24
Views
24
CrossRef citations to date
0
Altmetric
Original Article

α-Tocopherol, but not γ-tocopherol inhibits 7β-hydroxycholesterol-induced apoptosis in human U937 cells

, &
Pages 329-339 | Received 19 Jan 2001, Published online: 07 Jul 2009

References

  • Smith L.L., Johnson B.H. Biological activities of oxysterols. Free Radical Biology and Medicine 1989; 7: 285–332
  • Smith L.L. Another cholesterol hypothesis: Cholesterol as an antioxidant. Free Radical Biology and Medicine 1991; 11: 47–61
  • Peng S.K., Tham P., Taylor C.B., Mikkelson B. Cytotoxicity of oxygenated derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis. American Journal of Clinical Nutrition 1979; 32: 1033–1042
  • Yan S.P. Cholesterol oxidation products: their occurrence and detection in our foodstuffs. Advances in Experimental Medicine and Biology 1999; 459: 79–98
  • Nielsen J.H., Olsen C.E., Jensen C., Skibsted L.H. Cholesterol oxides in butter and dairy spreads during storage. Journal of Dairy Research 1996; 63: 159–167
  • Paniangvait P., King A.J., Jones A.D., German B.G. Cholesterol oxides in foods of animal origin. Journal of Food Science 1995; 60: 1159–1174
  • Vine D.F., Croft K.D., Beilin L.J., Mamo J.C.L. Absorption of dietary cholesterol oxidation products and incorporation into rat hepatocytes. Lipids 1997; 32: 887–893
  • Hodis H.N., Crawford D.W., Sevanian A. Cholesterol feeding increases plasma and aortic tissue cholesterol oxide levels in parallel: further evidence for the role of cholesterol oxidation in atherosclerosis. Atherosclerosis 1991; 89: 117–126
  • Zieden B., Kaminsaka A., Kristentson M., Kucinskiene Z., Vessby B., Olsson A.G., Diczfaulsy U. Increased plasma 7β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. Arteriosclerosis, Thrombosis and Vascular Biology 1999; 19: 967–971
  • Lizard G., Gueldry S., Sordet O., Monier S., Athias A., Miguet C., Bessede G., Lemaire S., Solary E., Gambert P. Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with reactive oxygen species production. FASEB Journal 1998; 12: 1651–1663
  • Van Poppel G., van de Vijver L.P.L., Kosmeyer-Schuil T., Johanns E.S.D., Kardinaal A.F.M., van de Bovenkamp P., Kruyssen D.A.C.M., Kok F.J. Plasma oxysterols and angiographically determined atherosclerosis: a case control study. Biomarkers 1997; 2: 373–378
  • Zhang H., Basra H.J.K., Steinbrecher U.P. Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages. Journal of Lipid Research 1990; 31: 1361–1369
  • Gray M.F.T., Lawrie T.D.V., Brooks C.J.W. Isolation and identification of cholesterol α-oxide and other main sterols in human serum. Lipids 1971; 6: 836–843
  • Brown J., Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142: 1–28
  • Lizard G., Monier S., Cordelet C., Gesquiere L., Deckert V., Gueldry S., Lagrost L., Gambert P. Characterisation and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arteriosclerosis, Thrombosis, and Vascular Biology 1999; 19: 1190–1200
  • Aupeix K., Weltin D., Mejia J.E., Christ M., Marchal J., Freyssinet J.M., Bischoff P. Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology 1995; 194: 415–428
  • Christ M., Luu B., Mejia J.E., Moosbrugger I., Bischoff P. Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes. Immunology 1993; 79: 455–460
  • Hietter H., Bischoff P., Beck J.P., Ourisson G., Luu B. Comparative effects of 7β-hydroxycholesterol towards murine lymphomas, lymphoblasts and lymphocytes: selective cytotoxicity and blastogenesis inhibition. Cancer Biochemistry Biophysics 1986; 9: 75–83
  • Brown M.S., Goldstein J.L. Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the inhibition of growth of human fibroblasts by 7-ketocholesterol. Journal of Biological Chemistry 1974; 249: 7306–7314
  • Parish J.E., Parish S.C., Li S. Side chain oxysterol regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Lipids 1995; 30: 247–251
  • Zhou O., Smith T.L., Jimi S., Kummerow F.A. The effect of 25-hydroxycholesterol on the accumulation of intercellular calcium. Cell Calcium 1991; 12: 467–478
  • Ramasamy S., Boissonneault G.A., Hennig B. Oxysterol-induced endothelial cell dysfunction in culture. Journal of the American College of Nutrition 1992; 11: 532–538
