Publication Cover
Endothelium
Journal of Endothelial Cell Research
Volume 14, 2007 - Issue 1
45
Views
19
CrossRef citations to date
0
Altmetric
Regular Articles

A Novel Lysophospholipid- and pH-Sensitive Receptor, GPR4, in Brain Endothelial Cells Regulates Monocyte Transmigration

, , , &
Pages 25-34 | Received 19 Sep 2006, Accepted 16 Dec 2006, Published online: 13 Jul 2009

REFERENCES

  • Amano M., Ito M., Kimura K., Fukata Y., Chihara K., Nakano T., Matsuura Y., Kaibuchi K. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). Journal of Biological Chemistry 1996; 271: 20246–20249
  • Boguslawski G., Lyons D., Harvey K. A., Kovala A. T., English D. Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. Biochemical Biophysical Research Commununications 2000; 272: 603–609
  • Caslake M. J., Packard C. J., Suckling K. E., Holmes S. D., Chamberlain P., Macphee C. H. Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: A potential new risk factor for coronary artery disease. Atherosclerosis 2000; 150: 413–419
  • Essler M., Amano M., Kruse H. J., Kaibuchi K., Weber P. C., Aepfelbacher M. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. Journal of Biological Chemistry 1998; 273: 21867–21874
  • Garcia J. G., Lazar V., Gilbert-McClain L. I., Gallagher P. J., Verin A. D. Myosin light chain kinase in endothelium: Molecular cloning and regulation. American Journal of Respiration Cellular and Molecular Biology 1997; 16: 489–494
  • Han K. H., Hong K. H., Ko J., Rhee K. S., Hong M. K., Kim J. J., Kim Y. H., Park S. J. Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells. Journal of Leukocyte Biology 2004; 76: 195–202
  • Huang F., Subbaiah P. V., Holian O., Zhang J., Johnson A., Gertzberg N., Lum H. Lysophosphatidylcholine increases endothelial permeability: Role of PKC{alpha} and RhoA cross talk. American Journal of Physiology 2005; 289: L176–L185
  • Huang Y. H., Schafer-Elinder L., Wu R., Claesson H. E., Frostegard J. Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. Clinical and Experimental Immunology 1999; 116: 326–331
  • Imokawa G., Takagi Y., Higuchi K., Kondo H., Yada Y. Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. Journal of Investigative Dermatology 1999; 112: 91–96
  • Inoue N., Takeshita S., Gao D., Ishida T., Kawashima S., Akita H., Tawa R., Sakurai H., Yokoyama M. Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells. Atherosclerosis 2001; 155: 45–52
  • Kabarowski J. H., Feramisco J. D., Le L. Q., Gu J. L., Luoh S. W., Simon M. I., Witte O. N. Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Proceedings of the National Academy of Sciences of the United States of America 2000; 97: 12109–12114
  • Katz A. M., Messineo F. C. Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. Circulation Research 1981; 48: 1–16
  • Kim K. S., Ren J., Jiang Y., Ebrahem Q., Tipps R., Cristina K., Xiao Y. J., Qiao J., Taylor K. L., Lum H., et al. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB Journal 2005; 19: 819–821
  • Kimura K., Ito M., Amano M., Chihara K., Fukata Y., Nakafuku M., Yamamori B., Feng J., Nakano T., Okawa K., et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996; 273: 245–248
  • Kougias P., Chai H., Lin P. H., Lumsden A. B., Yao Q., Chen C. Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis. Medical Science Monitor 2006; 12: RA5–R16
  • Kugiyama K., Sugiyama S., Ogata N., Oka H., Doi H., Ota Y., Yasue H. Burst production of superoxide anion in human endothelial cells by lysophosphatidylcholine. Atherosclerosis 1999; 143: 201–204
  • Kume N., Cybulsky M. I., Gimbrone M. A., Jr. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. Journal of Clinical Investigation 1992; 90: 1138–1144
  • Lerm M., Schmidt G., Aktories K. Bacterial protein toxins targeting rho GTPases. FEMS Microbiology Letters 2000; 188: 1–6
  • Lin P., Welch E. J., Gao X. P., Malik A. B., Ye R. D. Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. Journal of Immunology 2005; 174: 2981–2989
  • Ludwig M. G., Vanek M., Guerini D., Gasser J. A., Jones C. E., Junker U., Hofstetter H., Wolf R. M., Seuwen K. Proton-sensing G-protein-coupled receptors. Nature 2003; 425: 93–98
  • Lum H., Qiao J., Walter R. J., Huang F., Subbaiah P. V., Kim K. S., Holian O. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. American Journal of Physiology 2003; 285: H1786–H1789
  • Marinetti G. V. Chromatographic separation, identification, and analysis of phosphatides. Journal of Lipid Research 1962; 3: 1–20
  • McIntyre T. M., Zimmerman G. A., Prescott S. M. Biologically active oxidized phospholipids [review]. Journal of Biological Chemistry 1999; 274: 25189–25192
  • Mehta D., Tiruppathi C., Sandoval R., Minshall R. D., Holinstat M., Malik A. B. Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. Journal of Physiology 2002; 539: 779–789
