57
Views
22
CrossRef citations to date
0
Altmetric
Original Article

A Free Radical Scavenger, Edaravone, Attenuates Steatosis and Cell Death via Reducing Inflammatory Cytokine Production in Rat Acute Liver Injury

, , , , , , & show all
Pages 849-859 | Received 28 Jun 2004, Accepted 28 Jun 2004, Published online: 16 Jul 2012

  • Rojkind M., Valadez G., Evered D., Whelan J. Regulation of fibroblast proliferation by kupffer cells and monocytes 1985; 208-221Pitmann, Ciba Foundation Symposium
  • Bedossa P., Houglum K., Trautwein C., Holstage A., Chojkier M. Stimulation of collagen-α 1994; 19: 1262-1271
  • Cao Q., Batey R., Pang G., Russell A., Clancy R. IL-6, IFN-γα 1998; 76: 542-549
  • Adams J.K., Tepperman B.L. Colonic production and expression of IL-4, IL-6, and IL-10 in neonatal suckling rats after LPS challenge 2001; 280: G755-G762
  • Osada N., Mochida S., Inao M., Mashimo Y., Fujiwara K. Apoptosis in dissociation between DNA synthesis and cellular functions of activated hepatic stellate cells--A study with carbon tetrachloride-induced rat liver injury 2001; 282: 524-528
  • Kasai K., Sato S., Suzuki K. A novel prostaglandin E receptor subtype agonist, ONO-4819, attenuates acute experimental liver injury in rats 2001; 21: 252-260
  • Watanabe K., Watanabe K., Hayase T. Radical scavenging mechanism of MCl-186 1997; 25: S1699-S17077
  • Chvapil M., Ryan J.N., Zukosky C.F. Effect of zinc on lipid peroxidation in liver microsomes and mitochondria 1972; 141: 150-153
  • Takamatsu Y., Ono A., Tatsuno J., Yamamoto M. Pharmacokinetic studies of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCl-186) in rats (4)-Effects of MCl-186 on drug-metabolizing enzymes in rat liver 1997; 25: S1765-S17717
  • Yamamoto Y., Kuwahara T., Watanabe K., Watanabe K. Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one 1996; 2: 333-338
  • Paradis V., Kollinger M., Fabre M., Holstege A., Poynard T., Bedossa P. In situ 1997; 26: 135-142
  • Uchida K., Szweda L.I., Chae H.Z., Stadtman E.R. Immunochemical detection of 4-hydroxinonenal protein adducts in oxidized hepatocytes 1983; 90: 8742-8746
  • Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis 1997; 387: 147-163
  • Ihara Y., Toyokuni S., Uchida K., Odaka H., Tanaka T., Ikeda H., Hiai H., Seino Y., Yamada Y. Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes 1999; 48: 927-932
  • Iwai S., Karim R., Kitano M., Sukata T., Min W., Morimura K., Wanibuchi H., Seki S., Fukushima S. Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury-enhancement of MeIQ-induced gultathione S-transferase placental form-positive foci in rats 2002; 179: 15-24
  • Comporti M. Lipid peroxidation and cellular damage in toxic liver injury 1985; 53: 599-623
  • Shi J., Aisaki K., Iwata Y., Wake K. Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride 1988; 153: 515-525
  • Jarvelainen H.A., Fang C., Ingelman-Sundberg M., Lindros K.O. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and pro-inflammatory and anti-inflammatory cytokines 1999; 29: 1503-1510
  • Czaja M.J., Xu J., Alt E. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor 1995; 108: 1849-1854
  • Campo G.M., Squadrito F., Ceccarelli S., Calo M., Avenoso A., Campo S., Squadrito G., Altavilla D. Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual Vitamin E-like antioxidant 2000; 34: 379-393
  • Baik S.C., Youn H.S., Chung M.H., Lee W.K., Cho M.J., Ko G.H., Park C.K., Kasai H., Rhee K.H. Increaesd oxidative DNA damage in helicobacter pylori-infected human gastric mucosa 1996; 56: 1279-1282
  • Parola M., Leonarduzzi G., Biasi F., Albano E., Biocca M.E., Poli G., Dianzani M.U. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis 1992; 16: 1014-1021
  • Shimizu M., Morita S., Yamano T., Yamada A. Relationship between hepatic glutathione content and carbon tetrachloride-induced hepatotoxicity in vivo 1989; 47: 95-102
  • Rivera C.A., Bradford B.U., Hunt K.J., Adachi Y., Schrum L.W., Koop D.R., Burchardt E.R., Rippe R.A., Thurman R.G. Attenuation of CCl4-induced hepatic fibrosis by GdCl3 2001; 281: G200-G207
  • Thompson K., Maltby J., Fallowfield J., McAulay M., Millward-Sadler H., Sheron N. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis 1998; 28: 1597-1606
