Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols

References

• Rice-Evans CA, Packer L. Flavonoids in health and disease. Marcel Dekker Inc., New York 1998
   Google Scholar
• Manach C, Scalbert A, Morand C, Remesy C, Jimenez L. Polyphenols: Food sources and bioavailability. Am J Clin Nutr 2004; 79: 727–747
   PubMed Web of Science ®Google Scholar
• Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A, Nedeljkovic S. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995; 155: 381–386
   PubMed Web of Science ®Google Scholar
• Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen elderly study. Lancet 1993; 342: 1007–1011
   PubMed Web of Science ®Google Scholar
• Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: Flavonoids and isoflavonoids. Pharmacol Ther 2001; 90: 157–177
   PubMed Web of Science ®Google Scholar
• Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies. Eur J Clin Nutr 2003; 57: 904–908
   PubMed Web of Science ®Google Scholar
• Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 2005; 811(Suppl)243S–255S
   Google Scholar
• Rusznyak S, Szent-Györgyi A. Vitamin P: Flavonols as vitamins. Nature 1936; 138: 27–29
   Google Scholar
• Joint Committee on Nomenclature of the American Society of biological chemists -American Institute of nutrition. Term “vitamin P” recommended to be discontinued. Science 1950; 112: 268
   Web of Science ®Google Scholar
• Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27–36
   PubMed Web of Science ®Google Scholar
• Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004; 15: 1983–1992
   PubMed Web of Science ®Google Scholar
• Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899–1906
   PubMed Web of Science ®Google Scholar
• Widlansky ME, Gokce N, Keaney JF, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003; 42: 1149–1160
   PubMed Web of Science ®Google Scholar
• Kawashima S, Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 998–1005
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43: 109–142
   PubMed Web of Science ®Google Scholar
• Warner TD, Mitchell JA, Sheng H, Murad F. Effects of cyclic GMP on smooth muscle relaxation. Adv Pharmacol 1994; 26: 171–194
   PubMedGoogle Scholar
• Miwa Y, Hirata K, Kawashima S, Akita H, Yokoyama M. Lysophosphatidylcholine inhibits receptor-mediated Ca2+ mobilization in intact endothelial cells of rabbit aorta. Arterioscler Thromb Vasc Biol 1997; 17: 1561–1567
   PubMed Web of Science ®Google Scholar
• Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res 2000; 87: 840–844
   PubMed Web of Science ®Google Scholar
• Lentz A, Rodionov RN, Dayal S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: The potential role of ADMA. Atheroscler Suppl 2003; 4: 61–65
   PubMed Web of Science ®Google Scholar
• Babior BM. NADPH oxidase: An update. Blood 1999; 93: 1464–1476
   PubMed Web of Science ®Google Scholar
• Perez-Vizcaino F, Lopez-Lopez JG, Santiago R, Cogolludo A, Zaragoza-Arnaez F, Moreno L, Alonso MJ, Salaices M, Tamargo J. Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity. Am J Physiol Lung Cell Mol Physiol 2002; 283: L839–L848
   Google Scholar
• Griendling KK, Sorescu D, Ushio-Fukai M. NADP;H oxidase: Role in cardiovascular biology and disease. Circ Res 2000; 86: 494–501
   PubMed Web of Science ®Google Scholar
• Calo LA, Davis PA, Pagnin E, Semplicini A, Pessina AC. NADPH oxidase, superoxide overproduction and nitric oxide bioavailability in essential hypertension. J Hypertens 2005; 23: 665–666
   PubMed Web of Science ®Google Scholar
• Virdis A, Neves MF, Amiri F, Touyz RM, Schiffrin EL. Role of NADPH oxidase on vascular alterations in angiotensin II-infused mice. J Hypertens 2004; 22: 535–542
   PubMed Web of Science ®Google Scholar
• Vasquez-Vivar J, Kalyanaraman B, Martasek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: Enzymology and physiological implications. Free Radic Res 2003; 37: 121–127
   PubMed Web of Science ®Google Scholar
• Koppenol WH. The basic chemistry of nitrogen monoxide and peroxynitrite. Free Rad Biol Med 1998; 25: 385–391
