No Evidence for Oxidative Stress as a Mechanism of Action of Hyperhomocysteinemia in Humans

References

• McCully, K.S. (1969) "Vascular pathology of homocystein-emia: implications for the pathogenesis of arteriosclerosis", Am. J. Pathol. 56, 111–128.
   PubMed Web of Science ®Google Scholar
• Eikelboom, J.W., Lonn, E., Genest, J., Jr., Hankey, G. and Yusuf, S. (1999) "Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence", Ann. Intern. Med. 131, 363–375.
   PubMed Web of Science ®Google Scholar
• The Homocysteine Studies Collaboration (2002) "Homo-cysteine and risk of ischemic heart disease and stroke: a meta-analysis", JANIA 288, 2015–2022.
   PubMed Web of Science ®Google Scholar
• Vollset, S.E., Refsum, H., Tverdal, A., Nygard, 0., Nordrehaug, J.E., Tell, G.S. and Ueland, P.M. (2001) "Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the HORDALAND homocysteine study", Am. J. Clin. Nutr. 74, 130–136.
   Google Scholar
• Wald, N.J., Watt, H.C., Law, M.R., Weir, D.C., McPartlin, J. and Scott, J.M. (1998) "Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention", Arch. Intern. Med. 158, 862–867.
   PubMed Web of Science ®Google Scholar
• Boushey, C.J., Beresford, S.A., Omenn, GS. and Motulsky, A.G. (1995) "A quantitative assessment of plasma homo-cysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes", JAMA 274, 1049–1057.
   PubMed Web of Science ®Google Scholar
• Durand, P., Prost, M., Loreau, N., Lussier-Cacan, S. and Blache, D. (2001) "Impaired homocysteine metabolism and atherothrombotic disease", Lab. Investig. 81, 645–672.
   PubMed Web of Science ®Google Scholar
• Loscalzo, J. (1996) "The oxidant stress of hyperhomocyst(e) inemia", J. Clin. Investig. 98, 5–7.
   PubMed Web of Science ®Google Scholar
• Heinecke, J.W., Rosen, H., Suzuki, L.A. and Chait, A. (1987) "The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells", J. Biol. Chem. 262, 10098–10103.
   PubMed Web of Science ®Google Scholar
• Misra, H.P. (1974) "Generation of superoxide free radical during the autoxidation of thiols", J. Biol. Chem. 249, 2151–2155.
   PubMed Web of Science ®Google Scholar
• Chen, N., Liu, Y., Greiner, CD. and Holtzman, J.L. (2000) "Physiologic concentrations of homocysteine inhibit the human plasma GSH peroxidase that reduces organic hydroperoxides", J. Lab. Clin. Med. 136, 58–65.
   PubMed Web of Science ®Google Scholar
• Upchurch, CR., Jr., Welch, G.N., Fabian, A.J., Freedman, J.E., Johnson, J.L., Keaney, J.F., Jr. and Loscalzo, J. (1997) "Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione permddase", J. Biol. Chem. 272, 17012–17017.
   PubMed Web of Science ®Google Scholar
• Lentz, S.R., Sobey, CC., Piegors, D.J., Bhopatkar, M.Y., Faraci, F.M., Malinow, MR. and Heistad, D.D. (1996) "Vascular dysfunction in monkeys with diet-induced hyperhomo-cyst(e)inemia", J. Clin. Investig. 98, 24–29.
   PubMed Web of Science ®Google Scholar
• Nappo, F., de Rosa, N., Marfella, R., de Lucia, D., Ingrosso, D., Perna, A.F., Farzati, B. and Giugliano, D. (1999) "Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins", JANIA 281, 2113–2118.
   PubMed Web of Science ®Google Scholar
• Woo, KS., Chook, P., Lolin, Y.I., Cheung, AS., Chan, LT., Sun, Y.Y., Sanderson, J.E., Metreweli, C. and Celermajer, D.S. (1997) "Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans", Circulation 96, 2542–2544.
   PubMed Web of Science ®Google Scholar
• Mujumdar, VS., Aru, G.M. and Tyagi, S.C. (2001) "Induction of oxidative stress by homocyst(e)ine impairs endothelial function", J. Cell Biochem. 82, 491–500.
