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Original Articles

Homocysteine levels and risk of essential hypertension: A meta-analysis of published epidemiological studies

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Pages 160-167 | Received 12 Apr 2016, Accepted 29 Jul 2016, Published online: 01 Mar 2017

References

  • Kearney P; Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217–23.
  • Xi B, Cheng H, Shen Y, et al. Physical activity modifies the associations between genetic variants and hypertension in the chinese children. Atherosclerosis 2012;225:376–80.
  • Batis C, Gordon-Larsen P, Cole SR, et al. Sodium intake from various time frames and incident hypertension among chinese adults. Epidemiology 2013;24:410–8.
  • Hall ME; do Carmo JM; da Silva AA, et al. Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis 2014;7:75–88.
  • O’Donovan, C.; Lithander, F.E.; Raftery, T., et al. Inverse relationship between physical activity and arterial stiffness in adults with hypertension. J Phys Act Health 2014;11:272–7.
  • Shimbo D, Levitan EB, Booth JN, et al. The contributions of unhealthy lifestyle factors to apparent resistant hypertension: findings from the reasons for geographic and racial differences in stroke (regards) study. J Hypertens 2013;31:370–6.
  • Tang L, Xu T, Li H, et al. Hypertension, alcohol drinking and stroke incidence: a population-based prospective cohort study among inner mongolians in China. J Hypertens 2014;32:1091–6; discussion 1096.
  • Rodrigo R, Passalacqua W, Araya J, et al. Homocysteine and essential hypertension. J Clinic Pharm 2003;43:1299–306.
  • Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Sem Thrombosis Hemostasis 2000;26:219–25.
  • Selhub J. Homocysteine metabolism. Ann Rev Nutr 1999;19:217–46.
  • Sutton-Tyrrell K, Bostom A, Selhub J, et al. High homocysteine levels are independently related to isolated systolic hypertension in older adults. Circulation 1997;96:1745–9.
  • Tyagi N, Moshal K, Lominadze D, et al. Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip goldblatt hypertension mouse model. Can J Physiol Pharmacol 2005;83:583–94.
  • Lim U, Cassano P. Homocysteine and blood pressure in the third national health and nutrition examination survey, 1988-1994. Am J Epidemiol 2002;156:1105–13.
  • Sundström J, Sullivan L, D’Agostino R, et al. Plasma homocysteine, hypertension incidence, and blood pressure tracking: the framingham heart study. Hypertension 2003;42:1100–1105.
  • Borges MC, Hartwig FP, Oliveira IO, et al. Is there a causal role for homocysteine concentration in blood pressure? A mendelian randomization study. Am J Clin Nutr 2016;103:39–49.
  • 2003 european society of hypertension-european society of cardiology guidelines for the management of arterial hypertension. J Hypertens 2003;21:1011–53.
  • Stang A. Critical evaluation of the newcastle-ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–5.
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21:1539–58.
  • Higgins J, Thompson S, Deeks J, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557–60.
  • Baujat B, Mahe C, Pignon JP, et al. A graphical method for exploring heterogeneity in meta-analyses: application to a meta-analysis of 65 trials. Stat Med 2002;21:2641–52.
  • Pignon JP; Bourhis J; Domenge C, et al. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. Mach-nc collaborative group. Meta-analysis of chemotherapy on head and neck cancer. Lancet 2000;355:949–955.
  • Begg C, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50:1088–101.
  • Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629–34.
  • Baszczuk A, Musialik K, Kopczynski J, et al. Hyperhomocysteinemia, lipid and lipoprotein disturbances in patients with primary hypertension. Adv Med Sci 2014;59:68–73.
  • Bowman TS, Gaziano JM, Stampfer MJ, et al. Homocysteine and risk of developing hypertension in men. J Hum Hypertens 2006;20:631–4.
  • Forman JP, Choi H, Curhan GC. Uric acid and insulin sensitivity and risk of incident hypertension. Arch Int Med 2009;169:155–62.
  • Garfunkel VA, Porto PI, Garcia SI, et al. Hyperhomocysteinemia but not mthfr genotype is associated with young-onset essential hypertension. J Hum Hypertens 2003;17:361–4.
  • Jain S, Ram H, Kumari S, et al. Plasma homocysteine levels in indian patients with essential hypertension and their siblings. Renal Fail 2003;25:195–201.
  • Lim U, Cassano PA. Homocysteine and blood pressure in the third national health and nutrition examination survey, 1988-1994. Am J Epidemiol 2002;156:1105–13.
  • Rodriguez-Esparragon F, Hernandez-Perera O, Rodriguez-Perez JC, et al. The effect of methylenetetrahydrofolate reductase c677t common variant on hypertensive risk is not solely explained by increased plasma homocysteine values. Clinic Exp Hypertens (New York, N.Y.: 1993) 2003;25:209–20.
  • Virdis A, Ghiadoni L, Cardinal H, et al. Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension. J Am Coll Cardiol 2001;38:1106–15.
  • Wang Y, Chen S, Yao T, et al. Homocysteine as a risk factor for hypertension: a 2-year follow-up study. PLoS One 2014;9:e108223.
  • Xiao W, Bai Y, Ye P, et al. Plasma homocysteine is associated with aortic arterial stiffness but not wave reflection in chinese hypertensive subjects. PLoS One 2014;9:e85938.
  • Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217–46.
  • McRae MP. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials. J Chiropr Med 2009;8:15–24.
  • van Dijk RA, Rauwerda JA, Steyn M, et al. Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2001;21:2072–9.
  • McMahon JA; Skeaff CM; Williams SM, et al. Lowering homocysteine with b vitamins has no effect on blood pressure in older adults. J Nutr 2007;137:1183–7.
  • Szabo de Edelenyi F, Vergnaud AC, Ahluwalia N, et al. Effect of b-vitamins and n-3 pufa supplementation for 5 years on blood pressure in patients with cvd. Br J Nutr 2012;107:921–7.
  • Mangoni AA, Sherwood RA, Swift CG, et al. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Int Med 2002;252:497–503.
  • Williams C, Kingwell BA, Burke K, et al. Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of mthfr genotype. Am J Clin Nutr 2005;82:26–31.
  • Fakhrzadeh H, Ghotbi S, Pourebrahim R, et al. Plasma homocysteine concentration and blood pressure in healthy iranian adults: the tehran homocysteine survey (2003-2004). J Hum Hypertens 2005;19:869–76.
  • Holmes MV, Newcombe P, Hubacek JA, et al. Effect modification by population dietary folate on the association between mthfr genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet 2011;378:584–94.

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