  • Louis H., Le Moine O., Peny M.O., Quertinmont E., Fokan D., Goldman M., Deviere J. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice 1997; 25: 1382-1389
  • Atsukawa K., Saito H., Tsukada N., Akiba Y., Toda K., Kumagai N., Ohishi T., Kamegaya Y., Ishii H. Th1 and Th2 cytokines differentially regulate the transformation of kupffer cells into multinucleated giant cells but similarly enhance the kupffer cell-induced hepatic stellate cell proliferation 2001; 20: 193-206
  • Ohishi T., Saito H., Tsusaka K., Toda K., Inagaki H., Hamada Y., Kumagai N., Atsukawa K., Ishii H. Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats 2001; 21: 47-158
  • Cabre M., Ferre N., Folch J., Paternain J.L., Hernandez M., Castillo D.D., Joven J., Camps J. Inhibition of hepatic cell nuclear DNA flagmentation by zinc in carbon tetrachloride-treated rats 1999; 31: 228-234
  • Reuber M.D., Glover E.L. Cirrhosis and carcinoma of the liver in male rats given subcutaneous carbon tetrachloride 1970; 44: 419-427
  • Naziroglu M., Cay M., Ustundag B., Aksakal M., Yekeler H. Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats 1999; 17: 253-259
  • Watanabe T., Yuki S., Egawa M., Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions 1994; 268: 1597-1604
  • Watanabe T., Morita I., Nishi H., Murota S. Preventive effect of MCI-186 on 15-HPETE-induced vascular endothelial cell injury in vitro 1988; 33: 81-87
  • Abe K., Yuki S., Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger 1988; 19: 480-485
  • Nishi H., Watanabe T., Sakurai H., Yuki S., Ishibashi A. Effect of MCI-186 on brain edema in rats 1989; 20: 1236-1240
  • Minhaz U., Tanaka M., Tsukamoto H., Watanabe K., Koide S., Shohtsu A., Nakazawa H. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart 1996; 24: 361-367
  • Tada S., Saito H., Tsunematsu S., Ebinuma H., Wakabayashi K., Masuda T., Ishii H. Interferon regulatory factor-1 gene abnormality and loss of growth inhibitory effect of interferon-α 1998; 13: 1207-1216
  • Takahashi M., Saito H., Okuyama T., Miyashita T., Kosuga M., Sumisa F., Yamada M., Ebinuma H., Ishii H. Overexpression of Bcl-2 protects human hepatoma cells from Fas antibody-mediated apoptosis 1999; 31: 315-322
  • Mizuo A., Umemura K., Nakashima M. Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion 1998; 30: 575-578
  • Houkin K., Nakayama N., Kamada K., Noujou T., Abe H., Kashiwabe T. Neuroprotective effect of the free radical scavenger MCI-186 in patients with cerebral infarction: clinical evaluation using magnetic resonance imaging and spectroscopy 1998; 7: 315-322
  • Halliwell B., Gutteridge J.M.C. 1999; 3rd Ed.
  • Poli G., Albano E., Dianzani M.U. The role of lipid peroxidation in liver damage 1987; 45: 117-142
  • Hartley D.P., Kolaja K.L., Reichard J., Petersen D.R. 4-Hydroxynonenal and Malondialdehyde hepatic protein adducts in rats treated with carbon tetrachloride: immunochemical detection and lobular localization 1999; 161: 23-33
  • Arosio B., Gagliano N., Fusaro L.M., Parmeggiani L., Tagliabue J., Galetti P., De Castri D., Moscheni C., Annoni G. Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride 2000; 87: 229-233
  • Salazar-Montes A., Delgado-Rizo V., Armendariz-Borunda J. Differential gene expression of pro-inflammatory and anti-inflammatory cytokines in acute and chronic liver injury 2000; 16: 181-194
  • Bruccoleri A., Gallucci R., Germolec D.R., Blackshear P., Simeonova P., Thurman R.G., Luster M.I. Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity 1997; 25: 133-141
  • Scotte M., Daveau M., Hiron M., Teniere P., Lebreton J.P. Absence of expression of interleukin-6 (IL-6) mRNA in regenerating rat liver 1996; 315: 159-162
  • Hensley K., Robinson K.A., Gabbita S.P., Salsman S., Floyd R.A. Reactive oxygen species, cell signaling, and cell injury 2000; 28: 1456-1462
  • Brattin W.J., Glende E.A., Recknagel R.O. Pathological mechanism in carbon tetrachloride hepatotoxicity 1985; 1: 27-38
  • Tilg H., Vogel W., Wiedermann C.J., Shapiro L., Herold M., Judmaier G., Dinarello C.A. Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease 1993; 18: 1132-1138
  • Andus T., Bauer J., Gerok W. Effects of cytokines on the liver 1991; 13: 364-375
  • Kitada T., Seki S., Iwai S., Yamada T., Sakaguchi H., Wakasa K. In situ 2001; 35: 613-618

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.