Superoxide dismutase mimetic reduces hypoxia-induced , TGF-β, and VEGF production by macrophages

References

• Vujaskovic Z, Anscher MS, Feng QF, Rabbani ZN, Amin K, Samulski TS, Dewhirst MW, Haroon ZA. Radiation-induced hypoxia may perpetuate late normal tissue injury. Int J Radiat Oncol Biol Phys 2001; 50: 851–855
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z, Marks LB, Anscher MS. The physical parameters and molecular events associated with radiation induced lung toxicity. Semin Radiat Oncol 2000; 10: 296–307
   PubMed Web of Science ®Google Scholar
• Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, Samulski TS, Dewhirst MW, Anscher MS, Vujaskovic Z. Overexpression of extracellularl superoxide dismutase protects mice from radiation induced lung injury. Int J Radiat Oncol Biol Phys 2003; 57: 1056–1066
   PubMed Web of Science ®Google Scholar
• Barthelemy-Brichant N, Bosquee L, Cataldo D, Corhay JL, Gustin M, Seidel L, Thiry A, Ghaye B, Nizet M, Albert A, Deneufbourg JM, Bartsch P, Nusgens B. Increased IL-6 and TGF-beta1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy. Int J Radiat Oncol Biol Phys 2004, 58: 758–767
   PubMedGoogle Scholar
• Arpin D, Perol D, Blay JY, Falchero L, Claude L, Vuillermoz-Blas S, Martel-Lafay I, Ginestet C, Alberti L, Nosov D, Etienne-Mastroianni B, Cottin V, Perol M, Guerin JC, Cordier JF, Carrie C. Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis. J Clin Oncol 2005; 23: 8748–8756
   PubMed Web of Science ®Google Scholar
• Kong FM, Hayman JA, Griffith KA, Kalemkerian GP, Arenberg D, Lyons S, Turrisi A, Lichter A, Fraass B, Eisbruch A, Lawrence TS, Ten Haken RK. Final toxicity results of radiation-dose escalation study in patients with non-small cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 2006; 65: 1075–1086
   PubMed Web of Science ®Google Scholar
• Hope AJ, Lindsay PE, El Naqa I, Alaly JR, Vicic M, Bradley JD, Deasy JO. Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters. Int J Radiat Oncol Biol Phys 2006; 65: 112–124
   PubMed Web of Science ®Google Scholar
• Bradley J, Movsas B. Radiation pneumonitis and esophagitis in thoracic irradiation. Cancer Treat Res 2005; 128: 43–64
   Google Scholar
• Anscher MS, Chen L, Rabbani Z, Kang S, Larrier N, Huang H, Samulski TV, Dewhirst MW, Brizel DM, Folz RJ, Vujaskovic Z. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys 2005; 62: 255–259
   PubMed Web of Science ®Google Scholar
• Anscher MS, Vujaskovic Z. Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Semin Oncol 2005; 32: S86–S91
   PubMed Web of Science ®Google Scholar
• Murdoch C, Lewis CE. Macrophage migration and gene expression in response to tumor hypoxia. Int J Cancer 2005; 117: 701–708
   PubMed Web of Science ®Google Scholar
• Epperly M, Bray J, Kraeger S, Zwacka R, Engelhard J, Travis E, Greenberger J. Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Ther 1998; 5: 196–208
   PubMed Web of Science ®Google Scholar
• Crowther M, Brown NJ, Bishop ET, Lewis CE. Microevironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol 2001; 70: 478–490
   PubMed Web of Science ®Google Scholar
• Ushio Fukai M, Alexander RW. Reactive oxygen species as mediators of angiogenesis signaling: Role of NAD(P)H oxidase. Mol Cell Biochem 2004; 264: 85–97
   PubMed Web of Science ®Google Scholar
• Rabbani ZN, Anscher MS, Folz RJ, Archer E, Huang H, Chen L, Golson ML, Samulski TS, Dewhirst MW, Vujaskovic Z. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC Cancer 2005; 5: 59
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z, Batinic-Haberle I, Rabbani ZN, Feng QF, Kang SK, Spasojevic I, Samulski TV, Fridovich I, Dewhirst MW, Anscher MS. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med 2002; 33: 857–863
   PubMed Web of Science ®Google Scholar
• Batinic-Haberle I, Benov L, Spasojevic I, Hambright P, Crumbliss AL, Fridovich I. The relationship between redox potentials, proton dissociation constants of pyrrolic nitrogen and in vitro and in vivo superoxide dismutase activities of manganese (III) and iron (III) cationic and anionic porphyrins. Inorg Chem 1999; 38: 4011–4422
