Magnetic Resonance Imaging Studies in Early-Onset Bipolar Disorder: A Critical Review

REFERENCES

• Faedda G L, Baldessarini R J, Suppes T, Tondo L, Becker I, Lipschitz D S. Pediatric-onset bipolar disorder: a neglected clinical and public health problem. Harv Rev Psychiatry 1995; 3: 171–95, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Wozniak J, Biederman J, Kiely K, et al. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995; 34: 867–76, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Weller R A, Weller E B, Tucker S G, Fristad M A. Mania in prepubertal children: has it been underdiagnosed?. J Affect Disord 1986; 11: 151–4, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• LaRoche C, Cheifetz P, Lester E P, Schibuk L, DiTommaso E, Engelsmann F. Psychopathology in the offspring of parents with bipolar affective disorders. Can J Psychiatry 1985; 30: 337–43, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Grigoroiu-Serbanescu M, Martinez M, Nothen M M, et al. Different familial transmission patterns in bipolar I disorder with onset before and after age 25. Am J Med Genet 2001; 105: 765–73, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Schulze T G, Muller D J, Krauss H, et al. Further evidence for age of onset being an indicator for severity in bipolar disorder. J Affect Disord 2002; 68: 343–5, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Strober M, Morrell W, Burroughs J, Lampert C, Danforth H, Freeman R. A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance. J Affect Disord 1988; 15: 255–68, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Nasrallah H A. Neurodevelopmental aspects of bipolar affective disorder. Biol Psychiatry 1991; 29: 1–2, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cowan R L, Lyoo I K, Sung S M, et al. Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study. Drug Alcohol Depend 2003; 72: 225–35, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Frazier J A, Giedd J N, Kaysen D, et al. Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. Am J Psychiatry 1996; 153: 564–6, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pfefferbaum A, Rosenbloom M, Crusan K, Jernigan T L., Brain C T. changes in alcoholics: effects of age and alcohol consumption. Alcohol Clin Exp Res 1988; 12: 81–7, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Pfefferbaum A, Sullivan E V, Mathalon D H, Shear P K, Rosenbloom M J, Lim K O. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 1995; 19: 1177–91, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kowatch R A, Fristad M, Birmaher B, Wagner D K, Findling R L, Hellander M. Treatment guidelines for children and adolescents with bipolar disorders. J Am Acad Child Adolesc Psychiatry 2005; 44: 213–35, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Carlson G A. Bipolar affective disorders in childhood and adolescence. Affective disorders in childhood and adolescence, D P Cantwell, G A Carlson. Spectrum, New York 1983; 61–83
   Google Scholar
• Geller B, Craney J L, Bolhofner K, DelBello M P, Williams M, Zimerman B. One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2001; 158: 303–5, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. APA, Washington, DC 1994
   Google Scholar
• Faedda G L, Baldessarini R J, Glovinsky I P, Austin N B. Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord 2004; 6: 305–13, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Leibenluft E, Charney D S, Towbin K E, Bhangoo R K, Pine D S. Defining clinical phenotypes of juvenile mania. Am J Psychiatry 2003; 160: 430–7, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bellivier F, Golmard J L, Henry C, Leboyer M, Schurhoff F. Admixture analysis of age at onset in bipolar I affective disorder. Arch Gen Psychiatry 2001; 58: 510–2, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bellivier F, Golmard J L, Rietschel M, et al. Age at onset in bipolar I affective disorder: further evidence for three subgroups. Am J Psychiatry 2003; 160: 999–1001, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gogtay N, Sporn A, Clasen L S, et al. Comparison of progressive cortical gray matter loss in childhood-onset schizophrenia with that in childhood-onset atypical psychoses. Arch Gen Psychiatry 2004; 61: 17–22, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   Google Scholar
• Blumberg H P, Kaufman J, Martin A, Charney D S, Krystal J H, Peterson B S. Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Ann NY Acad Sci 2004; 1021: 376–83, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Soares J C, Mann J J. The anatomy of mood disorders: review of structural neuroimaging studies. Biol Psychiatry 1997; 41: 86–106, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pantelis C, Velakoulis D, McGorry P D, et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003; 361: 281–8, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kennedy D N, Makris N, Bates J F, Caviness V S, Jr., Thatcher R W, et al. Structural morphometry in the developing brain. Developmental Neuroimaging. Academic, San Diego, CA 1996; 29–41
   Google Scholar
• Botteron K N, Vannier M W, Geller B, Todd R D, Lee B C. Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year-olds with mania. J Am Acad Child Adolesc Psychiatry 1995; 34: 742–9, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Pillai J J, Friedman L, Stuve T A, et al. Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res 2002; 114: 51–6, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lyoo I K, Lee H K, Jung J H, Noam G G, Renshaw P F. White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders. Compr Psychiatry 2002; 43: 361–8, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Moore P B, El-Badri S M, Cousins D, et al. White matter lesions and season of birth of patients with bipolar affective disorder. Am J Psychiatry 2001; 158: 1521–4, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Stoll A L, Renshaw P F, Yurgelun-Todd D A, Cohen B M. Neuroimaging in bipolar disorder: what have we learned?. Biol Psychiatry 2000; 48: 505–17, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Norris S D, Krishnan K R, Ahearn E. Structural changes in the brain of patients with bipolar affective disorder by MRI: a review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 1997; 21: 1323–37, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Breeze J L, Hesdorffer D C, Hong X, Frazier J A, Renshaw P F. Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness. Harv Rev Psychiatry 2003; 11: 269–83, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Friedman L, Findling R L, Kenny J T, et al. An MRI study of adolescent patients with either schizophrenia or bipolar disorder as compared to healthy control subjects. Biol Psychiatry 1999; 46: 78–88, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dasari M, Friedman L, Jesberger J, et al. A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls. Psychiatry Res 1999; 91: 155–62, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Blumberg H P, Kaufman J, Martin A, et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry 2003; 60: 1201–8, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• DelBello M P, Zimmerman M E, Mills N P, Getz G E, Strakowski S M. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 2004; 6: 43–52, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chen H H, Nicoletti M A, Hatch J P, et al. Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study. Neurosci Lett 2004; 363: 65–8, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Frazier J A, Chiu S, Breeze J L, et al. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry 2005, (in press)
   Google Scholar
• McDonald C, Zanelli J, Rabe-Hesketh S, et al. Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder. Biol Psychiatry 2004; 56: 411–7, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Strakowski S M, Wilson D R, Tohen M, Woods B T, Douglass A W, Stoll A L. Structural brain abnormalities in first-episode mania. Biol Psychiatry 1993; 33: 602–9, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Strakowski S M, Del Bello M P, Sax K W, et al. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 1999; 56: 254–60, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zipursky R B, Seeman M V, Bury A, Langevin R, Wortzman G, Katz R. Deficits in gray matter volume are present in schizophrenia but not bipolar disorder. Schizophr Res 1997; 26: 85–92, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dupont R M, Jernigan T L, Heindel W, et al. Magnetic resonance imaging and mood disorders: localization of white matter and other subcortical abnormalities. Arch Gen Psychiatry 1995; 52: 747–55, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Harvey I, Persaud R, Ron M A, Baker G, Murray R M. Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychol Med 1994; 24: 689–99, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Schlaepfer T E, Harris G J, Tien A Y, et al. Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 1994; 151: 842–8, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pearlson G D, Barta P E, Powers R E, et al. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry 1997; 41: 1–14, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lim K O, Rosenbloom M J, Faustman W O, Sullivan E V, Pfefferbaum A. Cortical gray matter deficit in patients with bipolar disorder. Schizophr Res 1999; 40: 219–27, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lopez-Larson M P, Del Bello M P, Zimmerman M E, Schwiers M L, Strakowski S M. Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biol Psychiatry 2002; 52: 93–100, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wilke M, Kowatch R A, Del Bello M P, Mills N P, Holland S K. Voxel-based morphometry in adolescents with bipolar disorder: first results. Psychiatry Res 2004; 57–69, [INFOTRIEVE]
   Google Scholar
• Sanches M, Sassi R B, Axelson D, et al. Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study. Psychiatry Res 2005; 138: 43–9, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Castillo M, Kwock L, Courvoisie H, Hooper S R., Proton M R. spectroscopy in children with bipolar affective disorder: preliminary observations. Am J Neuroradiol 2000; 21: 832–8, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cecil K M, Jones B V. Magnetic resonance spectroscopy of the pediatric brain. Top Magn Reson Imaging 2001; 12: 435–52, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   Google Scholar
• Cecil K M, Del Bello M P, Sellars M C, Strakowski S M. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. J Child Adolesc Psychopharmacol 2003; 13: 545–55, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   Web of Science ®Google Scholar
• Chang K, Adleman N, Dienes K, Barnea-Goraly N, Reiss A, Ketter T. Decreased N-acetylaspartate in children with familial bipolar disorder. Biol Psychiatry 2003; 53: 1059–65, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Winsberg M E, Sachs N, Tate D L, Adalsteinsson E, Spielman D, Ketter T A. Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biol Psychiatry 2000; 47: 475–81, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cecil K M, Del Bello M P, Morey R, Strakowski S M. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 2002; 4: 357–65, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Urenjak J, Williams S R, Gadian D G, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13: 981–9, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Davanzo P, Thomas M A, Yue K, et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 2001; 24: 359–69, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Moore G J, Bebchuk J M, Parrish J K, et al. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. Am J Psychiatry 1999; 156: 1902–8, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Moore C M, Demopulos C M, Henry M E, et al. Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study. Am J Psychiatry 2002; 159: 1240–2, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Davanzo P, Yue K, Thomas M A, et al. Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. Am J Psychiatry 2003; 160: 1442–52, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zeffiro T, Eden G. What's the matter? White matter?. Neuron 2000; 25: 257–9, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   Google Scholar
