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Original

Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity

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Pages 1326-1337 | Received 17 Jul 2007, Published online: 07 Jul 2009

References

  • Carmichael WW. Cyanobacteria secondary metabolites: the cyanotoxins. J Appl Bacteriol 1992; 72: 445–459
  • Carmichael WW. The toxins of cyanobacteria. Sci Am 1994; 270: 78–86
  • Ho L, Onstad G, von Gunten U, Rinck-Pfeiffer S, Craig K, Newcombe G. Differences in the chlorine reactivity of four microcystin analogues. Water Res 2006; 40: 1200–1209
  • Sekijima M, Tsutsumi T, Yoshida T, Harada T, Tashiro F, Chen G, Yu SZ, Ueno Y. Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats. Carcinogenesis 1999; 20: 161–165
  • Honkanen RE, Zwiller J, Moore RE, Daily SL, Khatra BS, Dukelow M, Boynton AL. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem 1990; 265: 19401–19404
  • MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphoatase 1 and 2A from both mammals and higher plants. FEBS Lett 1990; 264: 187–192
  • Gehringer MM. Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett 2004; 557: 1–8
  • Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol Appl Pharmacol 2005; 203: 257–263
  • Monks NR, Liu S, Xu Y, Yu H, Bendelow AS, Moscow JA. Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther 2007; 6: 587–598
  • Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, Takeuchi T. Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol Sci 2007; 97: 407–416
  • Ding WX, Shen HM, Ong CN. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 2000; 32: 547–555
  • Ding WX, Shen HM, Ong CN. Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes. J Toxicol Environ Health A 2001; 64: 507–519
  • Ding WX, Shen HM, Ong CN. Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochem Biophys Res Commun 2002; 291: 321–331
  • Ding WX, Nam Ong C. Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity. FEMS Microbiol Lett 2003; 220: 1–7
  • Botha N, Gehringer MM, Downing TG, van de Venter M, Shephard EG. The role of microcystin-LR in the induction of apoptosis and oxidative stress in CaCo2 cells. Toxicon 2004; 43: 85–92
  • Chen T, Wang Q, Cui J, Yang W, Shi Q, Hua Z, Ji J, Shen P. Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy. Mol Cell Proteom 2005; 4: 958–974
  • Weng D, Lu Y, Wei Y, Liu Y, Shen P. The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology 2007; 232: 15–23
  • Doostdar H, Demoz A, Burke MD, Melvin WT, Grant MH. Variation in drug-metabolising enzyme activities during the growth of human HepG2 hepatoma cells. Xenobiotica 1990; 20: 435–441
  • Knasmuller S, Parzefall W, Sanyal R, Ecker S, Schwab C, Uhl M, Mersch-Sundermann V, Williamson G, Hietsch G, Langer T, Darroudi F, Natarajan AT. Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat Res 1998; 402: 185–202
  • Knasmuller S, Mersch-Sundermann V, Kevekordes S, Darroudi F, Huber WW, Hoelzl C, Bichler J, Majer BJ. Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 2004; 198: 315–328
  • Mersch-Sundermann V, Knasmuller S, Wu XJ, Darroudi F, Kassie F. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 2004; 198: 329–340
  • Eriksson JE, Gronberg L, Nygard S, Slotte JP, Meriluoto JA. Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin. Biochim Biophys Acta 1990; 1025: 60–66
  • Zegura B, Lah TT, Filipic M. Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells. Mutat Res 2006; 611: 25–33
  • Zegura B, Sedmak B, Filipic M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon 2003; 41: 41–48
  • Zegura B, Lah TT, Filipic M. The role of reactive oxygen species in microcystin-LR-induced DNA damage. Toxicology 2004; 200: 59–68
  • Komatsu M, Sumizawa T, Mutoh M, Chen ZS, Terada K, Furukawa T, Yang XL, Gao H, Miura N, Sugiyama T, Akiyama S. Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res 2000; 60: 1312–1316
  • Li D, Morimoto K, Takeshita T, Lu Y. Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaks in PHA-stimulated and unstimulated human lymphocytes. Environ Health Perspect 2001; 109: 523–526
  • Olive PL, Banath JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the ‘comet’ assay. Radiat Res 1990; 122: 86–94
