- Guyton, K.Z. and Kensler, T.W. (1993) "Oxidative mechanisms in carcinogenesis", Br. Med. Bull. 49, 523-544.
- Emerit, I. (1994) "Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis", Free Radic. Biol. Med. 16, 99-109.
- Marnett, L.J. (2000) "Oxyradicals and DNA damage", Cardnogenesis 21, 361-370.
- Randerath, K., Zhou, G.-D., Monk, S.A. and Randerath, E. (1997) "Enhanced levels in neonatal rat liver of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxydeoxyguanosine), a major mutagenic oxidative DNA lesion", Carcinogenesis 18, 1419-1421.
- Boiteux, S. and Radicella, J.P. (1999) "Base excision repair of 8-hydroxyguanosine protects DNA from endogenous oxidative stress", Biochemie 81, 59-67.
- Nomoto, M., Yamaguchi, R., Kawamura, M., Kohno, K. and Kasai, H. (2000) "Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate", Carcinogenesis 20, 837-841.
- Podmore, I.D., Cooper, D., Evans, M.D., Wood, M. and Lunec, J. (2000) "Simultaneous measurement of 8-oxo2'deoxyguanosine and 8-oxo-2'-deoxyadenosine by HPLC-MS/MS", Biochem. Biophys. Res. Commun. 275, 764-770.
- Yamamoto, F., Kasai, H., Togashi, Y, Takeichi, N., Hori, T. and Nishimura, S. (1993) "Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of Long-Evans Cinnamon rats", Jpn. J. Cancer Res. 84, 508-511.
- Kondo, S., Toyokuni, S., Tanaka, T., Hiai, H., Onodera, H., Kasai, H. and Imamura, M. (2000) "Overexpression of the hOGGI gene and high 8-hydroxy-2'-deoxyguanosine (8-OhdG ) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA", Clin. Cancer Res. 6, 1394-1400.
- Foksinski, M., Kotzbach, R., Szymanski, W. and Olinski, R. (2000) "The level of typical biomarker of oxidative stress 8-hydroxy-2'deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor", Free Radic. Biol. Med. 29, 597-601.
- Mecocci, P., Fano, G., Fulle, S., MacGarvey, U., Shinobu, L., Polidori, M.C., Cherubini, A., Vecchiet, J., Senin, U. and Beal, M.F. (1999) "Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle", Free Radic. Biol. Med. 26, 303-308.
- Calderon-Garciduenas, L., Wen-Wang, L., Zhang, Y.-J., Rodriguez-Alcaraz, A., Osnaya, N., Villarreal-Calderon, A. and Santella, R.M. (1999) "8-Hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution", Environ. Health Perspect. 107, 469-474.
- Lodovici, M., Casalini, C., Cariaggi, R., Michelucci, L. and Dolara, P. (2000) "Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes", Free Radic. Biol. Med. 28, 13-17.
- Simic, M.G. (1992) "Urinary biomarkers and the rate of DNA damage in carcinogenesis and anticarcinogenesis", Mutat. Res. 267, 277-290.
- Kasai, H. (1997) "Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis", Mutat. Res. 387, 147-163.
- Halliwell, B. (1998) "Can oxidative DNA damage be used as a biomarker of cancer risk in humans? Problems, resolutions and preliminary results from nutritional supplementation studies", Free Radic. Res. 29, 469-486.
- de Zwart, L.L., Meerman, J.H.N., Commandeur, J.N.M. and Vermeulen, N.P.E. (1999) "Biomarkers of free radical damage applications in experimental animals and humans", Free Radic. Biol. Med. 26, 202-226.
- Youdim, K.A. and Joseph, J.A. (2001) "A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects", Free Radie. Biol. Med. 30, 583-594.
- Floyd, R.A., West, M.S., Eneff, K.L., Hogsett, W.E. and Tingey, D.T. (1988) "Hydroxyl free radical mediated formation of 8-hydroxyguanosine in isolated DNA", Arch. Biochem. Biophys. 262, 266-272.
- Taylor, D.E., Ghio, A.J. and Piantadosi, C.A. (1995) "Reactive oxygen species produced by liver mitochondria of rats in sepsis", Arch. Biochem. Biophys. 316, 70-76.
- Abu-Shakra, A. and Zeiger, E. (1997) "Formation of 8-hydroxy-2'-deoxyguanosine following treatment of 2'-deoxyguanosine or DNA by hydrogen peroxide or glutathione", Mutat. Res. 390, 45-50.
- Lloyd, D.R. and Phillips, D.H. (1999) "Oxidative DNA damage mediated by copper (II), iron (II) and nickel (II) Fenton reactions: evidence for site-specific mechanisms in the formation of double-strand breaks, 8-hydroxydeoxyguanosine and putative intrastrand cross-links", Mutat. Res. 424, 23-36.
- Goldman, R., Claycamp, G.H., Sweetland, M.A., Sedlov, A.V., Tyurin, V.A., Kisin, E.R., Tyurina, YY, Ritov, V.B., Wenger, S.L., Grant, S.G. and Kagan, V.E. (1999) "Myeloperoxidasecatalyzed redox-cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells", Free Radie. Biol. Med. 27, 1050-1063.
- Kaneko, T. and Tahara, S. (2000) "Formation of 8-oxo-2'-deoxyguanosine in the DNA of human diploid fibroblasts by treatment with linoleic acid hydroperoxide and ferric ion", Lipids 35, 961-965.
