References
- Melgarejo JD, Maestre GE, Thijs L, Asayama K, Boggia J, Casiglia E, Hansen TW, Imai Y, Jacobs L, Jeppesen J, et al. Prevalence, treatment, and control rates of conventional and ambulatory hypertension across 10 populations in 3 continents. Hypertension. 2017;70(1):50–58. doi:https://doi.org/10.1161/HYPERTENSIONAHA.117.09188.
- Ellulu MS. 2018. Obesity, hypertension, and type-2 diabetes mellitus: The interrelationships and the determinants among adults in Gaza City, Palestine. Osong Public Health Res Perspect. 9(6):289–98. doi:https://doi.org/10.24171/j.phrp.2018.9.6.02
- Parati G, Ochoa JE, Lombardi C, Bilo G. 2013. Assessment and management of blood-pressure variability. Nature Reviews Cardiology. 10(3):143. doi:https://doi.org/10.1038/nrcardio.2013.1
- Gonçalvez LM. Genetic markers of hypertension: what will the future bring? Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology. An Official Journal of the Portuguese Society of Cardiology. 2002;21(1):39–43. PMID: 11941899.
- Wang W, Wang S, Yan L, Madara P, Cintron ADP, Wesley RA, Danner RL. Superoxide production and reactive oxygen species signaling by endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 2000;275(22):16899–903. doi:https://doi.org/10.1074/jbc.M000301200.
- Data SA, Roltsch MH, Hand B, Ferrell RE, Park -J-J, Brown MD. 2003. eNOS T-786C genotype, physical activity, and peak forearm blood flow in females. Medicine and Science in Sports and Exercise. 35(12):1991–97. doi:https://doi.org/10.1249/01.MSS.0000099105.99682.8B
- Campo S, Sardo AM, Campo GM, D’Ascola A, Avenoso A, Castaldo M, Saitta C, Lania A, Saitta A, Calatroni A. Extracellular superoxide dismutase (EC-SOD) gene mutations screening in a sample of Mediterranean population. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2005;578(1–2):143–48. doi:https://doi.org/10.1016/j.mrfmmm.2005.04.001.
- Heltianu C, Costache G, Gafencu A, Diaconu M, Bodeanu M, Cristea C, Azibi K, Poenaru L, Simionescu M. Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction. Journal of Cellular and Molecular Medicine. 2005;9(1):135–42. doi:https://doi.org/10.1111/j.1582-4934.2005.tb00343.x.
- Gladwin MT, Raat NJH, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, Patel RP. Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. American Journal of Physiology Heart and Circulatory Physiology. 2006;291(5):H2026–35. doi:https://doi.org/10.1152/ajpheart.00407.2006.
- Sandrim VC, Coelho EB, Nobre F, Arado GM, Lanchote VL, Tanus-Santos JE. 2006. Susceptible and protective eNOS haplotypes in hypertensive black and white subjects. Atherosclerosis. 186(2):428–32. doi:https://doi.org/10.1016/j.atherosclerosis.2005.08.003
- Tangurek B, Ozer N, Sayar N, Terzi S, Yilmaz H, Dayi SU, Ciloglu F, Aksu H, Asilturk R, Cagil A. The relationship between endothelial nitric oxide synthase gene polymorphism (T-786 C) and coronary artery disease in the Turkish population. Heart and Vessels. 2006;21(5):285–90. doi:https://doi.org/10.1007/s00380-005-0902-0.
- Dengel DR, Brown MD, Ferrell RE, Reynolds TH, Supiano MA. A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium. Physiological research/Academia Scientiarum Bohemoslovaca. 2007;56(4):393–401. PMID: 16925467.
- Matavelli IS, Judice ELD, Matavelli R, Hunger MS, Hipertensão Arterial MA. 2014. Sistêmica e a Prática Regular de Exercícios como Forma de Controle: Revisão de Literatura. Revista Brasileira De Ciências Da Saúde. 18(4):359–66. doi:https://doi.org/10.4034/RBCS.2014.18.04.12
- Silva RF, Sertorio JTC, Lacchini R, Trape AA, Tanus-Santos JE, Rush JWE, Amaral SL, Zago AS. Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study. Aging Clinical and Experimental Research. 2014;26(6):591–98. doi:https://doi.org/10.1007/s40520-014-0218-y.
