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Free Radical Research Volume 36, 2002 - Issue 11
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Research Article

Antioxidants Inhibit the Human Cortical Neuron Apoptosis Induced by Hydrogen Peroxide, Tumor Necrosis Factor Alpha, Dopamine and Beta-amyloid Peptide 1-42

Sonia Medina Department of Clinical Biochemistry, Hospital Universitario La Paz, Castellana 261, 28046, Madrid, Spain
,
Marcos Martínez Department of Pathology, Hospital General, Castellón, Spain
&
Angel Hernanz Department of Clinical Biochemistry, Hospital Universitario La Paz, Castellana 261, 28046, Madrid, Spain
Pages 1179-1184 | Published online: 07 Jul 2009

  • Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J. and Cotman, C.W. (1993) "Apoptosis is induced by beta-amyloid in cultured central nervous system neurons", Proc. Natl Acad. Sci. USA 90, 7951-7955.
  • Portera-Cailliau, C., Hedreen, J.C., Price, D.L. and Koliatsos, V.E. (1995) "Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models", J. Neurosci. 15, 3775-3787.
  • Lipton, S.A. (1996) "Similarity of neural cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species", Brain Pathol. 6, 507-517.
  • Burke, R.E. and Kholodilov, N.G. (1998) "Programmed cell death: does it play a role in Parkinson's disease?", Ann. Neural. 44, 126-133.
  • Clément; M.V., Ponton, A. and Pervaiz, S. (1998) "Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentrations and reduction of intracellular milieu", FEBS Lett. 440, 13-18.
  • Su, J.H., Anderson, A.J., Cummings, B.J. and Cotman, C.W. (1994) "Immunochemical evidende for apoptosis in Alzheimer's disease", Neuroreport 5, 2529-2533.
  • Jones, D.C., Gunasekar, P.G., Borowith, J.L. and Isom, G.E. (2000) "Dopamine-induced apoptosis is mediated by oxidative stress and is enhanced by cyanide in differentiated PC12 cells", J. Neurochem. 74, 2296-2304.
  • Offen, D., Ziv, I., Sternin, H., Melamed, E. and Hochman, A. (1996) "Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease", Exp. Neural. 141, 32-39.
  • Larrick, J.W. and Wright; S.C (1990) "Cytotoxic mechanism of tumor necrosis factor-alpha", FASEB J. 4, 3215-3223.
  • Talley, A.K., Dewhurst, S., Perry, S.W., Dollard, S.C, Gummuluru, S., Fine, S.M., New, D., Epstein, L.G., Gendelman, RE. and Gelbard, H.A. (1995) "Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA", Mol. Cell. Biol. 15, 2359-2366.
  • Zamzami, N., Susin, S.A., Marchetti, P., Hirech, T., Gomez Monterrey, L, Castedo, M. and Kroemer, G. (1996) "Mitochondrial control of nuclear apoptosis", J. Exp. Med. 183, 1533-1544.
  • Susin, S.A., Zamzami, N. and Kroemer, G. (1998) "Mitochondria as regulators of apoptosis; doubt no more", Biochim. Biophys. Acta 1366, 151-165.
  • Bossy-Wetzel, E., Newmeyer, D.D. and Green, D.R. (1998) "Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization", EMBO J. 17, 37-49.
  • Fulda, S., Scaffidi, C., Susin, S.A., Krammer, P.H., Kroemer, G., Peter, M.E. and Debatin, K.M. (1998) "Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid", J. Biol Chem. 273, 33942-33948.
  • Troyan, M.B., Gilman, V.R. and Gay, CV. (1997) "Mitochondrial membrane potential changes in osteoblasts treated with parathyroid hormone and estradiol", Exp. Cell Res. 233, 247-280.
  • Zamzami, N., Marchetti, R, Castedo, M., Zanin, C., Vayssiere, J.L, Petit, P.X. and Kroemer, G. (1995) "Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo", J. Exp. Med. 181, 1661-1672.
