Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

REFERENCES

• Albers J. J., Tollefson J. H., Wolfbauer G., Albright R. E., Jr. Cholesteryl ester transfer protein in human brain. Intrenational Journal of Clinical Laboratory Research 1992; 21: 264–266
   PubMed Web of Science ®Google Scholar
• Arvanitakis Z., Schneider J. A., Wilson R. S., Bienias J. L., Kelly J. F., Evans D. A., Bennett D. A. Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology 2008; 70: 1795–1802
   PubMed Web of Science ®Google Scholar
• Basu S. K., Goldstein J. L., Anderson G. W., Brown M. S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 1976; 73: 3178–3182
   PubMed Web of Science ®Google Scholar
• Betz A. L., Goldstein G. W. Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries. Science 1978; 202: 225–227
   PubMed Web of Science ®Google Scholar
• Booher J., Sensenbrenner M. Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures. Neurobiology 1972; 2: 97–105
   PubMedGoogle Scholar
• Bornstein M. B. Reconstituted rat tail collagen used as substrate for time tissue cultures on coverslips in Maximow slides abd roller tubes. Laboratory Investigation 1958; 7: 134–139
   PubMed Web of Science ®Google Scholar
• Brown M. S., Goldstein J. L. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232: 34–47
   PubMed Web of Science ®Google Scholar
• Cao D., Fukuchi K., Wan H., Kim H., Li L. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiology of Aging 2005; 27: 1632–1643
   PubMed Web of Science ®Google Scholar
• Cecchelli R., Berezowski V., Lundquist S., Culot M., Renftel M., Dehouck M. P., Fenart L. Modelling of the blood-brain barrier in drug discovery and development. Naturre Review in Drug Discovery 2007; 6: 650–661
   PubMed Web of Science ®Google Scholar
• Cecchelli R., Dehouck B., Descamps L., Fenart L., Buée-Scherrer V., Lundquist S., Rentfel M., Torpier G., Cecchelli R. In vitro model for evaluating drug transport across the blood-brain barrier. Advanced Drug Delivery Reviews 1999; 36: 165–178
   PubMed Web of Science ®Google Scholar
• Dehouck B., Dehouck M. P., Fruchart J. C., Cecchelli R. Upregulation of the low density lipoprotein receptor at the Blood-brain barrier: Intercommunication between brain capillary ECs and astrocytes. Journal of Cell Biology 1994; 126: 465–473
   PubMed Web of Science ®Google Scholar
• Dehouck B., Fenart L., Dehouck M. P., Pierce A., Torpier G., Cecchelli R. A new function of the LDL receptor: Transcytosis of LDL across the Blood-brain barrier. Journal of Cell Biology 1 1997; 38: 877–889
   Google Scholar
• Dehouck M. P., Jolliet-Riant P., Brée F., Fruchart J. C., Cecchelli R., Tillement J. P. Drug transfer across the blood-brain barrier: Correlation between in vitro in vivo models. Journal of Neurochemistry 1992; 58: 1790–1797
   PubMed Web of Science ®Google Scholar
• Demeule M., Jodoin J., Gringras D., Beliveau R. P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries. FEBS Letters 2000; 466: 219–224
   PubMed Web of Science ®Google Scholar
• Furuse M., Fujita K., Hiiragi T., Fujimoto K., Tsukita S. Claudin-1 and -2: Novel membrane proteins localizing at tight junctions with no sequence similarity to occludin. Journal of Cell Biology 1998; 141: 1539–1550
   PubMed Web of Science ®Google Scholar
• Furuse M., Sasaki H., Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. Journal of Cell Biology 1999; 147: 891–903
   PubMed Web of Science ®Google Scholar
• Galbiati F., Volonte D., Engelman J. A., Watanabe G., Burk R., Pestell R. G., Lisanti M. P. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase. EMBO Journal 1998; 16: 6633–6648
   Google Scholar
