15-Deoxy-Δ^12,14-prostaglandin J₂ up-regulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation

References

• Hugo HJ, Saunders C, Ramsay RG, et al. New insights on COX-2 in chronic inflammation driving breast cancer growth and metastasis. J Mammary Gland Biol Neoplasia. 2015;20:109–119.
   PubMed Web of Science ®Google Scholar
• Gawthorpe S, Brown JE, Arif M, et al. Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors. Anticancer Res. 2014;34:2797–2800.
   PubMed Web of Science ®Google Scholar
• Zhang X, Yang L, Chien S, et al. Suspension state promotes metastasis of breast cancer cells by up-regulating cyclooxygenase-2. Theranostics. 2018;8:3722–3736.
   PubMed Web of Science ®Google Scholar
• Chang SH, Liu CH, Conway R, et al. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci USA. 2004;101:591–596.
   PubMed Web of Science ®Google Scholar
• Zha S, Yegnasubramanian V, Nelson WG, et al. Cyclooxygenases in cancer: progress and perspective. Cancer Lett. 2004;215:1–20.
   PubMed Web of Science ®Google Scholar
• Liu Z, Wang X, Lu Y, et al. Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. Carcinogenesis. 2008;29:1219–1227.
   PubMed Web of Science ®Google Scholar
• Tai HH, Ensor CM, Tong M, et al. Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat. 2002;68–69:483–493.
   PubMed Web of Science ®Google Scholar
• Tai H, Cho H, Tong M, et al. NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions. Curr Pharm Des. 2006;12:955–962.
   PubMed Web of Science ®Google Scholar
• Yan M, Rerko RM, Platzer P, et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGFβ-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci USA. 2004;101:17468–17473.
   PubMed Web of Science ®Google Scholar
• Backlund MG, Mann JR, Holla VR, et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem. 2005;280:3217–3223.
   PubMed Web of Science ®Google Scholar
• Ding Y, Tong M, Liu S, et al. NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Carcinogenesis. 2004;26:65–72.
   PubMed Web of Science ®Google Scholar
• Wolf I, O'Kelly J, Rubinek T, et al. 15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res. 2006;66:7818–7823.
   PubMed Web of Science ®Google Scholar
• Thiel A, Ganesan A, Mrena J, et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. Clin Cancer Res. 2009;15:4572–4580.
   PubMed Web of Science ®Google Scholar
• Tong M, Ding Y, Tai HH. Histone deacetylase inhibitors and transforming growth factor-β induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Biochem Pharmacol. 2006;72:701–709.
   PubMed Web of Science ®Google Scholar
• Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene. 2002;21:5427–5440.
   PubMed Web of Science ®Google Scholar
• Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacol. 2013;38:23–38.
   PubMed Web of Science ®Google Scholar
• Pathania R, Ramachandran S, Elangovan S, et al. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. Nat Commun. 2015;6:6910.
   PubMed Web of Science ®Google Scholar
• Wang P, Chu W, Zhang X, et al. Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development. Int J Biochem Cell Biol. 2018;105:41–51.
   PubMed Web of Science ®Google Scholar
• Jahangiri R, Jamialahmadi K, Gharib M, et al. Expression and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in tamoxifen-treated breast cancer patients. Gene. 2019;685:24–31.
   PubMed Web of Science ®Google Scholar
• Xia D, Wang D, Kim SH, et al. Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med. 2012;18:224–226.
   PubMed Web of Science ®Google Scholar
• Clark SJ, Melki J. DNA methylation and gene silencing in cancer: which is the guilty party? Oncogene. 2002;21:5380–5387.
   PubMed Web of Science ®Google Scholar
• Walton TJ, Li G, Seth R, et al. DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor β and induce apoptosis in prostate cancer cell-lines. Prostate. 2008;68:210–222.
   PubMed Web of Science ®Google Scholar
• Subramaniam D, Thombre R, Dhar A, et al. DNA methyltransferases: a novel target for prevention and therapy. Front Oncol. 2014;4:80.
   PubMedGoogle Scholar
• Shin SW, Seo CY, Han H, et al. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. Clin Cancer Res. 2009;15:5414–5425.
   PubMed Web of Science ®Google Scholar
• Shen D, Deng C, Zhang M. Peroxisome proliferator-activated receptor γ agonists inhibit the proliferation and invasion of human colon cancer cells. Postgrad Med J. 2007;83:414–419.