   PubMed Web of Science ®Google Scholar
• Jin L, Ying Z, Webb RC. Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004; 287: H1495–H1500
   PubMed Web of Science ®Google Scholar
• Terlain B, Jouzeau JY, Gillet P, Lecompte T, Netter P. Inducible cyclooxygenase. New relationships between non-steroidal anti- inflammatory agents and inhibition of synthesis of prostaglandins. Presse Med 1995; 24: 491–496
   PubMedGoogle Scholar
• Moncada S, Vane JR. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev 1978; 30: 293–331
   PubMed Web of Science ®Google Scholar
• Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: Structures, properties, and functions. Physiol Rev 1999; 79: 1193–1226
   PubMed Web of Science ®Google Scholar
• Mitchell JA, Warner TD. Cyclo-oxygenase-2: Pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br J Pharmacol 1999; 128: 1121–1132
   PubMed Web of Science ®Google Scholar
• Fitzgerald GA. Cardiovascular pharmacology of nonselective nonsteroidal anti- inflammatory drugs and coxibs: Clinical considerations. Am J Cardiol 2002; 89: 26D–32D
   PubMed Web of Science ®Google Scholar
• Koga T, Takata Y, Kobayashi K, Takishita S, Yamashita Y, Fujishima M. Ageing suppresses endothelium-dependent relaxation and generates contraction mediated by the muscarinic receptors in vascular smooth muscle of normotensive Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens Suppl 1988; 6: S243–S245
   Google Scholar
• Matz RL, de Sotomayor MA, Schott C, Stoclet JC, Andriantsitohaina R. Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br J Pharmacol 2000; 131: 303–311
   PubMed Web of Science ®Google Scholar
• Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I, Salvetti A. Hypertension causes premature aging of endothelial function in humans. Hypertension 1997; 29: 736–743
   PubMed Web of Science ®Google Scholar
• Kung CF, Luscher TF. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension 1995; 25: 194–200
   PubMed Web of Science ®Google Scholar
• Heymes C, Habib A, Yang D, Mathieu E, Marotte F, Samuel J, Boulanger CM. Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing. Br J Pharmacol 2000; 131: 804–810
   PubMed Web of Science ®Google Scholar
• Ito T, Kato T, Iwama Y, Muramatsu M, Shimizu K, Asano H, Okumura K, Hashimoto H, Satake T. Prostaglandin H2 as an endothelium-derived contracting factor and its interaction with endothelium-derived nitric oxide. J Hypertens 1991; 9: 729–736
   PubMed Web of Science ®Google Scholar
• Auch-Schwelk W, Katusic ZS, Vanhoutte PM. Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta. Hypertension 1992; 195: 442–445
   Google Scholar
• Campbell WB, Harder DR. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ Res 1999; 84: 484–488
   PubMed Web of Science ®Google Scholar
• Dora KA, Garland CJ. Properties of smooth muscle hyperpolarization and relaxation to K+ in the rat isolated mesenteric artery. Am J Physiol Heart Circ Physiol 2001; 280: H2424–H2429
   Web of Science ®Google Scholar
• Busse R, Edwards G, Feletou M, Fleming I, Vanhoutte PM, Weston AH. EDHF: Bringing the concepts together. Trends Pharmacol Sci 2002; 23: 374–380
   PubMed Web of Science ®Google Scholar
• Marijic J, Li Q, Song M, Nishimaru K, Stefani E, Toro L. Decreased expression of voltage- and Ca2+-activated K+ channels in coronary smooth muscle during aging. Circ Res 2001; 88: 210–216
   PubMed Web of Science ®Google Scholar
• Barton M. Endothelial dysfunction and atherosclerosis: Endothelin receptor antagonists as novel therapeutics. Curr Hypertens Rep 2000; 2: 84–91
   PubMedGoogle Scholar
• Brunner F, Bras-Silva C, Cerdeira AS, Leite-Moreira AF. Cardiovascular endothelins: Essential regulators of cardiovascular homeostasis. Pharmacol Ther 2006, in press
   PubMed Web of Science ®Google Scholar
• Rossi GP, Seccia TM, Nussdorfer GG. Reciprocal regulation of endothelin-1 and nitric oxide: Relevance in the physiology and pathology of the cardiovascular system. Int Rev Cytol 2001; 209: 241–272
