The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives

References

• Munir S, Jiang B, Guilcher A, Brett S, Redwood S, Marber M, Chowienczyk P, et al. Exercise reduces arterial pressure augmentation through vasodilation of muscular arteries in humans. Am J Physiol Heart Circ Physiol. 2008;294(4):H1645–50.doi:10.1152/ajpheart.01171.2007.
   PubMed Web of Science ®Google Scholar
• Holland DJ, Sacre JW, McFarlane SJ, Coombes JS, Sharman JE. Pulse wave analysis is a reproducible technique for measuring central blood pressure during hemodynamic perturbations induced by exercise. Am J Hypertens. 2008;21:1100–06.
   PubMed Web of Science ®Google Scholar
• Myers J, Arena R, Franklin B, Pina I, Kraus WE, McInnis K, et al. Recommendations for clinical exercise laboratories: a scientific statement from the american heart association. Circulation. 2009;119:3144–61.
   PubMed Web of Science ®Google Scholar
• Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American heart association. Circulation. 2013;128:873–934.
   PubMed Web of Science ®Google Scholar
• Le VV, Mitiku T, Sungar G, Myers J, Froelicher V. The blood pressure response to dynamic exercise testing: a systematic review. Prog Cardiovasc Dis. 2008;51:135–60.
   PubMed Web of Science ®Google Scholar
• Miyai N, Arita M, Morioka I, Miyashita K, Nishio I, Takeda S. Exercise BP response in subjects with high-normal BP: exaggerated blood pressure response to exercise and risk of future hypertension in subjects with high-normal blood pressure. J Am Coll Cardiol. 2000;36:1626–31.
   PubMed Web of Science ®Google Scholar
• Stewart KJ, Sung J, Silber HA, Fleg JL, Kelemen MD, Turner KL, et al. Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function. Am J Hypertens. 2004;17:314–20.
   PubMed Web of Science ®Google Scholar
• Barbosa TC, Vianna LC, Fernandes IA, Prodel E, Rocha HN, Garcia VP, et al. Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men. J Physiol. 2016;594:715–25.
   PubMed Web of Science ®Google Scholar
• Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, Farquhar WB. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol. 2010;299:H1318–27.
   PubMed Web of Science ®Google Scholar
• Sausen MT, Delaney EP, Stillabower ME, Farquhar WB. Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol. 2009;105:351–56.
   PubMed Web of Science ®Google Scholar
• Greaney JL, Wenner MM, Farquhar WB. Exaggerated increases in blood pressure during isometric muscle contraction in hypertension: role for purinergic receptors. Auton Neurosci. 2015;188:51–57.
   PubMed Web of Science ®Google Scholar
• Ren JF, Hakki AH, Kotler MN, Iskandrian AS. Exercise systolic blood pressure: a powerful determinant of increased left ventricular mass in patients with hypertension. J Am Coll Cardiol. 1985;5:1224–31.
   PubMed Web of Science ®Google Scholar
• Mizuno R, Fujimoto S, Saito Y, Yamazaki M. Clinical importance of detecting exaggerated blood pressure response to exercise on antihypertensive therapy. Heart. 2016;102:849–54.
   PubMed Web of Science ®Google Scholar
• Mundal R, Kjeldsen SE, Sandvik L, Erikssen G, Thaulow E, Erikssen J. Exercise blood pressure predicts mortality from myocardial infarction. Hypertension. 1996;27:324–29.
   PubMed Web of Science ®Google Scholar
• Kjeldsen SE, Mundal R, Sandvik L, Erikssen G, Thaulow E, Erikssen J. Exercise blood pressure predicts cardiovascular death and myocardial infarction. Blood Press Monit. 1997;2:147–53.
   PubMedGoogle Scholar
• Laukkanen JA, Kurl S, Rauramaa R, Lakka TA, Venalainen JM, Salonen JT. Systolic blood pressure response to exercise testing is related to the risk of acute myocardial infarction in middle-aged men. Eur J Cardiovasc Prev Rehabil. 2006;13:421–28.
   PubMed Web of Science ®Google Scholar
• Schultz MG, Otahal P, Cleland VJ, Blizzard L, Marwick TH, Sharman JE. Exercise-induced hypertension, cardiovascular events, and mortality in patients undergoing exercise stress testing: a systematic review and meta-analysis. Am J Hypertens. 2013;26:357–66.
   PubMed Web of Science ®Google Scholar
• Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Systolic blood pressure response to exercise stress test and risk of stroke. Stroke. 2001;32:2036–41.
   PubMed Web of Science ®Google Scholar
• Fagard RH, Pardaens K, Staessen JA, Thijs L. Prognostic value of invasive hemodynamic measurements at rest and during exercise in hypertensive men. Hypertension. 1996;28:31–36.
