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Clinical and Experimental Hypertension Volume 43, 2021 - Issue 5
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Research Article

Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake

Nuno M. Piresa Division of Research and Development, BIAL-Portela & Cª, S.A, Coronado (S. Mamede & S. Romão), PortugalView further author information
,
Bruno Igrejaa Division of Research and Development, BIAL-Portela & Cª, S.A, Coronado (S. Mamede & S. Romão), PortugalView further author information
&
Patrício Soares-da-Silvaa Division of Research and Development, BIAL-Portela & Cª, S.A, Coronado (S. Mamede & S. Romão), Portugal;b Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal;c MedInUp – Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, PortugalCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2446-5078View further author information
ORCID Icon
Pages 428-435 | Received 17 Jan 2021, Accepted 18 Feb 2021, Published online: 10 Mar 2021

References

  • Bright NJ, Thornton C, Carling D. The regulation and function of mammalian AMPK-related kinases. Acta Physiol (Oxf). 2009;196(1):15–26. doi:10.1111/j.1748-1716.2009.01971.x.
  • Wang Z, Takemori H, Halder SK, Nonaka Y, Okamoto M. Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal. FEBS Lett. 1999;453(1–2):135–39. doi:10.1016/S0014-5793(99)00708-5.
  • Okamoto M, Takemori H, Katoh Y. Salt-inducible kinase in steroidogenesis and adipogenesis. Trends Endocrinol Metab. 2004;15(1):21–26. doi:10.1016/j.tem.2003.11.002.
  • Sakamoto K, Bultot L, Goransson O. The salt-inducible kinases: emerging metabolic regulators. Trends Endocrinol Metab. 2018;29(12):827–40. doi:10.1016/j.tem.2018.09.007.
  • Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM. Salt-inducible kinases: physiology, regulation by cAMP, and therapeutic potential. Trends Endocrinol Metab. 2018;29(10):723–35. doi:10.1016/j.tem.2018.08.004.
  • Sall J, Negoita F, Hansson B, Kopietz F, Linder W, Pettersson AML, Ekelund M, Laurencikiene J, Degerman E, Stenkula KG, et al. Insulin induces Thr484 phosphorylation and stabilization of SIK2 in adipocytes. Cell Signal. 2019;55:73–80.
  • Chen F, Chen L, Qin Q, Sun X. Salt-inducible kinase 2: an oncogenic signal transmitter and potential target for cancer therapy. Front Oncol. 2019;9:18.
  • Sjostrom M, Stenstrom K, Eneling K, Zwiller J, Katz AI, Takemori H, Bertorello AM. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proc Natl Acad Sci U S A. 2007;104(43):16922–27. doi:10.1073/pnas.0706838104.
  • Eneling K, Brion L, Pinto V, Pinho MJ, Sznajder JI, Mochizuki N, Emoto K, Soares-da-Silva P, Bertorello, AM. Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability. Faseb J 2012;26:3230–39.
  • Bertorello AM, Pires N, Igreja B, Pinho MJ, Vorkapic E, Wagsater D, Wikström J, Behrendt M, Hamsten A, Eriksson P, et al. Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1). Circ Res. 2015;116(4):642–52. doi:10.1161/CIRCRESAHA.116.304529.
  • Popov S, Takemori H, Tokudome T, Mao Y, Otani K, Mochizuki N, Pires N, Pinho MJ, Franco-Cereceda A, Torielli L, et al. Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake. PLoS One. 2014;9(4):e95771. doi:10.1371/journal.pone.0095771.
  • Pires NM, Igreja B, Serrao MP, Matias EF, Moura E, Antonio T, Campos FL, Brion L, Bertorello A, Soares-da-silva P. Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1). Hypertens Res. 2019;42(8):1114–24. doi:10.1038/s41440-019-0249-z.
  • Jaitovich A, Bertorello AM. Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure. Biochim Biophys Acta. 2010;1802(12):1140–49. doi:10.1016/j.bbadis.2010.03.009.
  • Popov S, Silveira A, Wagsater D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, et al. Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure. J Hypertens. 2011;29(12):2395–403. doi:10.1097/HJH.0b013e32834d3d55.
  • Taub M. Salt inducible kinase signaling networks: implications for acute kidney injury and therapeutic potential. Int J Mol Sci. 2019;20(13):3219. doi:10.3390/ijms20133219.

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