• Chang K, Adleman N E, Dienes K, Simeonova D I, Menon V, Reiss A. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder. Arch Gen Psychiatry 2004; 61: 781–92, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Phillips M L, Drevets W C, Rauch S L, Lane R. The neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003; 54: 504–14, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Phillips M L, Drevets W C, Rauch S L, Lane R D. The neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54: 515–28, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Giedd J N, Snell J W, Lange N, et al. Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb Cortex 1996; 6: 551–60, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• McIntosh A M, Job D E, Moorhead T W, et al. Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives. Biol Psychiatry 2004; 56: 544–52, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lyoo I K, Streeter C C, Ahn K H, et al. White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. Psychiatry Res 2004; 131: 135–45, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Altshuler L L, Bartzokis G, Grieder T, , An M RI, et al. study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biol Psychiatry 2000; 48: 147–62, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chen B K, Sassi R, Axelson D, et al. Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biol Psychiatry 2004; 56: 399–405, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Blumberg H P, Martin A, Kaufman J, et al. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry 2003; 160: 1345–7, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Noga J T, Vladar K, Torrey E F. A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder. Psychiatry Res 2001; 106: 25–34, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Strakowski S M, Adler C M, Del Bello M P. Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?. Bipolar Disord 2002; 4: 80–8, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Strakowski S M, Del Bello M P, Adler C M, Cecil K M, Sax K W. The neuropathology of bipolar disease. Bipolar Disord 2000; 2: 148–65, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Durston S, Hulshoff Pol H E, Casey B J, Giedd J N, Buitelaar J K, van Engeland H. Anatomical MRI of the developing human brain: what have we learned?. J Am Acad Child Adolesc Psychiatry 2001; 40: 1012–20, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Caviness V S, Jr, Kennedy D N, Richelme C, Rademacher J, Filipek P A. The human brain age 7–11 years: a volumetric analysis based on magnetic resonance images. Cereb Cortex 1996; 6: 726–36, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Goldstein J M, Kennedy D N, Caviness V S, Jr. Images in neuroscience. Brain Development, XI: sexual dimorphism. Am J Psychiatry 1999; 156: 352, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Goldstein J M, Seidman L J, O'Brien L M, et al. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Arch Gen Psychiatry 2002; 59: 154–64, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sigurdsson E, Fombonne E, Sayal K, Checkley S. Neurodevelopmental antecedents of early-onset bipolar affective disorder. Br Med J 1999; 174: 121–7
   Google Scholar
• van Os J, Jones P, Lewis G, Wadsworth M, Murray R. Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry 1997; 54: 625–31, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Goodman R, Graham P. Psychiatric problems in children with hemiplegia: cross-sectional epidemiological survey. BMJ 1996; 312: 1065–9, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hellgren L, Gillberg I C, Bagenholm A, Gillberg C. Children with deficits in attention, motor control and perception (DAMP) almost grown up: psychiatric and personality disorders at age 16 years. J Child Psychol Psychiatry 1994; 35: 1255–71, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Chang K D, Steiner H, Ketter T A. Psychiatric phenomenology of child and adolescent bipolar offspring. J Am Acad Child Adolesc Psychiatry 2000; 39: 453–60, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Frazier J A, Doyle R, Chiu S, Coyle J T. Treating a child with Asperger's disorder and comorbid bipolar disorder. Am J Psychiatry 2002; 159: 13–21, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Steele M, Fisman S. Bipolar disorder in children and adolescents: current challenges. Can J Psychiatry 1997; 42: 632–6, [PUBMED], [INFOTRIEVE], [CSA]
   Google Scholar
• Geller B, Luby J. Child and adolescent bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1997; 36: 1168–76, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sassi R B, Nicoletti M, Brambilla P, et al. Increased gray matter volume in lithium-treated bipolar disorder patients. Neurosci Lett 2002; 329: 243–5, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Moore G J, Bebchuk J M, Wilds I B, Chen G, Manji H K. Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1241–2, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mayberg H S, Brannan S K, Tekell J L, et al. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 2000; 48: 830–43, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Holcomb H H, Cascella N G, Thaker G K, Medoff D R, Dannals R F, Tamminga C A. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am J Psychiatry 1996; 153: 41–9, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Buschbaum M S, Hazlett E A, Haznedar M M, Spiegel-Cohen J, Wei T C. Visualizing front-striatal circuitry and neuroleptic effects in schizophrenia. Acta Psychiatri Scan 1999; 395: 129–37, [CSA]
   Google Scholar
• Brambilla P, Harenski K, Nicoletti M, et al. MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res 2003; 37: 287–95, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hoshi Y, Chen S J. Regional cerebral blood flow changes associated with emotions in children. Pediatr Neurol 2002; 27: 275–81, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Taylor W D, Hsu E, Krishnan K R, MacFall J R. Diffusion tensor imaging: background, potential, and utility in psychiatric research. Biol Psychiatry 2004; 55: 201–7, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar