The genotypic variation of the antioxidant potential of different tomato varieties

References

• Willcox JK, Catignani GL, Lazarus S. Tomatoes and cardiovascular health. Crit Rev Food Sci Nutr 2003; 43: 1–18.
   PubMed Web of Science ®Google Scholar
• Hertog MG, Feskens EJ and Kromhout D. Antioxidant flavonols and coronary heart disease risk, Lancet 1997; 349: 699.
   Google Scholar
• Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study, Arch Intern Med 1995 155: 381–386.
   Google Scholar
• Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study, Lancet 1993; 342: 1007–1011.
   Google Scholar
• Goldbohm RA, Hertog MG, Brants HA, van Poppel G, van den Brandt PA. Consumption of black tea and cancer risk: A prospective cohort study, J Natl Cancer Inst 1996; 88: 93–100.
   PubMed Web of Science ®Google Scholar
• Keli SO, Hertog MG, Feskens EJ, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: The Zutphen study, Arch Intern Med 1996; 156: 637–642.
   PubMed Web of Science ®Google Scholar
• Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids, Free Radic Biol Med 1996; 20: 933–956.
   Google Scholar
• Aviram M., Fuhrman B. Wine flavonoids protect against LDL oxidation and atherosclerosis, Ann N Y Acad Sci 2002; 957: 146–161.
   Google Scholar
• Fuhrman B., Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis, Curr Opin Lipidol 2001; 12: 41–48.
   Google Scholar
• Duthie SJ, Collins AR, Duthie GG, Dobson VL. Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes, Mutat Res 1997; 393: 223–231.
   Google Scholar
• Haenen GR, Paquay JB, Korthouwer RE, Bast A. Peroxy-nitrite scavenging by flavonoids, Biochem Biophys Res Commun 1997; 236: 591–593.
   PubMed Web of Science ®Google Scholar
• Pannala AS, Rice-Evans CA, Halliwell B., Singh S. Inhibition of peroxynitrite-mediated tyrosine nitration by catechin polyphenols, Biochem Biophys Res Commun 232: 1997; 164–168.
   PubMed Web of Science ®Google Scholar
• Kerry N, Rice-Evans C. Inhibition of peroxynitrite-mediated oxidation of dopamine by flavonoid and phenolic antioxidants and their structural relationships, J Neurochem 1999; 73: 247–253.
   Google Scholar
• Brown JE, Khodr H., Hider RC, Rice-Evans CA. Structural dependence of flavonoid interactions with Cu2+ ions: Implications for their antioxidant properties, Biochem J 1998; 330 (Pt 3), 1173–1178.
   Google Scholar
• Cheng IF, Breen K. On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex, Biometals 2000; 13: 77–83.
   Google Scholar
• Tournaire C., Croux S, Maurette MT, Beck I, Hocquaux M, Braun AM, Oliveros E. Antioxidant activity of flavonoids: Efficiency of singlet oxygen (1 delta g) quenching, J Photochem Photobiol B 1993; 19: 205–215.
   Google Scholar
• Proteggente AR, Pannala AS, Paganga G, Van Buren L, Wagner E, Wiseman S, Van De PF, Dacombe C., Rice-Evans CA The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition, Free Radic Res 2002; 36: 217–233.
   Google Scholar
• Stewart AJ, Bozonnet S, Mullen W, Jenkins GI, Lean ME, Crozier A. Occurrence of flavonols in tomatoes and tomato-based products, J Agric. Food Chem. 2000; 48: 2663–2669.
   Google Scholar
• Paganga G, Miller N., Rice-Evans CA The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute?, Free Radic Res 1999; 30: 153–162.
   PubMed Web of Science ®Google Scholar
• Mauri PL, Iemoli L, Gardana C, Riso P, Simonetti P, Porrini M, Pietta PG. Liquid chromatography/electrospray ionization mass spectrometric characterization of flavonol glycosides in tomato extracts and human plasma, Rapid Commun Mass Spectrom 1999; 13: 924–931.
   PubMed Web of Science ®Google Scholar
• Justesen U, Knuthsen P, Leth T. Quantitative analysis of flavonols, flavones, and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection, J Chromatogr A 1998; 799: 101–110.
   Google Scholar
• Le Gall G, Colquhoun IJ, Davis AL, Collins GJ, Verhoeyen ME. Metabolite profiling of tomato (Lycopersicon esculen-tum) using 1H NMR spectroscopy as a tool to detect potential unintended effects following a genetic modification, J Agric Food Chem 2003; 51: 2447–2456.
