163
Views
108
CrossRef citations to date
0
Altmetric
Research Article

Diabetes-induced Activation of Caspase-3 in Retina: Effect of Antioxidant Therapy

&
Pages 993-999 | Published online: 07 Jul 2009

  • Kador, P.F., Li, Y.M., Akagi, Y, Takahashi, H., Ikebe, M., Wyman, M. and Kinoshita, J.H. (1990) "Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors", Arch. Ophthalmol. 108, 1301-1309.
  • Stitt, A.W., Li, Y.M., Gardiner, T.A., Bucala, R., Archer, D.B. and Vlassara, H. (1997) "Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats", Am. J. Pathol. 150, 523-531.
  • Xia, P., Inoguchi, T., Kern, T.S., Engerman, R.L., Dates, P.J. and King, G.L. (1994) "Characterization of the mechanism for the chronic activation of DAG-PKC pathway in diabetes and hypergalactosemia", Diabetes 43, 1122-1129.
  • Kowluru, R.A., Jirousek, M.R., Stramm, L.E., Farid, N.A., Engerman, R.L. and Kern, T.S. (1998) "Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases", Diabetes 47, 464-469.
  • Baynes, J.W. (1991) "Role of oxidative stress in development of complications in diabetes", Diabetes 40, 405-412.
  • Ksowluru, R.A., Tang, J. and Kern, T.S. (2001) "Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy", Diabetes 50, 1938-1942.
  • Kern, T.S., Tang, J., Mizutani, M., Kowluru, R., Nagraj, R. and Lorenzi, M. (2000) "Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia", Investig. Ophthalmol. Vis. Sci. 41, 3972-3978.
  • Mizutani, M., Kern, T.S. and Lorenzi, M. (1996) "Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy", J. Clin. Investig. 97, 2883-2890.
  • Barber, A.J., Lieth, E., Khin, S.A., Antonetti, D.A., Buchanan, A.G. and Gardner, T.W. (1998) "Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin", J. Clin. Investig. 102, 783-791.
  • Kowluru, R.A., Kern, T.S. and Engerman, R.L. (1996) "Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system", Free Radic. Biol. Med. 22, 587-592.
  • Kowluru, R.A., Kern, T.S., Engerman, R.L. and Armstrong, D. (1996) "Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants", Diabetes 45, 1233-1237.
  • Kowluru, R.A., Engerman, R.L. and Kern, T.S. (1999) "Abnormalities of retinal metabolism in diabetes or experimental galactosemia. VI. Comparison of retinal and cerebral cortex metabolism, and effects of antioxidant therapy", Free Radic. Biol. Med. 26, 371-378.
  • Mohr, S. and Kern, T.S. (2000) "Hyperglycemia-induced caspase activation in the retina and retinal cells (abstract)", Investig. Ophthalmol. Vis. Sci. 41, S12.
  • Chen, H.Q. and Kowluru, R. (2001) "Antioxidants inhibit hyperglycemia-induced activation of caspase-3 in the retina (abstract)", Diabetes 50, A191.
  • Ho, F.M., Liu, S.H., Liau, C.S., Huang, P.J. and Lin-Shiau, S.Y. (2000) "High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3", Circulation 101, 2618-2624.
  • Kennedy, A., Frank, R.N., Sotolongo, L.B., Das, A. and Zhang, N.L. (1990) "Proliferative response and macromolecular synthesis by ocular cells cultured on extracellular matrix materials", Curr. Eye Res. 9, 307-322.
  • Mohr, S., McCormick, T.S. and Lapetina, E.G. (1998) "Macrophage resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: Dichotomous apoptotic response independent of caspase 3 and reversal by the mitogenactivated protein kinase (MEK) inhibitor PD 098059", Proc. Natl Acad. Sci. USA 95, 5048-5050.
  • Bradford, M.M. (1974) "A rapid and sensitive method for the quantitation of microgram quantities of protein", Anal. Biochem. 72, 248-258.
  • Li, W., Yanoff, M., Jian, B. and He, Z. (1999) "Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas", Cell. Mol. Biol. 45, 59-66.
  • Podesta, F., Romeo, G., Liu, W.H., Krajewski, S., Reed, J.C., Gerhardinger, C. and Lorenzi, M. (2000) "Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro", Am. J. Pathol. 156, 1025-1032.
  • Raff, M.C., Barres, B.A., Burne, J.F., Coles, H.S., Ishizaki, Y. and Jacobson, M.D. (1993) "Programmed cell death and the control of cell survival: lessons from the nervous system", Science 262, 695-700.
  • Roth, T., Podesta, F., Stepp, M.A., Boeri, D. and Lorenzi, M. (1993) "Integrin overexpression induced by high glucose and by human diabetes: Potential pathway to cell dysfunction in diabetic microangiopathy", Proc. Natl Acad. Sci. USA 90, 9640-9644.
  • Engerman, R.L., Pfaffenbach, D. and Davis, M.D. (1967) "Cell turnover of capillaries", Lab. Investig. 17, 738-743.
  • Armstrong, D. and Al-Awadi, F. (1991) "Lipid peroxidation and retinopathy in streptozotocin-induced diabetes", Free Radic. Biol. Med. 11, 433-436.
  • Stangel, M., Zettl, U.K., Mix, E., Zielasek, J., Toyka, K.V., Hartung, H.P. and Gold, R. (1996) "H2O2 and nitric oxidemediated oxidative stress induce apoptosis in rat skeletal muscle myoblasts", J. Neuropathol. Exp. Neural. 55, 36-43.
  • Kannan, K. and Jain, S.K. (2000) "Oxidative stress and apoptosis", Pathophysiology 7, 153-163.
  • Baumgartner-Parzer, S.M., Pettermann, L.M., Grillari, J., Gessl, A. and Waldhausl, W. (1995) "High-glucose-triggered apoptosis in cultured endothelial cells", Diabetes 44, 1323-1327.
  • Packer, L., Tritschler, H.J. and Wessel, K. (1997) "Neuroprotection by the metabolic antioxidant alpha lipoic acid", Free Radic. Biol. Med. 22, 359-378.
  • Sies, H. and Arteel, G.E. (2000) "Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics", Free Radic. Biol. Med. 28, 1451-1455.
  • Panasenko, O.M., Sharov, VS., Briviba, K. and Sies, H. (2000) "Interaction of peroxynitrite with carotenoids in human low density lipoproteins", Arch. Biochem. Biophys. 373, 302-305.
  • VanZandwijk, N. (1995) "N-acetylcysteine for lung cancer prevention", Chest 10, 1437-1441.
  • Kowluru, R.A., Engerman, R.L., Case, G.L. and Kern, T.S. (2001) "Retinal glutamate in diabetes and effect of antioxidants", Neurochem. Int. 38, 385-390.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.