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Original Article

IDH2 knockdown sensitizes tumor cells to emodin cytotoxicity in vitro and in vivo

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Pages 1089-1097 | Received 03 Mar 2016, Accepted 12 Apr 2016, Published online: 12 May 2016

References

  • Feig DI, Reid TM, Loeb LA. Reactive oxygen species in tumorigenesis. Cancer Res 1994;54:1890s–1894s.
  • Nishikawa M. Reactive oxygen species in tumor metastasis. Cancer Lett 2008;266:53–59.
  • Laurent A, Nicco C, Chéreau C, Goulvestre C, Alexandre J, Alves A, et al. Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 2005;65:948–956.
  • Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007;47:143–183.
  • Fico A, Paglialunga F, Cigliano L, Abrescia P, Verde P, Martini G, et al. Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis. Cell Death Differ 2004;11:823–831.
  • Kirsch M, de Groot H. NAD(P)H, a directly operating antioxidant? FASEB J 2001;15:1569–1574.
  • Jo SH, Son MK, Koh HJ, Lee SM, Song IH, Kim YO, et al. Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. J Biol Chem 2001;276:16168–16176.
  • Lee JH, Kim SY, Kil IS, Park J-W. Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. J Biol Chem 2007;282:13385–13394.
  • Jung KH, Park J-W. Suppression of mitochondrial NADP+-dependent isocitrate dehydrogenase activity enhances curcumin-induced apoptosis in HCT116 cells. Free Rad Res 2011;45:431–438.
  • Cai J, Niu X, Chen Y, Hu Q, Shi G, Wu H, et al. Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. Neoplasia 2008;10:41–51.
  • Yi J, Yang J, He R, Gao F, Sang H, Tang X, Ye RD. Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Res 2004;64:108–116.
  • Wang W, Sun YP, Huang XZ, He M, Chen YY, Shi GY, et al. Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation. Biochem Pharmacol 2010;79:1134–1140.
  • Reers M, Smiley ST, Mottola-Hartshorn C, Chen A, Lin M, Chen LB. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol1995;260:406–417.
  • Araki M, Nanri H, Ejima K, Murasato Y, Fujiwara T, Nakashima Y, Ikeda M. Antioxidant function of the mitochondrial protein SP-22 in the cardiovascular system. J Biol Chem 1999;274:2271–2278.
  • Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha. J Biol Chem 1998;273:6297–6301.
  • Watabe S, Hasegawa H, Takimoto K, Yamamoto Y, Takahashi S. Possible function of SP-22, a substrate of mitochondrial ATP-dependent protease, as a radical scavenger. Biochem Biophys Res Commun 1995;213:1010–1016.
  • Knoops B, Clippe A, Bogard C, Arsalane K, Wattiez R, Hermans C, et al. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. J Biol Chem 1999;274:30451–30458.
  • Smyth GE, Colman RF. Cysteinyl peptides of pig heart NADP-dependent isocitrate dehydrogenase that are modified upon inactivation by N-ethylmaleimide. J Biol Chem 1991;266:14918–14925.
  • Fatania HR, al-Nassar KE, Thomas N. Chemical modification of rat liver cytosolic NADP(+)-linked isocitrate dehydrogenase by N-ethylmaleimide. Evidence for essential sulphydryl groups. FEBS Lett 1993;322:245–248.
  • Lee SM, Huh TL, Park J-W. Inactivation of NADP(+)-dependent isocitrate dehydrogenase by reactive oxygen species. Biochimie 2001;83:1057–1065.
  • Lee JH, Yang ES, Park J-W. Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. J Biol Chem 2003;278:51360–51371.
  • Yang JH, Yang ES, Park J-W. Inactivation of NADP+-dependent isocitrate dehydrogenase by lipid peroxidation products. Free Radic Res 2004;38:241–249.
  • Park HS, Park J-W. Fluorescent labeling of the leukocyte NADPH oxidase subunit p47phox: evidence for amphiphile-induced conformational changes. Arch Biochem Biophys 1998;360:165–172.
  • Vary TC, Lang CH. Differential phosphorylation of translational initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. Cardiovasc Toxicol 2008;8:23–32.
  • Tak JK, Park JW. The use of ebselen for radioprotection in cultured cells and mice. Free Radic Biol Med 2009;46:1177–1185.
  • de Grey AD. The reductive hotspot hypothesis: an update. Arch Biochem Biophys 2000;373:295–301.
  • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1998;1366:177–196.
  • Liu J, Mao W, Ding B, Liang C. ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol 2008;295:H1956–H1965.
  • Marín-García J, Akhmedov AT, Moe GW. Mitochondria in heart failure: the emerging role of mitochondrial dynamics. Heart Fail Rev 2013;18:439–456.

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