   PubMedGoogle Scholar
• Duarte J, Perez-Vizcaino F, Utrilla P, Jimenez J, Tamargo J, Zarzuelo A. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. Gen Pharmacol 1993; 24: 857–862
   PubMedGoogle Scholar
• Duarte J, Perez-Vizcaino F, Zarzuelo A, Jimenez J, Tamargo J. Vasodilator effects of quercetin on isolated rat vascular smooth muscle. Eur J Pharmacol 1993; 239: 1–7
   PubMed Web of Science ®Google Scholar
• Fitzpatrick DF, Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993; 265: H774–H778
   PubMed Web of Science ®Google Scholar
• Ibarra M, Perez-Vizcaino F, Cogolludo A, Duarte J, Zaragoza-Arnaez F, Lopez-Lopez JG, Tamargo J. Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. Planta Med 2002; 68: 307–310
   PubMed Web of Science ®Google Scholar
• Perez-Vizcaino F, Ibarra M, Cogolludo AL, Duarte J, Zaragoza-Arnaez F, Moreno L, Lopez-Lopez JG, Tamargo J. Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Ther 2002; 302: 66–72
   PubMed Web of Science ®Google Scholar
• Moon SK, Cho GO, Jung SY, Gal SW, Kwon TK, Lee YC, Madamanchi NR, Kim CH. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: Role of ERK1/2, cell-cycle regulation and matrix metalloproteinase-9. Biochem Biophys Res Commun 2003; 301: 1069–1078
   PubMed Web of Science ®Google Scholar
• Yoshizumi M, Tsuchiya K, Suzaki Y, Kirima K, Kyaw M, Moon JH, Terao J, Tamaki T. Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway. Biochem Biophys Res Commun 2002; 293: 1458–1465
   PubMed Web of Science ®Google Scholar
• Iijima K, Yoshizumi M, Hashimoto M, Kim S, Eto M, Ako J, Liang YQ, Sudoh N, Hosoda K, Nakahara K, Toba K, Ouchi Y. Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene. Circulation 2000; 101: 805–811
   PubMed Web of Science ®Google Scholar
• Andriambeloson E, Kleschyov AL, Muller B, Beretz A, Stoclet JC, Andriantsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 1997; 120: 1053–1058
   PubMedGoogle Scholar
• Andriambeloson E, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, Stoclet JC, Andriantsitohaina R. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998; 128: 2324–2333
   PubMed Web of Science ®Google Scholar
• Stoclet JC, Kleschyov A, Andriambeloson E, Diebolt M, Andriantsitohaina R. Endothelial no release caused by red wine polyphenols. J Physiol Pharmacol 1999; 50: 535–540
   PubMed Web of Science ®Google Scholar
• Andriambeloson E, Stoclet JC, Andriantsitohaina R. Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol 1999; 33: 248–254
   PubMedGoogle Scholar
• Duarte J, Jimenez R, Villar IC, Perez-Vizcaino F, Jimenez J, Tamargo J. Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta. Planta Med 2001; 67: 567–569
   PubMed Web of Science ®Google Scholar
• Duarte J, Andriambeloson E, Diebolt M, Andriantsitohaina R. Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol Res 2004; 53: 595–602
   PubMedGoogle Scholar
• Lopez-Lopez G, Moreno L, Cogolludo A, Galisteo M, Ibarra M, Duarte J, Lodi F, Tamargo J, Perez-Vizcaino F. Nitric oxide NO; scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle. Mol Pharmacol 2004; 65: 851–859
   PubMed Web of Science ®Google Scholar
• Van Acker SA, Tromp MN, Haenen GR, Van der Vijgh WJ, Bast A. Flavonoids as scavengers of nitric oxide radical. Biochem Biophys Res Commun 1995; 214: 755–759
   PubMed Web of Science ®Google Scholar
• Vlachopoulos C, Tsekoura D, Alexopoulos N, Panagiotakos D, Aznaouridis K, Stefanadis C. Type 5 phosphodiesterase inhibition by sildenafil abrogates acute smoking-induced endothelial dysfunction. Am J Hypertens 2003; 17: 1040–1014
   Web of Science ®Google Scholar
• Picq M, Dubois M, Prigent AF, Nemoz G, Pacheco H. Inhibition of the different cyclic nucleotide phosphodiesterase isoforms separated from rat brain by flavonoid compounds. Biochem Int 1989; 18: 47–57
   PubMedGoogle Scholar
• Wallerath T, Poleo D, Li H, Forstermann U. Red wine increases the expression of human endothelial nitric oxide synthase: A mechanism that may contribute to its beneficial cardiovascular effects. J Am Coll Cardiol 2003; 41: 471–478
