- Foye, W.O. (1998) "History of radioprotector development", In: Bump, E.A. and Malaker, K., eds, Radioprotectors: Chemical, Biological, and Clinical Perspectives (CRC Press, Boca Raton, Boston), pp 15-24.
- Brizel, D.M., Wasserman, T.H., Henke, M., Strnad, V, Rudat, V, Monnier, A., Eschwege, F., Zhang, J., Russell, L., Oster, W. and Sauer, R. (2000) "Phase III randomized trial of amifostine as a radioprotector in head and neck cancer", Journal of Clinical Oncology 18, 3339-3345.
- Kimura, E., Koike, T., Shimizu, Y. and Kodama, M. (1986) "Complexes of the histamine H2-antagonist cimetidine with divalent and monovalent copper ions", Inorganic Chemistry 25, 2242-2246.
- Lapenna, D., De Gioia, S., Mezzetti, A., Grossi, L., Festi, D., Marzio, L. and Cuccurullo, F. (1994) "H2-receptor antagonists are scavengers of oxygen radicals", European Journal of Clinical Investigation 24, 476-481.
- Ching, T.L., Haenen, G.R. and Bast, A. (1993) "Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers", Chemico-biological Interactions 86, 119-127.
- Miura, Y, Anzai, K., Ueda, J. and Ozawa, T. (2000) "Novel approach to in vivo screening for radioprotective activity in whole mice: in vivo electron spin resonance study probing the redox reaction of nitroxyl", Journal of Radiation Research (Tokyo) 41, 103-111.
- Uchida, K. and Kawakishi, S. (1990) "Cimetidine anti-ulcer drug as a powerful hydroxyl radical scavenger", Agricultural and Biological Chemistry 54, 2485-2487.
- Mozdarani, H. and Gharbali, A. (1993) "Radioprotective effects of cimetidine in mouse bone marrow cells exposed to ·-rays as assayed by the micronucleus test", International Journal of Radiation Biology 64, 189-194.
- Mozdarani, H. and Khoshbin-Khoshnazar, A.R. (1998) "In vivo protection by cimetidine against fast neutron-induced micronuclei in mouse bone marrow cells", Cancer Letters 124, 65-71.
- Al-Mustafa, Z.H., Al-AIi, A.K., Qaw, F.S. and Abdul-Cader, Z. (1997) "Cimetidine enhances the hepatoprotective action of N-acetylcystein in mice treated with toxic doses of paracetamol", Toxicology 121, 223-228.
- Mozdarani, H. and Kamali, S. (1998) "Antigenotoxic effects of cimetidine against benzene induced micronuclei in mouse bone marrow erythrocytes", Toxicology Letters 99, 53-61.
- Shaw, S. and Jayatilleke, E. (1992) "Cimetidine as a scavenger of ethanol-induced free radicals", Alcohol 9, 363-367.
- Mitchell, M.C., Schenker, S., Avant, G.R. and Speeg, Jr., K.V. (1981) "Cimetidine protects against acetaminophen hepatotoxicity in rats", Gastroenterology 81, 1052-1060.
- Mera, E., Muriel, P., Castillo, C. and Mourelle, M. (1994) "Cimetidine prevents and partially reverses CCl4-induced liver cirrhosis", Journal of Applied Toxicology 14, 87-90.
- Fenech, M. and Morley, A.A. (1985) "Measurement of micronuclei in lymphocytes", Mutation Research 147, 29-36.
- Fenech, M. (1993) "The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations", Mutation Research 285, 35-44.
- Fenech, M. (2000) "The in vitro micronucleus technique", Mutation Research 455, 81-95.
- Thierens, H., Vrai, A. and De Ridder, L. (1991) "Biological dosimetry using the micronucleus assay for lymphocytes: interindividual differences in dose response", Health Physics 61, 623-630.
- Vrai, A., Thierens, H. and De Ridder, L. (1992) "Study of doserate and split-dose effects on the in vitro micronucleus yield in human lymphocytes exposed to X-rays", International Journal of Radiation Biology 61, 777-784.
- Silva, M.J., Carothers, A., Dias, A., Luis, J.H., Piper, J. and Boavida, M.G. (1994) "Dose dependence of radiation-induced micronuclei in cytokinesis-blocked human lymphocytes", Mutation Research 322, 117-128.
- Verhaegen, F. and Vrai, A. (1994) "Sensitivity of micronucleus induction in human lymphocytes to low-LET radiation qualities: RBE and correlation of RBE and LET", Radiation Research 139, 208-213.