  • Guardiola F., Codony R., Addis P.B., Rafecas M., Boatella J. Biological effects of oxysterols: Current status. Food and Chemical Toxicology 1996; 34: 193–211
  • Lizard G., Deckert V., Dubrez L., Miosant M., Gambert P., Lagrost L. Induction of apoptosis in endothelial cells treated with cholesterol oxides. American Journal of Pathology 1996; 148: 1625–1638
  • O'Callaghan Y.C., Woods J.A., O'Brien N.M. Oxysterol-induced cell death in U937 and HepG2 cells at reduced and normal serum concentrations. European Journal of Nutrition 1999; 38: 255–262
  • Lizard G., Miguet C., Bessede G., Monier S., Gueldry S., Neel D., Gambert P. Impairment with various antioxidants of the loss of transmembrane potential and of the cytosolic release of cytochrome c occurring during 7-ketocholesterol-induced apoptosis. Free Radical Biology and Medicine 2000; 28: 743–753
  • Cantwell H., Devery R. The response of the antioxidant defence system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. Cell Biology and Toxicology 1998; 14: 401–409
  • Salonen J.T., Nyyssonen K., Salonen R., Porkkala-Sataho E., Tuomainen T-P., Diczfalusy U., Bjorkhem I. Lipoprotein oxidation and progression of carotid atherosclerosis. Circulation 1997; 95: 840–845
  • Wolf G.W. γ-Tocopherol: An efficient protector of lipids against nitric oxide-initiated peroxidative damage. Nutrition Reviews 1997; 55: 376–378
  • Christen S., Woodall A.A., Shigenaga M.K., South-well-Keely P.T., Duncan M.W., Ames B.N. γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications. Proceedings of the National Academy of Sciences of the United States of America 1997; 94: 3217–3222
  • Tran K., Chan A.C. Comparative uptake of α-tocopherol and γ-tocopherol by human endothelial cells. Lipids 1992; 27: 38–41
  • Ohrvall M., Sundlof G., Vessby B. Gamma, but not alpha, tocopherol levels are reduced in coronary heart disease patients. Journal of Internal Medicine 1996; 239: 111–117
  • Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. Clarendon Press, Oxford 1989; 237–243
  • Mowles J.M. Mycoplasma detection. Methods in Molecular Biology, Vol. V: Animal Cell Culture, J.W. Pollard, J.M. Walker. Humana Press, New Jersey 1990; 65–74, In
  • Strauss G.H.S. Non random killing in cyropreservation: Implications for performance of the battery of leukocyte tests (BLT). Toxic and Immunotoxic effects. Mutation Research 1991; 252: 1–15
  • Dubrez L., Savoy I., Hamman A., Solary E. Pivotal role of DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO Journal 1996; 15: 5504–5512
  • Hissin P.J., Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry 1976; 74: 214–226
  • Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Analytical Biochemistry 1985; 150: 76–85
  • Swat W., Ignatowicz L., Kisielow P. Detection of apoptosis in immature CD4+8+ thymocytes by flow cytometry. Journal of Immunological Methods 1991; 137: 79–87
  • Lang J.K., Gohil K., Packer L. Simultaneous determination of tocopherols, ubiquinols, and ubiquinone in blood, plasma, tissue homogenates and subcellular fractions. Analytical Biochemistry 1986; 157: 106–116
  • Craft N.E., Wise S.A., Soares J.H., Jr. Optimisation of an isocratic high-performance liquid chromatographic separation of carotenoids. Journal of Chromatography 1992; 589: 171–176
  • Folch J., Lees M., Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 1957; 226: 497–509
  • Therond P., Abella A., Laurent D., Couturier M., Chalas J., Legrand A., Lindenbaum A. In vitro study of the cytotoxicity of isolated oxidized low-density lipoproteins fractions in human endothelial cells: Relationship with the glutathione status and cell morphology. Free Radical Biology and Medicine 2000; 28: 585–596
  • de Nigris F., Franconi F., Maida I., Palumbo G., Anania V., Napoli C. Modulation by α-tocopherol and γ-tocopherol and oxidised low-density lipoprotein of apoptotic signalling in human coronary smooth muscle cells. Biochemical Pharmacology 2000; 59: 1477–1487
  • Li D., Saldeen T., Mehta J.L. γ-Tocopherol decreases Ox-LDL-mediated activation of nuclear factor κ-B and apoptosis in human coronary artery endothelial cells. Biochemical and Biophysical Research Communications 1999; 259: 157–161

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.