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Free Radical Research Volume 37, 2003 - Issue 8
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Original Article

Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer, Cellular Time-keeping, Growth, Aging and Neurodegenerative Diseases

D. James Morré Department of Medicinal Chemistry and Molecular Pharmacology Hansen Life Sciences Research Building West Lafayette IN USA
&
Dorothy M. Morré Department of Foods and Nutrition, Stone Hall Purdue University West Lafayette IN 47907 USA
Pages 795-808 | Received 28 Jun 2004, Accepted 28 Jun 2004, Published online: 16 Jul 2012

  • Morré D.M., Lenaz G., Morré D.J. Surface oxidase and oxidative stress propagation in aging 2000; 203: 1513-1521
  • Morré D.J., Bridge A., Wu L.-Y., Morré D.M. Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture 2000; 60: 937-946
  • Gilberger T.W., Bergmann B., Walter R.D., Muller S. The role of the C-terminus for catalysis of the large thioredoxin reductase from Plasmodium falciparum 1998; 425: 407-410
  • Ohnishi K., Niimura Y., Hidaka M., Masaki H., Suzuki H., Uozumi T., Nishino T. Role of cysteine 337 and cysteine 340 in flavoprotein that functions as NADH oxidase from Amphibacillus xylanus 1995; 270: 5812-5817
  • Yantiri F., Morré D.J. Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface 2001; 391: 149-159
  • Morré D.J., Ternes P., Morré D.M. Cell enlargement of plant tissue explants oscillates with a temperature-compensated period length of ca. 24 min 2002; 38: 18-28
  • Bacon E., Morré D.J. Plasma membrane NADH oxidase of maize roots responds to gravity and imposed centrifugal forces 2001; 39: 487-494
  • Garcia C., Hicks C., Morré D.J. Plasma membrane NADH oxidase is gravi-responsive 1999; 37: 551-558
  • Barr R., Garcia C., Morré D.J. Touch-sensitive NADH oxidase activity of pea and cucumber tendrils and of soybean hypocotyl sections 2000; 161: 387-391
  • Baserga R. 1985; Harvard University Press
  • Wang S., Pogue R., Morré D.M., Morré D.J. NADH oxidase activity (NOX) and enlargement of HeLa cells oscillate with two different temperature-compensated period lengths of 22 and 24 minutes corresponding to different NOX forms 2001; 1539: 192-204
  • Sun P., Morré D.J., Morré D.M. Periodic NADH oxidase activity associated with an endoplasmic reticulum fraction from pig liver. Response to micromolar concentrations of retinal 2000; 1498: 52-63
  • Kliman R.M., Hey J. DNA sequence variation at the period locus within and among species of the Drosophila melanogaster 1993; 133: 375-387
  • Morré D.J., Penel C., Greppin H., Morré D.M. The plasma membrane-associated NADH oxidase of spinach leaves responds to blue light 2002; 163: 543-547
  • Chueh P.-J., Morré D.M., Morré D.J. A site-directed mutagenesis analysis of tNOX functional domains 2002; 1594: 74-83
  • Schininá M.E., Carlinin P., Polticelli F., Zappacosta F., Bossa F., Calabrese L. Amino acid sequence of chicken Cu, Zn-containing superoxide dismutase and identification of glutathionyl adducts at exposed cysteine residues 1996; 237: 433-439
  • Tompa P., Friedrich P. Prion proteins as memory molecules: an hypothesis 1998; 86: 1037-1043
  • Morré D.J., Wu L.-Y., Morré D.M. The antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984) inhibits NADH oxidase activity of HeLa plasma membrane 1995; 1240: 11-17
  • Morré D.J., Sedlak D., Tang X., Chueh P.-J., Geng T., Morré D.M. Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs 2001; 392: 251-256
  • Morré D.J., Chueh P.-J., Morré D.M. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture 1995; 92: 1831-1835
  • Morré D.J., Sun E., Geilen C., Wu L.-Y., de Cabo R., Krasagakis K., Orfanos C.E., Morré D.M. Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines 1996; 32A: 1995-2003