  • Ding WX, Shen HM, Zhu HG, Lee BL, Ong CN. Genotoxicity of microcystic cyanobacteria extract of a water source in China. Mutat Res 1999; 442: 69–77
  • Arima Y, Nishigori C, Takeuchi T, Oka S, Morimoto K, Utani A, Miyachi Y. 4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species. Toxicol Sci 2006; 91: 382–392
  • Takahashi M, Shibata M, Niki E. Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine. Free Radic Biol Med 2001; 31: 164–174
  • Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007; 7: 106–118
  • Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 2003; 278: 3170–3175
  • Shervington A, Mohammed K, Patel R, Lea R. Identification of a novel co-transcription of P450/1A1 with telomerase in A549. Gene 2007; 388: 110–116
  • Zhang X, Ding L, Sandford AJ. Selection of reference genes for gene expression studies in human neutrophils by real-time PCR. BMC Mol Biol 2005; 6: 4
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402–408
  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001; 120: 1689–1699
  • Halliwell B, Aruoma OI. DNA damage by oxygen-derived species. FEBS Lett 1991; 281: 9–19
  • Takeuchi T, Morimoto K. Crocidolite asbestos increased 8-hydroxydeoxyguanosine levels in cellular DNA of a human promyelocytic leukemia cell line, HL60. Carcinogenesis 1994; 15: 635–639
  • Kasai H, Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res 1984; 12: 2137–2145
  • Takeuchi T, Nakajima M, Morimoto K. Establishment of a human system that generates O2 and induces 8-hydroxydeoxyguanosine, typical of oxidative DNA damage, by a tumor promoter. Cancer Res 1994; 54: 5837–5840
  • Takeuchi T, Nakajima M, Morimoto K. Relationship between the intracellular reactive oxygen species and the induction of oxidative DNA damage in human neutrophil-like cells. Carcinogenesis 1996; 17: 1543–1548
  • Dizdaroglu M. Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med 1991; 10: 225–242
  • Maatouk I, Bouaicha N, Plessis MJ, Perin F. Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver. Mutat Res 2004; 564: 9–20
  • Afzal M, Matsugo S, Sasai M, Xu B, Aoyama K, Takeuchi T. Method to overcome photoreaction, a serious drawback to the use of dichlorofluorescin in evaluation of reactive oxygen species. Biochem Biophys Res Commun 2003; 304: 619–624
  • Lee YS, Kang YS, Lee JS, Nicolova S, Kim JA. Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells. Free Radic Res 2004; 38: 405–412
  • Kim JA, Lee YS. Role of reactive oxygen species generated by NADPH oxidase in the mechanism of activation of K(+)-Cl(−)-cotransport by N-ethylmaleimide in HepG2 human hepatoma cells. Free Radic Res 2001; 35: 43–53
  • Lee YS, Kang YS, Lee SH, Kim JA. Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells. Cell Death Differ 2000; 7: 925–932
  • Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology 2002; 35: 62–73
  • Gonzalez FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res 2005; 569: 101–110
  • Puntarulo S, Cederbaum AI. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free Radic Biol Med 1998; 24: 1324–1330
  • Dey A, Cederbaum AI. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. Arch Biochem Biophys 2007; 461: 275–286
  • Tindberg N, Baldwin HA, Cross AJ, Ingelman-Sundberg M. Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury. Mol Pharmacol 1996; 50: 1065–1072
  • Brady JF, Ishizaki H, Fukuto JM, Lin MC, Fadel A, Gapac JM, Yang CS. Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chem Res Toxicol 1991; 4: 642–647
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55–63
  • Dynlacht BD. Regulation of transcription by proteins that control the cell cycle. Nature 1997; 389: 149–152
  • Lew DJ, Kornbluth S. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol 1996; 8: 795–804
  • Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. Br J Pharmacol 2004; 142: 231–255
  • Kyle ME, Nakae D, Sakaida I, Miccadei S, Farber JL. Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide. J Biol Chem 1988; 263: 3784–3789
  • Li L, Wattiaux-De Coninck S, Wattiaux R. Endocytosis of superoxide dismutase by rat liver. Biochem Biophys Res Commun 1992; 184: 727–732
  • Waelti ER, Barton M. Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activity. Pharmacology 2006; 78: 198–201

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