- Feldman, P.L., Griffith, O.W. and Stuehr, DJ. (1993) "The surprising life of nitric oxide", Chem. Eng. News December 20, 26-38.
- Schmidt, H.H.H.W., Smith, R.M., Nakane, M. and Murad, F. (1992) "Ca2+/Calmodulin-dependent 'NO synthase type I: a biopteroflavoprotein with Ca2+/Calmodulin-independent diaphorase and reductase activities", Biochemistry 31, 3243-3249.
- Shesely, E.G., Maeda, N., Kirn, H.S., Desai, K.M., Krege, J.H., Laubach, V.E., Sherman, P.A., Sessa, W.C. and Smithies, O. (1996) "Elevated blood pressures in mice lacking endothelial nitric oxide synthase", Proc. Natl Acad. Sci. USA 93, 13176-13181.
- Duplain, H., Burcelin, R., Sartori, C, Cook, S., EgIi, M., Lepori, M, Vollemveider, P., Pedrazzini, T., Nkod, P., Thorens, B. and Scherrer, U. (2001) "Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase", Circulation 104,342-345.
- Sumeray, M.S., Rees, D.D. and Yellon, D.M. (2000) "Infarct size and nitric oxide synthase in murine myocardium", /. MoI. Cell. Cordial. 32,35-42.
- Gryglewski, R.J., Palmer, R.M and Moncada, S. (1986) "Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor", Nature 320, 454-456.
- Huie, R.E. and Padmaja, S. (1993) "The reaction of NO with Superoxide", Free Radie. Res. Commun. 18,195-199.
- Hemmens, B. and Mayer, B. (1998) "Enzymology of nitric oxide syntheses", Methods MoI. Biol. 100,1-32.
- Gorren, A.C.F., List, M.B., Schrammel, A., Fitters, E., Hemmens, B., Werner, E.R., Schmidt, K. and Mayer, B. (1996) "Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites", Biochemistry 35,16735-16745.
- Schmidt, K., Werner, E.R., Mayer, B., Wachter, H. and Kukovetz, W.R. (1992) "Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells", Biochem. J. 281,297-300.
- Scott-Burden, T. (1995) "Regulation of nitric oxide production by tetrahydrobiopterin", Circulation 91,248-250.
- Cosentino, F. and Katusic, Z. (1995) "Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries", Circulation 91,139-144.
- Cai, H. and Harrison, D.G. (2000) "Endothelial dysfunction in cardiovascular diseases. The role of oxidant stress", Circ. Res. 87,840-844.
- Vasquez-Vivar, J., Kalyanaraman, B., Martâsek, P., Hogg, N., Masters, B.S.S., Karoui, H., Tordo, P. and Pritchard, Jr., K.A. (1998) "Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors", Proc. Natl Acad. Sei. USA 95,9220-9225.
- Salerno, J.C., Harris, D.E., Irizarry, K., Patel, B., Morales, A.J., Smith, S.M.E., Martâsek, P., Roman, L.J., Masters, B.S.S., Jones, C.L., Weissman, B.A., Lane, P., Liu, Q. and Gross, S.S. (1997) "An autoinibitory control element defines calciumregulated isoforms of nitric oxide synthase", /. Biol. Chem. 272, 29769-29777.
- White, K.A. and Marietta, MA. (1992) "Nitric oxide is a P450 type heme protein", Biochemistry 31,6627-6631.
- Boggs, S., Huang, L. and Stuehr, DJ. (2000) "Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped flow spectroscopy under single turnover conditions", Biochemistry 39,2332-2339.
- Miller, T.R., Martâsek, P., Omura, T. and Masters, B.S.S. (1999) "Rapid kinetic studies of electron transfer in the three isoforms of nitric oxide synthase", Biochem. Biophys. Res. Commun. 265,184-188.
- Santolini, J., Adak, S., Curran, C.M.L. and Stuehr, DJ. (2001) "A kinetic simulation model that describes catalysis and regulation in nitric oxide synthase", /. Biol. Chem. 276, 1233-1243.
- Ortiz de Montellano, P.R., Nishida, C., Rodriguez-Crespo, I. and Gerber, N. (1998) "Nitric oxide synthase structure and electron transfer", Drug Metab. Dispos. 26,1185-1189.
- Adak, S., Aulak, K.S. and Stuehr, DJ. (2001) "Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity", /. Biol. Chem. 276, 23246-23252.
- Schelvis, J.P.M, Berka, V, Babcock, G.T. and Lai, A.L. (2002) "Resonance Raman detection of the Fe-S bond in endothelial nitric oxide synmase", Biochemistry 41, 5695-5701.
