Autophagy contributes to angiotensin II induced dysfunction of HUVECs

References

• Patel S, Rauf A, Khan H, Abu-Izneid T. Renin-angiotensin-aldosterone (RAAS): the ubiquitous system for homeostasis and pathologies. Biomed Pharmacother. 2017;94:317–25.
   PubMed Web of Science ®Google Scholar
• Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017;125(Pt A):21-38
   Web of Science ®Google Scholar
• Leung PS.The peptide hormone angiotensin II: its new functions in tissues and organs. Curr Protein Pept Sci. 2004;5(4):267–73. doi:10.2174/1389203043379693.
   PubMed Web of Science ®Google Scholar
• Kim S, Iwao H.Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev. 2000;52(1):11–34.
   PubMed Web of Science ®Google Scholar
• Ferrario CM, Mullick AE. Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease. Pharmacol Res. 2017;125(Pt A):57-71.
   PubMed Web of Science ®Google Scholar
• Kimura S, Zhang G-X, Nishiyama A, Shokoji T, Yao L, Fan -Y-Y, Rahman M, Abe Y. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension. 2005;45(3):438–44. doi:10.1161/01.HYP.0000157169.27818.ae.
   PubMed Web of Science ®Google Scholar
• Zhang GX, Lu X, Kimura S, Nishiyama A. Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res. 2007;76(2):204–12. doi:10.1016/j.cardiores.2007.07.014.
   PubMed Web of Science ®Google Scholar
• Lijnen PJ, Piccart Y, Coenen T, Prihadi JS. Angiotensin II-induced mitochondrial reactive oxygen species and peroxiredoxin-3 expression in cardiac fibroblasts. J Hypertens. 2012;30(10):1986–91. doi:10.1097/HJH.0b013e32835726c1.
   PubMed Web of Science ®Google Scholar
• Tsai IC, Pan Z-C, Cheng H-P, Liu C-H, Lin B-T, Jiang MJ. Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence. J Mol Cell Cardiol. 2016;98:18–27.
   PubMed Web of Science ®Google Scholar
• Dikalov SI, Nazarewicz RR.Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxid Redox Signal. 2013;19(10):1085–94. doi:10.1089/ars.2012.4604.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhu Y, Zhu Y, Lu Z, Xu F. Regulation of the angiotensin II-p22phox-reactive oxygen species signaling pathway, apoptosis and 8-oxoguanine-DNA glycosylase 1 retrieval in hyperoxia-induced lung injury and fibrosis in rats. Exp Ther Med. 2017;13(6):3397–407. doi:10.3892/etm.2017.4429.
   PubMed Web of Science ®Google Scholar
• Bian F, Cui J, Zheng T, Jin S. Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells. Int J Mol Med. 2017;39(3):629–35. doi:10.3892/ijmm.2017.2887.
   PubMed Web of Science ®Google Scholar
• Tang EH, Vanhoutte PM.Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch. 2010;459(6):995–1004. doi:10.1007/s00424-010-0786-4.
   PubMed Web of Science ®Google Scholar
• Holtz J, Goetz RM.Vascular renin-angiotensin-system, endothelial function and atherosclerosis? Basic Res Cardiol. 1994;89(Suppl 1):71–86. doi:10.1007/978-3-642-85660-0_7.
   PubMedGoogle Scholar
• Watanabe T, Barker TA, Berk BC.Angiotensin II and the endothelium: diverse signals and effects. Hypertension. 2005;45(2):163–69. doi:10.1161/01.HYP.0000153321.13792.b9.
   PubMed Web of Science ®Google Scholar
• Becher UM, Endtmann C, Tiyerili V, Nickenig G, Werner N. Endothelial damage and regeneration: the role of the renin-angiotensin-aldosterone system. Curr Hypertens Rep. 2011;13(1):86–92. doi:10.1007/s11906-010-0171-x.
   PubMed Web of Science ®Google Scholar
• Parzych KR, Klionsky DJ.An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–73. doi:10.1089/ars.2013.5371.
   PubMed Web of Science ®Google Scholar
• Kim KH, Lee MS.Autophagy–a key player in cellular and body metabolism. Nat Rev Endocrinol. 2014;10(6):322–37. doi:10.1038/nrendo.2014.35.
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Emr SD.Autophagy as a regulated pathway of cellular degradation. Science. 2000;290(5497):1717–21. doi:10.1126/science.290.5497.1717.
