y. , Nikaido , T. Koike , K. 2004 . Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins . Bioorganic & Medicinal Chemistry Letters , 14 ( 5 ) : 1329 – 1332 .
   Google Scholar
• Salvati , G. , Genovesi , G. , Marcellini , L. , Paolini , P. , DeNuccio , I. Pepe , M. 1996 . Effects of Panax ginseng C. A. Meyer saponins on male fertility . Panmiverva Medica , 38 : 249 – 254 .
   PubMed Web of Science ®Google Scholar
• Schellenberg , R. 2001 . Treatment for the premenstrual syndrome with agnus castus fruit extract: Prospective, randomized, placebo controlled study . British Medical Journal , 322 : 134 – 137 .
   PubMed Web of Science ®Google Scholar
• Shen , P. , Guo , B. L. , Gong , Y. , Hong , D. Y. , Hong , D. and Yong , E. L. 2007 . Taxonomic, genetic, chemical, and estrogenic characteristics of Epimedium species . Phytochemistry , 68 ( 10 ) : 1448 – 1458 .
   PubMed Web of Science ®Google Scholar
• Simonsen , U. , Prieto , D. , Hernandez , M. , de Tejada , I. Saenz and Garcia-Sacristan , A. 1997 . Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries . Journal of Urology , 157 : 2356 – 2360 .
   PubMed Web of Science ®Google Scholar
• Stute , P. , Nisslein , T. , Gotte , M. , Kamischke , A. , Kiesel , L. and Klockenbusch , W. 2007 . Effects of black cohosh on estrogen biosynthesis in normal breast tissue in vitro . Maturitas , 57 ( 4 ) : 382 – 391 .
   PubMed Web of Science ®Google Scholar
• Suzuki , M. , Oki , T. , Sugiyama , T. , Umegaki , K. , Uchida , S. and Yamada , S. 2007 . Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract . Urology , 69 ( 6 ) : 1216 – 1220 .
   PubMed Web of Science ®Google Scholar
• Viitamaa , T. , Haapalinna , A. and Agmo , A. 2006 . The adrenergic alpha2 receptor and sexual incentive motivation in male rats . Pharmacology, Biochemistry, and Behavior , 83 : 360 – 369 .
   PubMedGoogle Scholar
• Wayneburg , J. 1994 . Yohimbe vs. muira puama in the treatment of sexual dysfunction . American Journal of Natural Medicine , 1 : 8 – 9 .
   Google Scholar
• Wheatley , D. 1999 . Ginkgo biloba in the treatment of sexual dysfunction . Human Psychopharmacology: Clinical and Experimental , 14 : 512 – 513 .
   Google Scholar
• Wheatley , D. 2004 . Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs . Human Psychopharmacology , 19 ( 8 ) : 545 – 548 .
   PubMed Web of Science ®Google Scholar
• Wu , H. , Lien , E. J. and Lien , L. L. 2003 . Chemical and pharmacological investigations of Epemedium species: A survey . Progress in Drug Research , 60 : 1 – 57 .
   PubMedGoogle Scholar
• Xin , Z. C. , Kim , E. K. , Lin , C. S. , Liu , W. J. , Tian , L. Yuan , Y. M. 2003 . Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities . Asian Journal of Andrology , 5 : 15 – 18 .
   PubMed Web of Science ®Google Scholar
• Zava , D. T. , Dollbaum , C. M. and Blen , M. Estrogen and progestin bioactivity of foods, herbs, and spices . Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) . pp. 369 – 378 . 217, 3
   Google Scholar
• Zlotta , A. R. , Teillac , P. , Raynaud , J. P. and Schulman , C. C. 2005 . Evaluation of male sexual function in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon), Tamsulosin or Finasteride . European Urology , 48 : 269 – 276 .
   Google Scholar