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Ethridge RT, Evers BM. Peroxisome proliferator-activated receptor γ ligand inhibits cell growth and invasion of human pancreatic cancer cells. Int J Gastrointest Cancer. 2002;32:7–22.
   PubMedGoogle Scholar
• Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 2000;403:103–108.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Yamamoto T, Koma H, et al. Synergistic effects of 15-deoxy-Δ12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma. Biochem Biophys Rep. 2017;9:61–66.
   PubMedGoogle Scholar
• Kim HR, Lee HN, Lim K, et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells. Mutat Res. 2014;768:6–15.
   PubMed Web of Science ®Google Scholar
• Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9:2395–2402.
   PubMed Web of Science ®Google Scholar
• Surh YJ, Na HK, Park JM, et al. 15-Deoxy-Δ12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. Biochem Pharmacol. 2011;82:1335–1351.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Tanaka R, Hamada S, et al. Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors. Bioorg Med Chem Lett. 2010;20:1124–1127.
   PubMed Web of Science ®Google Scholar
• Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31:27–36.
   PubMed Web of Science ®Google Scholar
• Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042–2054.
   PubMed Web of Science ®Google Scholar
• Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov. 2006;5:37–50.
   PubMed Web of Science ®Google Scholar
• Na HK, Surh YJ. Peroxisome proliferator-activated receptor γ (PPARγ) ligands as bifunctional regulators of cell proliferation. Biochem Pharmacol. 2003;66:1381–1391.
   PubMed Web of Science ®Google Scholar
• Niki E. Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med. 2009;47:469–484.
   PubMed Web of Science ®Google Scholar
• Kim EH, Na HK, Kim DH, et al. 15-Deoxy-Δ12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. Carcinogenesis. 2008;29:688–695.
   PubMed Web of Science ®Google Scholar
• Kim DH, Kim JH, Kim EH, et al. 15-Deoxy-Δ12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. Carcinogenesis. 2009;30:645–654.
   PubMed Web of Science ®Google Scholar
• Lin TH, Tang CH, Wu K, et al. 15-Deoxy-Δ12,14-prostaglandin J2 and ciglitazone inhibit TNFα-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. J Cell Physiol. 2011;226:3242–3250.
   PubMed Web of Science ®Google Scholar
• Kim W, Lee HN, Jang JH, et al. 15-Deoxy-Δ12,14-prostaglandin J2 exerts proresolving effects through nuclear factor E2-related factor 2 -induced expression of CD36 and heme oxygenase-1. Antioxid Redox Signal. 2017;27:1412–1431.
   PubMed Web of Science ®Google Scholar
• Powell WS. 15-Deoxy-Δ12,14-prostaglandin J2: endogenous PPARγ ligand or minor eicosanoid degradation product? J Clin Invest. 2003;112:828–830.
   PubMed Web of Science ®Google Scholar
• Engdahl R, Monroy MA, Daly JM. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-α by decreasing levels of acetylated histone H3 and H4 at its promoter. Biochem Biophys Res Commun. 2007;359:88–93.
   PubMed Web of Science ®Google Scholar
• Uchida K, Shibata T. 15-Deoxy-Δ12,14-prostaglandin J2: an electrophilic trigger of cellular responses. Chem Res Toxicol. 2008;21:138–144.
   PubMed Web of Science ®Google Scholar
• Kantarjian H, Issa JPJ, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006;106:1794–1803.
   PubMed Web of Science ®Google Scholar
• Blum W, Marcucci G. Targeting epigenetic changes in acute myeloid leukemia. Clin Adv Hematol Oncol. 2005;3:855–865.
   PubMedGoogle Scholar
• Guibert S, Weber M. Functions of DNA methylation and hydroxymethylation in mammalian development. Curr Top Dev Biol. 2013;104:47–83.
   PubMed Web of Science ®Google Scholar
• Kim BG, Gao MQ, Kang S, et al. Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation. Cell Death Dis. 2017;8:e2646.
   PubMed Web of Science ®Google Scholar
• Pang Y, Liu J, Li X, et al. MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer. J Cell Mol Med. 2018;22:6262–6274.
   PubMed Web of Science ®Google Scholar
• Williams K, Christensen J, Pedersen MT, et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011;473:343–348.
   PubMed Web of Science ®Google Scholar