172
Views
7
CrossRef citations to date
0
Altmetric
Review Article

Chemical renal denervation-induced upregulation of the ACE2/Ang (1-7)/Mas axis attenuates blood pressure elevation in spontaneously hypertensive rats

ORCID Icon, , , , &

References

  • Turner AJ , Hooper NM. The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci. 2002;23:177–83. doi:10.1016/s0165-6147(00)01994-5.
  • Inagami T . A memorial to Robert Tiegerstedt: the centennial of renin discovery. Hypertension. 1998;32:953–57. doi:10.1161/01.hyp.32.6.-953.
  • Touyz RM , Berry C . Recent advances in angiotensin II signaling. Braz J Med Biol Res. 2002;35:1001–15. doi:10.1590/s0100879x20-02000900001.
  • Mehta PK , Griendling KK . Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292:C82–C97. doi:10.1152/ajpcell.00287.2006.
  • Campagnole-Santos MJ , Heringer SB , Santos RA , Khosla MC , Santos RA . Differential baroreceptor reflex modulation by centrally infused angiotensin peptides. Am J Physiol. 1992;263:R89–R94.
  • Fontes MA , Silva LC , Santos RA , . Evidence that angiotensin-(1-7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors. Brain Res. 1994;665:175–80.
  • Tipnis SR , Hooper NM , Turner AJ , Karran E , Christie G , Turner AJ . A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275:33238–43.
  • Donoghue M , Hsieh F , Baronas E , Godbout K , Gosselin M , Stagliano N , Donovan M , Woolf B , Robison K , Jeyaseelan R , et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87:E1–E9.
  • Vickers C , Hales P , Kaushik V , Dick L , Gavin J , Tang J , Godbout K , Parsons T , Baronas E , Hsieh F , et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002;277(17):14838–43. doi:10.1074/jbc.M200581200.
  • Santos RA , Simoes E Silva AC , Maric C , Silva DMR , Machado RP , de Buhr I , Heringer-Walther S , Pinheiro SVB , Lopes MT , Bader M , et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA. 2003;100(14):8258–63. doi:10.1073/pnas.14328-69100.
  • Krob HA , Vinsant SL , Ferrario CM , Friedman DP . Angiotensin-(1-7) immunoreactivity in the hypothalamus of the (mRen-2d)27 transgenic rat. Brain Res. 1998;798:36–45.
  • Sata Y , Kawada T , Shimizu S , Kamiya A , Akiyama T , Sugimachi M . Predominant role of neural arc in sympathetic baroreflex resetting of spontaneously hypertensive rats. Circ J. 2015;79:592–99.
  • Liard JF . Renal denervation delays blood pressure increase in the spontaneously hypertensive rats. Experientia. 1977;15:339–40. doi:10.1007/bf02002815.
  • Krum H , Schlaich M , Whitbourn R , Sobotka PA , Sadowski J , Bartus K , Kapelak B , Walton A , Sievert H , Thambar S , et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275–81. doi:10.1016/S0140-6736(09)60566-3.
  • Conrad CH , Brooks WW , Hayes JA , Sen S , Robinson KG , Bing OHL . Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 1995;91(1):161–70. doi:10.1161/01.cir.91.1.161.
  • Jöhren O , Golsch C , Dendorfer A , Qadri F , Häuser W , Dominiak P . Differential expression of AT 1 receptors in the pituitary and adrenal gland of SHR and WKY. Hypertension. 2003;41:984–90.
  • Wei S , Li D , Zhang Y , Su L , Zhang Y , Wang Q , Yang D , Li D , Yang Y , Ma S , et al. Perivascular radiofrequency renal denervation lowers blood pressure and ameliorates cardiorenal fibrosis in spontaneously hypertensive rats. PLoS One. 2017;12(4):e0176888.doi:10.1371/journal.pone.0176888.
  • Eriguchi M , Tsuruya K . Renal sympathetic denervation in rats. Methods Mol Biol. 2016;1397:45–52. doi:10.1371/journal.pone.0176888.
  • Uchida K , Baba H , Maezawa Y , Kubota C . Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical spinal cord compression in spinal hyperostotic mice. Spine. 2002;27:480–86.
  • Santos Robson AS , Ferreira AJ , Simões E Silva AC . Recent advances in the angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis. Exp Physiol. 2008;95:519–27.
  • Rice GI , Thomas DA , Grant PJ , Turner A , Hooper N . Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383:45–51.
  • Gurley SB , Allred A , Le TH , Griffiths R , Mao L , Philip N , Haystead TA , Donoghue M , Breitbart RE , Acton SL , et al. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006;116(8):2218–25. doi:10.1172/JCI16980.
  • Wysocki J , Ye M , Rodriguez E , González-Pacheco FR , Barrios C , Evora K , Schuster M , Loibner H , Brosnihan KB , Ferrario CM , et al. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010;55(1):90–98. doi:10.1161/HYPERTENSIONAHA.109.138420.
  • Vasan RS , Evans JC , Larson MG , Wilson PWF , Meigs JB , Rifai N , Benjamin EJ , Levy D . Serum aldosterone and the incidence of hypertension in non-hypertensive persons. N Engl J Med. 2004;351:33–41.
  • Huang PL , Huang Z , Mashimo H , Bloch KD , Moskowitz MA , Bevan JA , Fishman MC . Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377(6546):239–42. doi:10.1038/377239a0.
  • Cai H , Harrison DG . 2000. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 87(10):840–44. doi:10.1161/01.res.87.10.840
  • Hermann M , Flammer A , Luscher TF . 2006. Nitric oxide in hypertension. J Clin Hypertens (Greenwich). 8(12 Suppl 4):17–29. doi:10.1111/j.15246175.2006.06032.x
  • Feng Y , Xia H , Cai Y , Halabi CM , Becker LK , Santos RAS , Speth RC , Sigmund CD , Lazartigues E . Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res. 2010;106:373–82.
  • Zhang Y , Lu J , Shi J , Lin X , Dong J , Zhang S , Liu Y , Tong Q . Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats. Neuropeptides. 2008;42:593–600.
  • Carlstrom M , Brown RD , Yang T , Hezel M , Larsson E , Scheffer PG , Teerlink T , Lundberg JO , Persson AEG . Persson, L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake. Acta Physiol. 2013;207:732–41.
  • Datla SR , Griendling KK . Reactive oxygen species, NADPH oxidases, and hypertension. Hypertension. 2010;56:325–30. doi:10.1161/HYPERTENSIONAHA.109.142422.
  • Lopez-Real A , Rey P , Soto-Otero R , Mendez-Alvarez E , Labandeira-Garcia JL . Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. J Neurosci Res. 2005;81:865–73.
  • Wang G , Coleman CG , Chan J , Faraco G , Marques-Lopes J , Milner TA , Guruju MR , Anrather J , Davisson RL , Iadecola C , et al. Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. Am J Physiol. 2013;304:R1096–R1106.
  • Zheng J , Li G , Chen S , Bihl J , Buck J , Zhu Y , Xia H , Lazartigues E , Chen Y , Olson JE , et al. Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction. Neuroscience. 2014;273:39–51.
  • Zheng H , Liu X , Patel KP . Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure. Am J Physiol Heart Circ Physiol. 2011;301:H2402–H2412. doi:10.1152/ajpheart.00330.2011.
  • Yamazato M , Yamazato Y , Sun C , Diez-Freire C , Raizada MK . Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension. 2007;49:926–31.
  • Feng Y , Yue X , Xia H , Bindom SM , Hickman PJ , Filipeanu CM , Wu G , Lazartigues E . Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res. 2008;102:729–36.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.