141
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats

, , , , , & show all
Pages 531-538 | Received 13 May 2019, Accepted 27 Jan 2020, Published online: 05 Feb 2020

References

  • Bollag WB. Regulation of aldosterone synthesis and secretion. Compr Physiol. 2014;4:1017–55.
  • Xanthakis V, Vasan RS. Aldosterone and the risk of hypertension. Curr Hypertens Rep. 2013;15:102–07. doi:10.1007/s11906-013-0330-y.
  • Jackson L, Eldahshan W, Fagan SC, Ergul A. Within the brain: the renin angiotensin system. Int J Mol Sci. 2018 Mar 15;19(3):E876. doi:10.3390/ijms19030876.
  • Huber G, Schuster F, Raasch W. Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases. Pharmacol Res. 2017;125:72–90. doi:10.1016/j.phrs.2017.06.016.
  • Van Thiel BS, Goes Martini A, Te Riet L, Severs D, Uijl E, Garrelds IM, Leijten FP, van der Pluijm I, Essers J, Qadri F, et al. Brain renin-angiotensin system: does it exist? Hypertension. 2017;69:1136–44.
  • Mascolo A, Sessa M, Scavone C, De Angelis A, Vitale C, Berrino L, Rossi F, Rosano G, Capuano A. New and old roles of the peripheral and brain renin-angiotensin-aldosterone system (RAAS): focus on cardiovascular and neurological disease. Int J Cardiol. 2017;227:734–42.
  • Faraq E, Sessler DI, Ebrahim Z, Kurz A, Morgan J, Ahuja S, Maheshwari K, John DD. The renin angiotensin system and the brain: new developments. J Clin Neurosci. 2017;46:1–8.
  • Lorthois S, Lauwers F, Cassot F. Tortuosity and other vessel attributes for arterioles and venules of the human cerebral cortex. Microvasc Res. 2014;91:99–109. doi:10.1016/j.mvr.2013.11.003.
  • Papademetriou V. Hypertension and cognitive function. Blood pressure regulation and cognitive function: a review of the literature. Geriatrics. 2005;60:20–22, 24.
  • Sabbatini M, Catalani A, Consoli C, Marletta N, Tomassoni D, Avola R. The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia? Mech Ageing Dev. 2002;123:547–59. doi:10.1016/S0047-6374(01)00362-1.
  • Mckelvie RS, Yusuf S, Pericak D, Avezum A, Burns RJ, Probstfield J, Tsuyuki RT, White M, Rouleau J, Latini R, et al. Comparison of candesartan, enalapril and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction(RESOLVD) pilot study. Circulation. 1999;100:1056–64.
  • Stier CT, Chander PN, Rocha R. Aldosterone as a mediator in cardiovascular injury. Cardiol Rev. 2002;10:97–107. doi:10.1097/00045415-200203000-00008.
  • Rudolph AE, Rocha R, McMahon EG. Aldosterone target organ protection by eplerenone. Mol Cell Endocrinol. 2004;217:229–38. doi:10.1016/j.mce.2003.10.047.
  • Scuteri A, Nilsson PM, Tzourio C, Redon J, Laurent S. Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications. J Hypertens. 2011;29:1469–77. doi:10.1097/HJH.0b013e328347cc17.
  • Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the framingham heart study: a cross-sectional study. Lancet Neurol. 2012;11:1039–47. doi:10.1016/S1474-4422(12)70241-7.
  • Gonzalez-Quevedo A, Gonzalez-Garcia S, Hernandez-Diaz Z, Fernandez Concepcion O, Quevedo Sotolongo L, Pena-Sanchez M, Marquez Rosales B, Santiesteban Freixas R, Femandez-Almirall I, Menendez-Sainz MC, et al. Serum neuron specific enolase could predict subclinical brain damage and the subsequent occurrence of brain related vascular events during follow up in essential hypertension. J Neurol Sci. 2016;363:158–63. doi:10.1016/j.jns.2016.02.052.
  • Rossi GP, Di BV, Ganzaroli C, Sacchetto A, Cesari M, Bertini A, Giorgi D, Scognamiglio R, Mariani M, Pessina AC. Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism. Hypertension. 2002;40:23–27.
  • Wright JW, Harding JW. The brain renin-angiotensin system: A diversity of functions and implications for CNS diseases. Pflugers Arch. 2013;465:133–51. doi:10.1007/s00424-012-1102-2.
  • Chen A, Huang BS, Wang HW, Ahmad M, Leenen FHH. Konckdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats. J Physiol. 2014;592:3523–36.
  • Huang BS, Chen A, Ahmad M, Wang HW, Leenen FHH. Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct. J Physiol. 2014;592:3273–86.
  • Klingbeil AU, Schneider M, Martus P, Messerli FH, Schmieder RE. A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med. 2003;115:41–46.
  • Bomback AS, Klemmer PJ. The incidence and implications of aldosterone breakthrough. Nat Clin Pract Nephrol. 2007;3:486–92. doi:10.1038/ncpneph0575.
  • Schmidt BM, Schmieder RE. Aldosterone-induced cardiac damage: focus on blood pressure independent effects. Am J Hypertens. 2003;16:80–86. doi:10.1016/S0895-7061(02)03199-0.
  • Kosmala W, Przewlocka-Kosmala M, Szczepanik-Osadnik H, Mysiak A, O’Moore-Sullivan T, Marwick TH. A randomized study of the beneficial effects of aldosterone antagonism on LV function, structure, and fibrosis markers in metabolic syndrome. JACC Cardiovasc Imaging. 2011;4:1239–49.
  • Pitt B, Reichek N, Willenbrock R, Zannad F, Phillips RA, Roniker B, Kleiman J, Krause S, Burns D, Williams GH. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation. 2003;108:1831–38.
  • Schneider A, Schwab J, Karg MV, Kalizki T, Reinold A, Bar I, Schneider MP, Schmieder RE, Schmidt BMW. Low-dose eplerenone decreases left ventricularmass in treatment-resistant hypertension. J Hypertens. 2017;35:1086–92.
  • Braszko JJ, Wincewicz D, Jakubow P. Candesartan prevents impairment of recall caused by repeated stress in rats. Psychopharmacology (Berl). 2013;225:421–28. doi:10.1007/s00213-012-2829-3.
  • Villapol S, Balarezo MG, Affram K, Saavedra JM, Symes AJ. Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain. 2015;138:3299–315.
  • Avanzini G, Depaulis A, Tassinari A, de Curtis M. Do seizures and epileptic activity worsen epilepsy and deteriorate cognitive function?. Epilepsia. 2013;54(Suppl 8):14–21. doi:10.1111/epi.12418.
  • Huang BS, Cheung WJ, Wang H, Tan J, White RA, Leenen FH. Activation of the brain rennin - angiotensin - aldosterone system by central sodium in Wistar rats. Am J Physiol Heart Circ Physiol. 2006;291:1109–17.
  • Rocha R, Stier CT. Pathophysiological effects of aldosterone in cardiovascular tissues. Trends Endocrinol Metab. 2001;12:308–14. doi:10.1016/S1043-2760(01)00432-5.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.