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Rubinsztein DC.Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med. 2006;27(5–6):520–27. doi:10.1016/j.mam.2006.08.008.
   PubMedGoogle Scholar
• Codogno P, Meijer AJ.Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 2005;12(Suppl 2):1509–18. doi:10.1038/sj.cdd.4401751.
   PubMed Web of Science ®Google Scholar
• Denton D, Xu T, Kumar S.Autophagy as a pro-death pathway. Immunol Cell Biol. 2015;93(1):35–42. doi:10.1038/icb.2014.85.
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. Embo J. 2007;26(7):1749–60. doi:10.1038/sj.emboj.7601623.
   PubMed Web of Science ®Google Scholar
• Doria A, Gatto M, Punzi L.Autophagy in human health and disease. N Engl J Med. 2013;368(19):1845.
   PubMed Web of Science ®Google Scholar
• Yu KY, Wang Y-P, Wang L-H, Jian Y, Zhao X-D, Chen J-W, Murao K, Zhu W, Dong L, Wang G-Q, et al. Mitochondrial KATP channel involvement in angiotensin II-induced autophagy in vascular smooth muscle cells. Basic Res Cardiol. 2014;109(4):416. doi:10.1007/s00395-014-0416-y.
   PubMed Web of Science ®Google Scholar
• Shan H, Guo D, Li X, Zhao X, Li W, Bai X. From autophagy to senescence and apoptosis in Angiotensin II-treated vascular endothelial cells. APMIS. 2014;122(10):985–92. doi:10.1111/apm.12242.
   PubMed Web of Science ®Google Scholar
• Yao L, He J, Li B, Yan M, Wang H, Tan L, Liu M, Lv X, Lv H, Zhang X, et al. Regulation of YAP by mammalian target of rapamycin complex 1 in endothelial cells controls blood pressure through COX-2/mPGES-1/PGE2 cascade. Hypertension. 2019;74(4):936–46. doi:10.1161/HYPERTENSIONAHA.119.12834.
   PubMed Web of Science ®Google Scholar
• Guo J, Wang Z, Wu J, Liu M, Li M, Sun Y, Huang W, Li Y, Zhang Y, Tang W, et al. Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3.2-GATA5 signaling. Circ Res. 2019;124(10):1448–61. doi:10.1161/CIRCRESAHA.118.314032.
   PubMed Web of Science ®Google Scholar
• Gao J, Wei T, Huang C, Sun M, Shen W. Sirtuin 3 governs autophagy-dependent glycolysis during Angiotensin II-induced endothelial-to-mesenchymal transition. Faseb J. 2020;34(12):16645–61. doi:10.1096/fj.202001494R.
   PubMed Web of Science ®Google Scholar
• Chan SH, Chan JY.Angiotensin-generated reactive oxygen species in brain and pathogenesis of cardiovascular diseases. Antioxid Redox Signal. 2013;19(10):1074–84. doi:10.1089/ars.2012.4585.
   PubMed Web of Science ®Google Scholar
• Nguyen Dinh Cat A, Touyz RM.Cell signaling of angiotensin II on vascular tone: novel mechanisms. Curr Hypertens Rep. 2011;13(2):122–28. doi:10.1007/s11906-011-0187-x.
   PubMed Web of Science ®Google Scholar
• Hanna IR, Taniyama Y, Szöcs K, Rocic P, Griendling KK. NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. Antioxid Redox Signal. 2002;4(6):899–914. doi:10.1089/152308602762197443.
   PubMed Web of Science ®Google Scholar
• Kimura S, Zhang G-X, Nishiyama A, Shokoji T, Yao L, Fan -Y-Y, Rahman M, Suzuki T, Maeta H, Abe Y, et al. Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension. 2005;45(5):860–66. doi:10.1161/01.HYP.0000163462.98381.7f.
   PubMed Web of Science ®Google Scholar
• Li L, Tan J, Miao Y, Lei P, Zhang Q. ROS and Autophagy: interactions and molecular regulatory mechanisms. Cell Mol Neurobiol. 2015;35(5):615–21. doi:10.1007/s10571-015-0166-x.