   Google Scholar
• Le Gall G, DuPont MS, Mellon FA, Davis AL, Collins GJ, Verhoeyen ME, Colquhoun IJ. Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits, J Agric Food Chem 2003; 51: 2438–2446.
   Google Scholar
• Bovy A, de Vos R, Kemper M, Schijlen E, Almenar PM, Muir S, Collins G, Robinson S, Verhoeyen M, Hughes S, Santos-Buelga C, van Tunen A. High-flavonol tomatoes resulting from the heterologous expression of the maize transcription factor genes LC and Cl, Plant Cell 2002; 14: 2509–2526.
   Google Scholar
• Verhoeyen ME, Bovy A, Collins G, Muir S, Robinson S, de Vos CH, Colliver S. Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway, J Exp Bot 2002; 53: 2099–2106.
   Google Scholar
• Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic Biol Med 1999; 26: 1231–1237.
   Google Scholar
• Manach C, Donovan JL. Pharmacokinetics and metabolism of dietary flavonoids in humans, Free Radic Res 2004; 38: 771–785 .
   PubMed Web of Science ®Google Scholar
• Spencer JPE, Chowrimootoo G, Choudhury R, Debnarn ES, Srai SK, Rice-Evans C. The small intestine can both absorb and glucuronidate lumina flavonoids, FEBS Lett 1999; 458: 224–230.
   Google Scholar
• Spencer JPE, Schroeter H, Crossthwaithe AJ, Kuhnle G, Williams RJ, Rice-Evans C. Contrasting influences of glucuronidation and 0-methylation of epicatechin on hydro-gen peroxide-induced cell death in neurons and fibroblasts, Free Radic Biol Med 2001; 31: 1139–1146.
   Google Scholar
• Miyake Y., Shimoi K., Kumazawa S, Yamamoto K, Kinae N, Osawa T. Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats, J Agric Food Chem 2000; 48: 3217–3224.
   Google Scholar
• Terao J, Yamaguchi S, Shirai M, Miyoshi M, Moon JH, Oshima S, Inakuma T, Tsushida T, Kato Y. Protection by quercetin and quercetin 3-0-beta-D-glucuronide of peroxyni-trite-induced antioxidant consumption in human plasma low-density lipoprotein, Free Radic Res 2001; 35: 925–931.
   Google Scholar
• Shirai M, Moon JH, Tsushida T, Terao J. Inhibitory effect of a quercetin metabolite, quercetin 3-0-beta-D-glucuronide, on lipid peroxidation in liposomal membranes, 2001; J Agric Food Chem 49: 5602–5608.
   Google Scholar
• Yamamoto N, Moon JH, Tsushida T, Nagao A, Terao J. Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein, Arch Biochem Biophys 1999; 372: 347–354.
   Google Scholar
• da Silva EL, Piskula MK, Yamamoto N, Moon JH, Terao J Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma, FEBS Lett 1998; 430: 405–408.
   Google Scholar
• Schroeter H, Williams RJ, Matin R, Iversen L, Rice-Evans CA. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein, Free Radic Biol Med 2000; 29: 1222–1233.
   Google Scholar
• Spencer JPE, Schroeter H, Kuhnle G, Srai SK, Tyrrell R1\4, Hahn U., Rice-Evans C. Epicatechin and its in vivo metabolite, 3'-0-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 acti-vation, Biochem J 2001; 354: 493–500.
   Google Scholar
• Schroeter H, Spencer JP, Rice-Evans C, Williams RJ. Flavonoids protect neurons from oxidized low-density-lipo-protein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3, Biochem J 2001; 358: 547–557.
   Google Scholar
• Matter WF, Brown RF, Vlahos CJ. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs, Biochem Biophys Res Commun 1992; 186: 624–631.
   PubMed Web of Science ®Google Scholar
• Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholiny1)- 8-phenyl-4H-1-benzopyran-4-one (LY294002), J Biol Chem 1994; 269: 5241–5248.
   Google Scholar
• Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, Chap H, Payrastre B. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition, Biochem Pharmacol 1997; 53: 1649-1657.
   Google Scholar
• Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, Payrastre B. Flavonoids and the inhibition of PKC and PI 3-kinase, Gen. Pharmacol 1999; 32: 279–286.
   Google Scholar
• Kong AN, Yu R, Chen C, Mandlekar S, Primiano T. Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis, Arch Pharm Res 2000; 23: 1–16.
   Google Scholar
• Spencer JPE, Rice-Evans C, Williams RJ. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability, J Biol Chem 2003; 278: 34783–34793.
   Google Scholar