- Rush JWE, Denniss SG, Graham DA. 2005. Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity. Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee. 30(4):442–74. doi:https://doi.org/10.1139/h05-133
- INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. Censo demográfico [Internet]. 2010 [Access date October 30, 2014]. Available from: http://www.ibge.gov.br.
- Zago AS, Kokubun E, Fenty-Stewart N, Park J-Y, Attipoe S, Hagberg J, Brown M. Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas. Arq Bras Cardiol. 2010;95(4):510–782x2010005000126.doi:https://doi.org/10.1590/S0066-782X2010005000126.
- Da Silva RF, Sertorio JTC, Lacchini R, Trape AA, Tanus-Santos JE, Rush JWE, Amaral SL, Zago AS. Influence of training status and eNOS haplotypes on plasma nitrite concentrations in normotensive older adults: a hypothesis-generating study. Aging Clinical and Experimental Research. 2014;26(6):591–98. doi:https://doi.org/10.1007/s40520-014-0218-y.
- Malachias MVB, Barbosa ECD, Martim JFV, Rosito GBA, Toledo JY Júnior, Passarelli O. 2016. 7th Brazilian Guideline of Arterial Hypertension: chapter 14 - Hypertensive Crisis. Arq Bras Cardiol. 107(3 Suppl 3):79–83. doi:https://doi.org/10.5935/abc.20160164
- OPAS/OMS. Organização Pan-Americana da Saúde/Organização Mundial da Saúde. 2005.
- Negrão CE, Barretto ACP. Cardiologia do exercício do atleta ao cardiopata. Manole: São PAulo; 2006.
- Moore N, Dicker P, O’Brien JK, Stojanovic M, Conroy RM, Treumann A, O’Brien ET, Fitzgerald D, Shields D, Stanton AV, et al. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. Hypertension. 2007;50(2):340–47. doi:https://doi.org/10.1161/HYPERTENSIONAHA.106.085563.
- Osness WH Functional fitness assessment for adults over 60 years - A field based assessment.: AAHPERD - American Alliance for Health, Physical Education, Recreation and Dance; 1990. Access date October 20, 2019 Available from: https://eric.ed.gov/?id=ED324293.
- Zago AS, Gobbi S. [Normative values of functional fitness in 60-to-70 year-old women]. R Bras Ci E Mov. Available from 2003;11(2):77–86. https://www.researchgate.net/publication/288947876.
- Benedetti TRB, Antunes PDC, Rodriguez-Añez CR, Mazo GZ, Petroski ÉL. 2007. Reprodutibilidade e validade do Questionário Internacional de Atividade Física (IPAQ) em homens idosos. Rev Bras Med Esporte. 13(1):11–16. doi:https://doi.org/10.1590/S1517-86922007000100004
- Mazo GZ, Benedetti TRB, Gobbi S, Ferreira L, Lopes MA. 2010. Normative values and functional fitness in 60-to-69 year-old men. Rev Bras Cineantropom Desempenho Hum. 12(5):316–23. doi:https://doi.org/10.5007/1980-0037.2010V12N5P316
- Hollander M, Wolf DA, Chicken E. 2015. Nonparametric statistical method, 3rd Edition. Hoboken, New Jersey: John Wiley & Sons, Inc. doi:https://doi.org/10.1002/9781119196037.
- Nagassaki S, Sertorio JTC, Metzger IF, Bem AF, Rocha JBT, Tanus-Santos JE. 2006. eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite. Free Radical Biology & Medicine. 41(7):1044–49. doi:https://doi.org/10.1016/j.freeradbiomed.2006.04.026
- Muniz JJ, Lacchini R, Rinaldi TO, Nobre YT, Cologna AJ, Martins AC, Tanus-Santos JE. Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction. The Pharmacogenomics Journal. 2013;13(2):189–96. doi:https://doi.org/10.1038/tpj.2011.49.
- Lacchini R, Muniz JJ, Nobre YTDA, Cologna AJ, Martins ACP, Tanus-Santos JE. Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction. . Nitric Oxide: Biology and Chemistry/official Journal of the Nitric Oxide Society. 2015;51:36–42. https://doi.org/10.1016/j.niox.2015.10.003.
- Green MR, Sambrook J. Analysis of DNA by Agarose Gel Electrophoresis. Cold Spring Harbor Protocols. 2019;2019:1. https://doi.org/10.1101/pdb.top100388.
