Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats?

References

• Okamoto K, Tabei R, Fukushima M, Nosaka S, Yamori Y, Ichijima K, Haebara H, Matsumoto M, Maruyama T, Suziki Y, Tamegai IM. Further observations of the development of a strain of spontaneously hypertensive rats. Jpn Circ J 1966; 30: 703–716
   PubMedGoogle Scholar
• Nava M, Quiroz Y, Vaziri ND, Rodriguez-Iturbe B. Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. Am J Physiol Renal Physiol 2003; 284: F447–F454
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Mezzano S, Vaziri ND. Early and sustained inhibition of nuclear factor-κB prevents hypertension in spontaneously hypertensive rats. J Pharmacol Exp Ther 2005; 315: 51–57
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Pons H, Herrera-Acosta J, Johnson RJ. Role of immunocompetent cells in nonimmune renal diseases. Kidney Int 2001; 59: 1626–1640
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Quiroz Y, Ferrebuz A, Parra G, Vaziri ND. Evolution of renal interstitial inflammation and NF-κB activation in spontaneously hypertensive rats. Am J Nephrol 2004; 24: 587–594
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J, Johnson RJ, Pons HA. Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol 2002; 282: F191–F201
   PubMed Web of Science ®Google Scholar
• Rodriguez-Iturbe B, Zhan C, Quiroz Y, Sindhu RK, Vaziri ND. Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension 2003; 41: 341–346
   PubMed Web of Science ®Google Scholar
• Vaziri ND. Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension. Curr Opin Nephrol Hypertens 2004; 13: 93–99
   PubMedGoogle Scholar
• Chabrashvili T, Tojo A, Onozato ML, Kitiyakara C, Quinn MT, Fujita T, Welch WJ, Wilcox CS. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 2002; 39: 269–274
   PubMed Web of Science ®Google Scholar
• Righetti AE, Boer-Lima PA, Lopes de Faria JB. The presence of genetic hypertension stimulates early renal accumulation of fibronectin in experimental diabetes mellitus. Diabetologia 2001; 44: 2088–2091
   PubMedGoogle Scholar
• Silveira LA, Bacchi CE, Pinto GA, Lopes de Faria JB. The genetics of hypertension modifies the renal cell replication response induced by experimental diabetes. Diabetes 2002; 51: 1529–1534
   PubMed Web of Science ®Google Scholar
• Thai MV, Guruswamy S, Cao KT, Pessin JE, Olson AL. Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice regulation of MEF2 DNA binding activity in insulin-deficient diabetes. J Biol Chem 1998; 273: 14285–14292
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye binding. Anal Biochem 1976; 72: 248–254
   PubMed Web of Science ®Google Scholar
• Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–685
   PubMed Web of Science ®Google Scholar
• Beutler E, Duron O, Mikus B. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 16: 882–888
   Google Scholar
• Lopes de Faria JB, Zoukhri D, Lorenzi M. Mesangial cell abnormalities in spontaneously hypertensive rats before the onset of hypertension. Kidney Int 1997; 52: 387–392
   PubMed Web of Science ®Google Scholar
• Tak PP, Firestein GS. NF-κB: Key role in inflammatory disease. J Clin Invest 2001; 107: 7–11
   PubMed Web of Science ®Google Scholar
• Halliwell B. What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?. FEBS Lett 1997; 411: 157–160
   PubMed Web of Science ®Google Scholar
• Zhan DC, Sindhu RK, Vaziri ND. Up-regulation of kidney NADPH oxidase and calcineurin in SHR: Reversal by lifelong antioxidant supplementation. Kidney Int 2004; 65: 219–227
   PubMed Web of Science ®Google Scholar
• Kasai H, Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acid Res 1984; 12: 2137–2145
   PubMed Web of Science ®Google Scholar
• Griendling KK, Sorescu D, Ushio-Fukai M. NADPH oxidase: Role in cardiovascular biology and disease. Circ Res 2000; 86: 494–501
   PubMed Web of Science ®Google Scholar
• Vaziri ND, Ni Z. Expression of Nox-1, gp91phox, p47phox and p67phox in the aorta segments above and below coarctation. Biochim Biophys Acta 2005; 1723: 321–327
   PubMedGoogle Scholar
• Touyz RM. Molecular and cellular mechanisms in vascular injury in hypertension: Role of angiotensin II. Curr Opin Nephrol Hypertens 2005; 14: 125–131
   PubMed Web of Science ®Google Scholar
• Dickhout JG, Lee RM. Blood pressure and heart rate development in young spontaneously hypertensive rats. Am J Physiol 1998; 274: H794–H800
   Google Scholar
• Sies H. Oxidative stress: Oxidants and antioxidants. Academic Press, New York, NY 1991
   Google Scholar
• Welch WJ, Mendonca M, Blau J, Karber A, Dennehy K, Patel K, Lao YS, Jose PA, Wilcox CS. Antihypertensive response to prolonged tempol in the spontaneously hypertensive rat. Kidney Int 2005; 68: 179–187
   PubMedGoogle Scholar
• Babior BM. NADPH oxidase: An update. Blood 1999; 93: 1464–1476
   PubMed Web of Science ®Google Scholar
• Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: A critical link to hypertension?. Am J Physiol Regul Integr Comp Physiol 2005; 289: 913–935
   PubMed Web of Science ®Google Scholar
• Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ. Elevated renovascular tone in young spontaneously hypertensive rats: Role of cytochrome p-450. Hypertension 1993; 22: 357–364
   PubMed Web of Science ®Google Scholar