- Kasai, H. and Nishimura, S. (1984) "Hydroxylation of deoxyguanosine a the C-8 position by ascorbic acid and other reducing agents", Nucleic Acids Res. 12, 2137-2145.
- Nappi, A.H. and Vass, E. (1997) "Comparative studies of enhanced iron-mediated production of hydroxyl radical by glutathione, cysteine, ascorbic acid, and selected catechols", Biochim. Biophys. Acta 1336, 295-301.
- Yokozawa, T., Dong, E., Liu, Z.W. and Shimuzu, M. (1997) "Antioxidative activity of flavones and flavonols in vitro", Phytother. Res. 11, 446-449.
- Sugihara, N., Arakawa, T., Ohnishi, M. and Furuno, K. (1999) "Anti- and pro-oxidative effects of flavonoids on metalinduced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with a-linolenic acid", Free Radic. Biol. Med. 27, 1313-1323.
- Puppo, A. (1992) "Effect of flavonoids on hydroxyl radical formation by Fenton-type reactions; influence of the iron chelator", Phytochemistry 31, 85-88.
- Niki, E. (1990) "Free radical initiators as source of water- or lipid-soluble peroxyl radicals", Methods Enzymol. 186, 100-108.
- Simandan, T., Sun, J. and Dix, T.A. (1998) "Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicals", Biochem. J. 335, 233-240.
- Cadenas, E. and Davies, K.J.A. (2000) "Mitochondrial free radical generation, oxidative stress, and aging", Free Radic. Biol. Med. 29, 222-230.
- Atlante, A., Calissano, P., Bobba, A., Azzariti, A., Marra, E. and Passarella, S. (2000) "Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death", J. Biol. Chem. 275, 37159-37166.
- Blois, M.B. (1958) "Antioxidant determinations by the use of a stable free radical", Nature 181, 1199-1200.
- Sies, H. (1993) "Damage to plasmid DNA by singlet oxygen and its protection", Mutat. Res. 299, 183-191.
- Sully, B.D. (1954) "A modified iodimetric determination of organic peroxides", Analysts 79, 86-90.
- Lin, T.-S., Cheng, J.-C, Ishiguro, K. and Sartorelli, A.C. (1985) "8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells", J. Med. Chem. 28, 1194-1198.
- Ikehara, M., Uesugi, S. and Yoshida, K. (1972) "Studies on the conformation of purine nucleosides and their 5'-phosphates", Biochemistry 11, 830-836.
- Gulp, S.J., Cho, B.P., Kadlubar, F.F. and Evans, F.E. (1989) "Structural and conformational analyses of 8-hydroxy-2'-deoxygusanosine", Chem. Res. Toxicol. 2, 416-422.
- Uesugi, S. and Ikehara, M. (1977) "Carbon-13 magnetic resonance spectra of 8-substituted purine nucleosides. Characteristic shifts for the syn conformation", J. Am. Chem. Soc. 99, 3250-3253.
- Bros, W., Heller, W., Michel, C. and Saran, M. (1990) "Flavonoids as antioxidants: determination of radicalscavenging efficiencies", Methods Enzymol. 186, 343-355.
- Krinsky, N.I. (1989) "Antioxidant functions of carotenoids", Free Radic. Biol. Med. 7, 617-635.
- Mascio, P.D., Murphy, M.E. and Sies, H. (1991) "Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols", Am. J. Clin. Nutr. 53, 194S-200S.
- Cholbi, M.R., Paya, M. and Alcaraz, M.J. (1991) "Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation", Experimentia 47, 195-199.
- Yokozawa, T., Chen, C.P., Dong, E., Tanaka, T., Nonaka, G.-I. and Nishioka, I. (1998) "Study on the inhibitory effect of tannina and flavonoids against the 1, 1-diphenyl-2-picryl-hydrazyl radical", Biochem. Pharmacol. 56, 213-222.
- Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R.W., Washko, P.W, Dhariwal, K.R., Park, J.B., Lazarev, A., Graumlich, J.F., King, J. and Cantilena, L.R. (1996) "Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance", Proc. Natl Acad. Sci. USA 93, 3704-3709.
- Mecocci, P., Polidori, M.C., Troiano, L., Cherubini, A., Cecchetti, R., Pimi, G., Straatman, M., Monti, D., Stahl, W., Sies, H., Franceschi, C. and Senin, U. (2000) "Plasma antioxidants and longevity: a study on healthy centenarians", Free Radic. Biol. Med. 28, 1243-1248.
- Conquer, J.A., Maiani, G., Azzini, E., Raguzzini, A. and Holub, B.J. (1998) "Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects", J. Nutr. 128, 593-597.
- de Vries, J.H.M., Hollman, P.C.H., Meyboom, S., Buysman, M.N.C.R, Zock, P.L., van Staveren, WA. and Katan, M.B. (1998) "Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake", Am. J. Clin. Nutr. 68, 60-65.
- Nakagawa, K., Okuda, S. and Miyazawa, T. (1997) "Dosedependent incorporation of tea catechins, (-)-epigallocate-chin-3-gallate and (-)-epigallocatechin, into human plasma", Biosci. Biotechnol. Biochem. 61, 1981-1985.
A Novel Method Using 8-hydroperoxy-2′-deoxyguanosine Formation for Evaluating Antioxidative Potency
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.