• Griffith K. J., Chan E. K., Lung C. C., Hamel J. C., Guo X., Miyachi K., Fritzler M. J. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. Arthritis and Rheumatism 1997; 40: 1693–1702
   PubMed Web of Science ®Google Scholar
• Handley D. A., Arbeeny C. M., Eder H. A. Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 a-ethinyl estradiol. Journal of Cell Biology 1981; 90: 778–785
   PubMed Web of Science ®Google Scholar
• Hirase T., Staddon J. M., Saitou M., Ando-Akatsuka Y., Itoh M., Furuse M., Fujimoto K., Tsukita S., Rubin L. L. Occludin as a possible determinant of tight junction permeability in ECs. Journal of Cell Science 1997; 110: 1603–1613
   PubMed Web of Science ®Google Scholar
• Howland D. S., Trusko S. P., Savage M. J., Reaume A. G., Lang D. M., Hirsch J. D., Maeda N., Siman R., Greenberg B. D., Scott R. W., Flood D. G. Modulation of secreted β -amyloid precursor protein and amyloid β -peptide in brain by cholesterol. Journal of Biological Chemistry 1998; 273: 16576–16582
   PubMed Web of Science ®Google Scholar
• Ishizaki T., Chiba H., Kojima T., Fujibe M., Soma T., Miyajima H., Nagasawa K., Wada I., Sawada N. Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways. Experimental Cell Research 2003; 290: 275–288
   PubMed Web of Science ®Google Scholar
• Kenagy R., Bierman E. L., Schwartz S., Albers J. J. Metabolism of low density lipoprotein by bovine ECs as a function of cell density. Arteriosclerosis 1984; 4: 365–371
   PubMedGoogle Scholar
• Kirsch C., Eckert G. P., Koudinov A. R., Müller W. E. Brain cholesterol, statins and Alzheimer's Disease. Pharmacopsychiatry 2003; 36: 113–119
   PubMedGoogle Scholar
• Kurzchalia T. V., Dupree P., Parton R. G., Kellner R., Virat H., Lenhert M., Simons K. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. Journal of Cell Biology 1992; 118: 1003–1014
   PubMed Web of Science ®Google Scholar
• Lucarelli M., Borrelli V., Fiori A., Cucina A., Granata F., Potenza R. L., Scarpa S., Cavallaro A., Strom R. The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s). FEBS Letters 2002; 522: 19–23
   PubMed Web of Science ®Google Scholar
• Lundquist S., Renftel M., Brillault J., Fenart L., Cecchelli R., Dehouck M. P. Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro models. Pharmacy Research 2002; 19: 976–981
   Google Scholar
• Malavolti M., Fromm H., Ceryak S., Shenan K. L. Cerebral low-density lipoprotein (LDL) uptake is stimulated by acute bile drainage. Biochimica Biophysica Acta 1991; 108: 106–108
   Google Scholar
• Méresse S., Dehouck M. P., Delorme P., Fruchart J. C., Cecchelli R. Lipoproteins and reconstituted blood-brain barrier. Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport. 1991; 217–229
   Google Scholar
• Méresse S., Delbart C., Fruchart J. C., Cecchelli R. Low-density lipoprotein receptor on endothelium of brain capillaries. Journal of Neurochemistry 1989; 53: 340–345
   PubMed Web of Science ®Google Scholar
• Morris C. M., Keith A. B., Edwardson J. A., Pullen R. G. L. Uptake and distribution of iron and transferrin in the adult rat brain. Journal of Neurochemistry 1992; 59: 300–306
   PubMed Web of Science ®Google Scholar
• Nitta T., Hata M., Gotoh S., Seo Y., Sasaki H., Hashimoto N., Furuse M., Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. Journal of Cell Biology 2003; 161: 653–660
   PubMed Web of Science ®Google Scholar
• Norkin L. C., Anderson H. A., Wolfrom S. A., Oppenheim A. Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles. Journal of Virology 2002; 76: 5156–5166
   PubMed Web of Science ®Google Scholar
• Norkin L. C., Kuksin D. The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulum. Virological Journal 2005; 2: 38–44