   PubMed Web of Science ®Google Scholar
• Wallerath T, Li H, Godtel-Ambrust U, Schwarz PM, Forstermann U. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide 2005; 12: 97–104
   PubMed Web of Science ®Google Scholar
• O'Reilly JD, Sanders TA, Wiseman H. Flavonoids protect against oxidative damage to LDL in vitro: Use in selection of a flavonoid rich diet and relevance to LDL oxidation resistance ex vivo?. Free Radic Res 2000; 33: 419–426
   PubMed Web of Science ®Google Scholar
• Ozgova S, Hermanek J, Gut I. Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-: Fe-ascorbate- and Fe-microsomal systems. Biochem Pharmacol 2003; 66: 1127–1237
   PubMed Web of Science ®Google Scholar
• Moon JH, Tsushida T, Nakahara K, Terao J. Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 2001; 30: 1274–1285
   PubMed Web of Science ®Google Scholar
• Roland A, Patterson RA, Leake DS. Measurement of copper-binding sites on low density lipoprotein. Arterioscler Thromb Vasc Biol 2001; 21: 594–602
   PubMed Web of Science ®Google Scholar
• Chang WS, Lee YJ, Lu FJ, Chiang HC. Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res 1993; 13: 2165–2170
   PubMed Web of Science ®Google Scholar
• Tauber AI, Fay JR, Marletta MA. Flavonoid inhibition of the human neutrophil NADPH-oxidase. Biochem Pharmacol 1984; 33: 1367–1369
   PubMed Web of Science ®Google Scholar
• Ndiaye M, Chataigneau T, Andriantsitohaina R, Stoclet JC, Schini-Kerth VB. Red wine polyphenols cause endothelium dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochem Biophys Res Commun 2003; 310(371)377
   Google Scholar
• Villar IC, Galisteo M, Vera R, O'Valle F, Garcia-Saura MF, Zarzuelo A, Duarte J. Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed. J Vasc Res 2004; 41: 509–516
   PubMedGoogle Scholar
• Corder R, Douthwaite JA, Lees DM, Khan NQ, Viseu Dos Santos AC, Wood EG, Carrier MJ. Endothelin-1 synthesis reduced by red wine. Nature 2001; 414(863)864
   PubMedGoogle Scholar
• Zhao X, Gu Z, Attele AS, Yuan CS. Effects of quercetin on the release of endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture. J Ethnopharmacol 1999; 67: 279–285
   PubMed Web of Science ®Google Scholar
• Vieira O, Escargueil-Blanc I, Meilhac O, Basile JP, Laranjinha J, Almeida L, Salvayre R, Negre-Salvayre A. Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL. Br J Pharmacol 1998; 123: 565–573
   PubMed Web of Science ®Google Scholar
• Martin S, Giannone G, Andriantsitohaina R, Martinez MC. Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br J Pharmacol 2003; 139: 1095–1102
   PubMed Web of Science ®Google Scholar
• Pan MH, Liang YC, Lin-Shiau SY, Zhu NQ, Ho CT, Lin JK. Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. J Agric Food Chem 2000; 48: 6337–6346
   PubMed Web of Science ®Google Scholar
• Nam S, Smith DM, Dou QP. Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis. Cancer Epidemiol Biomarkers Prev 2001; 10: 1083–1088
   PubMed Web of Science ®Google Scholar
• Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercitin inhibit angiogenesis in vitro. Cancer Lett 2001; 171: 11–16
   PubMed Web of Science ®Google Scholar
• Favot L, Martin S, Keravis T, Andriantsitohaina R, Lugnier C. Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc Res 2003; 59: 479–487
   PubMedGoogle Scholar
• Kannel WB. Risk stratification in hypertension: New insights from the Framingham Study. Am J Hypertens 2000; 13: 3S–10S
   PubMed Web of Science ®Google Scholar
• Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 1997; 33: 1117–1124
   Web of Science ®Google Scholar
• Duarte J, Perez-Palencia R, Vargas F, Ocete MA, Perez-Vizcaino F, Zarzuelo A, Tamargo J. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 2001; 133: 117–124
   PubMed Web of Science ®Google Scholar
• Duarte J, Jimenez R, O'Valle F, Galisteo M, Perez-Palencia R, Vargas F, Perez-Vizcaino F, Zarzuelo A, Tamargo J. Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats. J Hypertens 2002; 20: 1843–1854