- Lee PY, Costumbrado J, Hsu C-Y, Kim YH. Agarose gel electrophoresis for the separation of DNA fragments. Journal of Visualized Experiments : JoVE. 2012; (62):62. doi: https://doi.org/10.3791/3923.
- Pinheiro LC, Montenegro MF, Amaral JH, Ferreira GC, Oliveira AM, Tanus-Santos JE. 2012. Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats. Free Radical Biology & Medicine. 53(4):701–09. doi:https://doi.org/10.1016/j.freeradbiomed.2012.06.001
- Fontana VSP, Silva PS, Izidoro-Toledo C, Biagi C, Oliveira EB, Gerlach RF, Tanus-Santos ,JE. 2012. Comprehensive evaluation of the effects of enalapril on matrix metalloproteinases levels in hypertension. Cardiovascular Drugs and Therapy/sponsored by the International Society of Cardiovascular Pharmacotherapy. 26(6):511–19. doi:https://doi.org/10.1007/s10557-012-6420-2
- Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. The American Journal of Human Genetics. 2001;69(1):138–47. doi:https://doi.org/10.1086/321276.
- Moore JH. 2004. Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Review of Molecular Diagnostics. 4(6):795–803. doi:https://doi.org/10.1586/14737159.4.6.795
- Moore JH. Detecting, characterizing, and interpreting nonlinear gene-gene interactions using multifactor dimensionality reduction. Advances in Genetics. 2010;72:101–16. https://doi.org/10.1016/B978-0-12-380862-2.00005-9.
- Gonçalves CG, Guedes MBOG, Lopes JM, Roing JJ, Guedes TSR, Cortez LCA, Lima Filho BFD, Soares MML.Comparação do perfil entre idosos hipertensos e normotensos no municipio de Belo Horizonte - MG. Caderno De Educação, Saúde E Fisioterapia. 2014; 1(1): Available fromhttps://www.researchgate.net/publication/290810307
- Hipertensão SB. VI DIRETRIZES BRASILEIRA DE HIPERTENSÃO. REVISTA BRASILEIRO DE HIPERTENSÃO. 2013; 17(1): Available fromhttp://publicacoes.cardiol.br/consenso/2010/Diretriz_hipertensao_associados.pdf
- Trape AA, Jacomini AM, Muniz JJ, Sertorio JTC, Tanus-Santos JE, do Amaral SL, Zago AS. The relationship between training status, blood pressure and uric acid in adults and elderly. BMC Cardiovascular Disorders. 2013;13(1):44. doi:https://doi.org/10.1186/1471-2261-13-44.
- Jacomini AM, de Souza HCD, Dias Dda S, Brito Jde O, Pinheiro LC, Da Silva AB, Da Silva RF, Trapé AA, De Angelis K, Tanus-Santos JE, et al. Training status as a marker of the relationship between nitric oxide, oxidative stress, and blood pressure in older adult women. Oxidative Medicine and Cellular Longevity. 2015;2015:8262383.
- Trape AA, Sacardo AL, Cássia AF, Monteiro HL, Zago AS. Relationship between the practice of unsupervised walking and risk factors for cardiovascular disease in adults and elderly. Medicina (Ribeirão Preto). Available from 2015;47(2):165–76. https://www.researchgate.net/publication/285132266.
- Abdel-Aziz TA, Mohamed RH. 2013. Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease. Molecular Biology Reports. 40(4):3065–71. doi:https://doi.org/10.1007/s11033-012-2380-7
- Yang Y, Du K, Liu Z, Lu X. 2014. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. International Journal of Molecular Sciences. 15(5):7987–8003. doi:https://doi.org/10.3390/ijms15057987
- Sung JH, Lee BE, Kim JO, Jeon YJ, Kim SH, Lim SW, Moon JY, Cha DH, Kim OJ, Kim IJ, et al. Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis. Genetics and Molecular Research: GMR. 2015;14(4):16508–20. doi:https://doi.org/10.4238/2015.December.9.23.
