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Original Article

Endothelium-dependent vasorelaxation is inhibited by in vivo depletion of vascular thiol levels: Role of endothelial nitric oxide synthase

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Pages 387-394 | Received 10 Oct 2000, Published online: 07 Jul 2009

References

  • Moncada S., Higgs E.A. Endogenous nitric oxide: Physiology, pathology and clinical relevance. European Journal of Clinical Investigation 1991; 21: 361–337
  • Henry P.J., Drummer O.H., Horowitz J.D. S-nitrosothiols as vasodilators. Implications regarding tolerance to nitric oxide-containing vasodilators. British Journal of Pharmacology 1989; 98: 757–766
  • Jia L., Furchgott R.F. Inhibition by sulfhydryl compounds of vascular relaxation induced by nitric oxide and endothelium-derived relaxing factor. Journal of Pharmacology and Experimental Therapeutics 1993; 267: 371–378
  • Förstermann U., Pollock J.S., Schmidt H.H.H.W., Heller M., Murad F. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proceedings of the National Academy of Science of the United States of America 1991; 88: 1788–1792
  • Stamler J.S., Singel D.J., Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 1992; 258: 1898–1902
  • Ghico D., Alessio P., Foco A., Bussolino F., Costamagna C., Heller R., Garbarino G., Pescarmona G.P., Bosia A. Nitric oxide synthesis is impaired in glutathione depleted human umbilical vein endothelial cells. American Journal of Physiology 1993; 265: C728–C732
  • Rubanyi G.M., Vanhoutte P.M. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. American Journal of Physiology 1986; 250: H1145–H1149
  • Ignarro L.J., Lippton H., Edwards J.C., Baricos W.H., Hyman A.L., Kadowitz P.J., Gruetter C.A. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. Journal of Pharmacology and Experimental Therapeutics 1981; 218: 739–749
  • Myers P.R., Minor R.L., Guerra R., Bates J.N., Harrison D.G. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature 1990; 345: 161–163
  • Mülsch A., Mordvintcev P., Vanin A.F., Busse R. The potent vasodilating and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols. FEBS Letters 1991; 294: 252–256
  • Brandwein H.J., Lewicki J.A., Murad F. Reversible inactivation of guanylate cyclase by mixed disulfide formation. Journal of Biological Chemistry 1981; 256: 2958–2962
  • Kugiyama K., Ohgushi M., Motoyam T., Hirashima O., Soejima H., Misumi K., Yoshimura M., Ogawa H., Sugiyama S., Yasue H. Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation. Circulation 1998; 97: 2299–2301
  • Vita J.A., Frei B., Holbrook M., Gocke N., Leaf C., Keaney J.F., Jr. L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease. Journal of Clinical Investigation 1998; 101: 1408–1414
  • Boesgaard S., Petersen J.S., Aldershvile J., Poulsen H.E., Flachs H. Nitrate tolerance: Effect of thiol supplementation during prolonged nitroglycerin infusion in an in vivo rat model. Journal of Pharmacology and Experimental Therapeutics 1991; 258: 851–856
  • Münzel T., Sayegh H., Freeman B.A., Tarpey M.M., Harrison D.G. Evidence for enhanced vascular superoxide anion production in nitrate tolerance: a novel mechanism of tolerance and cross tolerance. Journal of Clinical Investigation 1995; 95: 187–194
  • Münzel T., Kurz S., Rajagopalan S., Thoenes M., Berrington W.R., Thompson J.A., Freeman B.A., Harrison D.G. Hydralaxine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. Journal of Clinical Investigation 1996; 98: 1465–1470
  • Fabricius M., Rubin I., Bundgaard M., Lauritzen M. NOS activity in brain and endothelium: relation to hypercapnic rise of cerebral blood flow in rats. American Journal of Physiology 1996; 271: H2035–H2044
  • Meister A., Anderson M.E., Hwang O. Intracellular cysteine and glutathione delivery systems. Journal of American College of Nutrition 1986; 5: 137–151
  • Meister A. Gluthathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacology and Therapeutics 1991; 51: 155–194
  • Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-N-butyl homocysteine sulfoximine). Journal of Biological Chemistry 1979; 254: 7558–7560
  • Boesgaard S., Poulsen H.E., Aldershvile J., Loft S., Anderson M.E., Meister A. Acute effects of nitroglycerin depend on both plasma and intracellular sulfhydryl compound levels in vivo: Effects of agents with different sulfhydryl-modulating properties. Circulation 1993; 83: 324–331
  • Hofman H., Schmidt H.H.W. Thiol dependence of nitric oxide synthase. Biochemistry 1995; 34: 13443–13452
  • Komori Y., Hyun Y.J., Chiang K., Fukuto J.M. The role of thiols in the apparent activation of rat brain nitric oxide synthase. Journal of Biochemistry 1995; 117: 923–927
  • Sthuer D.J., Kwon N.S., Nathan C.F. FAD and GSH participate in macrophage synthesis of nitric oxide. Biochemical and Biophysical Research Communications 1990; 168: 558–565
  • Howells D.W., Hyland K. Direct analysis of tetrahydrobiopterin in cerobrospinal fluid by high performance liquid chromatografy with redox electrochemistry: prevention of autooxidation during storage and analysis. Clinical Chemistry Acta 1987; 167: 23–30
  • Li Y., Zhu H., Kuppusamy P., Roubaud V., Zweier J.L., Trush M.A. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. Journal of Biological Chemistry 1998; 273(4)2015–2023
  • Meister A. On the antioxidant effects of ascorbic acid and glutathione. Biochemical Pharmacology 1992; 44: 1905–1905
  • Boesgaard S., Aldershvile J., Poulsen H.E., Loft S., Anderson M.E., Meister A. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circulation Research 1994; 74: 115–120
  • Lahera V., Khraibi A.A., Romero J.C. Sulfhydryl group donors potentiate the hypotensive effect of acetylcholine in rats. Hypertension 1993; 22: 156–160
  • Cooke J.P., Stamler J., Andon N., Davies P.F., McKinley G., Loscalzo J. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. American Journal of Physiology 1990; 259: H804–H812
  • Pryor W.A., Church D.F., Govindan C.K., Crank A. Oxidation of thiols by nitric oxide and nitrogen dioxide: synthetic utility and toxicological implications. Journal of Organic Chemistry 1982; 47: 156–159

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