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Original Articles

Antipsychotic drugs scavenge radiation-induced hydroxyl radicals and intracellular ROS formation, and protect apoptosis in human lymphoma U937 cells

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Pages 304-312 | Received 15 Nov 2018, Accepted 04 Jan 2019, Published online: 04 Feb 2019

References

  • Lieberman JA, Bymaster FP, Meltzer HY, et al. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol Rev. 2008;60:358–403.
  • Park SW, Lee CH, Lee JG, et al. Protective effects of atypical antipsychotic drugs against MPP(+)-induced oxidative stress in PC12 cells. Neurosci Res. 2011;69:283–290.
  • Brinholi FF, Farias CCD, Bonifácio KL, et al. Clozapine and olanzapine are better antioxidants than haloperidol, quetiapine, risperidone and ziprasidone in in vitro models. Biomed Pharmacother. 2016;81:411–415.
  • Zeng Z, Wang X, Bhardwaj SK, et al. The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway. Mol Neurobiol. 2017;54:3395–3406.
  • Andersen JK. Oxidative stress in neurodegeneration: cause or consequence? Nat Med. 2004;10:(Suppl):S18–S25.
  • Birben E, Sahiner UM, Sackesen C, et al. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5:9–19.
  • Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 2nd ed. Clarendon Press: Oxford; 1989. p. 22–85.
  • Ciobica A, Padurariu M, Dobrin I, et al. Oxidative stress in schizophrenia – focusing on the main markers. Psychiatr Danub. 2011;23:237–245.
  • Reddy R, Reddy R. Antioxidant therapeutics for schizophrenia. Antioxid Redox Signal. 2011;15:2047–2055.
  • Koga M, Serritella AV, Sawa A, et al. Implications for reactive oxygen species in schizophrenia pathogenesis. Schizophr Res. 2016;176:52–71.
  • Joshi YB, Praticò D. Lipid peroxidation in psychiatric illness: overview of clinical evidence. Oxid Med Cell Longev. 2014;2014:1.
  • Sadowska-Bartosz I, Galiniak S, Bartosz G, et al. Antioxidant properties of atypical antipsychotic drugs used in the treatment of schizophrenia. Schizophr Res. 2016;176:245–251.
  • Wu JQ, Kosten TR, Zhang XY. Free radicals, antioxidant defense systems, and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013;46:200–206.
  • Clay HB, Sillivan S, Konradi C. Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci. 2011;29:311–324.
  • Gu F, Chauhan V, Chauhan A. Glutathione redox imbalance in brain disorders. Curr Opin Clin Nutr Metab Care. 2015;18:89–95.
  • Monin A, Baumann PS, Griffa A, et al. Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients. Mol Psychiatry 2015;20(7):827–838.
  • Sarandol A, Kirli S, Akkaya C, et al. Oxidative-antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia: effects of short term antipsychotic treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1164–1169.
  • Gilca M, Piriu G, Gaman L, et al. A study of antioxidant activity in patients with schizophrenia taking atypical antipsychotics. Psychopharmacology (Berl). 2014;231:4703–4710.
  • Wang H, Xu H, Dyck LE, Li XM. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis. J Neurosci Res. 2005;81:572–580.
  • Magliaro BC, Saldanha CJ. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res. 2009;1283:14–24.
  • Zhao QL, Fujiwara Y, Kondo T. Synergistic induction of apoptosis and caspase-independent autophagic cell death by a combination of nitroxide Tempo and heat shock in human leukemia U937 cells. Apoptosis. 2010;15:1270–1283.
  • Wu LH, Li P, Zhao QL, et al. Arbutin, an intracellular hydroxyl radical scavenger, protects radiation-induced apoptosis in human lymphoma U937 cells. Apoptosis. 2014;19:1654–1663.
  • Buxton GV, Greenstock CL, Helman WP, et al. Critical review of rate constants for reactions for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (・OH/・O−) in aqueous solution. J Phys Chem Ref Data. 1988;17:513–886.
  • Kojima Y, Kondo T, Zhao QL, et al. Protective effects of cimetidine on radiation-induced micronuclei and apoptosis in human peripheral blood lymphocytes. Free Radic Res. 2002;36:255–263.
  • Setsukinai KI, Urano Y, Kakinuma K, et al. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem. 2003;278:3170–3175.
  • Li P, Zhao QL, Jawaid P, et al. Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells. Int J Hyperthermia. 2017;22:1–11.
  • Lu TH, Hsieh SY, Yen CC, et al. Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicol Lett. 2011;204:71–80.
  • Huang SM, Cheung CW, Chang CS, et al. Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer. J Cell Biochem. 2011;112:643–652.
  • Han J, Back SH, Hur J, et al. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013;15:481–490.
  • Li Y, Guo Y, Tang J, et al. New insights into the roles of CHOP-induced apoptosis in ER stress. Acta Biochim Biophys Sin (Shanghai). 2014;46:629–640.
  • Motoori S, Majima HJ, Ebara M, et al. Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE. Cancer Res. 2001;61:5382–5388. [PubMed: 11454680].
  • Indo HP, Inanami O, Koumura T, et al. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radic Res. 2012;46:1029–1043.
  • Wei Z, Bai O, Richardson JS, et al. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J Neurosci Res. 2003;73:364–368.
  • Qing H, Xu H, Wei Z, et al. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis. Eur J Neurosci. 2003;17:1563–1570.
  • Kim NR, Park SW, Lee JG, et al. Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH − SY5Y cells. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:633–642.
  • Verheij M, Ruiter GA, Zerp SF, et al. The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis. Radiother Oncol. 1998;47:225–232.
  • Chen YR, Tan TH. The c-Jun N-terminal kinase pathway and apoptotic signaling (review). Int J Oncol. 2000;16:651–662.
  • Choi AY, Choi JH, Lee JY, et al. Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis. Neurochem Int. 2010;57:143–152.
  • Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381–389.
  • Miyazaki Y, Kaikita K, Endo M, et al. C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. Arterioscler Thromb Vasc Biol. 2011;31:1124–1132.
  • McCullough KD, Martindale JL, Klotz LO, et al. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001;21:1249–1259.

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