  • Chinopoulos, C., Tretter, L. and Adam-Vizi, V (1999) "Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals; inhibition of alpha-ketoglutarate dehydrogenase", J. Neurochem. 73, 220-228.
  • Laskay, G., Zarandi, M., Jost, K., Penke, B., Balint, E., Oscouszki, I., Tarcsa, M., Varszegi, S. and Gulya, K. (1999) "Beta-amyloid (1,40)-induced early hyperpolarization in M26-1F cells, an immortalized rat striatal cell line", Neurobiology 7, 431-436.
  • Krohn, A.J., Wahlbrink, T. and Prehn, J.H.M. (1999) "Mitochondrial depolarization is not required for neuronal apoptosis", J. Neurosci. 19, 7394-7404.
  • Budd, S.L., Tenneti, L, Lishnak, T. and Lipton, S.A. (2000) "Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons", PNAS 97, 6161-6166.
  • Jouvet, P., Rustin, P., Taylor, D.L., Pocock, J.M., FelderhoffMueser, U., Mazarakis, N.D., Sarraf, C., Joashi, U., Kozma, M., Greenwood, K., Edwards, A.D. and Mehmet, R (2000) "Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with Maple Syrup urine disease", Mol. Biol. Cell 11, 1919-1932.
  • Green, D.R. and Reed, J.C (1988) "Mitochondria and apoptosis", Science 281, 1309-1312.
  • Tsang, S.Y., Tam, S.C, Bremner, L and Burkitt, M.J. (1996) "Research communication copper-1, 10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical", Biochem. J. 317, 13-16.
  • McGowan, A.J., Fernandes, R.S., Samali, A. and Cotter, T.G. (1996) "Anti-oxidants and apoptosis", Biochem. Soc. Trans. 24, 229-233.
  • Hockenbery, D.M., Oltvai, Z.N., Yin, X.M., Milliman, C.L. and Korsmeyer, S.J. (1993) "Bcl-2 functions in an antioxidant pathway to prevent apoptosis", Cell 75, 241-251.
  • Ferrari, G., Yan, C.Y. and Greene, L.A. (1995) "N-acetylcysteine (D- and L-steroisomers) prevents apoptotic death of neuronal cells", J. Neurosci. 15, 2857-2866.
  • Elstein, K.H. and Zucker, R.M. (1994) "Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations", Exp. Cell Res. 211, 322-331.
  • Heiskanen, K.M., Bhat, M.B., Wang, H.W., Ma, J. and Nieminen, A.L. (1999) "Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells", J. Biol. Chem. 274, 5654-5658.
  • Mayer, M. and Noble, M. (1994) "N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro", Proc. Natl Acad. Sci. USA 91, 7496-7500.
  • Cossarizza, A., Franceschi, C., Monti, D., Salvioli, S., Bellesia, E., Rivabene, R., Biondo, L., Rainaldi, G., Tinari, A. and Malorni, W. (1995) "Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria", Exp. Cell Res. 220, 232-240.
  • Behl, C., Davis, J.B., Lesley, R. and Schubert, D. (1994) "Hydrogen peroxide mediates amyloid beta protein toxicity", Cell 77, 817-827.
  • Schubert, D., Behl, C., Lesley, R., Brack, A., Dargusch, R., Sagara, Y. and Kimura, R (1995) "Amyloid peptides are toxic via a common oxicative mechanism", Proc. Natl Acad. Sci. USA 92, 1989-1993.
  • Behl, C, Davis, J.B., Cole, G.M. and Schubert, D. (1992) "Vitamin E protects nerve cells from amyloid beta protein toxicity", Biochem. Biophys. Res. Commun. 186, 944-950.
  • Pappolla, M.A., Sos, M., Omar, R.A., Bick, R.J., Hickson-Bick, D.L., Reiter, R.J., Efthimiopoulos, S. and Robakis, N.K. (1997) "Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide", J. Neurosci. 17, 1683-1690.
  • Bonnefont; A.B., Muñoz, F.J. and Inestrosa, N.C. (1998) "Estrogen protects neuronal cells from the cytotoxidty induced by acetylcholinesterase-amyloid complexes", FEBS Lett. 441, 220-224.
  • Sakamoto, T., Repasky, W.T., Uchida, K., Hirata, A. and Hirata, F. (1996) "Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I", Biochem. Biophys. Res. Commun. 220, 643-664.

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