The absence of the SOD1 gene causes abnormal monoaminergic neurotransmission and motivational impairment-like behavior in mice

References

• Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci 2012;322:254–262.
   PubMed Web of Science ®Google Scholar
• Fujiwara N, Nakano M, Kato S, Yoshihara D, Ookawara T, Eguchi H, et al. Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase. J Biol Chem 2007;282:35933–35944.
   PubMed Web of Science ®Google Scholar
• Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T. A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS. Hum Mol Genet 2015;24:3427–3439
   PubMed Web of Science ®Google Scholar
• Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res 2010;68:261–275.
   PubMed Web of Science ®Google Scholar
• Gałecki P, Szemraj J, Bieńkiewicz M, Florkowski A, Gałecka E. Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment. Pharmacol Rep 2009;61:436–447.
   PubMed Web of Science ®Google Scholar
• Lucca G, Comim CM, Valvassori SS, Réus GZ, Vuolo F, Petronilho F, et al. Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochem Int 2009;54:358–362.
   PubMed Web of Science ®Google Scholar
• Cline BH, Anthony DC, Lysko A, Dolgov O, Anokhin K, Schroeter C, et al. Lasting downregulation of the lipid peroxidation enzymes in the prefrontal cortex of mice susceptible to stress-induced anhedonia. Behav Brain Res 2015;276:118–129
   PubMed Web of Science ®Google Scholar
• Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 1996;93:9782–9787.
   PubMed Web of Science ®Google Scholar
• Watanabe K, Shibuya S, Ozawa Y, Nojiri H, Izuo N, Yokote K, Shimizu T. Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes. Biomed Res Int 2014;2014:140165.
   PubMed Web of Science ®Google Scholar
• Tsunoda S, Kawano N, Miyado K, Kimura N, Fujii J. Impaired fertilizing ability of superoxide dismutase 1-deficient mouse sperm during in vitro fertilization. Biol Reprod 2012;87:121.
   PubMed Web of Science ®Google Scholar
• Iuchi Y, Okada F, Onuma K, Onoda T, Asao H, Kobayashi M, Fujii J. Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production. Biochem J 2007;402:219–227.
   PubMed Web of Science ®Google Scholar
• Uchiyama S, Shimizu T, Shirasawa T. CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem 2006;281:31713–31719.
   PubMed Web of Science ®Google Scholar
• Sakiyama H, Fujiwara N, Yoneoka Y, Yoshihara D, Eguchi H, Suzuki K. Cu, Zn-SOD deficiency induces the accumulation of hepatic collagen. Free Radic Res 2016;50:666–677
   PubMed Web of Science ®Google Scholar
• Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci USA 1995;92:954–958.
   PubMed Web of Science ®Google Scholar
• Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, et al. SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease. J Biol Chem 2011;286:44557–44568.
   PubMed Web of Science ®Google Scholar
• Fornai F, Carrì MT, Ferri A, Paolucci E, Prisco S, Bernardi G, et al. Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu, Zn superoxide dismutase. Neurosci Lett 2002;325:124–128.
   PubMed Web of Science ®Google Scholar
• Saito A, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J Neurosci 2003;23:1710–1718.
   PubMed Web of Science ®Google Scholar
• Puig MV, Antzoulatos EG, Miller EK. Prefrontal dopamine in associative learning and memory. Neuroscience 2014;282C:217–229.
   PubMed Web of Science ®Google Scholar
• Seyedabadi M, Fakhfouri G, Ramezani V, Mehr SE, Rahimian R. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Exp Brain Res 2014;232:723–738
   PubMed Web of Science ®Google Scholar
• Meneses A, Perez-Garcia G, Ponce-Lopez T, Tellez R, Castillo C. Serotonin transporter and memory. Neuropharmacology 2011;61:355–363.
   PubMed Web of Science ®Google Scholar
• Yoshihara D, Fujiwara N, Ookawara T, Kato S, Sakiyama H, Yokoe S, et al. Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. Free Radic Biol Med 2009;47:559–567.
   PubMed Web of Science ®Google Scholar
• Yoshihara D, Fujiwara N, Kato S, Sakiyama H, Eguchi H, Suzuki K. Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency. Free Radic Res 2012;46:750–757.
   PubMed Web of Science ®Google Scholar
• Budzynska B, Boguszewska-Czubara A, Kruk-Slomka M, Skalicka-Wozniak K, Michalak A, Musik I, et al. Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice. Physiol Behav 2013;122:46–55.
   PubMed Web of Science ®Google Scholar
• Akita H, Matsuyama T, Iso H, Sugita M, Yoshida S. Effects of oxidative stress on the expression of limbic-specific protease neuropsin and avoidance learning in mice. Brain Res 1997;769:86–96.
   PubMed Web of Science ®Google Scholar
• Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, et al. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav 2004;3:287–302.
   PubMed Web of Science ®Google Scholar
• Nadler JJ, Moy SS, Dold G, Trang D, Simmons N, Perez A, et al. Automated apparatus for quantitation of social approach behaviors in mice. Genes Brain Behav 2004;3:303–314.
