Vitamin E ingestion improves several immune functions in elderly men and women

References

• Makinodan T, Kay M. Age influence on the immune system. Adv Immunol 1980; 29: 287–329
   PubMedGoogle Scholar
• Pawelec G. Immunity and ageing in man. Exp Gerontol 2006; 41: 1239–1242
   PubMed Web of Science ®Google Scholar
• De la Fuente M. Effects of antioxidants on immune system ageing. Eur J Clin Nutr 2002; 56: S5–S8
   PubMed Web of Science ®Google Scholar
• De la Fuente M, Hernanz A, Vallejo MC. The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise. Antioxid Redox Signal 2005; 7: 1356–1366
   PubMed Web of Science ®Google Scholar
• High KP. Infection as a cause of age-related morbidity and mortality. Ageing Res Rev 2004; 3: 1–14
   PubMed Web of Science ®Google Scholar
• Wayne SJ, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbility and mortality in subjects over 60. J Gerontol 1990; 45: 45–98
   Google Scholar
• Guayerbas N, Puerto M, Victor VM, Miquel J, De la Fuente M. Leukocyte function and life span in a murine model of premature immunosenescence. Exp Gerontol 2002; 37: 249–256
   PubMedGoogle Scholar
• Puerto M, Guayerbas N, Alvarez P, De la Fuente M. Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice. J Neuroimmunol 2005; 165: 33–40
   PubMedGoogle Scholar
• Harman D. Ageing: a theory based on free radical and radiation chemistry. J Gerontol 1956; 2: 298–300
   Google Scholar
• Miquel J, Economos AC, Fleming JE, Johnson JE. Mitochondrial role in cell aging. Exp Gerontol 1980; 15: 575–591
   PubMed Web of Science ®Google Scholar
• Sastre J, Pallardo FV, Garcia de la Asuncion J, Vina J. Mitochondria, oxidative stress and aging. Free Radic Res 2000; 32: 189–198
   PubMed Web of Science ®Google Scholar
• Brigelius-Flohe R. Glutathione peroxidases and redox-regulated transcription factors. Biol Chem 2006; 387: 1329–1335
   PubMed Web of Science ®Google Scholar
• Knight JA. The biochemistry of aging. Adv Clin Chem 2000; 35: 1–62
   PubMed Web of Science ®Google Scholar
• Meydani SN, Wu D, Santos MS, Hayek M. Antioxidants and immune response in aged persons: overview of present evidence. Am J Clin Nutr 1995; 62: 1462S–1476S
   PubMed Web of Science ®Google Scholar
• Meydani M, Lipman RD, Han SN, Wu D, Beharka A, Martin KR, Bronson R, Cao G, Smith D, Meydani SN. The effect of long-term dietary supplementation with antioxidants. Ann NY Acad Sci 1998; 854: 352–360
   PubMed Web of Science ®Google Scholar
• De la Fuente M, Hernanz A, Guayerbas N, Puerto M, Alvarez P, Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol 2004; 50: OL683–OL690
   PubMedGoogle Scholar
• Coquette A, Vray B, Vanderpas J. Role of vitamin E in the protection of the resident macrophage membrane against oxidative damage. Arch Int Physiol Biochem 1986; 94: 529–534
   Google Scholar
• Daynes RA, Enioutina EY, Jones DC. Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. Antioxid Redox Signal 2003; 5: 537–548
   PubMed Web of Science ®Google Scholar
• Serafini M. Dietary vitamin E and T cell-mediated function in the elderly: effectiveness and mechanism of action. Int J Dev Neurosci 2000; 18: 401–410
   PubMedGoogle Scholar
• Meydani SN, Han SN, Wu D. Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immunol Rev 2005; 205: 269–284
   PubMed Web of Science ®Google Scholar
• Alvarado C, Alvarez P, Puerto M, Gausserés N, Jimenez L, De la Fuente M. Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Nutrition 2006; 22: 767–777
   PubMed Web of Science ®Google Scholar
• Sies H, Murphy ME. Role of tocopherols in the protection of biological systems against oxidative damage. J Photochem Photobiol B 1981; 8: 211–224
   Google Scholar
• Polito A, Intorre F, Andriollo-Sanchez M, Azzini E, Raguzzini A, Meunier N, Ducros V, O'Connor JM, Coudray C, Roussel AM, Maiani G. Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. Eur J Clin Nutr 2005; 59: S42–S47
   Google Scholar
• Kowdley KV, Mason JB, Meydni SN, Cornwall S, Grand RJ. Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption. Gastroenterology 1992; 102: 2139–2142
   PubMed Web of Science ®Google Scholar
• Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, Thompson C, Pedrosa MC, Diamond RD, Strollar BD. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 1997; 277: 1380–1386
   PubMed Web of Science ®Google Scholar
• Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH. Vitamin E and respiratory tract infections in elderly nursing home residents. A randomized controlled trial. JAMA 2004; 292: 828–836
   PubMed Web of Science ®Google Scholar
• De la Fuente M, Victor VM. Anti-oxidants as modulators of immune function. Immunol Cell Biol 2000; 78: 49–54
   PubMed Web of Science ®Google Scholar
• Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R, Blumberg JB. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 1990; 52: 557–563
   PubMed Web of Science ®Google Scholar
• De la Fuente M, Carazo M, Correa R, Del Rio M. Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion. Br J Nutr 2000; 84: 25–29
   PubMedGoogle Scholar
• Moriguchi S, Kobayashi N, Kishino Y. High dietary intakes of vitamin E and cellular immune functions in rats. J Nutr 1990; 120: 1096–1102
   PubMed Web of Science ®Google Scholar
• Del Rio M, Ruedas G, Medina S, Victor VM, De la Fuente M. Improvement by several antioxidants of macrophage function in vitro. Life Sci 1998; 63: 871–881
   PubMed Web of Science ®Google Scholar
• Ferrandez MD, Correa R, Del Rio M, De la Fuente M. Effects in vitro of several antioxidants on the natural killer function of aging mice. Exp Gerontol 1999; 34: 675–685
   PubMed Web of Science ®Google Scholar
• Sakamoto W, Nishihira J, Fujie K, Handa H, Ozaki M, Yukawa S. Inhibition of macrophage migration inhibitory factor secretion from macrophages by vitamin E. Biochim Biophys Acta 1998; 1404: 427–434
   PubMed Web of Science ®Google Scholar
• Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Muller-Hermelink HK, Steinmann GG. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 1984; 28: 47–55
   PubMed Web of Science ®Google Scholar
• McGregor R, Spagnoulo P, Lentnek A. Inhibition of granulocyte adherence by ethanol, prednisone and aspirin, measured with a new assay system. N Engl J Med 1974; 291: 642–646
   PubMed Web of Science ®Google Scholar
• De la Fuente, Carrasco M, Hernanz A. Modulation of human neutrophil function in vitro by gastrin. J Endocrinol 1997;153:475–483.
   PubMedGoogle Scholar
• De la Fuente M, Ferrandez MD, Burgos MS, Soler A, Prieto A, Miquel J. Immune function in aged women is improved by ingestion of vitamin C and E. Can J Pharmacol 1998; 76: 373–380
   Google Scholar
• Boyden SV. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J Exp Med 1962; 115: 453–456
   PubMed Web of Science ®Google Scholar
• Carrasco M, Hernanz A, De La Fuente M. Effect of cholecystokinin and gastrin on human peripheral blood lymphocyte functions, implication of cyclic AMP and interleukin 2. Regul Pept 1997; 70: 135–142
   PubMedGoogle Scholar
• Medina S, Del Rio M, Hernanz A, De la Fuente M. Age-related changes in the neuropeptide Y effects on murine lymphoproliferation and interleukin-2 production. Peptides 2000; 21: 1403–1409
   PubMedGoogle Scholar
• Miquel J, Economos AC. Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Exp Gerontol 1979; 14: 279–285
   PubMed Web of Science ®Google Scholar
• Weng NP. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006; 24: 491–494
   PubMedGoogle Scholar
• Ortega E, Garcia JJ, De La Fuente M. Ageing modulates some aspects of the non-specific immune response of murine macrophages and lymphocytes. Exp Physiol 2000; 85: 519–525
   PubMedGoogle Scholar
• Stout RD, Suttles J. Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes. Immunol Rev 2005; 205: 60–71
   PubMedGoogle Scholar
• Spaulding C, Guo W, Effros RB. Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol 1999; 34: 633–644
   PubMedGoogle Scholar
• Adolfsson O, Huber BT, Meydani SN. Vitamin E-enhanced IL-2 production in old mice: naïve but not memory T cells show increased cell division cycling and IL-2 producing capacity. J Immunol 2001; 167: 3809–3817
   PubMed Web of Science ®Google Scholar
• Marko MG, Ahmed T, Bunnell SC, Wu D, Chung H, Huber BT, Meydani SN. Age-associated decline in effective immune synapse formation of CD4(+) T cell is reversed by vitamin E supplementation. J Immunol 2007; 178: 1443–1449
   PubMed Web of Science ®Google Scholar
• Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Age and vitamin E-induced changes in gene expression profiles of T cells. J Immunol 2006; 177: 6052–6061
   PubMed Web of Science ®Google Scholar
• Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr 2005; 25: 151–174
   PubMed Web of Science ®Google Scholar