   PubMed Web of Science ®Google Scholar
• Riebe D, Ehrman JK, Liguori G, Magal M. ACSM’s guidelines for exercise testing and prescription. 10 ed. Philadelphia: Wolters Kluwer; 2018.
   Google Scholar
• Daida H, Allison TG, Squires RW, Miller TD, Gau GT. Peak exercise blood pressure stratified by age and gender in apparently healthy subjects. Mayo Clinic Proc. 1996;71:445–52.
   PubMed Web of Science ®Google Scholar
• Toda N, Okamura T. Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: an overview. J Clin Pharmacol. 2013;53:1228–39.
   PubMed Web of Science ®Google Scholar
• Chant B, Bakali M, Hinton T, Burchell AE, Nightingale AK, Paton JFR, et al. Antihypertensive treatment fails to control blood pressure during exercise. Hypertension. 2018;72:102–09.
   PubMedGoogle Scholar
• Kokkinos P, Chrysohoou C, Panagiotakos D, Narayan P, Greenberg M, Singh S. Beta-blockade mitigates exercise blood pressure in hypertensive male patients. J Am Coll Cardiol. 2006;47:794–98.
   PubMed Web of Science ®Google Scholar
• Wilson MF, Sung BH, Pincomb GA, Lovallo WR. Exaggerated pressure response to exercise in men at risk for systemic hypertension. Am J Cardiol. 1990;66:731–36.
   PubMed Web of Science ®Google Scholar
• Galbo H. The hormonal response to exercise. Diabetes Metab Rev. 1986;1:385–408.
   PubMedGoogle Scholar
• Fallo F. Renin-angiotensin-aldosterone system and physical exercise. J Sports Med Phys Fitness. 1993;33:306–12.
   PubMed Web of Science ®Google Scholar
• Warner JG Jr., Metzger DC, Kitzman DW, Wesley DJ, Little WC. Losartan improves exercise tolerance in patients with diastolic dysfunction and a hypertensive response to exercise. J Am Coll Cardiol. 1999;33:1567–72.
   PubMed Web of Science ®Google Scholar
• Mert KU, Ilguy S, Dural M, Mert GO, Ozakin E. Effects of creatine supplementation on cardiac autonomic functions in bodybuilders. Pacing Clin Electrophysiol. 2017;40:721–27.
   PubMed Web of Science ®Google Scholar
• Mert KU, Ilguy S, Mert GO, Dural M, Iskenderov K. Noninvasive predictors of cardiac arrhythmias in bodybuilders. Rev Port Cardiol. 2018;37:693–701.
   PubMedGoogle Scholar
• Herman RB, Jesudason PJ, Mustafa AM, Husain R, Choy AMJ, Lang CC. Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans. Br J Clin Pharmacol. 2003;55:134–38.
   PubMed Web of Science ®Google Scholar
• Van Bortel LM, van Baak MA. Exercise tolerance with nebivolol and atenolol. Cardiovasc Drugs Ther. 1992;6:239–47.
   PubMed Web of Science ®Google Scholar
• White WB, Schulman P, McCabe EJ, Hager WD. Effects of chronic cetamolol therapy on resting, ambulatory, and exercise blood pressure and heart rate. Clin Pharmacol Ther. 1986;39:664–68.
   PubMed Web of Science ®Google Scholar
• Haasis R, Bethge H.Exercise blood pressure and heart rate reduction 24 and 3 hours after drug intake in hypertensive patients following 4 weeks of treatment with bisoprolol and metoprolol: a randomized multicentre double-blind study (BISOMET). Eur Heart J. 1987;8(Suppl M):103–13.
   PubMedGoogle Scholar
• Franz IW, Behr U, Ketelhut R. Resting and exercise blood pressure with atenolol, enalapril and a low-dose combination. J Hypertens Suppl. 1987;5:S37–41.
   PubMedGoogle Scholar
• Lorimer AR, Barbour MB, Lawrie TD. An evaluation of the effect on resting and exercise blood pressure of some first line treatments in hypertension. Ann Clin Res. 1983;15:30–34.
   PubMedGoogle Scholar
• Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–605.
   PubMed Web of Science ®Google Scholar
• Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–27.
   PubMed Web of Science ®Google Scholar
• Fossum E, Hoieggen A, Moan A, Rostrup M, Kjeldsen SE. Insulin sensitivity is related to physical fitness and exercise blood pressure to structural vascular properties in young men. Hypertension. 1999;33:781–86.
   PubMed Web of Science ®Google Scholar
• Tzemos N, Lim PO, MacDonald TM. Exercise blood pressure and endothelial dysfunction in hypertension. Int J Clin Pract. 2009;63:202–06.
   PubMed Web of Science ®Google Scholar
• Chang HJ, Chung J, Choi SY, Yoon MH, Hwang GS, Shin JH, et al. Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test. Clin Cardiol. 2004;27:421–25.
   PubMed Web of Science ®Google Scholar