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Original Article

Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions

ORCID Icon, , , & ORCID Icon
Pages 198-209 | Received 29 Sep 2018, Accepted 21 Dec 2018, Published online: 16 Jan 2019

References

  • Reiter RJ, Tan DX, Sainz RM, et al. Melatonin: reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 2002;54:1299–1321.
  • Stehle J, Reuss S, Riemann R, et al. The role of arginine-vasopressin for pineal melatonin synthesis in the rat: involvement of vasopressinergic receptors. Neurosci Lett. 1991;123:131–134.
  • Rodriguez C, Mayo JC, Sainz RM, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res. 2004;36:1–9.
  • Cagnacci A, Cannoletta M, Renzi A, et al. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hypertens. 2005;18:1614–1618.
  • Maarman GJ, Reiter RJ. Melatonin therapy for blunt trauma and strenuous exercise: a mechanism involving cytokines, NFκB, Akt, MAFBX and MURF-1. J Sports Sci. 2018;36:1897–1901.
  • Reiter RJ, Mayo JC, Tan DX, et al. Melatonin as an antioxidant: under promises but over delivers. J Pineal Res. 2016;61:253–278.
  • Tan DX, Chen LD, Poeggeler B, et al. Melatonin: a potent, endogenous hydroxyl radical scavenger. J Endocrinol. 1993;1:57–60.
  • Gedikli S, Gelen V, Sengul E, et al. Therapeutic effects of melatonin on liver and kidney damages in intensive exercise model of rats. EMIDDT. 2015;15:308–314.
  • Leonardo-Mendonça RC, Ocaña-Wilhelmi J, de Haro T, et al. The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes. Appl Physiol Nutr Metab. 2017;42:700–707.
  • Ochoa JJ, Díaz-Castro J, Kajarabille N, et al. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J Pineal Res. 2011;51:373–380.
  • Ji LL. Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med. 1999;222:283–292.
  • Maldonado MD, Manfredi M, Ribas-Serna J, et al. Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players. Physiol Behav. 2012;105:1099–1103.
  • Reiter RJ, Tan DX, Mayo JC, et al. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 2003;50:1129–1146.
  • Borges LdS, Dermargos A, Junior EPdS, et al. Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis. J Pineal Res. 2015; 58:166–172.
  • Pedersen BK, Akerström TCA, Nielsen AR, et al. Role of myokines in exercise and metabolism. J Appl Physiol. 2007;103:1093–1098.
  • Plomgaard P, Penkova M, Pedersen BK. Fiber type specific expression of TNF-alpha, IL-6 and IL-8 in human skeletal muscles. Exerc Immunol Rev. 2005;11:53–63.
  • Djordjevic DZ, Cubrilo DG, Puzovic VS, et al. Changes in athlete’s redox state induced by habitual and unaccustomed exercise. Oxid Med Cell Longev. 2012;2012:1–7.
  • Jackson MJ, Edwards RHT, Symons MCR. Electron spin resonance studies of intact mammalian skeletal muscle. Biochim Biophys Acta. 1985;847:185–190.
  • Mastaloudis A, Morrow JD, Hopkins DW, et al. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radical Biol Med. 2004;36:1329–1341.
  • Marzatico F, Pansarasa O, Bertorelli L, et al. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performance in highly trained aerobic and sprint athletes. J Sports Med Phys Fit. 1997;37:235–239.
  • Lu SC. Glutathione synthesis. Biochim Biophys Acta 2013;1830:3143–3153.
  • Beutler E. Red cell metabolism. In: Beutler E, editor. Red cell metabolism. A manual of biochemical methods. New York: Grune-Stratton; 1971. p. 103–105.
  • Placer ZA, Cushman LL, Johnson BC. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 1966;16:359–364.
  • Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158–169.
  • Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170–3175.
  • Flohe L, Gunzler W. Assays of glutathione peroxidase. Methods Enzymol. 1984;105:114–121.
  • Drabkin DL. The crystallographic and optical properties of the haemoglobin of man in comparison with those of other species. J Biol Chem. 1946;164:703–723.
  • Buxton OM, L’Hermite-Balériaux ML, Hirschfeld U, et al. Acute and delayed effects of exercise on human melatonin secretion. J Biol Rhythm. 1997;12:568–574.
  • Skrinar GS, Bullen BA, Reppert SM, et al. Melatonin response to exercise training in women. J Pineal Res. 1989;7:185–194.
  • Monteleone P, Maj M, Fusco M, et al. Physical exercise at night blunts the nocturnal increase of plasma melatonin levels in healthy humans. Life Sci. 1990;47:1989–1995.
  • Monteleone P, Maj M, Fuschino A, et al. Physical stress in the middle of the dark phase does not affect light-depressed plasma melatonin levels in humans. Neuroendocrinology. 1992;55:367–371.
  • Miyazaki T, Hashimoto S, Masubuchi S, et al. Phase-advance shifts of human circadian pacemaker are accelerated by daytime physical exercise. Am J Physiol Regul Integr Comp Physiol. 2001;281:R197–R205.
  • Escames G, Ozturk G, Baño-Otálora B, et al. Exercise and melatonin in humans: reciprocal benefits. J Pineal Res. 2012;52:1–11.
  • Chahbouni M, Escames G, López LC, et al. Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy. Clin Biochem. 2011;44:853–858.
  • Leonardo-Mendonça RC, Concepción-Huertas M, Guerra-Hernández E, et al. Redox status and antioxidant response in professional cyclists during training. Eur J Sport Sci. 2014;14:830–838.
  • Urata Y, Honma S, Goto S, et al. Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells. Free Radic Biol Med. 1999;27:838–847.
  • Brites FD, Evelson PA, Christiansen MG, et al. Soccer players under regular training show oxidative stress but an improved plasma antioxidant status. Clin Sci. 1999;96:381–385.
  • Djordjevic D, Cubrilo D, Macura M, et al. The influence of training status on oxidative stress in young male handball players. Mol Cell Biochem. 2011;351:251–259.
  • Ji LL. Antioxidant enzyme response to exercise and aging. Med Sci Sports Exerc. 1993;25:225–231.
  • Powers SK, Criswell D, Lawler J, et al. Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am J Physiol. 1993;265:2094–2098.
  • Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metabol. 1999;84:2603–2607.
  • Garfinkel D, Laudon M, Nof D, et al. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet. 1995;346:541–544.
  • Reiter RJ, Tan DX, Galano A. Melatonin: exceeding expectations. Physiology. 2014;29:325–333.

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