   Web of Science ®Google Scholar
• Batinic-Haberle I, Spasojevic I, Stevens RD, Bondurant B, Okado-Matsumoto A, Fridovich I, Vujaskovic Z, Dewhirst MW. New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. Dalton Trans 2006; 617–624
   PubMed Web of Science ®Google Scholar
• Ferrer-Sueta G, Hannibal L, Batinic-Haberle I, Radi R. Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles and the catalytic redox cycle of peroxynitrite. Free Radic Biol Med 2006; 41: 503–512
   PubMed Web of Science ®Google Scholar
• McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erthrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049–6055
   PubMed Web of Science ®Google Scholar
• Kirby TW, Fridovich I. A picomolar spectrophotometric assay for superoxide dismutase. Anal Biochem 1982; 127: 435–440
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z, Down JD, van Waarde MA, van Assen AJ, Szabo BG, Konings AW. Plasma TGFbeta level in rats after hemithoracic irradiation. Radiother Oncol 1997; 44: 41–43
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z, Groen HJ. TGF-beta, radiation-induced pulmonary injury and lung cancer. Int J Radiat Biol 2000; 76: 511–516
   PubMed Web of Science ®Google Scholar
• Vujaskovic Z. Structural and physiological properties of peripheral nerves after intraoperative irradiation. J Peripher Nerv Syst 1997; 2: 343–349
   PubMedGoogle Scholar
• Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS. Hypoxia in radiation-induced blood spinal cord barrier breakdown. Cancer Res 2000; 61: 3348–3354
   Web of Science ®Google Scholar
• Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843–845
   PubMed Web of Science ®Google Scholar
• Zhong Z, Arteel GE, Connor HD, Yin M, Frankenberg MV, Stachlewitz RF, Raleigh JA, Mason RP, Thurman RG. Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine. Am J Physiol 1998; 275: F595–F604
   PubMedGoogle Scholar
• Haroon ZA, Raleigh JA, Greenberg CS, Dewhirst MW. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg 2000; 231: 137–147
   PubMed Web of Science ®Google Scholar
• Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol 1996; 10: 1077–1083
   PubMed Web of Science ®Google Scholar
• Yi ES, Bedoya A, Lee H, Chin E, Saunders W, Kim SJ, Danielpour D, Remick DG, Yin S, Ulich TR. Radiation-induced lung injury in vivo: Expression of transforming growth factor-beta precedes fibrosis. Inflammation 1996; 20: 339–352
   PubMed Web of Science ®Google Scholar
• Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH. Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res 2002; 62: 5627–5631
   PubMed Web of Science ®Google Scholar
• Martin J, Lefaix J, Delanian S. TGF-beta1 and radiation fibrosis: A master switch and a specific therapeutic target?. Int J Radiat Oncol Biol Phys 2000; 47: 277–290
   PubMed Web of Science ®Google Scholar
• Papkonstantinou E, Aletras AJ, Roth M, Tamm M, Karakiulakis G. Hypoxia modulates the effects of transforming growth factor-beta isoforms on matrix-formation by primary human lung fibroblasts. Cytokine 2003; 24: 25–35
   PubMed Web of Science ®Google Scholar
• Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, Willich N, Rube C. Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 2000; 47: 1033–1042
   PubMed Web of Science ®Google Scholar
• Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB. Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol 2003; 163: 2247–2257
   PubMed Web of Science ®Google Scholar
• Von Pfeil A, Hakenjos L, Herskind C, Dittman K, Weller M, Rodemann HP. Irradiated homozygous TGF-beta1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF-beta1 wild-type fibroblasts. Int J Radiat Bio 2002; 78: 331–339
   PubMed Web of Science ®Google Scholar
• Moeller BJ, Cao Y, Li CY, Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004; 5: 429–441
   PubMed Web of Science ®Google Scholar
• Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St Clair W, Epstein CJ, St Clair D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res 2005; 65: 1401–1405
   PubMed Web of Science ®Google Scholar