- Agachan B, Isbir T, Yilmaz H, Akoglu E. 2003. Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients. Experimental & Molecular Medicine. 35(6):545–49. doi:https://doi.org/10.1038/emm.2003.71
- Firouzabadi N, Tajik N, Bahramali E, Bakhshandeh H, Maadani M, Shafiei M. 2013. Gender specificity of a genetic variant of angiotensin-converting enzyme and risk of coronary artery disease. Molecular Biology Reports. 40(8):4959–65. doi:https://doi.org/10.1007/s11033-013-2596-1
- Miao H-W, Gong H. 2015. Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: a meta-analysis based on 10,236 subjects. Journal of the Renin-angiotensin-aldosterone System: JRAAS. 16(4):982–94. doi:https://doi.org/10.1177/1470320315588872
- Pinheiro DS, Santos RS, Jardim PCBV, Silva EG, Reis AAS, Pedrino GR, Ulhoa CJ. The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: a genetic association study in Brazilian patients. PloS One. 2019;14(8):e0221248. doi:https://doi.org/10.1371/journal.pone.0221248.
- Suchting S, Freitas C, Le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(9):3225–30. doi:https://doi.org/10.1073/pnas.0611177104.
- Ji L-D, Li J-Y, Yao -B-B, Cai X-B, Shen Q-J, Xu J. 2017. Are genetic polymorphisms in the renin–angiotensin–aldosterone system associated with essential hypertension? Evidence from genome-wide association studies. Journal of Human Hypertension. 31(11):695–98. doi:https://doi.org/10.1038/jhh.2017.29
- Freitas SRS, Cabello PH, Moura-Neto RS, Dolinsky LC, Bóia MN.Análise combinada de fatores genéticos e ambientais na hipertensão essencial em um município da região Amazônica. Arq Bras Cardiol. 2007;88(4):447–51.doi:https://doi.org/10.1590/S0066-782X2007000400014.
- Bortolotto LA. Physiopathological mechanisms of arterial hypertension in the elderly. Brazilian Journal of Hypertension. Available from 2012;19(3):61–64. http://docs.bvsalud.org/biblioref/2018/03/881720/rbh_v19n3_61-64.pdf.
- Stanley S, Franklin MD. 2007. Hypertension in Older People: part 1. The Journal of Clinical Hypertension. 8(6):444–49. doi:https://doi.org/10.1111/j.1524-6175.2006.05113.x
- Fagard RH. 2005. Physical activity, physical fitness and the incidence of hypertension. Journal of Hypertension. 23(2):265–67. doi:https://doi.org/10.1097/00004872-200502000-00005
- Kokkinos P, Pittaras A, Manolis A, Panagiotakos D, Narayan P, Manjoros D, Amdur RL, Singh S. Exercise capacity and 24-h blood pressure in prehypertensive men and women. American Journal of Hypertension. 2006;19(3):251–58. doi:https://doi.org/10.1016/j.amjhyper.2005.07.021.
- Rossi GP, Ceolotto G, Caroccia B, Lenzini L. 2017. Genetic screening in arterial hypertension. Nature Reviews Endocrinology. 13(5):289–98. doi:https://doi.org/10.1038/nrendo.2016.196
- Oliveira-Paula GH, Lacchini R, Tanus-Santos JE. Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases. Nitric Oxide: Biology and Chemistry/official Journal of the Nitric Oxide Society. 2017;63:39–51. https://doi.org/10.1016/j.niox.2016.08.004.
- Hyndman ME, Parsons HG, Verma S, Peter PJ, Edworthy S, Jones C, Lonn E, Charbonneau F, Anderson TJ. The T-786→C Mutation in Endothelial Nitric Oxide Synthase Is Associated With Hypertension. Hypertension. 2002;39(4):919–22. doi:https://doi.org/10.1161/01.hyp.0000013703.07316.7f.
- Yugar-Toledo JC, Martin JFV, Krieger JE, Pereira AC, Demacq C, Coelho OR, Pimenta E, Calhoun DA, Júnior HM. Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes. DNA and Cell Biology. 2011;30(8):555–64. doi:https://doi.org/10.1089/dna.2010.1156.
- Mokretar K, Velinov H, Postadzhiyan A, Apostolova M. 2016. Association of polymorphisms in endothelial nitric oxide synthesis and renin–angiotensin–aldosterone system with developing of coronary artery disease in bulgarian patients. Genetic Testing and Molecular Biomarkers. 20(2):67–73. doi:https://doi.org/10.1089/gtmb.2015.0195