- Fisher, M.T. and Sligar, S.G. (1985) "Control of heme protein redox potential and reduction rate: linear free energy relation between potential and ferric spin state equilibrium", /. Am. Chem. Soc. 107,5018-5019.
- Salerno, J.C., McMillan, K. and Masters, B.S.S. (1996) "Binding of intermediate, product and substrate analogs to neuronal nitric oxide synthase: ferriheme is sensitive to ligand-specific effects in the L-arginine binding site", Biochemistry 35,11839-11845.
- Négrerie, M, Berka, V., Vos, M, Liebl, U., Lambry, J.C., Tsai, A.L. and Martin, J.L. (1999) "Germinate recombination of nitric oxide to endothelial nitric oxide synthase and mechanistic implications", /. Biol. Chem. 274,24694-24702.
- Kaufman, S. (1997) Tetrahydrobiopterin: Bask Chemistry and Role in Human Disease (The John Hopkins University Press, Baltimore).
- Witteveen, C.F.B., Giovanelli, J. and Kaufman, S. (1999) "Reactivity of tetrahydrobiopterin bound nitric oxide synthase", /. Biol. Chem. 274,29755-29762.
- Rodriguez-Crespo, I., Gerber, N.C. and Ortiz de Montellano, PR. (19%) "Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation", /. Biol. Chem. 271, 11462-11467.
- Klatt, P., Schmid, M, Leopold, E., Schmidt, K., Werner, E.R. and Mayer, B. (1994) "The pteridine binding site of brain nitric oxide synthase", /. Biol. Chem. 269,13861-13866.
- Vâsquez-Vivar, J., Martâsek, P., Whitsett, J., Joseph, J. and Kalyanaraman, B. (2002) "The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogs controls Superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study", Biochem. J. 362, 733-739.
- Bee, N., Gorren, A.C.F., Voelker, C, Mayer, B. and Lange, R. (1998) "Reaction of neuronal nitric oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin", /. Biol. Chem. 273,13502-13508.
- Vâsquez-Vivar, J., Hogg, N., Martâsek, P., Karoui, H., Pritchard, Jr., K.A. and Kalyanaraman, B. (1999) "Tetrahydrobiopterin-dependent inhibition of Superoxide generation from neuronal nitric oxide synthase", /. Biol. Chem. 274, 26736-26742.
- Culcasi, M, Lafon-Cazal, M, Pietri, S. and Bockaert, J. (1994) "Glutamate receptors induce a burst of Superoxide via activation of nitric oxide synthase in arginine-depleted neurons", /. Biol. Chem. 269,12589-12593.
- Xia, Y., Dawson, V.L., Dawson, T.M., Snyder, S.H. and Zweier, J.L. (1996) "Nitric oxide synthase generates Superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury", Proc. Natl Acad. Sei. U S A 93, 6770-6774.
- Cosentino, F., Patten, S., d'Uscio, L.V., Werner, E.R., WernerFehnayer, G., Moreau, R, Malinski, T. and Luscher, T.F. (1998) "Tetrahydrobiopterin alters Superoxide and nitric oxide release in prehypertensive rats", /. Clin. Investig. 101, 1530-1537.
- Stroes, E., Kastelein, J., Cosentino, F., Erkelens, W., Wever, R., Koomans, H., Luscher, T. and Rabelink, T. (1997) "Tetrahydrobiopterin restores endothelial function in hypercholesterolemia", /. Clin. Investig. 99,41-46.
- Pieper, GM. (1997) "Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin", /. Cardiovasc. Pharmacol. 29,8-15.
- Kinoshita, H., Tsutsui, M., Milstein, S. and Katusic, ZS. (1997) "Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone", Prog. Neurobiol. 52, 295-302.
- Heller, R., Munscher-Pauling, F., Grabner, R. and Till, U. (1999) "L-Ascorbk acid potentiates nitric oxide synthesis in endothelial cells", /. Biol. Cfiem. 274,8254-8260.
- Hyndman, ME., Verma, S., Rosenfel, R.J., Andersen, T.J. and Parsons, H.G. (2002) "Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function", Am. J. Physiol. Heart Circ. Physiol. 282, H2167-H2172.
- Verhaar, M.C., Stroes, E. and Rabelink, T.J. (2002) "Folates and cardiovascular disease", Arteriosder. Thromb. Vase. Biol. 22, 6-13.
- Vâsquez-Viar, J., Whitsett, J., Martasek, P., Hogg, N. and Kalyanaraman, B. (2001) "Reaction of tetrahydrobiopterin with Superoxide: EPR-kinetic analysis and characterization of the pteridine radical", Free Radie. Biol. Med. 31, 975-985.
The Role of Tetrahydrobiopterin in Superoxide Generation from eNOS: Enzymology and Physiological Implications
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