   PubMed Web of Science ®Google Scholar
• Stamler, J.S., Osborne, J.A., Jaraki, 0., Rabbani, L.E., Mullins, M., Singel, D. and Loscalzo, J. (1993) "Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen", J. Clin. Investig. 91, 308–318.
   PubMed Web of Science ®Google Scholar
• Lang, D., Kredan, MB., Moat, S.J., Hussain, S.A., Powell, CA., Bellamy, M.F., Powers, H.J. and Lewis, M.J. (2000) "Homocysteine-induced inhibition of endothelium-depen-dent relaxation in rabbit aorta: role for superoxide anions", Arterioscler. Thromb. Vasc. Biol. 20, 422–427.
   PubMed Web of Science ®Google Scholar
• Chambers, J.C., McGregor, A., Jean-Marie, J., Obeid, O.A. and Kooner, J.S. (1999) "Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy", Circulation 99, 1156–1160.
   PubMed Web of Science ®Google Scholar
• Blom, H.J., Engelen, D.P., Boers, G.H., Stadhouders, AM., Sengers, R.C., de Abreu, R., TePoele-Pothoff, UT. and Trijbels, J.M. (1992) "Lipid peroxidation in homocyst-einaemia", J. Inherit. Metab. Dis. 15, 419–422.
   Google Scholar
• Carluccio, F., Siems, W., Stefanelli, G., Sommerburg, 0., Grune, T., Riedel, E. and Hampl, H. (2002) "Homocysteine in chronic renal failure in relation to renal anemia and to oxidative stress parameters 4-hydroxynonenal and malon-dialdehyde", Clin. Nephrol. 58\(Suppl. 1), S26—S30.
   Web of Science ®Google Scholar
• Moat, S.J., Hill, M.H., McDowell, IF., Pullin, C.H., Ashfield-Watt, PA., Clark, Z.E., Whiting, J.M., Newcombe, R.G., Lewis, M.J. and Powers, H.J. (2003) "Reduction in plasma total homocysteine through increasing folate intake in healthy individuals is not associated with changes in measures of antioxidant activity or oxidant damage", Fur. J. Clin. Nutr. 57, 483–489.
   Google Scholar
• Sebekova, K., Krajcovicova-Kudlackova, M., Blazicek, P., Parrak, V, Schinzel, R. and Heidland, A. (2003) "Functional hyperhomocysteinemia in healthy vegetarians: no association with advanced glycation end products, markers of protein oxidation, or lipid peroxidation after correction with vitamin B(12)", Clin. Chem. 49, 983–986.
   PubMed Web of Science ®Google Scholar
• Bilici, M., Efe, H., Koroglu, M.A., Uydu, HA., Bekaroglu, M. and Deger, 0. (2001) "Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments", J. Affect. Disord. 64, 43–51.
   Google Scholar
• Catargi, B., Parrot-Roulaud, F., Cochet, C., Ducassou, D., Roger, P. and Tabarin, A. (1999) "Homocysteine, hypothy-roidism, and effect of thyroid hormone replacement", Thyroid 9, 1163–1166.
   PubMed Web of Science ®Google Scholar
• Varela-Moreiras, G. (2001) "Nutritional regulation of homo-cysteine: effects of drugs", Biomed. Pharmacother. 55, 448–453.
   PubMed Web of Science ®Google Scholar
• Araki, A. and Sako, Y. (1987) "Determination of free and total homocysteine in human plasma by high- performance liquid chromatography with fluorescence detection", J. Chromatogr. 422, 43–52.
   PubMed Web of Science ®Google Scholar
• Panemangalore, M. and Lee, C.J. (1992) "Evaluation of the indices of retinol and alpha-tocopherol status in free-living elderly", J. Gerontol. 47, B98—B104.
   Google Scholar
• Kang, S.S., Wong, P.W. and Malinow, MR. (1992) "Hyper-homocyst(e)inemia as a risk factor for occlusive vascular disease", Annu. Rev. Nutr. 12, 279–298.
   PubMed Web of Science ®Google Scholar
• Powers, R.W., Majors, AK., Lykins, DL., Sims, C.J., Lain, K.Y. and Roberts, J.M. (2002) "Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner", Metabolism 51, 1433–1438.