- Littlefield, L.G., Sayer, A.M. and Frome, E.L. (1989) "Comparisons of dose-response parameters for radiationinduced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes", Mutagenesis 4, 265-270.
- Louagie, H., Philippe, J., Vrai, A., Cornelissen, M., Thierens, H. and De Ridder, L. (1998) "Induction of micronuclei and apoptosis in natural killer cells compared to T lymphocytes after y-irradiation", International Journal of Radiation Biology 73, 179-185.
- Hertveldt, K., Philippe, J., Thierens, H., Cornelissen, M., Vral, A. and De Ridder, L. (1997) "Flow cytometry as a quantitative and sensitive method to evaluate low dose radiation induced apoptosis in vitro in human peripheral blood lymphocytes", International Journal of Radiation Biology 71, 429-433.
- Philippe, J., Louagie, H., Thierens, H., Vrai, A., Cornelissen, M. and De Ridder, L. (1997) "Quantification of apoptosis in lymphocytes subsets and effect of apoptosis on apparent expression of membrane antigens", Cytometry 29, 242-249.
- Ramakrishnan, N., Kalinich, J.F. and McClain, D.E. (1998) "Radiation-induced apoptosis in lymphoid cells: induction, prevention, and molecular mechanisms", In: Bump, E.A. and Malapert, K., eds, Radioprotectors: Chemical, Biological, and Clinical Perspectives (CRC Press, Boca Raton, Boston), pp 253-273.
- Seki, H., Kanegane, H., Iwai, K., Konno, A., Ohta, K., Yachie, A., Taniguchi, N. and Miyawaki, T. (1994) "Ionizing radiation induces apoptotic cell death in human TcR-¾/ä + T and natural killer cells without detectable p53 protein", European Journal of Immunology 24, 2914-2917.
- Vandeputte, C., Guizon, L, Genestie-Denis, I., Vannier, B. and Lorenzon, G. (1994) "A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol", Cell Biology and Toxicology 10, 415-421.
- Griffith, O.W. (1980) "Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine", Analytical Biochemistry 106, 207-212.
- Baker, M.A., Cerniglia, G.J. and Zaman, A. (1990) "Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples", Analytical Biochemistry 190, 360-365.
- Buxton, G.V., Greenstock, C.L., Phillip Helman, W. and Ross, A.B. (1988) "Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (.OH/.O) in aqueous solution", Journal of Physical and Chemical Reference Data 17, 513-886.
- Miller, B.M., Wemer, T., Weier, H.-U. and Nusse, M. (1992) "Analysis of radiation-induced micronuclei by fluorescence in situ hybridization (FISH) simultaneously using telomeric and centromeric DNA probes", Radiation Research 131, 177-185.
- Louagie, H., Schotte, P., Vrai, A., Cornelissen, M., Thierens, H., Beyaert, R., De Ridder, L. and Philippe, J. (1999) "Apoptosis induced by y irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases", Cell Biology International 23, 611-617.
- Kirkova, M., Atanassova, M. and Russanov, E. (1999) "Effects of cimetidine and its metal complexes on nitroblue tetrazolium and ferricytochrome c reduction by Superoxide radicals", General Pharmacology 33, 271-276.
- Zhao, Q.-L., Kondo, T., Noda, A. and Fujiwara, Y. (1999) "Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells", International Journal of Radiation Biology 75, 493-504.
- Kimura, C., Zhao, Q.-L., Kondo, T., Amatsu, M. and Fujiwara, Y. (1998) "Mechanism of UV-induced apoptosis in human leukemia cells: roles of Ca2+-Mg2+-dependent endonuclease, caspase-3, and stress-activated protein kinase", Experimental Cell Research 239, 411-422.
- Li, F.-J., Kondo, T., Zhao, Q.-L., Tanabe, K., Ogawa, R., Li, M. and Arai, Y. (2001) "Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis(2-amidino-propane)dihydrochloride, in human histiocytic lymphoma U937 cells", Free Radical Research 35, 281-299.
- Li, M., Kondo, T., Zhao, Q.L., Li, F.J., Tanabe, K., Arai, Y., Zhou, Z.C. and Kasuya, M. (2000) "Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+ calpain and caspase-mitochondria-dependent pathways", Journal of Biological Chemistry 275, 39702-39709.
Protective Effects of Cimetidine on Radiation-induced Micronuclei and Apoptosis in Human Peripheral Blood Lymphocytes
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.