   PubMed Web of Science ®Google Scholar
• Fujiwara N, Iso H, Kitanaka N, Kitanaka J, Eguchi H, Ookawara T, et al. Effects of copper metabolism on neurological functions in Wistar and Wilson's disease model rats. Biochem Biophys Res Commun 2006;349:1079–1086.
   PubMed Web of Science ®Google Scholar
• Snyder SH, Hendley ED. A simple and sensitive fluorescence assay for monoamine oxidase and diamine oxidase. J Pharmacol Exp Ther 1968;163:386–392.
   PubMed Web of Science ®Google Scholar
• Kato T, Kuzuya H, Nagatsu T. A simple and sensitive assay for dopamine-beta-hydroxylase activity by dual-wavelength spectrophotometry. Biochem Med 1974;10:320–328.
   PubMed Web of Science ®Google Scholar
• Nagatsu T, Udenfriend S. Photometric assay of dopamine-hydroxylase activity in human blood. Clin Chem 1972;18:980–983.
   PubMed Web of Science ®Google Scholar
• Flood DG, Reaume AG, Gruner JA, Hoffman EK, Hirsch JD, Lin YG, et al. Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions. Am J Pathol 1999;155:663–672.
   PubMed Web of Science ®Google Scholar
• Brown DR, Clive C, Haswell SJ. Antioxidant activity related to copper binding of native prion protein. J Neurochem 2001;76:69–76.
   PubMed Web of Science ®Google Scholar
• Kralovicova S, Fontaine SN, Alderton A, Alderman J, Ragnarsdottir KV, Collins SJ, Brown DR. The effects of prion protein expression on metal metabolism. Mol Cell Neurosci 2009;41:135–147
   PubMed Web of Science ®Google Scholar
• Rahman MK, Choudhary MI, Arif M, Morshed MM. Dopamine-β-hydroxylase activity and levels of its cofactors and other biochemical parameters in the serum of arsenicosis patients of Bangladesh. Int J Biomed Sci 2014;10:52–60.
   PubMedGoogle Scholar
• Bromberg-Martin ES, Matsumoto M, Hikosaka O. Dopamine in motivational control: rewarding, aversive, and alerting. Neuron 2010;68:815–834.
   PubMed Web of Science ®Google Scholar
• Uchihara Y, Tanaka K, Asano T, Tamura F, Mizushima T. Superoxide dismutase overexpression protects against glucocorticoid-induced depressive-like behavioral phenotypes in mice. Biochem Biophys Res Commun 2016;469:873–877.
   PubMed Web of Science ®Google Scholar
• Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, et al. Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proc Natl Acad Sci USA 2013;110:12462–12467.
   PubMed Web of Science ®Google Scholar
• Salahpour A, Ramsey AJ, Medvedev IO, Kile B, Sotnikova TD, Holmstrand E, et al. Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proc Natl Acad Sci USA 2008;105:4405–4410.
   PubMed Web of Science ®Google Scholar
• Frisch C, Dere E, Silva MA, Godecke A, Schrader J, Huston JP. Superior water maze performance and increase in fear-related behavior in the endothelial nitric oxide synthase-deficient mouse together with monoamine changes in cerebellum and ventral striatum. J Neurosci 2000;20:6694–6700.
   PubMed Web of Science ®Google Scholar
• Romano A, Pace L, Tempesta B, Lavecchia AM, Macheda T, Bedse G, et al. Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer’s disease. Int J Neuropsychopharmacol 2014;18:pyu020. doi: 10.1093/ijnp/pyu020.
   PubMed Web of Science ®Google Scholar
• Garratt M, Brooks RC. A genetic reduction in antioxidant function causes elevated aggression in mice. J Exp Biol 2015;218:223–227.
   PubMed Web of Science ®Google Scholar
• Kim J, Wessling-Resnick M. Iron and mechanisms of emotional behavior. J Nutr Biochem 2014;25:1101–1107.
   PubMed Web of Science ®Google Scholar
• Rahman MK, Rahman F, Rahman T, Kato T. Dopamine-β-hydroxylase (DBH), its cofactors and other biochemical parameters in the serum of neurological patients in Bangladesh. Int J Biomed Sci 2009;5:395–401.
   PubMedGoogle Scholar
• Beard JL, Felt B, Schallert T, Burhans M, Connor JR, Georgieff MK. Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res 2006;170:224–232.
   PubMed Web of Science ®Google Scholar
• Felt BT, Beard JL, Schallert T, Shao J, Aldridge JW, Connor JR, et al. Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats. Behav Brain Res 2006;171:261–270.
   PubMed Web of Science ®Google Scholar
• Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000;105:E51.
   PubMed Web of Science ®Google Scholar
• Ward MS, Lamb J, May JM, Harrison FE. Behavioral and monoamine changes following severe vitamin C deficiency. J Neurochem 2013;124:363–375
   PubMed Web of Science ®Google Scholar
• Kawai K, Ito H, Kubota H, Takemori K, Makino S, Horio F. Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid. Life Sci 2003;72:1717–1732.
   PubMed Web of Science ®Google Scholar
• Sentman ML, Granström M, Jakobson H, Reaume A, Basu S, Marklund SL. Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase. J Biol Chem 2006;281:6904–6909.
   PubMed Web of Science ®Google Scholar