   PubMed Web of Science ®Google Scholar
• Godo S, Shimokawa H. Endothelial Functions. Arterioscler Thromb Vasc Biol. 2017;37(9): e108-e114. DOI: 10.1161/ATVBAHA.117.309813
   PubMed Web of Science ®Google Scholar
• Kanaan GN, Harper ME.Cellular redox dysfunction in the development of cardiovascular diseases. Biochim Biophys Acta. 2017;1861(11):2822–29. doi:10.1016/j.bbagen.2017.07.027.
   Web of Science ®Google Scholar
• Li J, Geng XY, Cong XL. PGC-1alpha ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells. Vascul Pharmacol. 2016;83:90–97. doi:10.1016/j.vph.2016.05.005.
   PubMed Web of Science ®Google Scholar
• Sheldon RD, Meers GM, Morris EM, Linden MA, Cunningham RP, Ibdah JA, Thyfault JP, Laughlin MH, Rector RS. eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH. Am J Physiol Endocrinol Metab. 2019;317(4):E605–E616. E605-E616. doi:10.1152/ajpendo.00096.2019.
   PubMed Web of Science ®Google Scholar
• Shao J, Miao C, Geng Z, Gu M, Wu Y, Li Q. Effect of eNOS on ischemic postconditioning-induced autophagy against ischemia/reperfusion injury in mice. Biomed Res Int. 2019;2019:5201014.
   PubMed Web of Science ®Google Scholar
• Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. Free Radic Biol Med. 2013;65:1215–28.
   PubMed Web of Science ®Google Scholar
• Jin L, Gao H, Wang J, Yang S, Wang J, Liu J, Yang Y, Yan T, Chen T, Zhao Y, et al. Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure. Liver Int. 2017;37(11):1651–59. doi:10.1111/liv.13476.
   PubMed Web of Science ®Google Scholar
• Guo F, Li X, Peng J, Tang Y, Yang Q, Liu L, Wang Z, Jiang Z, Xiao M, Ni C, et al. Autophagy regulates vascular endothelial cell eNOS and ET-1 expression induced by laminar shear stress in an ex vivo perfused system. Ann Biomed Eng. 2014;42(9):1978–88. doi:10.1007/s10439-014-1033-5.
   PubMed Web of Science ®Google Scholar
• Chen J, Wang L, Liu WH, Shi J, Zhong Y, Liu SJ, Liu SM. Aspirin protects human coronary artery endothelial cells by inducing autophagy. Physiol Int. 2020;107(2):294–305. doi:10.1556/2060.2020.00029.
   PubMed Web of Science ®Google Scholar
• Wang K, Peng S, Xiong S, Niu A, Xia M, Xiong X, Zeng G, Huang Q. Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress. Eur J Pharmacol. 2020;874:173003.
   PubMed Web of Science ®Google Scholar
• Lamark T, Johansen T. Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol. 2012;2012:736905. doi:10.1155/2012/736905.
   PubMedGoogle Scholar
• Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. Autophagy regulates lipid metabolism. Nature. 2009;458(7242):1131–35. doi:10.1038/nature07976.
   PubMed Web of Science ®Google Scholar
• Kirshenbaum LA.Regulation of autophagy in the heart in health and disease. J Cardiovasc Pharmacol. 2012;60(2):109. doi:10.1097/FJC.0b013e31825f6faa.
   PubMed Web of Science ®Google Scholar
• Verheye S, Martinet W, Kockx MM, Knaapen MWM, Salu K, Timmermans J-P, Ellis JT, Kilpatrick DL, De Meyer GRY. Selective clearance of macrophages in atherosclerotic plaques by autophagy. J Am Coll Cardiol. 2007;49(6):706–15. doi:10.1016/j.jacc.2006.09.047.
   PubMed Web of Science ®Google Scholar
• Liao X, Sluimer J, Wang Y, Subramanian M, Brown K, Pattison J, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab. 2012;15(4):545–53. doi:10.1016/j.cmet.2012.01.022.
   PubMed Web of Science ®Google Scholar
• He H, Feng Y-S, Zang L-H, Liu -W-W, Ding L-Q, Chen L-X, Kang N, Hayashi T, Tashiro S-I, Onodera S, et al. Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells. Food Chem Toxicol. 2014;71:128–35.
   PubMed Web of Science ®Google Scholar
• Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HHHW, Busse R, Schröder K, Brandes RP. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension. 2008;51(2):211–17. doi:10.1161/HYPERTENSIONAHA.107.100214.
   PubMed Web of Science ®Google Scholar