  • Meyerzu H. D., Himmel H. M., Jakobs K. H. Sphingosylphosphorylcholine-biological functions and mechanisms of action. Biochimica Biophysica Acta 2002; 1582: 178–189
  • Murohara T., Scalia R., Lefer A. M. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circulation Research 1996; 78: 780–789
  • Murugesan G., Sandhya Rani M. R., Gerber C. E., Mukhopadhyay C., Ransohoff R. M., Chisolm G. M., Kottke-Marchant K. Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines. Journal of Molecular and Cellular Cardiology 2003; 35: 1375–1384
  • Ousman S. S., David S. Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord. Glia 2000; 30: 92–104
  • Qiao J., Huang F., Lum H. PKA inhibits RhoA activation: A protection mechanism against endothelial barrier dysfunction. American Journal of Physiology 2003; 284: L972–L980
  • Qiao J., Huang F., Naikawadi R. P., Kim K. S., Said T., Lum H. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4. American Journal of Physiology 2006; 291: L91–L101
  • Quinn M. T., Parthasarathy S., Steinberg D. Lysophosphatidylcholine: A chemotactic factor for human monocytes and its potential role in atherogenesis. Proceedings of the National Academy of Sciences of the United States of America 1988; 85: 2805–2809
  • Radu C. G., Yang L. V., Riedinger M., Au M., Witte O. N. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proceedings of the National Academy of Sciences of the United States of America 2004; 101: 245–250
  • Ryborg A. K., Deleuran B., Sogaard H., Kragballe K. Intracutaneous injection of lysophosphatidylcholine induces skin inflammation and accumulation of leukocytes. Acta Dermato-Venereologica 2000; 80: 242–246
  • Saito H., Minamiya Y., Kitamura M., Saito S., Enomoto K., Terada K., Ogawa J. Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer. Journal of Immunology 1998; 161: 1533–1540
  • Saito H., Minamiya Y., Saito S., Ogawa J. Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation. Journal of Leukocyte Biology 2002; 72: 829–836
  • Seufferlein T., Rozengurt E. Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. Journal of Biological Chemistry 1995; 270: 24343–24351
  • Sin W. C., Zhang Y., Zhong W., Adhikarakunnathu S., Powers S., Hoey T., An S., Yang J. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene 2004; 23: 6299–6303
  • Sobel B. E., Corr P. B., Robison A. K., Goldstein R. A., Witkowski F. X., Klein M. S. Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium. Journal of Clinical Investigation 1978; 62: 546–553
  • Stamatovic S. M., Keep R. F., Kunkel S. L., Andjelkovic A. V. Potential role of MCP-1 in endothelial cell tight junction “opening”: Signaling via Rho and Rho kinase. Journal of Cell Science 2003; 116: 4615–4628
  • Stins M. F., Gilles F., Kim K. S. Selective expression of adhesion molecules on human brain microvascular endothelial cells. Journal of Neuroimmunology 1997a; 76: 81–90
  • Stins M. F., Prasadarao N. V., Zhou J., Arditi M., Kim K. S. Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: Development of an immortalized cell line to study pathophysiology of CNS disease [letter]. In Vitro Cellular.& Developmental. Biology Animal 1997b; 33: 243–247
  • Takahara N., Kashiwagi A., Maegawa H., Shigeta Y. Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells. Metabolism: Clinical & Experimental 1996; 45: 559–564
  • Takeshita S., Inoue N., Gao D., Rikitake Y., Kawashima S., Tawa R., Sakurai H., Yokoyama M. Lysophosphatidylcholine enhances superoxide anions production via endothelial NADH/NADPH oxidase. Journal of Atherosclerosis and Thrombosis 2000; 7: 238–246
  • Tinsley J. H., de Lanerolle P., Wilson E., Ma W., Yuan S. Y. Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability. American Journal of Physiology 2000; 279: C1285–C1289
  • Tomura H., Mogi C., Sato K., Okajima F. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors. Cell Signaling 2005; 17: 1466–1476
  • Wojciak-Stothard B., Williams L., Ridley A. J. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering. Journal of Cell Biology 1999; 145: 1293–1307
  • Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochimica Biophysica Acta 2002; 1582: 81–88
  • Yan S., Chai H., Wang H., Yang H., Nan B., Yao Q., Chen C. Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells. Surgery 2005; 138: 464–473
  • Yokoyama K., Ishibashi T., Ohkawara H., Kimura J., Matsuoka I., Sakamoto T., Nagata K., Sugimoto K., Sakurada S., Maruyama Y. HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells. Circulation 2002; 105: 962–967
  • Zhu Y., Lin J. H., Liao H. L., Verna L., Stemerman M. B. Activation of ICAM-1 promoter by lysophosphatidylcholine: Possible involvement of protein tyrosine kinases. Biochimica Biophysica Acta 1997; 1345: 93–98

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.