  • Dunlap J.C. Genetics and molecular analysis of circadian rhythms 1996; 30: 579-601
  • Morré D.J., Morré D.M., Penel C., Greppin H. NADH oxidase periodicity of spinach leaves synchronized by light 1999; 160: 855-860
  • Wang S., Pogue R., Morré D.M., Morré D.J. NADH oxidase activity (NOX) and enlargement of HeLa cells oscillate with two different temperature-compensated period lengths of 22 and 24 minutes corresponding to different NOX forms 2001; 1539: 192-204
  • Edmunds L.N. Cellular and Molecular Basis of Biological Clocks 1988; 497Springer-Verlag
  • Lyles M.M., Gilbert H.F. Catalysis of the oxidative unfolding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer 1991; 30: 613-619
  • Morré D.J., Chueh P.-J., Pletcher J., Tang X., Wu L.-Y., Morré D.M. Biochemical basis for the biological clock 2002; 41: 11941-11945
  • Foster K., Anwar N., Pogue R., Morré D.M., Morré D.J. Decomposition analyses applied to a complex ultradian biorhythm--the oscillating NADH oxidase activity of plasma membranes having a potential time-keeping (clock) function 2003; 1:
  • Morré D.J., Gomez-Ray M.L., Schrmke K.C., Em O., Lawler J., Hobeck J., Morré D.M. Use of dipyridyl-dithio substrates to measure directly the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes 1999; 207: 7-13
  • Chueh P.-J., Morré D.J., Wilkinson F.E., Gibson J., Morré D.M. A 33.5 kDa heat-and protease-resistant NADH oxidase inhibited by capsaicin from sera of cancer patients 1997; 342: 38-47
  • Bruno M., Brightman A.O., Lawrence J., Werderitsh D., Morré D.M., Morré D.J. Stimulation of NADH oxidase activity from rat liver plasma membranes by growth factors and hormones is decreased or absent with hepatoma plasma membrane 1992; 284: 625-628
  • Morré D.J., Pogue R., Morré D.M. Soybean cell enlargement oscillates with a temperature-compensated period of ca. 24 min 2001; 37: 19-23
  • Sedlak D., Morré D.M., Morré D.J. A drug-unresponsive and protease-resistant CNOX protein from human sera 2001; 386: 106-116
  • Rutter J., Reick M., Wu L.C., McKnight S.L. Regulation of clock and NPAS2 DNA binding by the redox state of NADH cofactors 2001; 293: 510-514
  • Morré D.J., Chueh P.-J., Morré D.M. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture 1995; 92: 1831-1835
  • Konopka R.J., Benzer S. Clock mutants of Drosophila melanogaster 1971; 68: 2112-2116
  • Young M.W. Life's 24-hour clock: molecular control of circadian rhythms in animal cells 2000; 25: 601-606
  • Morré D.M., Morré D.J. Mechanism of killing of HeLa cells by the antitumor sulfonylurea, N-(4-methylphenylsulfonyl)-N-(chlorophenyl)urea (LY181984) 1995; 184: 188-195
  • de Grey, A.D.N.J. (1999) "The mitochondrial free radical theory of aging", R.G. Landes
  • Morré D.J. The hormone- and growth factor-stimulated NADH oxidase 1994; 26: 421-433
  • Morré D.J., Brightman A.O. Parallel inhibition by external osmotica of auxin-induced elongation in stem sections and auxin-stimulated NADH oxidase activity of plasma membrane vesicles from soybean hypocotyls 1997; 35: 311-319
  • Sun E., Lawrence J., Morré D.M., Sun I., Crane F.L., MacKellar W.C., Morré D.J. Proton release from HeLa cells and alkalization of cytoplasm induced by diferric transferrin or ferricyanide and its inhibition by the diarysulfonylurea antitumor drug N-(4-methylphenylsulfonyl)-N-(chlorophenyl)urea (LY181984) 1995; 50: 1461-1468
  • Barr R., Morré D.J., Crane F.L. Oxidation of NADH by hypocotyl segments of soybean is stimulated by 2,4-D 2000; 38: 739-745
  • Larm J.A., Vaillant F., Linnane A.W., Lawen A. Upregulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rhoo 1994; 269: 30097-30100
  • Levi F. Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status 2000; 6: 3038-3045
  • Morré D.J., Caldwell S., Mayorga A., Wu L.-Y., Morré D.M. NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients 1997; 342: 224-230