   PubMed Web of Science ®Google Scholar
• Galisteo M, Garcia-Saura MF, Jimenez R, Villar IC, Wangensteen R, Zarzuelo A, Vargas F, Duarte J. Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil. Planta Med 2004; 70: 334–341
   PubMedGoogle Scholar
• Aoi W, Niisato N, Miyazaki H, Marunaka Y. Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat. Biochem Biophys Res Commun 2004; 315: 892–896
   PubMedGoogle Scholar
• García-Saura MF, Galisteo M, Villar IC, Bermejo A, Zarzuelo A, Vargas F, Duarte J. Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem 2005; 270: 147–155
   PubMed Web of Science ®Google Scholar
• Sanchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Perez-Vizcaino F, Duarte J. Quercetin downregulates NADPH oxidase: Increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 2006; 24: 75–84
   PubMed Web of Science ®Google Scholar
• Auch-Schwelk W, Katusic ZS, Vanhoutte PM. Thromboxane A2 receptor antagonists inhibit endothelium-dependent contractions. Hypertension 1990; 15: 699–703
   PubMed Web of Science ®Google Scholar
• Yang D, Feletou M, Levens N, Zhang JN, Vanhoutte PM. A diffusible substances;mediates endothelium-dependent contractions in the aorta of SHR. Hypertension 2003; 41: 143–148
   PubMed Web of Science ®Google Scholar
• Macha A, Mustafa MR. Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol 2005; 46: 36–40
   PubMedGoogle Scholar
• Takizawa H, DelliPizzi AM, Nasjletti A. Prostaglandin I2 contributes to the vasodepressor effect of baicalein in hypertensive rats. Hypertension 1998; 31: 866–871
   PubMed Web of Science ®Google Scholar
• Conquer JA, Maiani G, Azzini E, Raguzzini A, Holub BJ. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr 1998; 128: 593–597
   PubMed Web of Science ®Google Scholar
• Pechanova O, Bernatova I, Babal P, Martinez MC, Kysela S, Stvrtina S, Andriantsitohaina R. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens 2003; 22: 1551–1559
   Google Scholar
• Soares De Moura R, Costa Viana FS, Souza MA, Kovary K, Guedes DC, Oliveira EP, Rubenich LM, Carvalho LC, Oliveira RM, Tano T, Gusmao Correia ML. Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract. J Pharm Pharmacol 2002; 54: 1515–1520
   PubMed Web of Science ®Google Scholar
• Grassi D, Necocione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri C. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 2005; 46: 398–405
   PubMed Web of Science ®Google Scholar
• Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H. Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens 2005; 18: 1360–1363
   PubMed Web of Science ®Google Scholar
• Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 2006; 103: 1024–1029
   PubMed Web of Science ®Google Scholar
• Vinson JA, Teufel K, Wu N. Red wine, dealcoholized red wine, and especially grape juice, inhibit atherosclerosis in a hamster model. Atherosclerosis 2001; 156: 67–72
   PubMed Web of Science ®Google Scholar
• Fuhrman B, Lavy A, Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr 1995; 61: 549–554
   PubMed Web of Science ®Google Scholar
• Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999; 100: 1050–1055
   PubMed Web of Science ®Google Scholar
• Naissides M, Mamo JC, James AP, Pal S. The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women. Atherosclerosis 2005, in press
   PubMedGoogle Scholar
• de Rijke YB, Demacker PN, Assen NA, Sloots LM, Katan MB, Stalenhoef AF. Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. Am J Clin Nutr 1996; 63: 329–334
   PubMed Web of Science ®Google Scholar
• O'Reilly JD, Mallet AI, McAnlis GT, Young IS, Halliwell B, Sanders TA, Wiseman H. Consumption of flavonoids in onions and black tea: Lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am J Clin Nutr 2001; 73: 1040–1044
   PubMed Web of Science ®Google Scholar
• Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005; 135: 1911–1917
   PubMed Web of Science ®Google Scholar
• Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A, Aviram M. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997; 17: 2744–2752
   PubMed Web of Science ®Google Scholar
• Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001; 104: 365–372
   PubMed Web of Science ®Google Scholar
• Larosa JC, He J, Vupputuri S. Effect of statins on risk of coronary disease. JAMA 1999; 282: 2340–2346
   PubMed Web of Science ®Google Scholar
• Gryglewski RJ, Korbut R, Robak J, Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987; 36: 317–322
   PubMed Web of Science ®Google Scholar
• de Gaetano G, De Curtis A, di Castelnuovo A, Donati MB, Iacoviello L, Rotondo S. Antithrombotic effect of polyphenols in experimental models: A mechanism of reduced vascular risk by moderate wine consumption. Ann N Y Acad Sci 2004; 957: 174–188
   Web of Science ®Google Scholar
• Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, Huang CJ, Kandaswami C, Middleton E, Jr, Lee MT. Effects of luteolin and quercetin: Inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. Br J Pharmacol 1999; 128: 999–1010
   PubMed Web of Science ®Google Scholar
• Rendig SV, Symons JD, Longhurst JC, Amsterdam EA. Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries. J Cardiovasc Pharmacol 2001; 38: 219–227
   PubMed Web of Science ®Google Scholar
• Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046–1051
   PubMed Web of Science ®Google Scholar
• Duffy SJ, Keaney JF, Jr, Holbrook M, Gokce N, Swerdloff PL, Frei B, Vita JA. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001; 104: 151–156
   PubMed Web of Science ®Google Scholar
• Cui J, Cordis GA, Tosaki A, Maulik N, Das DK. Reduction of myocardial ischemia reperfusion injury with regular consumption of grapes. Ann N Y Acad Sci 2002; 957: 302–307
   PubMed Web of Science ®Google Scholar
• Sato M, Ray PS, Maulik G, Maulik N, Engelman RM, Bertelli AA, Bertelli A, Das DK. Myocardial protection with red wine extract. J Cardiovasc Pharmacol 2000; 35: 263–268
   PubMed Web of Science ®Google Scholar
• Ning XH, Ding X, Childs KF, Bolling SF, Gallagher KP. Flavone improves functional recovery after ischemia in isolated reperfused rabbit hearts. J Thorac Cardiovasc Surg 1993; 105: 541–549
   PubMed Web of Science ®Google Scholar
• Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. Mitochondrial function in response to cardiac ischemiareperfusion after oral treatment with quercetin. Free Radic Biol Med 2002; 32: 1220–1228
   PubMed Web of Science ®Google Scholar
• Ranaivo HR, Diebolt M, Andriantsitohaina R. Wine polyphenols induce hypotension, and decrease cardiac reactivity and infarct size in rats: Involvement of nitric oxide. Br J Pharmacol 2004; 142: 671–678
   PubMed Web of Science ®Google Scholar
• Simonyi A, Wang Q, Miller RL, Yusof M, Shelat PB, Sun AY, Sun GY. Polyphenols in cerebral ischemia: Novel targets for neuroprotection. Mol Neurobiol 2005; 31: 135–148
   PubMed Web of Science ®Google Scholar
• Wang Q, Simonyi A, Li W, Sisk BA, Miller RL, MacDonald RS, Lubahn DE, Sun GY, Sun AY. Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbils. Mol Nutr Food Res 2005; 49: 443–451
   PubMed Web of Science ®Google Scholar
• Dajas F, Rivera F, Blasina F, Arredondo F, Echeverry C, Lafon L, Morquio A, Heizen H. Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotox Res 2003; 5: 425–432
   PubMed Web of Science ®Google Scholar
• Curin Y, Ratajczak P, Dupont A, Ritz M-F, Mendelowitsch A, Pinet F, Andriantsitohaina R. Identification par analyse protéomique des déterminants moléculaires de la neuroprotection induite par les polyphenols dands l'ischémie cérébrale. Arch Mal Coeur Vaiss 2005; 98: 392
   Google Scholar
• Curin Y, Ritz M-F, Cam E, Andriantsitohaina R, Mendelowitsch A. Chronic treatment with red wine polyphenolic compounds protects against vascular and neuronal excito-toxicity in response to focal cerebral ischemia in male rats. Arch Mal Coeur Vaiss 2004; 97: 417
   Google Scholar
• Waterhouse AL. Wine phenolics. Ann NY Acad Sci 2002; 957: 21–36
   PubMed Web of Science ®Google Scholar