Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model

References

• Dorsey ER, Constantinescu R, Thompson JP, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007;68(5):384–386. doi:10.1212/01.wnl.0000247740.47667.03.
   PubMed Web of Science ®Google Scholar
• Parkinson’s disease: pathogenesis and clinical aspects. Brisbane (AU):Codon Publications; 2018.
   Google Scholar
• Fearnley JM, Lees AJ. Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain. 1991;114 (Pt 5)(5):2283–2301. doi:10.1093/brain/114.5.2283.
   PubMedGoogle Scholar
• Balestrino R, Schapira A. Parkinson disease. Eur J Neurol. 2020;27(1):27–42. doi:10.1111/ene.14108.
   PubMed Web of Science ®Google Scholar
• Raza C, Anjum R, Shakeel N. Parkinson’s disease: mechanisms, translational models and management strategies. Life Sci. 2019;226:77–90. doi:10.1016/j.lfs.2019.03.057.
   PubMed Web of Science ®Google Scholar
• Picca A, Guerra F, Calvani R, et al. Mitochondrial dysfunction, protein misfolding and neuroinflammation in parkinson’s disease: roads to biomarker discovery. Biomolecules. 2021;11(10):1508. doi:10.3390/biom11101508.
   PubMed Web of Science ®Google Scholar
• de Andrade R, de Araujo NK, Torres-Rego M, et al. Production and characterization of chitooligosaccharides: evaluation of acute toxicity, healing, and anti-inflammatory actions. Int J Mol Sci. 2021;22(19):10631. doi:10.3390/ijms221910631.
   PubMed Web of Science ®Google Scholar
• Anil S. Potential medical applications of chitooligosaccharides. Polymers. 2022;14(17):3558. doi:10.3390/polym14173558.
   PubMed Web of Science ®Google Scholar
• Wu W, Wei W, Lu M, et al. Neuroprotective effect of chitosan oligosaccharide on hypoxic-ischemic brain damage in neonatal rats. Neurochem Res. 2017;42(11):3186–3198. doi:10.1007/s11064-017-2356-z.
   PubMed Web of Science ®Google Scholar
• Zhang X, Liang S, Gao X, et al. Protective effect of chitosan oligosaccharide against hydrogen peroxide-mediated oxidative damage and cell apoptosis via activating Nrf2/ARE signaling pathway. Neurotox Res. 2021;39(6):1708–1720. doi:10.1007/s12640-021-00419-w.
   PubMed Web of Science ®Google Scholar
• Wang B, Wang L, Qu Y, et al. Chitosan oligosaccharides exert neuroprotective effects via modulating the PI3K/akt/bcl-2 pathway in a Parkinsonian model. Food Funct. 2022;13(10):5838–5853. doi:10.1039/d1fo04374a.
   PubMed Web of Science ®Google Scholar
• Zhu L, Li R, Jiao S, et al. Blood-brain barrier permeable chitosan oligosaccharides interfere with beta-amyloid aggregation and alleviate beta-amyloid protein mediated neurotoxicity and neuroinflammation in a dose- and degree of polymerization-dependent manner. Mar Drugs. 2020;18(10):488. doi:10.3390/md18100488.
   Web of Science ®Google Scholar
• Chae SY, Jang MK, Nah JW. Influence of molecular weight on oral absorption of water soluble chitosans. J Control Release. 2005;102(2):383–394. doi:10.1016/j.jconrel.2004.10.012.
   PubMed Web of Science ®Google Scholar
• van de Waterbeemd H, Camenisch G, Folkers G, et al. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J Drug Target. 1998;6(2):151–165. doi:10.3109/10611869808997889.
   PubMed Web of Science ®Google Scholar
• Chen Q, Fan J, Lin L, et al. Combination of Lycium barbarum L. and Laminaria japonica polysaccharides as a highly efficient prebiotic: optimal screening and complementary regulation of gut probiotics and their metabolites. Int J Biol Macromol. 2023;246:125534. doi:10.1016/j.ijbiomac.2023.125534.
   PubMed Web of Science ®Google Scholar
• Sharma P, Kishore A, De I; Negi S, et al. Mitigating neuroinflammation in Parkinson’s disease: exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics. Neurochem Int. 2023;170:105604. doi:10.1016/j.neuint.2023.105604.
   PubMed Web of Science ®Google Scholar
• Li Y, Dong J, Xiao H, et al. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes. 2020;11(4):789–806. doi:10.1080/19490976.2019.1709387.
