189
Views
6
CrossRef citations to date
0
Altmetric
Articles

Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice

, , , , &
Pages 312-318 | Received 01 Apr 2016, Accepted 18 Sep 2016, Published online: 17 May 2017

References

  • Hwang MH, Kim S. Type 2 diabetes: Endothelial dysfunction and exercise. J Exerc Nutr Biochem 2014;18:239–247.
  • Hamilton SJ, Watts GF. Endothelial dysfunction in diabetes: Pathogenesis, significance, and treatment. Rev Diabet Stud 2013;10:133–156.
  • Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des 2013;19:5695–5703.
  • Kellow NJ, Savige GS. Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: A systematic review. Eur J Clin Nutr 2013;67:239–248.
  • Wang S, Peng Q, Zhang J, Liu L. Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain. Cardiovasc Res 2008;80:255–262.
  • Alfranca A, Iniguez MA, Fresno M, Redondo JM. Prostanoid signal transduction and gene expression in the endothelium: Role in cardiovascular diseases. Cardiovasc Res 2006;70:446–456.
  • Takayama K, Yuhki K, Ono K, et al. Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med 2005;11:562–566.
  • Kobayashi T, Tahara Y, Matsumoto M, et al. Roles of thromboxane a(2) and prostacyclin in the development of atherosclerosis in apoe-deficient mice. J Clin Invest 2004;114:784–794.
  • Zuccollo A, Shi C, Mastroianni R, et al. The thromboxane A2 receptor antagonist s18886 prevents enhanced atherogenesis caused by diabetes mellitus. Circulation 2005;112:3001–3008.
  • Gao Y, Yokota R, Tang S, et al. Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of Akt phosphorylation in endothelial cells by thromboxane A(2). Circ Res 2000;87:739–745.
  • Ashton AW, Ware JA. Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Circ Res 2004;95:372–379.
  • Li P, Chen GR, Wang F, et al. Inhibition of Na(+)/H(+) exchanger 1 attenuates renal dysfunction induced by advanced glycation end products in rats. J Diabetes Res 2016;2016:1802036.
  • Yang JJ, Li P, Wang F, et al. Activation of activator protein 2 alpha by aspirin alleviates atherosclerotic plaque growth and instability in vivo. Oncotarget 2016;
  • Wang S, Zhang C, Zhang M, et al. Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med 2012;18:902–910.
  • Wang S, Zhang M, Liang B, et al. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: Role of 26s proteasomes. Circ Res 2010;106:1117–1128.
  • Wang S, Liang B, Viollet B, et al. Inhibition of the AMP-activated protein kinase-alpha2 accentuates agonist-induced vascular smooth muscle contraction and high blood pressure in mice. Hypertension 2011;57:1010–1017.
  • Wang J, Guo T, Peng QS, et al. Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice. J Cell Mol Med 2015;19:2607–2616.
  • Liu Z, Li P, Zhao ZH, et al. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (−/−) mice fed with high-fat diet. J Diabetes Res. 2016;2016:1748065.
  • Yang XH, Li P, Yin YL, et al. Rosiglitazone via PPARgamma-dependent suppression of oxidative stress attenuates endothelial dysfunction in rats fed homocysteine thiolactone. J Cell Mol Med 2015;19:826–835.
  • Dimmeler S, Fleming I, Fisslthaler B, et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601–605.
  • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597–601.
  • Wang XL, Zhang L, Youker K, et al. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 2006;55:2301–2310.
  • Ming XF, Viswambharan H, Barandier C, et al. Rho GTPase/rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 2002;22:8467–8477.
  • Wang S, Xu J, Song P, et al. In vivo activation of amp-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes 2009;58:1893–1901.
  • Heasman SJ, Ridley AJ. Mammalian rho GTPases: New insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 2008;9:690–701.
  • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995;81:53–62.
  • Nobes CD, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 1999;144:1235–1244.
  • Mihm MJ, Jing L, Bauer JA. Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage. J Cardiovasc Pharmacol 2000;36:182–187.
  • Nohria A, Grunert ME, Rikitake Y, et al. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res 2006;99:1426–1432.
  • Utsugi T, Yoon JW, Park BJ, et al. Major histocompatibility complex class I-restricted infiltration and destruction of pancreatic islets by nod mouse-derived beta-cell cytotoxic CD8+ t-cell clones in vivo. Diabetes 1996;45:1121–1131.
  • Paneni F, Costantino S, Cosentino F. Insulin resistance, diabetes, and cardiovascular risk. Curr Atheroscler Rep 2014;16:419.
  • Shafrir E. Development and consequences of insulin resistance: Lessons from animals with hyperinsulinaemia. Diabetes Metab 1996;22:122–131.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.