   PubMedGoogle Scholar
• Ohtsuki S., Sato S., Yamaguchi H., Kamoi M., Asashima T., Terasaki T. Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells. Journal of Cellular Physiology 2007; 210: 81–86
   PubMed Web of Science ®Google Scholar
• Parton R. G., Richards A. A. Lipid rafts and caveolae as portals for endocytosis: New insight and common mechanisms. Traffic 2003; 4: 724–738
   PubMed Web of Science ®Google Scholar
• Pelkmans L., Burli T., Zerial M., Helenius A. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell 2004; 118: 767–780
   PubMed Web of Science ®Google Scholar
• Pelkmans L., Kartenbeck J., Helenius A. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nature Cell Biology 2001; 3: 473–483
   PubMed Web of Science ®Google Scholar
• Régina A., Jodoin J., Khoueir P., Rolland Y., Berthelet F., Moumdjian R., Fenart L., Cecchelli R., Demeule M., Béliveau R. Down-regulation of caveolin-1 in glioma vasculature: Modulation by radiotherapy. Journal of Neuroscience Research 2004; 75: 291–299
   PubMed Web of Science ®Google Scholar
• Refolo L. M., Malester B., LaFrancois J., Bryant-Thomas T., Wang R., Tint G. S., Sambamurti K., Duff K., Pappolla M. A. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiological Disease 2000; 7: 321–331
   PubMed Web of Science ®Google Scholar
• Rothberg K. G., Henser J. E., Donzell W. C., Ying Y. S., Glenney J. R., Anderson R. G.W. Caveolin, a protein component of caveolae membrane coats. Cell 1992; 68: 673–682
   PubMed Web of Science ®Google Scholar
• Rothberg K. G., Ying Y. S., Kamen B. A., Anderson R. G. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. Journal of Cell Biology 1990; 111: 2931–2938
   PubMed Web of Science ®Google Scholar
• Shie F. S., Jin L. W., Cook D. G., Leverenz J. B., LeBoeuf R. C. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport 2002; 13: 455–459
   PubMed Web of Science ®Google Scholar
• Simionescu M., Simionescu N. Endothelial transport of macromolecules: Transcytosis and endocytosis. A look from cell biology. Cell Biology Review 1991; 25: 5–78
   PubMedGoogle Scholar
• Smart E. J., Ying Y. S., Mineo C., Anderson R. G. A detergent-free method for purifying caveolae membrane from tissue culture cells. Proceedings of the National Academy of Sciences of the United States of America 1995; 92: 10104–10108
   PubMed Web of Science ®Google Scholar
• Stewart P. A. Endothelial vesicles in the blood-brain barrier: Are they related to permeability?. Cellular and Molecular Neurobiology 2000; 20: 149–163
   PubMed Web of Science ®Google Scholar
• Spencer B. J., Verma I. M. Targeted delivery of proteins across the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America 2007; 104: 7315–7316
   PubMedGoogle Scholar
• Traber M. G., Kayden H J. Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein. American Journal of Clinical Nutrition 1984; 40: 747–751
   PubMed Web of Science ®Google Scholar
• Vasile E., Simionescu M., Simionescu N. Visualization of the binding, endocytosis, and transcytosis of low density lipoprotein in the arterial endothelium. in situ. Journal of Cell Biology 1983; 96: 1677–1689
   PubMed Web of Science ®Google Scholar
• Virgintino D., Robertson D., Errede M., Benagiano V., Girolamo F., Maiorano E., Roncali L., Bertossi M. Expression of Caveolin-1 in human brain microvessels. Neuroscience 2002; 115: 145–152
   PubMed Web of Science ®Google Scholar
• Wolburg H., Lippoldt A. Tight junctions of the blood-brain barrier: Development, composition and regulation. Vascular Pharmacology 2002; 38: 323–337
   PubMed Web of Science ®Google Scholar