  • Morré D.J., Pogue R., Morré D.M. A multifunctional ubiquinol oxidase of the external cell surface and sera 1999; 9: 179-187
  • Cho N.M., Chueh P.-J., Kim C., Caldwell S., Morré D.M., Morré D.J. Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients 2002; 51: 121-129
  • Kim C., MacKellar W.C., Cho N., Byrn S.R., Morré D.J. Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture. Identification of binding proteins from sera of cancer patients 1997; 1324: 171-181
  • Morré D.J., Wu L.-Y., Morré D.M. The antitumor sulfonylurea N-(4-methylphenylsulfonylurea)-N'-(chlorophenyl)urea (LY181984) inhibits NADH oxidase activity of HeLa plasma membrane 1995; 1240: 11-17
  • Morré D.J., Reust T. A circulating form of NADH oxidase activity responsive to the antitumor sulfonylurea N-(4-methylphenylsulfonylurea)-N'-(chlorophenyl)urea (LY181984) specific to sera from cancer patients 1997; 29: 281-289
  • Morré D.J., Kim C., Paulik M., Morré D.M., Faulk W.P. Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin? 1997; 29: 269-280
  • del Castillo-Olivares A., Chueh P.-J., Wang S., Sweeting M., Yantiri F., Sedlak D., Morré D.M., Burgess J., Morré D.J. A drug-responsive and protease-resistant 34 kDa NADH oxidase from the surface of HeLa cells 1998; 358: 125-140
  • Bridge A., Barr R., Morré D.J. The plasma membrane NADH oxidase of soybean has vitamin K1 2000; 1463: 448-458
  • Forsmark-Andree P., Dallner G., Ernster L. Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial particles 1995; 19: 749-757
  • Morré D.J., Chueh P.-J., Lawler J., Morré D.M. The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity 1998; 30: 477-487
  • Chueh P.-J., Morré D.M., Penel C., DeHahn T., Morré D.J. The hormone-responsive NADH oxidase of the plant plasma membrane has properties of a NADH: protein disulfide reductase 1997; 272: 11221-11227
  • Morré D.J. Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor 2002; 4: 207-212
  • Morré D.J., Morré D.M. Applications of aqueous two-phase partition to isolation of membranes from plants: a periodic NADH oxidase activity as a marker for right side-out plasma membrane vesicles 2000; 743: 377-387
  • Hicks C., Morré D.J. Oxidation of NADH by intact segments of soybean hypocotyls and stimulation by 2,4-D 1998; 1375: 1-5
  • Kishi T., Morré D.M., Morré D.J. The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity 1999; 1412: 66-77
  • Kelker M., Kim C., Chueh P.-J., Guimont R., Morré D.M., Morré D.J. Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion 2001; 40: 7351-7354
  • Morré D.J., Morré D.M. NADH oxidase activity of soybean plasma membranes oscillates with a temperature compensated period of 24 min 1998; 16: 279-284
  • Chueh P.-J., Kim C., Cho N., Morré D.M., Morré D.J. Molecular cloning and characterization of a tumor-associated, growth-related and time-keeping hydroquinone (NADH) oxidase (NOX) of the HeLa cell surface 2002; 41: 3732-3741
  • Morré D.J., Asard H., Bérczi A., Caubergs R. NADH oxidase: a multifunctional ectoprotein of the eukaryotic cell surface 1998; 121-156Kluwer Academic Publishers
  • Lambeth J.D., Cheng G., Arnold R.S., Edens W.A. Novel homologs of gp91 phox 2000; 25: 459-461
  • Morré D.J. NADH oxidase activity of HeLa plasma membranes inhibited by the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea (LY181984) at an external site 1995; 1240: 201-208
  • Pogue R., Morré D.M., Morré D.J. CHO cell enlargement oscillates with a temperature-compensated period of 24 minutes 2000; 1498: 44-51
  • Morré D.J., Lawler J., Wang S., Keenan T.W., Morré D.M. Entrainment in solution of an oscillating NADH oxidase activity from the bovine milk fat globule membrane with a temperature-compensated period length suggestive of an ultradian time-keeping (clock) function 2002; 1559: 10-20

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