   PubMed Web of Science ®Google Scholar
• Jara-Prado, A., Ortega-Vázquez, A., Martinez-Ruano, L., Rios, C. and Santamaria, A. (2003) "Homocysteine-induced brain lipid permddation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition", Neurotox. Res. 5, 237–243.
   PubMed Web of Science ®Google Scholar
• Streck, E.L., Vieira, P.S., Wannmacher, C.M., Dutra-Filho, C.S., Wajner, M. and Wyse, A.T. (2003) "In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus", Metab. Brain. Dis. 18, 147–154.
   PubMed Web of Science ®Google Scholar
• Jacobsen, D.W. (2000) "Hyperhomocysteinemia and oxidative stress: time for a reality check?", Arterioscler.Thromb. Vasc. Biol. 20, 1182–1184.
   PubMed Web of Science ®Google Scholar
• Heydrick, S.J., Weiss, N., Thomas, SR., Cap, A.P., Pimentel, DR., Loscalzo, J. and Keaney, J.F., Jr. (2004) "L-homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxi-dation in endothelial cells", Free Radic. Biol. Med. 36, 632–640.
   PubMed Web of Science ®Google Scholar
• Moat, S.J., Bonham, J.R., Cragg, R.A. and Powers, H.J. (2000) "Elevated plasma homocysteine elicits an increase in antioxidant enzyme activity", Free Radic. Res. 32, 171–179.
   PubMed Web of Science ®Google Scholar
• Lasheras, C., Huerta, J.M., Gonzilez, S., Brafta, A.F., Patterson, A.M. and Fernindez, S. (2002) "Independent and interactive association of blood antioxidants and oxidative damage in elderly people", Free Radic. Res. 36, 875–882.
   PubMed Web of Science ®Google Scholar
• Steghens, J.P., van Kappel, A.L., Denis, I. and Collombel, C. (2001) "Diaminonaphtalene, a new highly specific reagent for HPLC-UV measurement of total and free malondialdehyde in human plasma or serum", Free Radic. Biol. Med. 31, 242–249.
   PubMed Web of Science ®Google Scholar
• Chao, C.L., Kuo, T.L. and Lee, Y.T. (2000) "Effects of methionine-induced hyperhomocysteinemia on endo-thelium-dependent vasodilation and oxidative status in healthy adults", Circulation 101, 485–490.
   PubMed Web of Science ®Google Scholar
• Nightingale, A.K., James, P.P., Morris-Thurgood, J., Harrold, F., Tong, R., Jackson, S.K., Cockcroft, J.R. and Frenneaux, M.P. (2001) "Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model", Am. J. Physiol. Heart Circ. Physiol. 280, H1334—H1339.
   Web of Science ®Google Scholar
• El Kossi, M.M. and Zakhary, M.M. (2000) "Oxidative stress in the context of acute cerebrovascular stroke", Stroke 31, 1889–1892.
   PubMed Web of Science ®Google Scholar
• Moselhy, S.S. and Demerdash, S.H. (2003) "Plasma homo-cysteine and oxidative stress in cardiovascular disease", Dis. Markers 19, 27–31.
   PubMed Web of Science ®Google Scholar
• Koga, T., Claycombe, K. and Meydani, M. (2002) "Homo-cysteine increases monocyte and T-cell adhesion to human aortic endothelial cells", Atherosclerosis 161, 365–374.
   PubMed Web of Science ®Google Scholar
• Li, H., Lewis, A., Brodsky, S., Rieger, R., Iden, C. and Goligorsky, M.S. (2002) "Homocysteine induces 3-hydroxy-3-methylglutaryl coenzyme A reductase in vascular endothelial cells: a mechanism for development of atherosclerosis?", Circulation 105, 1037–1043.
   PubMed Web of Science ®Google Scholar
• Werstuck, G.H., Lentz, SR., Dayal, S., Hossain, CS., Sood, S.K., Shi, Y.Y., Zhou, J., Maeda, N., Krisans, S.K., Malinow, M.R. and Austin, R.C. (2001) "Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways", J. Clin. Investig. 107, 1263–1273.
   PubMed Web of Science ®Google Scholar