111
Views
31
CrossRef citations to date
0
Altmetric
Original

Natural vitamin E α-tocotrienol: Retention in vital organs in response to long-term oral supplementation and withdrawal

, , , &
Pages 763-771 | Received 01 Feb 2006, Published online: 07 Jul 2009

References

  • Sen CK, Khanna S, Roy S. Tocotrienol: The natural vitamin E to defend the nervous system?. Ann N Y Acad Sci 2004; 1031: 127–142
  • Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci 2006, in press
  • Traber MG, Burton GW, Hamilton RL. Vitamin E trafficking. Ann N Y Acad Sci 2004; 1031: 1–12
  • Khanna S, Patel V, Rink C, Roy S, Sen CK. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic Biol Med 2005; 39: 1310–1319
  • Schaffer S, Muller WE, Eckert GP. Tocotrienols: Constitutional effects in aging and disease. J Nutr 2005; 135: 151–154
  • Pearce BC, Parker RA, Deason ME, Dischino DD, Gillespie E, Qureshi AA, Volk K, Wright JJ. Inhibitors of cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols. J Med Chem 1994; 37: 526–541
  • Pearce BC, Parker RA, Deason ME, Qureshi AA, Wright JJ. Hypocholesterolemic activity of synthetic and natural tocotrienols. J Med Chem 1992; 35: 3595–3606
  • Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alphatocotrienol. Free Radic Biol Med 1991; 10: 263–275
  • Serbinova EA, Packer L. Antioxidant properties of alpha-tocopherol and alphatocotrienol. Methods Enzymol 1994; 234: 354–366
  • Suzuki YJ, Tsuchiya M, Wassall SR, Choo YM, Govil G, Kagan VE, Packer L. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: Implication to the molecular mechanism of their antioxidant potency. Biochemistry 1993; 32: 10692–10699
  • Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M, Miyazawa T. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem 2003; 67: 1623–1627
  • Miyazawa T, Inokuchi H, Hirokane H, Tsuzuki T, Nakagawa K, Igarashi M. Anti-angiogenic potential of tocotrienol in vitro. Biochemistry (Mosc) 2004; 69: 67–69
  • Blatt DH, Leonard SW, Traber MG. Vitamin E kinetics and the function of tocopherol regulatory proteins. Nutrition 2001; 17: 799–805
  • Kaempf-Rotzoll DE, Traber MG, Arai H. Vitamin E and transfer proteins. Curr Opin Lipidol 2003; 14: 249–254
  • Traber MG, Arai H. Molecular mechanisms of vitamin E transport. Annu Rev Nutr 1999; 19: 343–355
  • Stocker A. Molecular mechanisms of vitamin E transport. Ann N Y Acad Sci 2004; 1031: 44–59
  • Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H, Inoue K. Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 1997; 409: 105–108
  • Panagabko C, Morley S, Hernandez M, Cassolato P, Gordon H, Parsons R, Manor D, Atkinson J. Ligand specificity in the CRAL-TRIO protein family. Biochemistry 2003; 42: 6467–6474
  • Podda M, Weber C, Traber MG, Packer L. Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones. J Lipid Res 1996; 37: 893–901
  • Roy S, Lado BH, Khanna S, Sen CK. Vitamin E sensitive genes in the developing rat fetal brain: A high-density oligonucleotide microarray analysis. FEBS Lett 2002; 530: 17–23
  • Khanna S, Roy S, Ryu H, Bahadduri P, Swaan PW, Ratan RR, Sen CK. Molecular basis of vitamin E action: Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 2003; 278: 43508–43515
  • Sen CK, Khanna S, Roy S, Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 2000; 275: 13049–13055
  • Khanna S, Roy S, Slivka A, Craft TKS, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL, Sen CK. Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke 2005; 36: 2258–2264
  • O'Byrne D, Grundy S, Packer L, Devaraj S, Baldenius K, Hoppe PP, Kraemer K, Jialal I, Traber MG. Studies of LDL oxidation following alpha-, gamma-, or deltatocotrienyl acetate supplementation of hypercholesterolemic humans. Free Radic Biol Med 2000; 29: 834–845
  • Khosla P, Patel V, Whinter J, Khanna S, Rakhkovskaya M, Roy S, Sen CK. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal 2006; 8, in press
  • van der Worp HB, Bar PR, Kappelle LJ, de Wildt DJ. Dietary vitamin E levels affect outcome of permanent focal cerebral ischemia in rats. Stroke 1998; 29: 1002–1005, discussion 1005–1006
  • Roy S, Venojarvi M, Khanna S, Sen CK. Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC-coulometric electrode array. Methods Enzymol 2002; 352: 326–332
  • Adachi K, Miki M, Tamai H, Tokuda M, Mino M. Adipose tissues and vitamin E. J Nutr Sci Vitaminol (Tokyo) 1990; 36: 327–337
  • Garry PJ, Hunt WC, Bandrofchak JL, VanderJagt D, Goodwin JS. Vitamin A intake and plasma retinol levels in healthy elderly men and women. Am J Clin Nutr 1987; 46: 989–994
  • Lodge JK, Hall WL, Jeanes YM, Proteggente AR. Physiological factors influencing vitamin E biokinetics. Ann N Y Acad Sci 2004; 1031: 60–73
  • Aten RF, Kolodecik TR, Behrman HR. Ovarian vitamin E accumulation: Evidence for a role of lipoproteins. Endocrinology 1994; 135: 533–539
  • Datta S, Wang L, Moore DD, Osborne TF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: A mechanism for differential regulation of cholesterol synthesis and uptake. J Biol Chem 2006; 281: 807–812
  • Baliarsingh S, Beg ZH, Ahmad J. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Atherosclerosis 2005; 182: 367–374
  • Traber MG, Sies H. Vitamin E in humans: Demand and delivery. Annu Rev Nutr 1996; 16: 321–347
  • Cuddihy SL, Musiek ES, Morrow JD, Dugan LL. Long-term vitamin E deficiency in mice decreases superoxide radical production in brain. Ann N Y Acad Sci 2004; 1031: 428–431
  • Birringer M, Pfluger P, Kluth D, Landes N, Brigelius-Flohe R. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr 2002; 132: 3113–3118
  • Packer L, Weber SU, Rimbach G. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr 2001; 131: 369S–373S
  • Yap SP, Yuen KH, Wong JW. Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. J Pharm Pharmacol 2001; 53: 67–71
  • Bairati I, Meyer F, Gelinas M, Fortin A, Nabid A, Brochet F, Mercier JP, Tetu B, Harel F, Masse B, Vigneault E, Vass S, del Vecchio P, Roy J. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 2005; 97: 481–488
  • Miller ER, 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142: 37–46
  • Devaraj S, Jialal I. Failure of vitamin E in clinical trials: Is gamma-tocopherol the answer?. Nutr Rev 2005; 63: 290–293
  • Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, Mou S, Pye QN, Stoddard MF, Wallis G, Williamson KS, West M, Wechter WJ, Floyd RA. New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med 2004; 36: 1–15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.