Mitochondrial dynamics altered by oxidative stress in cancer

References

• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029–1033.
   PubMed Web of Science ®Google Scholar
• Weinberg SE, Chandel NS. Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol 2015;11:9–15.
   PubMed Web of Science ®Google Scholar
• Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007;8:870–879.
   PubMed Web of Science ®Google Scholar
• Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001;1:515–525.
   PubMed Web of Science ®Google Scholar
• Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 2004;15:5001–5011.
   PubMed Web of Science ®Google Scholar
• Frank M, Duvezin-Caubet S, Koob S, Occhipinti A, Jagasia R, Petcherski A, et al. Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim Biophys Acta 2012;1823:2297–2310.
   PubMed Web of Science ®Google Scholar
• Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res 2008;79:341–351.
   PubMed Web of Science ®Google Scholar
• Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science 2012;337:1062–1065.
   PubMed Web of Science ®Google Scholar
• Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, et al. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J 2011;30:2762–2778.
   PubMed Web of Science ®Google Scholar
• Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010;191:1141–1158.
   PubMed Web of Science ®Google Scholar
• de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008;456:605–610.
   PubMed Web of Science ®Google Scholar
• Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A 2004;101:15927–15932.
   PubMed Web of Science ®Google Scholar
• John GB, Shang Y, Li L, Renken C, Mannella CA, Selker JM, et al. The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell 2005;16:1543–1554.
   PubMed Web of Science ®Google Scholar
• Gao Q, Frohman MA. Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis. BMB Rep 2012;45:7–13.
   PubMed Web of Science ®Google Scholar
• Boonstra J, Post JA. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004;337:1–13.
   PubMed Web of Science ®Google Scholar
• Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001;30:1191–1212.
   PubMed Web of Science ®Google Scholar
• Belia S, Santilli F, Beccafico S, De Feudis L, Morabito C, Davi G, et al. Oxidative-induced membrane damage in diabetes lymphocytes: effects on intracellular Ca(2+) homeostasis. Free Radic Res 2009;43:138–148.
   PubMed Web of Science ®Google Scholar
• Malik Q, Herbert KE. Oxidative and non-oxidative DNA damage and cardiovascular disease. Free Radic Res 2012;46:554–564.
   PubMed Web of Science ®Google Scholar
• Indo HP, Yen HC, Nakanishi I, Matsumoto K, Tamura M, Nagano Y, et al. A mitochondrial superoxide theory for oxidative stress diseases and aging. J Clin Biochem Nutr 2015;56:1–7.
   PubMed Web of Science ®Google Scholar
• Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 2006;103:2653–2658.
   PubMed Web of Science ®Google Scholar
• Wu S, Zhou F, Zhang Z, Xing D. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J 2011;278:941–954.
   PubMed Web of Science ®Google Scholar
• Fan X, Hussien R, Brooks GA. H2O2-induced mitochondrial fragmentation in C2C12 myocytes. Free Radic Biol Med 2010;49:1646–1654.
   PubMed Web of Science ®Google Scholar
• Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C. Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One 2011;6:e16746.
   PubMed Web of Science ®Google Scholar
• Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, et al. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J 2013;32:2348–2361.
   PubMed Web of Science ®Google Scholar
• Tang S, Le PK, Tse S, Wallace DC, Huang T. Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production. PLoS One 2009;4:e4492.
   PubMed Web of Science ®Google Scholar
• Park J, Choi C. Contribution of mitochondrial network dynamics to intracellular ROS signaling. Commun Integr Biol 2012;5:81–83.
   PubMedGoogle Scholar
• Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 2010;123:2533–2542.
   PubMed Web of Science ®Google Scholar
• Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010;11:872–884.
   PubMed Web of Science ®Google Scholar
• Archer SL. Mitochondrial dynamics – mitochondrial fission and fusion in human diseases. N Engl J Med 2013;369:2236–2251.
   PubMed Web of Science ®Google Scholar
• Kim B, Kim HS, Jung EJ, Lee JY, K Tsang B, Lim JM, Song YS. Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells. Mol Carcinog 2016;55:918–928.
   PubMed Web of Science ®Google Scholar
• Hong YH, Uddin MH, Jo U, Kim B, Song J, Suh DH, et al. ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis. Front Oncol 2015;5:167.
   PubMed Web of Science ®Google Scholar
• LeBleu VS, O’Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, et al. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol 2014;16:992–1003.
   PubMed Web of Science ®Google Scholar
• Vellinga TT, Borovski T, de Boer VC, Fatrai S, van Schelven S, Trumpi K, et al. SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer. Clin Cancer Res 2015;21:2870–2879.
   PubMed Web of Science ®Google Scholar
• Ferreira-da-Silva A, Valacca C, Rios E, Populo H, Soares P, Sobrinho-Simões M, et al. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS One 2015;10:e0122308.
   PubMed Web of Science ®Google Scholar
• Wan YY, Zhang JF, Yang ZJ, Jiang LP, Wei YF, Lai QN, et al. Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells. Oncol Rep 2014;32:619–626.
   PubMed Web of Science ®Google Scholar
• Elgass K, Pakay J, Ryan MT, Palmer CS. Recent advances into the understanding of mitochondrial fission. Biochim Biophys Acta 2013;1833:150–161.
   PubMed Web of Science ®Google Scholar
• Boldogh IR, Pon LA. Interactions of mitochondria with the actin cytoskeleton. Biochim Biophys Acta 2006;1763:450–462.
   PubMed Web of Science ®Google Scholar
• Zhao J, Zhang J, Yu M, Xie Y, Huang Y, Wolff DW, et al. Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Oncogene 2013;32:4814–4824.
   PubMed Web of Science ®Google Scholar
• Ballestrem C, Wehrle-Haller B, Hinz B, Imhof BA. Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration. Mol Biol Cell 2000;11:2999–3012.
   PubMed Web of Science ®Google Scholar
• Keller HU. Redundancy of lamellipodia in locomoting Walker carcinosarcoma cells. Cell Motil Cytoskeleton 2000;46:247–256.
   PubMed Web of Science ®Google Scholar
• Serasinghe MN, Wieder SY, Renault TT, Elkholi R, Asciolla JJ, Yao JL, et al. Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. Mol Cell 2015;57:521–536.
   PubMed Web of Science ®Google Scholar
• Xie Q, Wu Q, Horbinski CM, Flavahan WA, Yang K, Zhou W, et al. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci 2015;18:501–510.
   PubMed Web of Science ®Google Scholar
• Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006;443:658–662.
   PubMed Web of Science ®Google Scholar
• Boland ML, Chourasia AH, Macleod KF. Mitochondrial dysfunction in cancer. Front Oncol 2013;3:292.
   PubMedGoogle Scholar
• Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes Dev 2008;22:1577–1590.
   PubMed Web of Science ®Google Scholar
• Sheridan C, Delivani P, Cullen SP, Martin SJ. Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol Cell 2008;31:570–585.
   PubMed Web of Science ®Google Scholar
• Jeong SY, Seol DW. The role of mitochondria in apoptosis. BMB Rep 2008;41:11–22.
   PubMed Web of Science ®Google Scholar
• Qi X, Qvit N, Su YC, Mochly-Rosen D. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 2013;126:789–802.
   PubMed Web of Science ®Google Scholar
• Reddy PH. Increased mitochondrial fission and neuronal dysfunction in Huntington’s disease: implications for molecular inhibitors of excessive mitochondrial fission. Drug Discov Today 2014;19:951–955.
   PubMed Web of Science ®Google Scholar