   PubMed Web of Science ®Google Scholar
• Onyszkiewicz M, Gawrys-Kopczynska M, Salagaj M, et al. Valeric acid lowers arterial blood pressure in rats. Eur J Pharmacol. 2020;877:173086. doi:10.1016/j.ejphar.2020.173086.
   PubMed Web of Science ®Google Scholar
• Dalile B, Van Oudenhove L, Vervliet B, et al. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019;16(8):461–478. doi:10.1038/s41575-019-0157-3.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhang Y, Niu M, et al. Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson’s disease by inducing autophagy. Nan Fang Yi Ke Da Xue Xue Bao. 2023;43(8):1268–1278. doi:10.12122/j.issn.1673-4254.2023.08.02.
   PubMedGoogle Scholar
• Braniste V, Al-Asmakh M, Kowal C, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6(263):263ra158. doi:10.1126/scitranslmed.3009759.
   PubMed Web of Science ®Google Scholar
• Hou YF, Shan C, Zhuang SY, et al. Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease. Microbiome. 2021;9(1):34. doi:10.1186/s40168-020-00988-6.
   PubMed Web of Science ®Google Scholar
• MacFabe DF, Cain DP, Rodriguez-Capote K, et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res. 2007;176(1):149–169. doi:10.1016/j.bbr.2006.07.025.
   PubMed Web of Science ®Google Scholar
• Abdelli LS, Samsam A, Naser SA. Propionic acid induces gliosis and neuro-inflammation through modulation of PTEN/AKT pathway in autism spectrum disorder. Sci Rep. 2019;9(1):8824. doi:10.1038/s41598-019-45348-z.
   PubMedGoogle Scholar
• Kakoty V, K CS, Dubey SK, et al. Neuroprotective effects of trehalose and sodium butyrate on preformed fibrillar form of alpha-synuclein-induced rat model of parkinson’s disease. ACS Chem Neurosci. 2021;12(14):2643–2660. doi:10.1021/acschemneuro.1c00144.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang F, Liu S, et al. Sodium butyrate exerts protective effect against Parkinson’s disease in mice via stimulation of glucagon like peptide-1. J Neurol Sci. 2017;381:176–181. doi:10.1016/j.jns.2017.08.3235.
   PubMed Web of Science ®Google Scholar
• Qiao CM, Sun MF, Jia XB, et al. Sodium butyrate exacerbates parkinson’s disease by aggravating neuroinflammation and colonic inflammation in MPTP-induced mice model. Neurochem Res. 2020;45(9):2128–2142. doi:10.1007/s11064-020-03074-3.
   PubMed Web of Science ®Google Scholar
• Han R, Nusbaum O, Chen X, et al. Valeric acid suppresses liver cancer development by acting as a novel HDAC inhibitor. Mol Ther Oncolytics. 2020;19:8–18. doi:10.1016/j.omto.2020.08.017.
   PubMed Web of Science ®Google Scholar
• Shi F, Li Y, Han R, et al. Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021;11(1):2519. doi:10.1038/s41598-021-81620-x.
   PubMed Web of Science ®Google Scholar
• Yuille S, Reichardt N, Panda S, et al. Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLOS One. 2018;13(7):e0201073. doi:10.1371/journal.pone.0201073.
   PubMed Web of Science ®Google Scholar
• Vishwakarma S, Goyal R, Gupta V, et al. GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats. Revista brasileira de farmacognosia. 2016;26(4):484–489. doi:10.1016/j.bjp.2016.02.008.
   Google Scholar
• Dulla BS, S B, K LP. A study on the effect of valeric acid in alzheimer’s induced rats by the estimation of Aβ 1-42 biomarker. J Allied Health Sciences NU. 2022;12(02):134–138. doi:10.1055/s-0041-1736274.
   Google Scholar
• Lai Z, Shan W, Li J, et al. Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice. Mol Psychiatry. 2021;26(12):7167–7187. doi:10.1038/s41380-021-01291-y.
   PubMed Web of Science ®Google Scholar
• Zeng X, Li J, Shan W, et al. Gut microbiota of old mice worsens neurological outcome after brain ischemia via increased valeric acid and IL-17 in the blood. Microbiome. 2023;11(1):204. doi:10.1186/s40168-023-01648-1.
   PubMed Web of Science ®Google Scholar
• Jayaraj RL, Beiram R, Azimullah S, et al. Valeric acid protects dopaminergic neurons by suppressing oxidative stress, neuroinflammation and modulating autophagy pathways. Int J Mol Sci. 2020;21(20):7670. doi:10.3390/ijms21207670.
   PubMed Web of Science ®Google Scholar