324
Views
39
CrossRef citations to date
0
Altmetric
Original

25-Hydroxycholesterol, 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages

, &
Pages 260-266 | Received 26 Sep 2006, Published online: 07 Jul 2009

References

  • Greaves DR, Channon KM. Inflammation and immune responses in atherosclerosis. Trends Immunol 2002; 23: 535–541
  • Ross R. Atherosclerosis is an inflammatory disease. Am Heart J 1999; 138: S419–S420
  • Bjorkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signalling pathways. Nat Med 2004; 10: 416–421
  • Michelson KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA 2004; 101: 10679–10684
  • Mullick AE, Tobias PS, Curtiss LK. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 2005; 115: 3149–3156
  • Underhill DM, Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 2002; 14: 103–110
  • Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002; 347: 185–192
  • Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, Lamotte M, Lebret D, Ollivier V, de Prost D. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 2003; 23: 61–64
  • Edfeldt K, Swedenborg J, Hansson GK, Yan Z. Expression of Toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation. Circulation 2002; 105: 1158–1160
  • Barath P, Fishbein MC, Cao J, Berenson J, Helfant RH, Forrester JS. Detection and localisation of tumor necrosis factor in human atheroma. Am J Cardiol 1990; 65: 297–302
  • Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA, Neumeier D. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest 1996; 97: 1715–1722
  • Watson AD, Leitinger N, Navab M, Faull KF, Horkko S, Witztum JL, Palinski W, Schwenke D, Salomon RG, Sha W, Subbanagounder G, Fogelman AM, Berliner JA. Structural identification by mass spectrometry of oxidised phospholipids in minimally oxidised low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem 1997; 272: 13597–13607
  • Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999; 142: 1–28
  • Brown AJ, Leong SL, Dean RT, Jessup W. 7-hydroperoxycholesterol and its products in oxidised low density lipoprotein and human atherosclerotic plaque. J Lipid Res 1997; 38: 1730–1745
  • Liu Y, Hulten LM, Wiklund O. Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production. Arterioscler Thromb Vasc Biol 1997; 17: 317–323
  • Rydberg EK, Salomonsson L, Hultén LM, Norén K, Bondjers G, Wiklund O, Björnheden T, Ohlsson BG. Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages. Atherosclerosis 2003; 170: 245–252
  • Walton KA, Hsieh X, Gharavi N, Wang S, Wang G, Yeh M, Cole AL, Berliner JA. Receptors involved in the oxidised 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8: A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. J Biol Chem 2003; 278: 29661–29668
  • Erridge C, Webb DJ, Spickett CM. Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression. Atherosclerosis 2006, in press
  • Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2 and inhibits phagocytosis of apoptotic cells. J Biol Chem 2003; 278: 1561–1568
  • Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol 2005; 25: 1213–1219
  • Leonarduzzi G, Gamba P, Sottero B, Kadl A, Robbesyn F, Calogero RA, Biasi F, Chiarpotto E, Leitinger N, Sevanian A, Poli G. Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. Free Radic Biol Med 2005; 39: 1152–1161
  • Landis MS, Patel HV, Capone JP. Oxysterol activators of liver x receptor and 9-cis-retinoic acid promote steps in the synthesis and secretion of tumor necrosis factor-α from human monocytes. J Biol Chem 2002; 277: 4713–4721
  • Rosklint T, Ohlsson BG, Wiklund O, Norén K, Hultén LM. Oxysterols induce interleukin-1 beta production in human macrophages. Eur J Clin Invest 2002; 32: 35–42
  • Russell DW. Oxysterol biosynthetic enzymes. Biochim Biophys Acta 2000; 1529: 126–135
  • Schroepfer GJ. Oxysterols: Modulators of cholesterol metabolism and other processes. Physiol Rev 2000; 80: 361–554
  • Brown A, Dean R, Jessup W. Free and esterified oxysterol: Formation during copper-oxidation of low density lipoprotein and uptake by macrophages. J Lipid Res 1996; 37: 320–335
  • Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. Cutting edge: Repurification of lipopolysaccharide eliminates signalling through both human and murine Toll-like receptor 2. J Immunol 2000; 165: 618–622
  • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G. Quantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531–4537
  • Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by co-operation between Toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766–13771
  • Reape TJ, Groot PHE. Chemokines and atherosclerosis. Atherosclerosis 1999; 147: 213–225
  • Boekholdt SM, Peters RJ, Hack CE, Day NE, Luben R, Bingham SA, Wareham NJ, Reitsma PH, Khaw KT. IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: The EPIC-Norfolk prospective population study. Arterioscler Thromb Vasc Biol 2004; 24: 1503–1508
  • Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 1998; 101: 353–363
  • Aiello RJ, Bourassa PA, Lindsey S, Weng W, Natoli E, Rollins BJ, Milos PM. Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 1999; 19: 1518–1525
  • Akashi S, Nagai Y, Ogata H, Oikawa M, Fukase K, Kusumoto S, Kawasaki K, Nishijima M, Hayashi S, Kimoto M, Miyake K. Human MD-2 confers on mouse Toll-like receptor 4 species specific lipopolysaccharide recognition. Int Immunol 2001; 13: 1595–1599
  • Hajjar AM, Ernst RK, Tsai JH, Wilson CB, Miller SI. Human Toll-like receptor 4 recognises host-specific LPS modifications. Nat Immunol 2003; 3: 354–359

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.