Advanced search
Publication Cover
Free Radical Research Volume 36, 2002 - Issue 6
Submit an article Journal homepage
76
Views
42
CrossRef citations to date
0
Altmetric
Research Article

The Neuroprotective Antioxidant α-lipoic Acid Induces Detoxication Enzymes in Cultured Astroglial Cells

Jacoba Flier Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
,
Freek L. van Muiswinkel Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
,
Cornelis A.M. Jongenelen Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
&
Benjamin Drukarch Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
Pages 695-699 | Published online: 07 Jul 2009

  • Jenner, P. and Olanow, C.W. (1998) "Understanding cell death in Parkinson's disease", Ann. Neural. 44, S72-S84.
  • Drukarch, B. and van Muiswinkel, F.L. (2000) "Drug treatment of Parkinson's disease. Time for phase II", Biochem. Pharmacol. 59, 1023-1031.
  • Dinkova-Kostova, A.T. and Talalay, P. (2000) "Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen", Free Radic. Biol. Med. 29, 231-240.
  • Talalay, P., Fahey, J.W., Holtzclaw, W.D., Prestera, T. and Zhang, Y. (1995) "Chemoprotection against cancer by phase 2 enzyme induction", Toxicol. Lett. 82-83, 173-179.
  • Kwak, M., Egner, P.A., Dolan, P.M., Ramos-Gomez, M., Groopman, J.D., Itoh, K., Yamamoto, M. and Kensler, TW. (2001) "Role of phase 2 enzyme induction in chemoprotection by dithiolethiones", Mutât. Res. 480-481, 305-315.
  • Prestera, T, Holtzclaw, W.D., Zhang, Y. and Talalay, P. (1993) "Chemical and molecular regulation of enzymes that detoxify carcinogens", Proc. Natl Acad. Sd. USA 90, 2965-2969.
  • Packer, L., Tritschler, HJ. and Wessel, K. (1997) "Neuroprotection by the metabolic antioxidant alpha-lipoic acid", Free Radic. Biol. Med. 22, 359-378.
  • Biewenga, G.P., Haenen, G.R. and Bast, A. (1997) "The pharmacology of the antioxidant lipoic acid", Gen. Pharmacol. 29, 315-331.
  • Packer, L., Witt, E.H. and Tritschler, HJ. (1995) "Alpha-Lipoic acid as a biological antioxidant", Free Radic. Biol. Med. 19, 227-250.
  • van Muiswinkel, EL., Riemers, P.M., Peters, GJ., LaFleur, M.V., Siegel, D., Jongenelen, C.A. and Drukarch, B. (2000) "L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells", Free Radic. Biol. Med. 29, 442-453.
  • Drukarch, B., Schepens, E., Stoof, J.C. and Langeveld, C.H. (1997) "Anethole dithiolethione prevents oxidative damage in glutathione-depleted astrocytes", Eur. J. Pharmacol. 329, 259-262.
  • Habig, W.H., Pabst, MJ. and Jakoby, W.B. (1974) "Glutathione S-transferases. The first enzymatic step in mercapturic acid formation", /. Biol. Chem. 249, 7130-7139.
  • Bustin, S.A. (2000) "Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays", /. MoI. Endocrinol. 25, 169-193.
  • Jaiswal, A.K. (2000) "Regulation of genes encoding NAD(P)H:quinone oxidoreductases", Free Radie. Aßï/. Med. 29, 254-262.
  • Schultzberg, M., Segura-Aguilar, J. and Lind, C. (1988) "Distribution of DT diaphorase in the rat brain: biochemical and immunohistochemical studies", Neuroscience 27, 763-776.
  • Johnson, J.A., el Barbary, A., Kornguth, S.E., Brugge, J.F. and Siegel, F.L. (1993) "Glutathione S-transferase isoenzymes in rat brain neurons and glia", J. Neurosci. 13, 2013-2023.
  • Xie, C., Lovell, M.A. and Markesbery, W.R. (1998) "Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity", Free Radic. Biol. Med. 25, 979-988.
  • Handelman, G.J., Ran, D., Tritschler, H. and Packer, L. (1994) "Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium", Biochem. Pharmacol. 47, 1725-1730.
  • McCarty, M.F. (2001) "Versatile cytoprotective activity of lipoic acid may reflect its ability to activate signalling intermediates that trigger the heat-shock and phase II responses", Med. Hypotheses 57, 313-317.
  • Otieno, M.A., Kensler, T.W. and Guyton, K.Z. (2000) "Chemoprotective 3H-l,2-dithiole-3-thione induces antioxidant genes in vivo", Free Radic. Biol. Med. 28, 944-952.
  • Rayes, J.D., Ellis, E.M., Neal, G.E., Harrison, DJ. and Manson, M.M. (1999) "Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress", Biochem. Soc. Symp. 64, 141-168.
  • Ansher, S.S., Dolan, P. and Bueding, E. (1986) "Biochemical effects of dithiolthiones", Food Chem. Toxicol. 24, 405-415.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.